Colchicine

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  • Identifiers

    CAS number
    64-86-8

    Molecular formula
    C22H25NO6

    SMILES
    CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Vanilla 37.09%
    Odorless 33.23%
    Sweet 32.99%
    Spicy 26.97%
    Powdery 26.37%
    Fruity 26.2%
    Milky 25.27%
    Floral 25.12%
    Creamy 23.68%
    Savory 23.62%

     

    Flavor
    Bitter 75.3%
    Bland 28.07%
    Odorless 27.47%
    Parsley 21.27%
    Sweet-like 20.33%
    Lovage 19.38%
    Eugenol 19.33%
    Cedarleaf 19.31%
    Ham 19.17%
    Ethyl benzoate 19.05%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    6.66 (neutral)

    Molecular weight
    399.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 288 to 302 °F (EPA, 1998)
    • 150-160
    • 142-150 °C

    Boiling point

    • 522.37 undefined

    Flash point

    • 215.88 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
    • 10 mg/mL
    • 1 g dissolves in 22 mL water, 220 mL ether, 100 mL benzene; freely sol in alcohol or chloroform; practically insoluble in petroleum ether
    • SOL IN METHANOL; SLIGHTLY SOL IN CARBON TETRACHLORIDE
    • At 25 °C, 4.5 g/100 g water

  • Synonyms

    • colchicine
    • 64-86-8
    • Colchisol
    • Colchicinum
    • Colchicin
    • Colchicina
    • Colchineos
    • Condylon
    • Colcin
    • Colsaloid
    • Colcrys
    • 7alphaH-Colchicine
    • Goutnil
    • Kolkicin
    • (S)-colchicine
    • (-)-colchicine
    • Colchysat
    • Mitigare
    • spindle poison
    • 7-alpha-H-Colchicine
    • NSC 757
    • LODOCO
    • CCRIS 691
    • Colchcine
    • NSC757
    • N-Acetyl trimethylcolchicinic acid methylether
    • HSDB 3044
    • NSC-757
    • UNII-SML2Y3J35T
    • (S)-colchicina
    • (S)-colchicin
    • EINECS 200-598-5
    • SML2Y3J35T
    • MFCD00078484
    • GLOPERBA
    • (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
    • N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
    • DTXSID5024845
    • CHEBI:27882
    • AI3-31149
    • Colchicine [USP:JAN]
    • N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
    • (S)-Colchicine >95%
    • CHEMBL107
    • DTXCID204845
    • XD25
    • EC 200-598-5
    • MITIGARE COMPONENT COLCHICINE
    • PROBEN-C COMPONENT COLCHICINE
    • Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-
    • Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
    • COLBENEMID COMPONENT COLCHICINE
    • Colchicine [JAN]
    • Colchicin [German]
    • NCGC00025125-07
    • Colchicina [Italian]
    • Colchicine (USP:JAN)
    • COLCHICINE (MART.)
    • COLCHICINE [MART.]
    • COLCHICINE (USP-RS)
    • COLCHICINE [USP-RS]
    • COLCHICINE (EP IMPURITY)
    • COLCHICINE [EP IMPURITY]
    • COLCHICINE (EP MONOGRAPH)
    • COLCHICINE [EP MONOGRAPH]
    • COLCHICINE (USP MONOGRAPH)
    • COLCHICINE [USP MONOGRAPH]
    • Colstat
    • N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide
    • Colchicine; Thiocolchicoside Impurity A
    • Acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-
    • Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
    • Colchicine (TN)
    • N-[(7s)-1,2,3,10-Tetramethoxy-9-Oxo-6,7-Dihydro-5h-Benzo[d]heptalen-7-Yl]ethanamide
    • (S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)ACETAMIDE
    • 30512-31-3
    • ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-,(S)-
    • LOC
    • SMR000058323
    • 7alpha-H-Colchicine
    • 7.alpha.H-Colchicine
    • SR-01000075794
    • SR-01000597576
    • Colchicine conformational isomer
    • 4lzr
    • Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(.alpha.)heptalen-7-yl)-
    • Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-
    • MPC-004
    • N-((7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo(a)heptalen-7-yl)acetamide
    • N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide
    • CAS-64-86-8
    • Prestwick_695
    • COLCHICENOS
    • COLCIGEL
    • MYINFLA
    • Colchicine (Standard)
    • COLCHICINUM 4x
    • Spectrum_000842
    • Tocris-1364
    • 4o2b
    • COLCHICINE [MI]
    • Prestwick0_000363
    • Prestwick1_000363
    • Prestwick2_000363
    • Prestwick3_000363
    • Spectrum2_000075
    • Spectrum3_000362
    • Spectrum4_000298
    • Spectrum5_000787
    • COLCHCINE [VANDF]
    • COLCHICINE [HSDB]
    • COLCHICINUM [HPUS]
    • Colchicine (JP18/USP)
    • UPCMLD-DP065
    • C 9754
    • SCHEMBL8469
    • Colchicine Tablets 0.5 mg
    • 7JX9WZ3SJ5
    • COLCHICINE [WHO-DD]
    • COLCHICINE [WHO-IP]
    • N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
    • Lopac0_000310
    • BSPBio_000485
    • BSPBio_002083
    • KBioGR_000856
    • KBioSS_001322
    • Colchicine (contains 5% Ethyl Acetate at maximum)
    • MLS001055448

  • Applications

    Colchicine is used primarily in pharmaceutical development as a pharmacologically active natural product and as a scaffold for tubulin-inhibitor research; its handling is subject to strict regulatory controls. In biomedical and cellular biology research, it serves as a tool compound to inhibit microtubule polymerization, enabling cell-cycle arrest and the preparation of samples at metaphase for cytogenetic analyses. In medicinal chemistry, colchicine-derived scaffolds are explored for SAR studies to optimize tubulin-targeting agents. In research laboratories and industrial settings, it is widely used as a biochemical reagent to study cytoskeleton dynamics and cell division, supporting assay development and mechanistic investigations under appropriate safety and handling protocols.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.67
    methanol 9.76
    isopropanol 4.51
    water 0.19
    ethyl acetate 14.25
    n-propanol 6.5
    acetone 19.89
    n-butanol 5.54
    acetonitrile 12.18
    DMF 34.06
    toluene 2.12
    isobutanol 5.06
    1,4-dioxane 19.47
    methyl acetate 16.81
    THF 19.86
    2-butanone 16.37
    n-pentanol 6.95
    sec-butanol 4.6
    n-hexane 0.3
    ethylene glycol 5.83
    NMP 43.71
    cyclohexane 0.47
    DMSO 45.08
    n-butyl acetate 10.61
    n-octanol 3.71
    chloroform 28.87
    n-propyl acetate 12.82
    acetic acid 33.14
    dichloromethane 31.46
    cyclohexanone 25.31
    propylene glycol 3.24
    isopropyl acetate 8.38
    DMAc 56.91
    2-ethoxyethanol 23.82
    isopentanol 5.46
    n-heptane 0.28
    ethyl formate 15.03
    1,2-dichloroethane 21.83
    n-hexanol 5.82
    2-methoxyethanol 25.35
    isobutyl acetate 8.25
    tetrachloromethane 5.45
    n-pentyl acetate 10.65
    transcutol 18.7
    n-heptanol 5.0
    ethylbenzene 2.38
    MIBK 7.95
    2-propoxyethanol 22.04
    tert-butanol 5.09
    MTBE 3.49
    2-butoxyethanol 15.93
    propionic acid 14.17
    o-xylene 2.41
    formic acid 24.04
    diethyl ether 5.6
    m-xylene 1.72
    p-xylene 3.37
    chlorobenzene 7.9
    dimethyl carbonate 14.94
    n-octane 0.27
    formamide 29.43
    cyclopentanone 28.01
    2-pentanone 11.85
    anisole 5.91
    cyclopentyl methyl ether 6.45
    gamma-butyrolactone 37.39
    1-methoxy-2-propanol 13.54
    pyridine 18.39
    3-pentanone 11.78
    furfural 37.16
    n-dodecane 0.3
    diethylene glycol 26.11
    diisopropyl ether 1.5
    tert-amyl alcohol 5.0
    acetylacetone 19.78
    n-hexadecane 0.35
    acetophenone 12.9
    methyl propionate 16.14
    isopentyl acetate 9.84
    trichloroethylene 39.77
    n-nonanol 4.3
    cyclohexanol 6.15
    benzyl alcohol 11.27
    2-ethylhexanol 4.65
    isooctanol 4.44
    dipropyl ether 3.87
    1,2-dichlorobenzene 9.78
    ethyl lactate 11.62
    propylene carbonate 20.47
    n-methylformamide 21.9
    2-pentanol 3.07
    n-pentane 0.25
    1-propoxy-2-propanol 11.5
    1-methoxy-2-propyl acetate 13.76
    2-(2-methoxypropoxy) propanol 13.77
    mesitylene 1.19
    ε-caprolactone 24.92
    p-cymene 2.56
    epichlorohydrin 35.77
    1,1,1-trichloroethane 13.54
    2-aminoethanol 7.27
    morpholine-4-carbaldehyde 39.33
    sulfolane 48.14
    2,2,4-trimethylpentane 0.25
    2-methyltetrahydrofuran 10.75
    n-hexyl acetate 9.14
    isooctane 0.12
    2-(2-butoxyethoxy)ethanol 15.22
    sec-butyl acetate 7.08
    tert-butyl acetate 7.99
    decalin 0.5
    glycerin 11.04
    diglyme 26.89
    acrylic acid 19.78
    isopropyl myristate 4.36
    n-butyric acid 15.77
    acetyl acetate 15.29
    di(2-ethylhexyl) phthalate 8.16
    ethyl propionate 10.49
    nitromethane 48.35
    1,2-diethoxyethane 9.95
    benzonitrile 12.09
    trioctyl phosphate 5.83
    1-bromopropane 6.91
    gamma-valerolactone 42.87
    n-decanol 3.36
    triethyl phosphate 8.97
    4-methyl-2-pentanol 2.48
    propionitrile 10.4
    vinylene carbonate 23.16
    1,1,2-trichlorotrifluoroethane 48.54
    DMS 14.7
    cumene 2.08
    2-octanol 3.15
    2-hexanone 12.28
    octyl acetate 6.16
    limonene 3.24
    1,2-dimethoxyethane 25.08
    ethyl orthosilicate 7.6
    tributyl phosphate 6.93
    diacetone alcohol 12.93
    N,N-dimethylaniline 5.29
    acrylonitrile 16.41
    aniline 6.24
    1,3-propanediol 11.02
    bromobenzene 6.27
    dibromomethane 17.93
    1,1,2,2-tetrachloroethane 29.85
    2-methyl-cyclohexyl acetate 10.27
    tetrabutyl urea 10.18
    diisobutyl methanol 2.57
    2-phenylethanol 11.2
    styrene 2.68
    dioctyl adipate 8.46
    dimethyl sulfate 27.66
    ethyl butyrate 9.26
    methyl lactate 15.47
    butyl lactate 10.5
    diethyl carbonate 8.59
    propanediol butyl ether 9.53
    triethyl orthoformate 7.88
    p-tert-butyltoluene 2.03
    methyl 4-tert-butylbenzoate 13.08
    morpholine 20.38
    tert-butylamine 2.26
    n-dodecanol 2.61
    dimethoxymethane 22.73
    ethylene carbonate 19.34
    cyrene 22.98
    2-ethoxyethyl acetate 17.1
    2-ethylhexyl acetate 8.65
    1,2,4-trichlorobenzene 12.58
    4-methylpyridine 13.64
    dibutyl ether 3.82
    2,6-dimethyl-4-heptanol 2.57
    DEF 19.31
    dimethyl isosorbide 21.72
    tetrachloroethylene 25.13
    eugenol 15.34
    triacetin 14.0
    span 80 10.03
    1,4-butanediol 7.6
    1,1-dichloroethane 12.26
    2-methyl-1-pentanol 6.87
    methyl formate 21.29
    2-methyl-1-butanol 5.52
    n-decane 0.47
    butyronitrile 8.8
    3,7-dimethyl-1-octanol 3.64
    1-chlorooctane 2.43
    1-chlorotetradecane 1.28
    n-nonane 0.36
    undecane 0.37
    tert-butylcyclohexane 0.32
    cyclooctane 0.19
    cyclopentanol 6.81
    tetrahydropyran 9.72
    tert-amyl methyl ether 4.02
    2,5,8-trioxanonane 21.51
    1-hexene 1.52
    2-isopropoxyethanol 16.02
    2,2,2-trifluoroethanol 26.57
    methyl butyrate 13.69

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction