creatinine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    60-27-5

    Molecular formula
    C4H7N3O

    SMILES
    CN1CC(=O)N=C1N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 54.4%
    Nutty 35.73%
    Roasted 34.33%
    Popcorn 31.15%
    Burnt 26.13%
    Sweet 24.95%
    Caramellic 20.94%
    Meaty 20.83%
    Fishy 20.74%
    Savory 19.16%

     

    Flavor
    Bitter 44.64%
    Nutty 31.09%
    Roasted 31.03%
    Odorless 24.93%
    Taco 21.96%
    Cooked 21.76%
    Roast 21.37%
    Roasted peanuts 20.77%
    Bread crust 20.62%
    Shellfish 19.56%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.8

    pKa est.
    8.61 (weak base)

    Molecular weight
    113.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    345°C

    Melting point expt.

    • 303 °C (decomposes)

    Flash point

    • 103.4 ˚C est.

    Solubility expt.

    • 80.1 mg/mL at 16 °C

  • Synonyms

    • 2-Imino-1-methylimidazolidin-4-one
    • 1-Methylglycocyamidine
    • 1-Methylhydantoin-2-imide
    • Creatinine,heated
    • Kreatininum
    • 2-amino-3-methyl-4H-imidazol-5-one
    • 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-
    • NSC-13123
    • NSC13123
    • AYI8EX34EU
    • CHEBI:16737
    • Salt, Creatinine Sulfate
    • Sulfate Salt, Creatinine
    • RefChem:5708
    • 200-466-7
    • 60-27-5
    • creatinine
    • DTXCID6025987
    • DTXSID8045987
    • Krebiozen
    • Kreatinin
    • 2-amino-1-methyl-1,5-dihydro-4H-imidazol-4-one
    • 2-Amino-1,5-dihydro-1-methyl-4H-imidazol-4-one
    • 2-Amino-1-methyl-2-imidazolin-4-one
    • Creatinine (VAN) (8CI)
    • 4H-Imidazol-4-one, 2-imino-1,5-dihydro-1-methyl-
    • creatinina
    • Creatinine, anhydrous
    • Spectrum_000429
    • CREATININE [II]
    • CREATININE [MI]
    • Spectrum2_000764
    • Spectrum3_001717
    • Spectrum4_001806
    • Spectrum5_000511
    • bmse000155
    • bmse000789
    • bmse001001
    • CREATININE [MART.]
    • CREATININE [USP-RS]
    • CREATININE [WHO-DD]
    • BSPBio_003334
    • KBioGR_002415
    • KBioSS_000909
    • MLS001306430
    • CHEMBL65567
    • DivK1c_000351
    • SPECTRUM1600300
    • SPBio_000808
    • orb1310556
    • Creatinine, anhydrous, >=98%
    • HMS501B13
    • KBio1_000351
    • KBio2_000909
    • KBio2_003477
    • KBio2_006045
    • KBio3_002554
    • NINDS_000351
    • Creatinine, 98.5-102.0%
    • HMS2233P20
    • HMS3372L11
    • Pharmakon1600-01600300
    • BB_NC-00783
    • CCG-40153
    • MSK001352
    • NSC760435
    • s3102
    • STK530885
    • STL268897
    • 2-Imino-1-methyl-imidazolidin-4-one
    • AKOS000121140
    • AKOS005458367
    • 2-Imino-1-methyl-4-imidazolidinone #
    • Creatinine, NIST(R) SRM(R) 914a
    • NSC-760435
    • SDCCGMLS-0066864.P001
    • IDI1_000351
    • NCGC00095762-02
    • NCGC00247664-01
    • 4H-Imidazol-4-one,5-dihydro-1-methyl-
    • AS-12671
    • SMR000718791
    • MSK001352-100000-5ml
    • IMIDAZOLIDIN-4-ONE, 2-IMINO-1-METHYL
    • 2-amino-1-methyl-1,5-dihydro-imidazol-4-one
    • C00791
    • D03600
    • AB00052404_03
    • AB00052404_04
    • 059C730
    • 2-amino-3-methyl-4H-imidazol-5-one,dichlorozinc
    • 2-amino-4,5-dihydro-1-methyl-1H-imidazol-4-one
    • 2-Imino-1,5-dihydro-1-methyl-4H-imidazol-4-one
    • AO-840/40806907
    • SR-01000837526
    • SR-01000837526-3
    • BRD-K13495773-001-11-4
    • BRD-K13495773-001-12-2
    • F0001-1578
    • C5CF605C-9352-48F2-A5A4-561B97D42C30
    • Creatinine, United States Pharmacopeia (USP) Reference Standard
    • Creatinine, Pharmaceutical Secondary Standard; Certified Reference Material
    • InChI=1/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8
    • 2-Amino-1-methyl-2-imidazolin-4-one, 2-Imino-1-methylimidazolidin-4-one, 2-Imino-N-methylhydantoin
    • 60-27-5

  • Applications

    creatinine (CAS 60-27-5) is primarily used as a clinical biomarker for kidney function, measured in serum, plasma, or urine to estimate glomerular filtration rate and monitor renal status. In analytical and clinical laboratories, it is commonly used as a calibration standard or reference material for quantifying creatinine or related metabolites, using LC-MS/MS or HPLC methods. In research settings, creatinine serves as a biomarker of muscle metabolism and renal clearance and is frequently encountered in urine-based metabolomics studies. In analytical workflows, creatinine or isotopically labeled analogs such as creatinine-d3 can function as internal standards to improve quantification accuracy. Applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 67.85
    methanol 200.39
    isopropanol 26.94
    water 677.09
    ethyl acetate 4.81
    n-propanol 28.75
    acetone 12.69
    n-butanol 15.7
    acetonitrile 15.59
    DMF 181.06
    toluene 1.17
    isobutanol 15.36
    1,4-dioxane 9.42
    methyl acetate 8.57
    THF 21.23
    2-butanone 7.52
    n-pentanol 6.67
    sec-butanol 14.23
    n-hexane 0.15
    ethylene glycol 118.06
    NMP 136.48
    cyclohexane 0.18
    DMSO 119.97
    n-butyl acetate 1.73
    n-octanol 1.6
    chloroform 14.22
    n-propyl acetate 1.59
    acetic acid 134.87
    dichloromethane 17.72
    cyclohexanone 11.12
    propylene glycol 82.32
    isopropyl acetate 2.13
    DMAc 136.71
    2-ethoxyethanol 31.26
    isopentanol 8.2
    n-heptane 0.14
    ethyl formate 18.2
    1,2-dichloroethane 6.13
    n-hexanol 3.36
    2-methoxyethanol 149.37
    isobutyl acetate 0.96
    tetrachloromethane 3.48
    n-pentyl acetate 2.2
    transcutol 19.39
    n-heptanol 2.88
    ethylbenzene 0.44
    MIBK 2.53
    2-propoxyethanol 18.43
    tert-butanol 13.18
    MTBE 1.83
    2-butoxyethanol 12.62
    propionic acid 37.7
    o-xylene 1.34
    formic acid 606.88
    diethyl ether 2.12
    m-xylene 1.26
    p-xylene 0.94
    chlorobenzene 2.34
    dimethyl carbonate 8.32
    n-octane 0.08
    formamide 460.69
    cyclopentanone 21.2
    2-pentanone 4.65
    anisole 1.81
    cyclopentyl methyl ether 4.96
    gamma-butyrolactone 40.79
    1-methoxy-2-propanol 54.6
    pyridine 12.37
    3-pentanone 3.25
    furfural 63.3
    n-dodecane 0.06
    diethylene glycol 36.95
    diisopropyl ether 0.4
    tert-amyl alcohol 9.77
    acetylacetone 6.24
    n-hexadecane 0.06
    acetophenone 3.46
    methyl propionate 8.96
    isopentyl acetate 1.69
    trichloroethylene 16.48
    n-nonanol 1.5
    cyclohexanol 5.91
    benzyl alcohol 5.91
    2-ethylhexanol 1.33
    isooctanol 2.05
    dipropyl ether 0.9
    1,2-dichlorobenzene 2.74
    ethyl lactate 5.22
    propylene carbonate 16.96
    n-methylformamide 159.06
    2-pentanol 5.16
    n-pentane 0.24
    1-propoxy-2-propanol 8.25
    1-methoxy-2-propyl acetate 4.3
    2-(2-methoxypropoxy) propanol 8.52
    mesitylene 0.73
    ε-caprolactone 12.67
    p-cymene 0.65
    epichlorohydrin 27.26
    1,1,1-trichloroethane 4.38
    2-aminoethanol 128.98
    morpholine-4-carbaldehyde 71.06
    sulfolane 54.32
    2,2,4-trimethylpentane 0.12
    2-methyltetrahydrofuran 8.78
    n-hexyl acetate 2.22
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 10.32
    sec-butyl acetate 0.88
    tert-butyl acetate 1.97
    decalin 0.1
    glycerin 157.73
    diglyme 18.45
    acrylic acid 60.28
    isopropyl myristate 0.67
    n-butyric acid 26.45
    acetyl acetate 3.76
    di(2-ethylhexyl) phthalate 2.79
    ethyl propionate 1.81
    nitromethane 115.8
    1,2-diethoxyethane 1.78
    benzonitrile 5.19
    trioctyl phosphate 1.68
    1-bromopropane 2.08
    gamma-valerolactone 47.58
    n-decanol 1.03
    triethyl phosphate 1.79
    4-methyl-2-pentanol 2.26
    propionitrile 7.47
    vinylene carbonate 20.74
    1,1,2-trichlorotrifluoroethane 69.72
    DMS 3.42
    cumene 0.46
    2-octanol 1.31
    2-hexanone 1.63
    octyl acetate 1.26
    limonene 0.79
    1,2-dimethoxyethane 16.42
    ethyl orthosilicate 1.5
    tributyl phosphate 1.7
    diacetone alcohol 9.22
    N,N-dimethylaniline 2.21
    acrylonitrile 18.04
    aniline 6.98
    1,3-propanediol 95.25
    bromobenzene 1.53
    dibromomethane 6.93
    1,1,2,2-tetrachloroethane 11.79
    2-methyl-cyclohexyl acetate 1.66
    tetrabutyl urea 2.69
    diisobutyl methanol 0.81
    2-phenylethanol 4.2
    styrene 0.49
    dioctyl adipate 1.56
    dimethyl sulfate 24.54
    ethyl butyrate 1.54
    methyl lactate 23.43
    butyl lactate 4.98
    diethyl carbonate 1.38
    propanediol butyl ether 13.3
    triethyl orthoformate 1.5
    p-tert-butyltoluene 0.61
    methyl 4-tert-butylbenzoate 5.79
    morpholine 22.78
    tert-butylamine 3.91
    n-dodecanol 0.7
    dimethoxymethane 27.67
    ethylene carbonate 12.21
    cyrene 16.82
    2-ethoxyethyl acetate 4.09
    2-ethylhexyl acetate 1.25
    1,2,4-trichlorobenzene 4.0
    4-methylpyridine 10.02
    dibutyl ether 0.55
    2,6-dimethyl-4-heptanol 0.81
    DEF 14.01
    dimethyl isosorbide 11.44
    tetrachloroethylene 9.8
    eugenol 8.17
    triacetin 3.78
    span 80 7.76
    1,4-butanediol 26.77
    1,1-dichloroethane 5.32
    2-methyl-1-pentanol 4.19
    methyl formate 79.3
    2-methyl-1-butanol 9.83
    n-decane 0.09
    butyronitrile 7.23
    3,7-dimethyl-1-octanol 1.29
    1-chlorooctane 0.36
    1-chlorotetradecane 0.16
    n-nonane 0.08
    undecane 0.07
    tert-butylcyclohexane 0.09
    cyclooctane 0.08
    cyclopentanol 16.12
    tetrahydropyran 4.13
    tert-amyl methyl ether 2.03
    2,5,8-trioxanonane 12.95
    1-hexene 0.49
    2-isopropoxyethanol 10.29
    2,2,2-trifluoroethanol 96.85
    methyl butyrate 3.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction