Clostripain

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  • Identifiers

    CAS number
    9028-00-6

    Molecular formula
    C192H456O6

    SMILES
    [HH].[HH].[HH].[HH].[HH].[HH].CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CCC.CC(C)CCC(CC(C)C)O.CC(C)CCC(CC(C)C)O.CC(C)CCC(CC(C)C)O.CC(C)CCC(CC(C)C)O.CC(C)CCC(CC(C)C)O.CC(C)CCC(CC(C)C)O.CC(C)CC=CCC(C)C.CC(C)CC=CCC(C)C.CC(C)CC=CCC(C)C.CC(C)CC=CCC(C)C.CC(C)CC=CCC(C)C.CC(C)CC=CCC(C)C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fruity 59.76%
    Herbal 54.19%
    Fresh 50.51%
    Green 50.31%
    Ethereal 43.26%
    Sweet 37.98%
    Woody 33.0%
    Pungent 32.82%
    Fermented 31.9%
    Citrus 31.85%

     

    Flavor
    Fishy 37.25%
    Ethereal 28.79%
    Fresh 26.29%
    Citrus 24.34%
    Ammonia 24.14%
    Ammoniacal 23.85%
    Oily 23.21%
    Glue 23.15%
    Solvent 22.37%
    Yeasty 22.16%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    17.2 (strong base)

    Molecular weight
    2862.0 g/mol

    Flash point

    • -109.21 ˚C est.

  • Synonyms

    • 9028-00-6
    • Clostripain
    • 1451592-07-6
    • deuterium monohydride;2,7-dimethyloctan-4-ol;(Z)-2,7-dimethyloct-4-ene;propane
    • 49596-05-6
    • SCHEMBL27910549
    • Clostripain from Clostridium histolyticum
    • FAPbI3 CH(NH2)2PbI3 pound not Formamidinium Iodide Perovskite
    • 69898-00-6
    • 95482-05-6
    • 95482-05-6

  • Applications

    Clostripain (CAS 9028-00-6) is a cysteine protease with Arg-specific cleavage. In practice, it is used in proteomics and peptide mapping to perform limited proteolysis, generating peptides with C-terminal Arg for sequence determination and structural characterization of proteins. It is also applied in antibody characterization and protein analysis to support biopharmaceutical development and quality control. Additionally, it is routinely used in sample preparation for mass spectrometry-based analyses and in proteolysis workflows for protein engineering studies to understand cleavage patterns and structure-function relationships.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 14.24
    methanol 16.23
    isopropanol 9.97
    water 0.13
    ethyl acetate 4.99
    n-propanol 11.32
    acetone 9.17
    n-butanol 9.87
    acetonitrile 8.92
    DMF 14.8
    toluene 1.5
    isobutanol 7.56
    1,4-dioxane 8.88
    methyl acetate 5.61
    THF 12.31
    2-butanone 6.7
    n-pentanol 5.77
    sec-butanol 8.32
    n-hexane 2.84
    ethylene glycol 6.1
    NMP 12.43
    cyclohexane 1.84
    DMSO 13.35
    n-butyl acetate 6.29
    n-octanol 4.5
    chloroform 11.09
    n-propyl acetate 3.13
    acetic acid 14.39
    dichloromethane 8.45
    cyclohexanone 8.51
    propylene glycol 7.58
    isopropyl acetate 2.85
    DMAc 8.08
    2-ethoxyethanol 5.43
    isopentanol 6.97
    n-heptane 2.07
    ethyl formate 3.99
    1,2-dichloroethane 5.0
    n-hexanol 10.23
    2-methoxyethanol 11.68
    isobutyl acetate 2.11
    tetrachloromethane 2.66
    n-pentyl acetate 2.92
    transcutol 14.82
    n-heptanol 4.31
    ethylbenzene 1.22
    MIBK 3.06
    2-propoxyethanol 9.77
    tert-butanol 10.58
    MTBE 6.09
    2-butoxyethanol 5.42
    propionic acid 9.71
    o-xylene 1.31
    formic acid 5.58
    diethyl ether 6.26
    m-xylene 1.24
    p-xylene 1.6
    chlorobenzene 2.81
    dimethyl carbonate 2.15
    n-octane 0.82
    formamide 5.43
    cyclopentanone 11.86
    2-pentanone 5.19
    anisole 2.76
    cyclopentyl methyl ether 5.66
    gamma-butyrolactone 12.92
    1-methoxy-2-propanol 8.71
    pyridine 5.87
    3-pentanone 3.99
    furfural 8.31
    n-dodecane 0.62
    diethylene glycol 7.57
    diisopropyl ether 1.95
    tert-amyl alcohol 8.31
    acetylacetone 4.34
    n-hexadecane 0.66
    acetophenone 2.53
    methyl propionate 4.57
    isopentyl acetate 5.02
    trichloroethylene 8.46
    n-nonanol 3.66
    cyclohexanol 6.15
    benzyl alcohol 2.51
    2-ethylhexanol 5.35
    isooctanol 3.19
    dipropyl ether 5.15
    1,2-dichlorobenzene 2.63
    ethyl lactate 2.34
    propylene carbonate 6.92
    n-methylformamide 8.2
    2-pentanol 6.33
    n-pentane 2.21
    1-propoxy-2-propanol 7.9
    1-methoxy-2-propyl acetate 4.2
    2-(2-methoxypropoxy) propanol 4.3
    mesitylene 0.98
    ε-caprolactone 6.75
    p-cymene 1.47
    epichlorohydrin 8.81
    1,1,1-trichloroethane 5.28
    2-aminoethanol 9.91
    morpholine-4-carbaldehyde 8.95
    sulfolane 14.57
    2,2,4-trimethylpentane 0.98
    2-methyltetrahydrofuran 9.63
    n-hexyl acetate 4.98
    isooctane 0.73
    2-(2-butoxyethoxy)ethanol 6.25
    sec-butyl acetate 2.05
    tert-butyl acetate 3.35
    decalin 0.92
    glycerin 8.22
    diglyme 8.61
    acrylic acid 9.13
    isopropyl myristate 2.13
    n-butyric acid 9.91
    acetyl acetate 3.05
    di(2-ethylhexyl) phthalate 2.04
    ethyl propionate 2.82
    nitromethane 12.05
    1,2-diethoxyethane 5.06
    benzonitrile 3.58
    trioctyl phosphate 1.81
    1-bromopropane 4.38
    gamma-valerolactone 10.42
    n-decanol 2.77
    triethyl phosphate 1.81
    4-methyl-2-pentanol 3.36
    propionitrile 6.97
    vinylene carbonate 5.45
    1,1,2-trichlorotrifluoroethane 7.52
    DMS 3.08
    cumene 1.11
    2-octanol 2.86
    2-hexanone 3.84
    octyl acetate 2.84
    limonene 2.56
    1,2-dimethoxyethane 7.53
    ethyl orthosilicate 1.81
    tributyl phosphate 2.12
    diacetone alcohol 5.15
    N,N-dimethylaniline 2.08
    acrylonitrile 8.13
    aniline 3.08
    1,3-propanediol 9.98
    bromobenzene 2.59
    dibromomethane 6.32
    1,1,2,2-tetrachloroethane 7.62
    2-methyl-cyclohexyl acetate 2.98
    tetrabutyl urea 2.69
    diisobutyl methanol 2.73
    2-phenylethanol 3.45
    styrene 1.53
    dioctyl adipate 2.8
    dimethyl sulfate 3.44
    ethyl butyrate 3.56
    methyl lactate 3.72
    butyl lactate 2.93
    diethyl carbonate 2.42
    propanediol butyl ether 5.61
    triethyl orthoformate 2.57
    p-tert-butyltoluene 1.55
    methyl 4-tert-butylbenzoate 3.28
    morpholine 11.01
    tert-butylamine 7.62
    n-dodecanol 2.19
    dimethoxymethane 5.63
    ethylene carbonate 4.52
    cyrene 3.37
    2-ethoxyethyl acetate 3.28
    2-ethylhexyl acetate 3.95
    1,2,4-trichlorobenzene 3.09
    4-methylpyridine 5.2
    dibutyl ether 4.25
    2,6-dimethyl-4-heptanol 2.73
    DEF 6.09
    dimethyl isosorbide 5.89
    tetrachloroethylene 5.34
    eugenol 3.44
    triacetin 3.56
    span 80 4.81
    1,4-butanediol 4.0
    1,1-dichloroethane 5.82
    2-methyl-1-pentanol 4.55
    methyl formate 5.16
    2-methyl-1-butanol 6.94
    n-decane 0.96
    butyronitrile 6.99
    3,7-dimethyl-1-octanol 3.82
    1-chlorooctane 2.6
    1-chlorotetradecane 1.14
    n-nonane 1.06
    undecane 0.75
    tert-butylcyclohexane 1.06
    cyclooctane 0.71
    cyclopentanol 8.33
    tetrahydropyran 8.76
    tert-amyl methyl ether 4.51
    2,5,8-trioxanonane 6.08
    1-hexene 5.25
    2-isopropoxyethanol 3.85
    2,2,2-trifluoroethanol 4.08
    methyl butyrate 3.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction