Clofentezine

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  • Identifiers

    CAS number
    74115-24-5

    Molecular formula
    C14H8Cl2N4

    SMILES
    C1=CC=C(C(=C1)C2=NN=C(N=N2)C3=CC=CC=C3Cl)Cl

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 58.8%
    Fruity 44.7%
    Animal 40.11%
    Grape 38.23%
    Neroli 37.68%
    Sweet 32.27%
    Orange 30.97%
    Honey 27.25%
    Rose 27.07%
    Musty 25.99%

     

    Flavor
    Bitter 73.35%
    Very strong 23.38%
    Odorless 23.15%
    Indole 22.75%
    Moth ball 21.46%
    Nitrile 21.24%
    Scallion 21.06%
    Naphthelene 20.97%
    Cereal 20.84%
    Bread crust 20.28%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    3.31 (weak acid)

    Molecular weight
    303.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    587°C

    Flash point

    • 221.64 ˚C est.

  • Synonyms

    • Clofentezine
    • 74115-24-5
    • 3,6-Bis(2-chlorophenyl)-1,2,4,5-tetrazine
    • Bisclofentazin
    • Bisclofentazine
    • bisclofentezin
    • 3,6-Bis(o-chlorophenyl)-1,2,4,5-tetrazine
    • DTXSID9023881
    • JS4U0R0033
    • NC-21314
    • DTXCID703881
    • CHEBI:39315
    • bis(2-chlorophenyl)-1,2,4,5-tetrazine
    • RefChem:577729
    • clofentezine (ISO); 3,6-bis(o-chlorophenyl)-1,2,4,5-tetrazine
    • 277-728-2
    • 1,2,4,5-Tetrazine, 3,6-bis(2-chlorophenyl)-
    • Acaristop
    • MFCD00143998
    • Clofentezine 10 microg/mL in Cyclohexane
    • Panatac
    • Apollo (pesticide)
    • Apollo 50W
    • Caswell No. 593A
    • C14H8Cl2N4
    • CAS-74115-24-5
    • NC 21314
    • EINECS 277-728-2
    • EPA Pesticide Chemical Code 125501
    • UNII-JS4U0R0033
    • Clofentezine [ANSI:BSI:ISO]
    • Clofentezine solution
    • Clofentezine (Standard)
    • CLOFENTEZINE [MI]
    • CLOFENTEZINE [ISO]
    • SCHEMBL74002
    • CHEMBL17888
    • orb1304149
    • orb3025757
    • SCHEMBL29375770
    • SCHEMBL30917908
    • HY-B2066R
    • GLXC-21912
    • HY-B2066
    • MSK25055
    • Tox21_201688
    • Tox21_300904
    • AKOS015902583
    • CS-5202
    • NCGC00163794-01
    • NCGC00163794-02
    • NCGC00163794-03
    • NCGC00163794-04
    • NCGC00254808-01
    • NCGC00259237-01
    • AC-12667
    • AS-76292
    • SY465110
    • DB-055841
    • NS00005836
    • A12808
    • C18576
    • Clofentezine, PESTANAL(R), analytical standard
    • 115C245
    • Q2979540
    • Pesticide4_Clofentezine_C14H8Cl2N4_1,2,4,5-Tetrazine, 3,6-bis(2-chlorophenyl)-
    • 74115-24-5

  • Applications

    Clofentezine (CAS 74115-24-5) is an acaricide used in agriculture to control mite pests on crops such as fruit trees, vegetables, and ornamentals, including greenhouse and field crops. It is typically formulated into crop-protection products (for example emulsifiable concentrates and wettable powders) and applied as foliar sprays. The chemical is employed in integrated pest management (IPM) programs to provide contact mite control, with some translaminar activity reported. As an active ingredient, it is formulated into a range of pesticide products for agricultural and horticultural use, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.39
    methanol 2.29
    isopropanol 1.51
    water 0.0
    ethyl acetate 25.7
    n-propanol 2.66
    acetone 28.72
    n-butanol 2.74
    acetonitrile 8.18
    DMF 79.25
    toluene 22.35
    isobutanol 1.82
    1,4-dioxane 27.39
    methyl acetate 27.86
    THF 114.57
    2-butanone 34.41
    n-pentanol 2.94
    sec-butanol 2.49
    n-hexane 0.33
    ethylene glycol 0.79
    NMP 84.94
    cyclohexane 0.41
    DMSO 24.02
    n-butyl acetate 21.15
    n-octanol 1.31
    chloroform 54.98
    n-propyl acetate 17.03
    acetic acid 7.27
    dichloromethane 77.36
    cyclohexanone 51.99
    propylene glycol 1.69
    isopropyl acetate 16.82
    DMAc 111.45
    2-ethoxyethanol 11.14
    isopentanol 2.87
    n-heptane 0.75
    ethyl formate 13.57
    1,2-dichloroethane 44.14
    n-hexanol 3.6
    2-methoxyethanol 20.02
    isobutyl acetate 9.37
    tetrachloromethane 2.69
    n-pentyl acetate 12.53
    transcutol 47.11
    n-heptanol 2.32
    ethylbenzene 8.47
    MIBK 14.62
    2-propoxyethanol 17.96
    tert-butanol 2.34
    MTBE 6.46
    2-butoxyethanol 9.08
    propionic acid 6.25
    o-xylene 9.73
    formic acid 2.27
    diethyl ether 8.02
    m-xylene 9.75
    p-xylene 10.55
    chlorobenzene 30.63
    dimethyl carbonate 23.76
    n-octane 0.35
    formamide 7.25
    cyclopentanone 95.46
    2-pentanone 26.01
    anisole 20.87
    cyclopentyl methyl ether 26.85
    gamma-butyrolactone 89.32
    1-methoxy-2-propanol 15.5
    pyridine 69.12
    3-pentanone 25.65
    furfural 89.03
    n-dodecane 0.35
    diethylene glycol 11.53
    diisopropyl ether 2.91
    tert-amyl alcohol 3.27
    acetylacetone 50.63
    n-hexadecane 0.42
    acetophenone 27.82
    methyl propionate 28.04
    isopentyl acetate 18.19
    trichloroethylene 139.41
    n-nonanol 1.82
    cyclohexanol 4.79
    benzyl alcohol 13.29
    2-ethylhexanol 4.49
    isooctanol 2.41
    dipropyl ether 9.99
    1,2-dichlorobenzene 28.12
    ethyl lactate 9.5
    propylene carbonate 39.44
    n-methylformamide 18.13
    2-pentanol 2.37
    n-pentane 0.28
    1-propoxy-2-propanol 14.6
    1-methoxy-2-propyl acetate 35.63
    2-(2-methoxypropoxy) propanol 16.77
    mesitylene 4.8
    ε-caprolactone 44.97
    p-cymene 6.58
    epichlorohydrin 123.22
    1,1,1-trichloroethane 28.03
    2-aminoethanol 1.87
    morpholine-4-carbaldehyde 68.64
    sulfolane 82.51
    2,2,4-trimethylpentane 0.44
    2-methyltetrahydrofuran 38.39
    n-hexyl acetate 9.3
    isooctane 0.29
    2-(2-butoxyethoxy)ethanol 16.78
    sec-butyl acetate 13.35
    tert-butyl acetate 18.26
    decalin 0.79
    glycerin 3.98
    diglyme 43.16
    acrylic acid 8.3
    isopropyl myristate 6.56
    n-butyric acid 9.93
    acetyl acetate 21.38
    di(2-ethylhexyl) phthalate 8.15
    ethyl propionate 19.02
    nitromethane 40.37
    1,2-diethoxyethane 25.73
    benzonitrile 23.98
    trioctyl phosphate 4.67
    1-bromopropane 15.23
    gamma-valerolactone 112.12
    n-decanol 1.68
    triethyl phosphate 12.1
    4-methyl-2-pentanol 2.16
    propionitrile 8.98
    vinylene carbonate 37.87
    1,1,2-trichlorotrifluoroethane 50.34
    DMS 24.17
    cumene 4.8
    2-octanol 1.74
    2-hexanone 17.9
    octyl acetate 7.1
    limonene 8.18
    1,2-dimethoxyethane 34.83
    ethyl orthosilicate 10.4
    tributyl phosphate 7.16
    diacetone alcohol 18.36
    N,N-dimethylaniline 12.81
    acrylonitrile 18.7
    aniline 16.93
    1,3-propanediol 3.69
    bromobenzene 37.27
    dibromomethane 32.13
    1,1,2,2-tetrachloroethane 65.93
    2-methyl-cyclohexyl acetate 15.92
    tetrabutyl urea 11.56
    diisobutyl methanol 3.88
    2-phenylethanol 14.78
    styrene 11.49
    dioctyl adipate 12.44
    dimethyl sulfate 41.87
    ethyl butyrate 20.73
    methyl lactate 16.44
    butyl lactate 10.36
    diethyl carbonate 13.98
    propanediol butyl ether 6.05
    triethyl orthoformate 14.63
    p-tert-butyltoluene 6.0
    methyl 4-tert-butylbenzoate 17.67
    morpholine 31.77
    tert-butylamine 1.4
    n-dodecanol 1.55
    dimethoxymethane 44.09
    ethylene carbonate 25.41
    cyrene 22.95
    2-ethoxyethyl acetate 26.07
    2-ethylhexyl acetate 15.69
    1,2,4-trichlorobenzene 38.94
    4-methylpyridine 50.99
    dibutyl ether 5.72
    2,6-dimethyl-4-heptanol 3.88
    DEF 34.17
    dimethyl isosorbide 47.57
    tetrachloroethylene 37.13
    eugenol 18.39
    triacetin 17.54
    span 80 10.89
    1,4-butanediol 1.45
    1,1-dichloroethane 25.07
    2-methyl-1-pentanol 3.87
    methyl formate 21.33
    2-methyl-1-butanol 2.92
    n-decane 0.43
    butyronitrile 8.53
    3,7-dimethyl-1-octanol 2.84
    1-chlorooctane 1.96
    1-chlorotetradecane 1.41
    n-nonane 0.33
    undecane 0.38
    tert-butylcyclohexane 0.73
    cyclooctane 0.23
    cyclopentanol 6.62
    tetrahydropyran 21.07
    tert-amyl methyl ether 8.3
    2,5,8-trioxanonane 33.16
    1-hexene 2.4
    2-isopropoxyethanol 8.19
    2,2,2-trifluoroethanol 4.38
    methyl butyrate 22.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction