Cortisol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    50-23-7

    Molecular formula
    C21H30O5

    SMILES
    C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Woody 58.15%
    Sweet 33.6%
    Odorless 31.1%
    Spicy 29.52%
    Mint 29.17%
    Cedar 27.55%
    Balsamic 26.59%
    Camphoreous 26.49%
    Cooling 24.45%
    Amber 24.14%

     

    Flavor
    Bitter 79.02%
    Sweet-like 22.88%
    Cedarleaf 21.35%
    Odorless 20.9%
    Fenugreek 20.68%
    Leaves 20.34%
    Ripe apricot 20.09%
    Lovage 20.03%
    Seedy 20.0%
    Extremely sweet 19.96%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    6.19 (neutral)

    Molecular weight
    362.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    315°C

    Melting point expt.

    • 220 °C
    • 217-220 °C with some decomposition

    Flash point

    • 273.19 ˚C est.

    Solubility expt.

    • 320 mg/L (at 25 °C)
    • Amorphous, hygroscopic, white powder. Mp 169.0-171.2 °C. Solubility in water: approx 500 mg/mL. Similarly soluble in methanol, ethanol,; sparingly soluble in chloroform. /21-Sodium succinate/
    • Solubilities in various solvents [Table#4538]
    • Soluble in concentrated sulfuric acid with intense green flourescence
    • Soluble in dioxane
    • In water, 320 mg/L at 25 °C
    • 0.32 mg/mL

  • Synonyms

    • hydrocortisone
    • Cortisol
    • 50-23-7
    • Acticort
    • Cetacort
    • Hydrocortisyl
    • Cobadex
    • Hytone
    • Cortenema
    • Dermacort
    • Proctocort
    • Tarcortin
    • Cort-Dome
    • Efcorbin
    • Hycortol
    • Signef
    • Kendall's compound F
    • 17-Hydroxycorticosterone
    • Hytone lotion
    • Scheroson F
    • Incortin-H
    • Alacort
    • Corticreme
    • Cremesone
    • Eldecort
    • Epicort
    • Otosone-F
    • Penecort
    • Dihydrocostisone
    • Reichstein's substance M
    • Hidro-Colisona
    • Ala-Scalp
    • Epiderm H
    • Aeroseb-HC
    • Maintasone
    • Nutracort
    • Synacort
    • Ala-Cort
    • Anflam
    • Dioderm
    • Hydrocorticosterone
    • H-Cort
    • Flexicort
    • Evacort
    • Texacort
    • Timocort
    • Colocort
    • Lubricort
    • Meusicort
    • Sigmacort
    • Glycort
    • Balneol-hc
    • Dome-cort
    • Stie-cort
    • 11beta-Hydroxycortisone
    • Beta-hc
    • Aquanil HC
    • Heb Cort
    • Nogenic HC
    • Hydrocortisonum
    • Medicort
    • Zenoxone
    • Hydrocortisone free alcohol
    • Anusol HC
    • Hi-cor
    • Plenadren
    • 11beta-Hydrocortisone
    • Genacort (lotion)
    • Proctozone HC
    • Hydro-RX
    • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione
    • HC (HYDROCORTISONE)
    • Proctosol-HC
    • 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
    • NSC 10483
    • NSC-10483
    • HYDROCORTISONE IN ABSORBASE
    • WI4X0X7BPJ
    • (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
    • (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
    • 4-Pregnene-11beta,17alpha,21-triol-3,20-dione
    • DTXSID7020714
    • CHEBI:17650
    • ALKINDI SPRINKLE
    • 4-Pregnen-11beta,17alpha,21-triol-3,20-dione
    • DTXCID10714
    • Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
    • Hydrocortizone
    • Proctozone
    • Quadrydern
    • Alkindi
    • Assured
    • Cortenem
    • Dermarest
    • Econacort
    • Gregoderm
    • Hydroderm
    • Hydroxym
    • Makesense
    • Nybadex
    • Otoseptil
    • Quinocort
    • Scalpicin
    • Sunmark
    • Theraplex
    • Topisone
    • Xyloproct
    • Anusol
    • Loesch
    • Publix
    • Shopko
    • CliniCalm
    • Eurax-hydrocort
    • Hartz
    • Thera
    • Anti-pruritic
    • Germoloids hc
    • Anugesic hc
    • Efcortelan p
    • Family Wellness
    • Hydroderm hc
    • Hydroxym Cream
    • Medi-Cortisone
    • Tri-cicatrin
    • Corticol-Aloe
    • Cvs Cortisone
    • Hydroxate Gel
    • 50-23-7

  • Applications

    Cortisol (CAS 50-23-7) is used primarily in pharmaceuticals as a corticosteroid active ingredient for topical anti-inflammatory therapy (hydrocortisone) and, in some formulations, systemically as an oral or injectable agent for inflammatory and certain endocrine disorders. In analytical chemistry and reference materials, cortisol serves as a reference standard for quantitative assays (LC-MS/MS, immunoassays) and method validation. In biomedical research, cortisol is employed as a model glucocorticoid hormone to study stress responses and as a tool in cell- and tissue-based experiments. In veterinary medicine, cortisol/hydrocortisone is used in formulations for animal conditions requiring anti-inflammatory or anti-pruritic effects. Depending on local regulations, cortisol may appear in certain cosmetic/personal care products or topical formulations, but usage is strictly regulated.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 22.41
    methanol 78.22
    isopropanol 9.14
    water 0.29
    ethyl acetate 5.62
    n-propanol 13.51
    acetone 17.78
    n-butanol 7.05
    acetonitrile 10.74
    DMF 69.76
    toluene 3.07
    isobutanol 4.43
    1,4-dioxane 27.18
    methyl acetate 5.26
    THF 68.36
    2-butanone 7.31
    n-pentanol 2.23
    sec-butanol 1.79
    n-hexane 0.08
    ethylene glycol 13.32
    NMP 19.23
    cyclohexane 0.29
    DMSO 97.25
    n-butyl acetate 4.2
    n-octanol 1.88
    chloroform 17.14
    n-propyl acetate 2.94
    acetic acid 18.92
    dichloromethane 10.75
    cyclohexanone 13.85
    propylene glycol 6.68
    isopropyl acetate 4.94
    DMAc 27.92
    2-ethoxyethanol 18.04
    isopentanol 4.3
    n-heptane 0.1
    ethyl formate 6.12
    1,2-dichloroethane 6.72
    n-hexanol 4.82
    2-methoxyethanol 68.31
    isobutyl acetate 2.13
    tetrachloromethane 2.4
    n-pentyl acetate 4.8
    transcutol 24.87
    n-heptanol 3.94
    ethylbenzene 1.31
    MIBK 6.27
    2-propoxyethanol 34.73
    tert-butanol 6.42
    MTBE 1.45
    2-butoxyethanol 17.14
    propionic acid 5.98
    o-xylene 1.92
    formic acid 26.92
    diethyl ether 4.1
    m-xylene 2.53
    p-xylene 1.51
    chlorobenzene 3.41
    dimethyl carbonate 10.13
    n-octane 0.08
    formamide 41.53
    cyclopentanone 25.83
    2-pentanone 7.75
    anisole 4.63
    cyclopentyl methyl ether 7.42
    gamma-butyrolactone 22.56
    1-methoxy-2-propanol 40.15
    pyridine 14.63
    3-pentanone 4.96
    furfural 21.91
    n-dodecane 0.04
    diethylene glycol 44.78
    diisopropyl ether 0.97
    tert-amyl alcohol 1.66
    acetylacetone 16.05
    n-hexadecane 0.05
    acetophenone 6.2
    methyl propionate 7.21
    isopentyl acetate 4.57
    trichloroethylene 15.38
    n-nonanol 2.23
    cyclohexanol 3.09
    benzyl alcohol 6.18
    2-ethylhexanol 1.87
    isooctanol 2.93
    dipropyl ether 2.23
    1,2-dichlorobenzene 3.59
    ethyl lactate 4.93
    propylene carbonate 8.65
    n-methylformamide 42.53
    2-pentanol 1.98
    n-pentane 0.13
    1-propoxy-2-propanol 15.08
    1-methoxy-2-propyl acetate 12.56
    2-(2-methoxypropoxy) propanol 11.4
    mesitylene 1.48
    ε-caprolactone 9.52
    p-cymene 1.14
    epichlorohydrin 27.76
    1,1,1-trichloroethane 3.81
    2-aminoethanol 22.28
    morpholine-4-carbaldehyde 36.56
    sulfolane 33.51
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 6.91
    n-hexyl acetate 4.54
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 15.39
    sec-butyl acetate 1.9
    tert-butyl acetate 6.0
    decalin 0.14
    glycerin 22.91
    diglyme 29.37
    acrylic acid 8.9
    isopropyl myristate 1.58
    n-butyric acid 9.24
    acetyl acetate 6.64
    di(2-ethylhexyl) phthalate 3.89
    ethyl propionate 3.37
    nitromethane 34.61
    1,2-diethoxyethane 5.28
    benzonitrile 5.99
    trioctyl phosphate 2.64
    1-bromopropane 1.9
    gamma-valerolactone 42.17
    n-decanol 1.27
    triethyl phosphate 2.93
    4-methyl-2-pentanol 2.06
    propionitrile 7.25
    vinylene carbonate 11.04
    1,1,2-trichlorotrifluoroethane 28.13
    DMS 6.44
    cumene 0.92
    2-octanol 1.53
    2-hexanone 3.32
    octyl acetate 2.23
    limonene 1.24
    1,2-dimethoxyethane 24.95
    ethyl orthosilicate 2.61
    tributyl phosphate 2.26
    diacetone alcohol 11.96
    N,N-dimethylaniline 3.37
    acrylonitrile 13.34
    aniline 6.07
    1,3-propanediol 28.2
    bromobenzene 2.72
    dibromomethane 5.4
    1,1,2,2-tetrachloroethane 10.87
    2-methyl-cyclohexyl acetate 3.92
    tetrabutyl urea 3.66
    diisobutyl methanol 1.46
    2-phenylethanol 9.23
    styrene 1.36
    dioctyl adipate 3.41
    dimethyl sulfate 16.44
    ethyl butyrate 3.33
    methyl lactate 12.67
    butyl lactate 7.18
    diethyl carbonate 2.68
    propanediol butyl ether 10.95
    triethyl orthoformate 3.55
    p-tert-butyltoluene 1.11
    methyl 4-tert-butylbenzoate 9.51
    morpholine 28.51
    tert-butylamine 1.85
    n-dodecanol 0.72
    dimethoxymethane 61.63
    ethylene carbonate 9.19
    cyrene 14.92
    2-ethoxyethyl acetate 9.97
    2-ethylhexyl acetate 3.05
    1,2,4-trichlorobenzene 4.56
    4-methylpyridine 8.26
    dibutyl ether 1.06
    2,6-dimethyl-4-heptanol 1.46
    DEF 7.93
    dimethyl isosorbide 18.9
    tetrachloroethylene 9.88
    eugenol 12.54
    triacetin 7.17
    span 80 8.84
    1,4-butanediol 5.9
    1,1-dichloroethane 3.92
    2-methyl-1-pentanol 1.65
    methyl formate 25.53
    2-methyl-1-butanol 2.52
    n-decane 0.1
    butyronitrile 4.9
    3,7-dimethyl-1-octanol 1.64
    1-chlorooctane 0.58
    1-chlorotetradecane 0.18
    n-nonane 0.09
    undecane 0.06
    tert-butylcyclohexane 0.11
    cyclooctane 0.12
    cyclopentanol 4.93
    tetrahydropyran 9.21
    tert-amyl methyl ether 1.13
    2,5,8-trioxanonane 19.35
    1-hexene 0.39
    2-isopropoxyethanol 7.98
    2,2,2-trifluoroethanol 11.08
    methyl butyrate 4.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction