Creatine Monohydrate

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  • Identifiers

    CAS number
    6020-87-7

    Molecular formula
    C4H11N3O3

    SMILES
    CN(CC(=O)O)C(=N)N.O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 72.53%
    Savory 28.92%
    Meaty 23.94%
    Fishy 19.77%
    Pungent 19.71%
    Cheesy 19.32%
    Cooked 19.09%
    Cooling 18.86%
    Roasted 16.45%
    Sulfurous 16.14%

     

    Flavor
    Odorless 52.24%
    Mild 29.05%
    Bland 24.58%
    Yeast 21.56%
    Very mild 21.48%
    Cooked 21.39%
    Taco 19.81%
    Stinky 19.62%
    Roasted peanuts 19.54%
    Sour 19.53%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    8.14 (weak base)

    Molecular weight
    149.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    379°C

    Flash point

    • 136.47 ˚C est.

  • Synonyms

    • Creatine monohydrate
    • 6020-87-7
    • Creatine, monohydrate
    • Creapure
    • Glycine, N-(aminoiminomethyl)-N-methyl-, monohydrate
    • UNII-9603LN7R2Q
    • 9603LN7R2Q
    • N-(Aminoiminomethyl)-N-methylglycine monohydrate
    • DTXSID10208954
    • CREATINE MONOHYDRATE [WHO-DD]
    • Glycine, N-(aminoiminomethyl)-N-methyl-, hydrate (1:1)
    • Creatine Supplement
    • RefChem:128421
    • DTXCID60131445
    • N-(aminoiminomethyl)-N-methyl-Glycine, monohydrate
    • 611-954-8
    • 2-(1-Methylguanidino)acetic acid hydrate
    • Creatine hydrate
    • MFCD00071582
    • 2-[carbamimidoyl(methyl)amino]acetic acid;hydrate
    • Creatine (monohydrate)
    • N-Guanyl-N-methylglycine
    • creatine-monohydrate
    • Creatine (hydrate)
    • Glycine, N-(aminoiminomethyl)-N-methyl-, hydrate (1:1); Creatine, monohydrate (8CI); Glycine, N-(aminoiminomethyl)-N-methyl-, monohydrate (9CI); Creapure
    • SCHEMBL53010
    • Creatine monohydrate, >=98%
    • orb1306019
    • orb3025739
    • CHEMBL5275950
    • MSK001351W
    • Methylguanidoacetic acid monohydrate
    • s6023
    • SBB067296
    • N-Amidinosarcosine monohydrate
    • AKOS002391125
    • CS-W018178
    • DS-9420
    • FC15780
    • HY-W017462
    • AC-15066
    • SY036143
    • DB-053557
    • 2-(amidinomethylamino)acetic acid, oxamethane
    • 2-(N-methylcarbamimidamido)acetic acid hydrate
    • D70219
    • N-Carbamimidoyl-N-methylglycine--water (1/1)
    • Q27271832
    • F1902-0139
    • Creatine, United States Pharmacopeia (USP) Reference Standard
    • Glycine,N-(aminoiminomethyl)-N-(methyl-d3)-,monohydrate(9ci)
    • 6020-87-7

  • Applications

    Creatine Monohydrate (CAS 6020-87-7) is primarily used as a dietary supplement in sports nutrition to support short-duration, high-intensity exercise by replenishing phosphocreatine stores in muscle. It is also considered for inclusion in functional foods and nutraceutical formulations as an energy-supporting ingredient. In pharmaceutical and life-science contexts, it is used in research to study cellular energy metabolism and as a potential nutraceutical formulation component. Additionally, it serves as a reference material and analytical standard for method development and quality control in laboratories.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.19
    methanol 0.62
    isopropanol 0.08
    water 22.75
    ethyl acetate 0.08
    n-propanol 0.14
    acetone 0.08
    n-butanol 0.09
    acetonitrile 0.08
    DMF 4.62
    toluene 0.05
    isobutanol 0.09
    1,4-dioxane 0.27
    methyl acetate 0.11
    THF 0.57
    2-butanone 0.08
    n-pentanol 0.06
    sec-butanol 0.09
    n-hexane 0.02
    ethylene glycol 3.34
    NMP 10.63
    cyclohexane 0.02
    DMSO 4.38
    n-butyl acetate 0.09
    n-octanol 0.07
    chloroform 0.2
    n-propyl acetate 0.05
    acetic acid 1.15
    dichloromethane 0.23
    cyclohexanone 0.35
    propylene glycol 1.59
    isopropyl acetate 0.05
    DMAc 5.77
    2-ethoxyethanol 0.71
    isopentanol 0.08
    n-heptane 0.03
    ethyl formate 0.63
    1,2-dichloroethane 0.11
    n-hexanol 0.14
    2-methoxyethanol 2.54
    isobutyl acetate 0.03
    tetrachloromethane 0.22
    n-pentyl acetate 0.07
    transcutol 0.61
    n-heptanol 0.16
    ethylbenzene 0.04
    MIBK 0.06
    2-propoxyethanol 0.89
    tert-butanol 0.17
    MTBE 0.04
    2-butoxyethanol 0.71
    propionic acid 0.45
    o-xylene 0.11
    formic acid 22.11
    diethyl ether 0.03
    m-xylene 0.07
    p-xylene 0.07
    chlorobenzene 0.05
    dimethyl carbonate 0.35
    n-octane 0.01
    formamide 8.1
    cyclopentanone 0.69
    2-pentanone 0.07
    anisole 0.1
    cyclopentyl methyl ether 0.21
    gamma-butyrolactone 1.64
    1-methoxy-2-propanol 0.96
    pyridine 0.24
    3-pentanone 0.08
    furfural 5.13
    n-dodecane 0.01
    diethylene glycol 2.95
    diisopropyl ether 0.02
    tert-amyl alcohol 0.19
    acetylacetone 0.18
    n-hexadecane 0.01
    acetophenone 0.21
    methyl propionate 0.18
    isopentyl acetate 0.1
    trichloroethylene 0.25
    n-nonanol 0.08
    cyclohexanol 0.14
    benzyl alcohol 0.2
    2-ethylhexanol 0.11
    isooctanol 0.12
    dipropyl ether 0.08
    1,2-dichlorobenzene 0.12
    ethyl lactate 0.33
    propylene carbonate 0.99
    n-methylformamide 2.75
    2-pentanol 0.05
    n-pentane 0.01
    1-propoxy-2-propanol 0.46
    1-methoxy-2-propyl acetate 0.25
    2-(2-methoxypropoxy) propanol 0.85
    mesitylene 0.06
    ε-caprolactone 0.53
    p-cymene 0.08
    epichlorohydrin 0.64
    1,1,1-trichloroethane 0.11
    2-aminoethanol 2.55
    morpholine-4-carbaldehyde 5.71
    sulfolane 5.66
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.22
    n-hexyl acetate 0.08
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 0.72
    sec-butyl acetate 0.03
    tert-butyl acetate 0.09
    decalin 0.02
    glycerin 10.35
    diglyme 1.46
    acrylic acid 1.03
    isopropyl myristate 0.04
    n-butyric acid 0.36
    acetyl acetate 0.09
    di(2-ethylhexyl) phthalate 0.23
    ethyl propionate 0.08
    nitromethane 1.22
    1,2-diethoxyethane 0.06
    benzonitrile 0.17
    trioctyl phosphate 0.14
    1-bromopropane 0.04
    gamma-valerolactone 2.36
    n-decanol 0.06
    triethyl phosphate 0.26
    4-methyl-2-pentanol 0.05
    propionitrile 0.08
    vinylene carbonate 1.11
    1,1,2-trichlorotrifluoroethane 4.86
    DMS 0.14
    cumene 0.05
    2-octanol 0.07
    2-hexanone 0.05
    octyl acetate 0.07
    limonene 0.09
    1,2-dimethoxyethane 0.91
    ethyl orthosilicate 0.21
    tributyl phosphate 0.14
    diacetone alcohol 0.44
    N,N-dimethylaniline 0.22
    acrylonitrile 0.22
    aniline 0.15
    1,3-propanediol 1.14
    bromobenzene 0.05
    dibromomethane 0.12
    1,1,2,2-tetrachloroethane 0.31
    2-methyl-cyclohexyl acetate 0.16
    tetrabutyl urea 0.29
    diisobutyl methanol 0.08
    2-phenylethanol 0.25
    styrene 0.03
    dioctyl adipate 0.09
    dimethyl sulfate 1.9
    ethyl butyrate 0.11
    methyl lactate 1.15
    butyl lactate 0.32
    diethyl carbonate 0.11
    propanediol butyl ether 0.77
    triethyl orthoformate 0.17
    p-tert-butyltoluene 0.08
    methyl 4-tert-butylbenzoate 0.59
    morpholine 0.41
    tert-butylamine 0.07
    n-dodecanol 0.05
    dimethoxymethane 0.82
    ethylene carbonate 0.59
    cyrene 2.29
    2-ethoxyethyl acetate 0.12
    2-ethylhexyl acetate 0.08
    1,2,4-trichlorobenzene 0.15
    4-methylpyridine 0.24
    dibutyl ether 0.03
    2,6-dimethyl-4-heptanol 0.08
    DEF 0.53
    dimethyl isosorbide 1.81
    tetrachloroethylene 0.4
    eugenol 0.93
    triacetin 0.19
    span 80 0.61
    1,4-butanediol 0.45
    1,1-dichloroethane 0.06
    2-methyl-1-pentanol 0.07
    methyl formate 2.45
    2-methyl-1-butanol 0.1
    n-decane 0.01
    butyronitrile 0.08
    3,7-dimethyl-1-octanol 0.07
    1-chlorooctane 0.03
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 0.33
    tetrahydropyran 0.08
    tert-amyl methyl ether 0.08
    2,5,8-trioxanonane 1.4
    1-hexene 0.03
    2-isopropoxyethanol 0.26
    2,2,2-trifluoroethanol 2.52
    methyl butyrate 0.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction