Clothianidin

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  • Identifiers

    CAS number
    210880-92-5

    Molecular formula
    C6H8ClN5O2S

    SMILES
    CN/C(=N\[N+](=O)[O-])/NCC1=CN=C(S1)Cl

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 65.16%
    Meaty 46.03%
    Savory 39.92%
    Roasted 31.99%
    Cooked 30.76%
    Fishy 20.56%
    Beefy 20.37%
    Nutty 20.01%
    Sulfurous 18.25%
    Popcorn 18.23%

     

    Flavor
    Bitter 66.93%
    Odorless 49.97%
    Bland 28.46%
    Mild 24.24%
    Roasted 24.08%
    Cooked 20.56%
    Sweet-like 20.31%
    Nitrile 19.89%
    Yeast 19.65%
    Taco 19.53%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    7.82 (neutral)

    Molecular weight
    249.68 g/mol

    Melting point expt.

    • 176.8 °C

    Flash point

    • 144.94 ˚C est.

    Solubility expt.

    • In water, 0.304 (pH 4), 0.340 (pH 10) (both g/L, 20 °C)
    • In water, 327 mg/L at 20 °C
    • In heptane less than 0.00104, xylene 0.0128, dichloromethane 1.32, methanol 6.26, octanol 0.938, acetone 15.2, ethyl acetate 2.03 (all in g/L, 25 °C)

  • Synonyms

    • Clothianidin
    • 210880-92-5
    • Celero
    • Poncho
    • TI 435
    • Poncho 600
    • Pancho
    • TI-435
    • 2V9906ABKQ
    • DTXSID2034465
    • DTXCID0014465
    • CGA-322704
    • 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine
    • CHEBI:39178
    • 1-((2-chloro-1,3-thiazol-5-yl)methyl)-3-methyl-2-nitroguanidine
    • RefChem:577765
    • 433-460-1
    • 1-((2-chloro-1,3-thiazol-5-yl)methyl)-2-methyl-3-nitroguanidine
    • (E)-clothianidin
    • 205510-53-8
    • Clothianidin [ISO]
    • MFCD06200753
    • CLOTHIANIDINE
    • 1-(2-chloro-5-thiazolylmethyl)-3-methyl-2-nitroguanidine
    • CHEBI:39177
    • (E)-1-(2-Chloro-5-thiazolylmethyl)-3-methyl-2-nitroguanidine
    • (E)-N-(2-chloro-5-thiazolyl)methyl-N'-methyl-N''-nitroguanidine
    • (E)-1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine
    • Guanidine, N-(2-chloro-5-thiazolyl)methyl-N'-methyl-N''-nitro-, (E)-
    • HSDB 7281
    • Thiamethoxam metabolite
    • CLOTHIANIDIN [MI]
    • UNII-2V9906ABKQ
    • SCHEMBL21214
    • Guanidine, N-[(2-chloro-5-thiazolyl)methyl]-N'-methyl-N''-nitro-
    • CCRIS 9264
    • CHEMBL259727
    • (E)-N'-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-methyl-N''-nitroguanidine
    • GLXC-15985
    • KIA88092
    • MSK20351
    • Tox21_301191
    • (E)-1-(2-Chloro-1,3-thiazole-5-ylmethyl)-3-methyl-2-nitroguanidine
    • BDBM50486231
    • ((e)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine)
    • AKOS015900249
    • AKOS040744778
    • EBC-252130
    • NCGC00163946-01
    • NCGC00163946-02
    • NCGC00163946-03
    • NCGC00255089-01
    • SY067060
    • Clothianidin 100 microg/mL in Acetonitrile
    • HY-133167
    • CAS-210880-92-5
    • CS-0112847
    • NS00009180
    • <p>Clothianidine</p>
    • C18508
    • EC 433-460-1
    • F14766
    • Clothianidin, PESTANAL(R), analytical standard
    • A814674
    • Q419355
    • 1-(2-chlorothiazol-5-yl)-1,2-dimethyl-3-nitro-guanidine
    • N-((2-CHLORO-5-THIAZOLYL)METHYL)-N'-METHYL-N''-NITROGUANIDINE
    • N-[(2-Chloro-1,3-thiazol-5-yl)methyl]-N'-methyl-N''-nitroguanidine
    • (E)-1-(2-CHLORO-1,3-THIAZOL-5-YL METHYL)-3-METHYL-2-NITROGUANIDINE
    • (E)-1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3- methyl-2-nitroguanidine (clothianidin)
    • 210880-92-5

  • Applications

    Clothianidin (CAS 210880-92-5) is a systemic insecticide in the neonicotinoid class, widely used in agriculture to protect crops from a range of pests. Typical applications include seed treatment for corn, canola, and cereals to reduce early-season pest damage; soil- or seed-applied formulations (granules or liquids) to control soil-dwelling pests; foliar sprays to manage sucking pests such as aphids and whiteflies on vegetables and other crops grown under greenhouse or field conditions; and use in commercial pesticide products as an active ingredient within integrated pest management (IPM) programs, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.06
    methanol 9.08
    isopropanol 3.3
    water 0.32
    ethyl acetate 6.64
    n-propanol 3.35
    acetone 50.91
    n-butanol 2.94
    acetonitrile 12.76
    DMF 494.82
    toluene 1.49
    isobutanol 2.55
    1,4-dioxane 10.3
    methyl acetate 15.12
    THF 50.81
    2-butanone 37.43
    n-pentanol 3.28
    sec-butanol 2.86
    n-hexane 0.05
    ethylene glycol 7.43
    NMP 372.5
    cyclohexane 0.07
    DMSO 405.81
    n-butyl acetate 7.07
    n-octanol 1.08
    chloroform 13.07
    n-propyl acetate 8.75
    acetic acid 22.33
    dichloromethane 20.79
    cyclohexanone 33.23
    propylene glycol 8.6
    isopropyl acetate 4.74
    DMAc 442.85
    2-ethoxyethanol 22.45
    isopentanol 3.19
    n-heptane 0.09
    ethyl formate 14.16
    1,2-dichloroethane 12.96
    n-hexanol 2.75
    2-methoxyethanol 53.29
    isobutyl acetate 4.8
    tetrachloromethane 0.95
    n-pentyl acetate 5.13
    transcutol 33.18
    n-heptanol 1.84
    ethylbenzene 0.92
    MIBK 8.16
    2-propoxyethanol 21.92
    tert-butanol 4.6
    MTBE 2.47
    2-butoxyethanol 12.48
    propionic acid 8.48
    o-xylene 1.53
    formic acid 32.97
    diethyl ether 1.71
    m-xylene 1.4
    p-xylene 1.88
    chlorobenzene 3.22
    dimethyl carbonate 15.47
    n-octane 0.04
    formamide 68.2
    cyclopentanone 73.43
    2-pentanone 16.88
    anisole 5.63
    cyclopentyl methyl ether 6.09
    gamma-butyrolactone 68.93
    1-methoxy-2-propanol 33.5
    pyridine 23.33
    3-pentanone 12.7
    furfural 88.36
    n-dodecane 0.05
    diethylene glycol 26.83
    diisopropyl ether 0.48
    tert-amyl alcohol 4.52
    acetylacetone 28.69
    n-hexadecane 0.06
    acetophenone 15.93
    methyl propionate 14.29
    isopentyl acetate 6.61
    trichloroethylene 38.18
    n-nonanol 1.26
    cyclohexanol 2.52
    benzyl alcohol 10.73
    2-ethylhexanol 1.88
    isooctanol 1.61
    dipropyl ether 1.93
    1,2-dichlorobenzene 4.37
    ethyl lactate 12.9
    propylene carbonate 27.84
    n-methylformamide 86.79
    2-pentanol 1.57
    n-pentane 0.05
    1-propoxy-2-propanol 13.84
    1-methoxy-2-propyl acetate 13.74
    2-(2-methoxypropoxy) propanol 20.36
    mesitylene 0.85
    ε-caprolactone 24.6
    p-cymene 1.21
    epichlorohydrin 64.28
    1,1,1-trichloroethane 6.13
    2-aminoethanol 10.03
    morpholine-4-carbaldehyde 146.75
    sulfolane 167.21
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 12.27
    n-hexyl acetate 4.38
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 18.15
    sec-butyl acetate 4.32
    tert-butyl acetate 6.29
    decalin 0.07
    glycerin 25.67
    diglyme 38.51
    acrylic acid 16.22
    isopropyl myristate 2.13
    n-butyric acid 9.62
    acetyl acetate 5.56
    di(2-ethylhexyl) phthalate 6.24
    ethyl propionate 6.87
    nitromethane 92.64
    1,2-diethoxyethane 6.01
    benzonitrile 11.74
    trioctyl phosphate 3.59
    1-bromopropane 2.54
    gamma-valerolactone 107.6
    n-decanol 1.06
    triethyl phosphate 5.48
    4-methyl-2-pentanol 1.31
    propionitrile 7.14
    vinylene carbonate 24.87
    1,1,2-trichlorotrifluoroethane 82.07
    DMS 9.98
    cumene 0.81
    2-octanol 1.04
    2-hexanone 14.03
    octyl acetate 3.28
    limonene 1.51
    1,2-dimethoxyethane 42.8
    ethyl orthosilicate 4.07
    tributyl phosphate 4.63
    diacetone alcohol 21.33
    N,N-dimethylaniline 6.29
    acrylonitrile 19.27
    aniline 4.94
    1,3-propanediol 11.04
    bromobenzene 2.57
    dibromomethane 7.71
    1,1,2,2-tetrachloroethane 25.63
    2-methyl-cyclohexyl acetate 6.81
    tetrabutyl urea 9.79
    diisobutyl methanol 1.17
    2-phenylethanol 8.57
    styrene 1.23
    dioctyl adipate 5.7
    dimethyl sulfate 62.37
    ethyl butyrate 6.42
    methyl lactate 25.38
    butyl lactate 9.11
    diethyl carbonate 4.74
    propanediol butyl ether 13.78
    triethyl orthoformate 4.9
    p-tert-butyltoluene 1.13
    methyl 4-tert-butylbenzoate 13.95
    morpholine 22.16
    tert-butylamine 1.31
    n-dodecanol 0.82
    dimethoxymethane 53.69
    ethylene carbonate 14.73
    cyrene 40.45
    2-ethoxyethyl acetate 10.37
    2-ethylhexyl acetate 4.74
    1,2,4-trichlorobenzene 7.92
    4-methylpyridine 22.1
    dibutyl ether 1.17
    2,6-dimethyl-4-heptanol 1.17
    DEF 39.39
    dimethyl isosorbide 35.95
    tetrachloroethylene 11.5
    eugenol 18.22
    triacetin 11.39
    span 80 12.1
    1,4-butanediol 6.57
    1,1-dichloroethane 7.16
    2-methyl-1-pentanol 3.51
    methyl formate 66.07
    2-methyl-1-butanol 2.86
    n-decane 0.07
    butyronitrile 6.49
    3,7-dimethyl-1-octanol 1.57
    1-chlorooctane 0.48
    1-chlorotetradecane 0.26
    n-nonane 0.05
    undecane 0.06
    tert-butylcyclohexane 0.07
    cyclooctane 0.03
    cyclopentanol 6.3
    tetrahydropyran 4.29
    tert-amyl methyl ether 2.7
    2,5,8-trioxanonane 30.59
    1-hexene 0.4
    2-isopropoxyethanol 13.02
    2,2,2-trifluoroethanol 18.73
    methyl butyrate 13.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction