(+)-Corydine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    476-69-7

    Molecular formula
    C20H23NO4

    SMILES
    CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=C3C(=C(C=C4)OC)OC)O)OC

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 42.13%
    Vanilla 39.18%
    Spicy 36.14%
    Smoky 32.34%
    Sweet 31.96%
    Odorless 31.59%
    Powdery 29.01%
    Burnt 27.49%
    Balsamic 27.38%
    Animal 25.03%

     

    Flavor
    Bitter 93.54%
    Bland 26.26%
    Sweet-like 21.15%
    Cedarleaf 20.6%
    Parsley 20.46%
    Eugenol 19.15%
    Odorless 18.89%
    Lovage 18.59%
    Very strong 18.59%
    Indole 18.5%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    7.53 (neutral)

    Molecular weight
    341.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    745°C

    Flash point

    • 214.11 ˚C est.

  • Synonyms

    • Corydine
    • 476-69-7
    • (+)-Corydine
    • d-Corydine
    • Glaucentrin
    • Glaucentrine
    • (S)-(+)-Corydine
    • 1O1D15OP5R
    • (6aS)-2,10,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol
    • (6aS)-2,10,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinolin-1-ol
    • Glaucocerinite 8120
    • RefChem:56426
    • (6aS)-2,10,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline-1-ol
    • CHEMBL489524
    • (6aS)-5,6,6a,7-Tetrahydro-2,10,11-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-1-ol
    • O(sup 11)-Methylcorytuberine
    • 4H-Dibenzo(de,g)quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (S)-
    • BRN 0095568
    • UNII-1O1D15OP5R
    • MFCD00076020
    • (S)-Corydine
    • (6AS)-5,6,6A,7-TETRAHYDRO-2,10,11-TRIMETHOXY-6-METHYL-4H-DIBENZO(DE,G)QUINOLIN-1-OL
    • O11-Methylcorytuberine
    • CORYDINE [MI]
    • 5-21-06-00134 (Beilstein Handbook Reference)
    • SCHEMBL680230
    • 6a-alpha-APORPHIN-1-OL, 2,10,11-TRIMETHOXY-
    • orb1698421
    • SCHEMBL30475141
    • DTXSID00963883
    • WLZ4636
    • 4H-DIBENZO(DE,G)QUINOLIN-1-OL, 5,6,6A,7-TETRAHYDRO-2,10,11-TRIMETHOXY-6-METHYL-, (6AS)-
    • HY-N2571
    • BDBM50250271
    • AKOS000277266
    • CORYTUBERINE METHYL ETHER [MI]
    • FS-7047
    • AC-35116
    • DA-72598
    • FC156955
    • CS-0022908
    • NS00094085
    • Q27252668
    • 476-69-7

  • Applications

    (+)-Corydine is an aporphine-type isoquinoline alkaloid that is primarily used in chemical research as an intermediate and building block for isoquinoline alkaloid derivatives; in pharmaceutical research it supports medicinal chemistry investigations and scaffold development; it is employed in natural product synthesis and SAR studies to explore structure-activity relationships; in analytical chemistry it serves as a reference standard for alkaloid profiling and quantification in plant extracts; and it can function as a chiral starting material for asymmetric synthesis and method development in related compound families.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.44
    methanol 6.47
    isopropanol 3.5
    water 0.21
    ethyl acetate 14.84
    n-propanol 5.47
    acetone 9.01
    n-butanol 5.46
    acetonitrile 5.42
    DMF 35.64
    toluene 1.85
    isobutanol 4.56
    1,4-dioxane 10.3
    methyl acetate 12.32
    THF 12.24
    2-butanone 9.45
    n-pentanol 4.82
    sec-butanol 3.0
    n-hexane 0.24
    ethylene glycol 7.42
    NMP 41.39
    cyclohexane 0.54
    DMSO 34.38
    n-butyl acetate 16.83
    n-octanol 3.25
    chloroform 50.28
    n-propyl acetate 13.53
    acetic acid 40.97
    dichloromethane 51.61
    cyclohexanone 22.61
    propylene glycol 2.76
    isopropyl acetate 11.03
    DMAc 46.32
    2-ethoxyethanol 19.51
    isopentanol 6.54
    n-heptane 0.37
    ethyl formate 17.56
    1,2-dichloroethane 29.24
    n-hexanol 7.07
    2-methoxyethanol 26.45
    isobutyl acetate 9.85
    tetrachloromethane 11.64
    n-pentyl acetate 14.66
    transcutol 39.0
    n-heptanol 6.28
    ethylbenzene 2.0
    MIBK 8.33
    2-propoxyethanol 28.71
    tert-butanol 4.79
    MTBE 2.86
    2-butoxyethanol 23.45
    propionic acid 16.36
    o-xylene 2.95
    formic acid 27.43
    diethyl ether 4.2
    m-xylene 2.46
    p-xylene 2.96
    chlorobenzene 7.92
    dimethyl carbonate 22.14
    n-octane 0.26
    formamide 36.52
    cyclopentanone 21.26
    2-pentanone 9.07
    anisole 5.29
    cyclopentyl methyl ether 6.73
    gamma-butyrolactone 38.21
    1-methoxy-2-propanol 16.59
    pyridine 12.5
    3-pentanone 8.65
    furfural 50.03
    n-dodecane 0.25
    diethylene glycol 37.57
    diisopropyl ether 2.03
    tert-amyl alcohol 4.25
    acetylacetone 17.08
    n-hexadecane 0.29
    acetophenone 13.61
    methyl propionate 15.98
    isopentyl acetate 16.1
    trichloroethylene 59.87
    n-nonanol 4.0
    cyclohexanol 6.37
    benzyl alcohol 10.22
    2-ethylhexanol 6.22
    isooctanol 5.8
    dipropyl ether 4.8
    1,2-dichlorobenzene 14.29
    ethyl lactate 15.43
    propylene carbonate 32.08
    n-methylformamide 23.81
    2-pentanol 3.35
    n-pentane 0.29
    1-propoxy-2-propanol 16.16
    1-methoxy-2-propyl acetate 25.7
    2-(2-methoxypropoxy) propanol 19.72
    mesitylene 2.11
    ε-caprolactone 29.0
    p-cymene 4.48
    epichlorohydrin 35.7
    1,1,1-trichloroethane 19.13
    2-aminoethanol 7.06
    morpholine-4-carbaldehyde 52.77
    sulfolane 55.33
    2,2,4-trimethylpentane 0.34
    2-methyltetrahydrofuran 6.45
    n-hexyl acetate 11.43
    isooctane 0.25
    2-(2-butoxyethoxy)ethanol 22.15
    sec-butyl acetate 9.0
    tert-butyl acetate 11.14
    decalin 0.61
    glycerin 13.68
    diglyme 44.38
    acrylic acid 24.96
    isopropyl myristate 5.17
    n-butyric acid 21.64
    acetyl acetate 20.12
    di(2-ethylhexyl) phthalate 10.8
    ethyl propionate 12.23
    nitromethane 55.51
    1,2-diethoxyethane 11.55
    benzonitrile 11.77
    trioctyl phosphate 7.73
    1-bromopropane 6.93
    gamma-valerolactone 47.87
    n-decanol 3.03
    triethyl phosphate 14.53
    4-methyl-2-pentanol 3.59
    propionitrile 6.9
    vinylene carbonate 41.91
    1,1,2-trichlorotrifluoroethane 73.91
    DMS 21.78
    cumene 2.48
    2-octanol 3.08
    2-hexanone 8.36
    octyl acetate 7.04
    limonene 5.02
    1,2-dimethoxyethane 22.97
    ethyl orthosilicate 12.47
    tributyl phosphate 9.25
    diacetone alcohol 16.87
    N,N-dimethylaniline 6.56
    acrylonitrile 12.83
    aniline 6.46
    1,3-propanediol 12.15
    bromobenzene 7.1
    dibromomethane 24.36
    1,1,2,2-tetrachloroethane 46.3
    2-methyl-cyclohexyl acetate 15.76
    tetrabutyl urea 11.61
    diisobutyl methanol 4.04
    2-phenylethanol 14.37
    styrene 2.27
    dioctyl adipate 11.14
    dimethyl sulfate 43.65
    ethyl butyrate 13.83
    methyl lactate 20.77
    butyl lactate 16.44
    diethyl carbonate 14.61
    propanediol butyl ether 12.44
    triethyl orthoformate 13.38
    p-tert-butyltoluene 3.91
    methyl 4-tert-butylbenzoate 20.64
    morpholine 13.58
    tert-butylamine 2.41
    n-dodecanol 2.33
    dimethoxymethane 23.76
    ethylene carbonate 33.81
    cyrene 30.36
    2-ethoxyethyl acetate 26.42
    2-ethylhexyl acetate 14.12
    1,2,4-trichlorobenzene 17.88
    4-methylpyridine 9.62
    dibutyl ether 3.27
    2,6-dimethyl-4-heptanol 4.04
    DEF 21.07
    dimethyl isosorbide 36.05
    tetrachloroethylene 42.87
    eugenol 22.7
    triacetin 21.66
    span 80 14.62
    1,4-butanediol 6.23
    1,1-dichloroethane 12.68
    2-methyl-1-pentanol 5.85
    methyl formate 23.98
    2-methyl-1-butanol 5.35
    n-decane 0.39
    butyronitrile 6.18
    3,7-dimethyl-1-octanol 4.11
    1-chlorooctane 2.07
    1-chlorotetradecane 1.05
    n-nonane 0.3
    undecane 0.3
    tert-butylcyclohexane 0.47
    cyclooctane 0.26
    cyclopentanol 5.91
    tetrahydropyran 5.92
    tert-amyl methyl ether 3.37
    2,5,8-trioxanonane 32.96
    1-hexene 1.06
    2-isopropoxyethanol 14.17
    2,2,2-trifluoroethanol 39.82
    methyl butyrate 16.16

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction