Clioquinol

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  • Identifiers

    CAS number
    130-26-7

    Molecular formula
    C9H5ClINO

    SMILES
    C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 43.47%
    Phenolic 38.85%
    Burnt 37.91%
    Smoky 25.47%
    Animal 23.57%
    Meaty 22.07%
    Savory 20.62%
    Fruity 20.62%
    Bitter 20.14%
    Roasted 18.67%

     

    Flavor
    Bitter 87.03%
    Odorless 31.32%
    Mild 23.21%
    Very strong 21.6%
    Sweet-like 21.02%
    Indole 20.94%
    Nitrile 20.28%
    Scallion 19.87%
    Rotten 19.86%
    Bread crust 19.8%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    6.12 (neutral)

    Molecular weight
    305.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    421°C

    Melting point expt.

    • 352 to 354 °F (NTP, 1992)
    • 178.5 °C
    • 178-179 °C

    Flash point

    • 169.96 ˚C est.

    Solubility expt.

    • 0.8 [ug/mL] (The mean of the results at pH 7.4)
    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • One part dissolves in 43 parts of boiling alcohol, 128 parts chloroform, 17 parts of boiling ethyl acetate, 170 parts of cold acetic acid, 13 parts of boiling acetic acid. Almost insol in water, and alcohol, ether.
    • Practically insol water and in alcohol

  • Synonyms

    • clioquinol
    • 130-26-7
    • 5-Chloro-7-iodoquinolin-8-ol
    • Iodochlorhydroxyquin
    • 5-Chloro-8-hydroxy-7-iodoquinoline
    • Chinoform
    • Chloroiodoquin
    • 5-Chloro-7-iodo-8-quinolinol
    • Chloroiodoquine
    • Vioform
    • Iodochloroxyquinoline
    • Cliquinol
    • Iodochlorohydroxyquinoline
    • Chlorojodochin
    • Enteroquinol
    • Iodochloroquine
    • Iodochloroxine
    • Iodoenterol
    • 5-Chloro-7-iodo-8-hydroxyquinoline
    • 7-Iodo-5-chloroxine
    • Entero-Vioform
    • Iodochlorhydroxyquinoline
    • Iodoxyquinoline
    • Alchloquin
    • Barquinol
    • Budoform
    • Cifoform
    • Dermaform
    • Dioquinol
    • Domeform
    • Eczecidin
    • Enteroseptol
    • Enterozol
    • Enterseptol
    • Entrokin
    • Iodenterol
    • Lekosept
    • Mycoquin
    • Quinambicide
    • Rheaform
    • Amebil
    • Amoenol
    • Bactol
    • Emaform
    • Nioform
    • Rometin
    • Entero-Bioform
    • Iodochlorohydroxyquin
    • Hi-Enterol
    • Iodochlorhydroxyquinol
    • Hydriodide-enterol
    • Quin-O-Creme
    • Entero-Septol
    • Enterum locorten
    • 5-Chloro-7-iodo-quinolin-8-ol
    • Domeform-HC
    • 8-Quinolinol, 5-chloro-7-iodo-
    • 7-Iodo-5-chloro-8-hydroxyquinoline
    • Clioquinolum
    • Chloro-8-hydroxyiodoquinoline
    • Quinoform (antiseptic)
    • Vioform n.n.r.
    • Quinoline, chloro-8-hydroxyiodo-
    • 5-Chlor-7-jod-8-hydroxy-chinolin
    • Rheaform boluses
    • MFCD00006787
    • iodochlorhydroxyquinolone
    • NSC-3531
    • Chinoformum
    • Cliochinolum
    • 7BHQ856EJ5
    • Enterovalodon
    • Alioform
    • DTXSID7022837
    • Enteritan
    • Jodchloroxychinolinum
    • Oralcer
    • CHEBI:74460
    • Corque
    • Cortin
    • Iodo
    • Iodochloroxychinolinum
    • Cremo-quin
    • Entero-bio form
    • Entero-Vioformio
    • Ala-Quin
    • UAD Lotion
    • NSC-74938
    • NCGC00016391-05
    • Cliochinolo
    • CAS-130-26-7
    • Cliochinolo [DCIT]
    • TG2-36-2
    • Caswell No. 193
    • Formtone-HC
    • Clioquinolum [INN-Latin]
    • DTXCID502837
    • loquinol
    • Vioformio
    • Hi-eneterol
    • Iodochlorhydroxyquin Cream
    • Vioform-Hydrocortisone Mild
    • SMR000058282
    • Rheaform Boluses (Veterinary)
    • CCRIS 6050
    • HSDB 6843
    • 5-Chlor-7-jod-8-hydroxy-chinolin [German]
    • SR-01000002987
    • NSC 3531
    • EINECS 204-984-4
    • EPA Pesticide Chemical Code 024001
    • BRN 0153637
    • UNII-7BHQ856EJ5
    • Linolasept
    • Clioquinol [USP:INN:BAN]
    • Cloquinol
    • AI3-16451
    • Clioquinol (CQ)
    • component of Hyquin
    • NSC 74938
    • Clioquinol (Standard)
    • Nystaform (Salt/Mix)
    • Clioquinol (USP/INN)
    • CLIOQUINOL [INN]
    • component of Formtone-HC
    • component of Heb-Cort V
    • Prestwick0_000886
    • Prestwick1_000886

  • Applications

    Clioquinol (CAS 130-26-7) is primarily used as a topical antiseptic and antifungal agent in pharmaceutical and personal care formulations, including creams, ointments, and some shampoos for skin and scalp conditions. It also functions as a metal-chelating agent to sequester metal ions in formulations and manufacturing processes, helping stabilize or tailor metal content in various products. It serves as an organic synthesis intermediate and building block for quinoline-based compounds in chemical production. In research contexts, clioquinol is studied as a metal-ligand agent and in metal–protein interaction studies, including CNS-related investigations, though these uses are exploratory and not indicative of clinical claims. The use of clioquinol is subject to local regulatory limits and formulation restrictions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.09
    methanol 1.42
    isopropanol 1.54
    water 0.01
    ethyl acetate 6.45
    n-propanol 2.16
    acetone 5.69
    n-butanol 2.17
    acetonitrile 2.25
    DMF 32.77
    toluene 6.28
    isobutanol 2.18
    1,4-dioxane 19.92
    methyl acetate 7.14
    THF 36.31
    2-butanone 7.06
    n-pentanol 5.15
    sec-butanol 2.35
    n-hexane 0.74
    ethylene glycol 1.1
    NMP 26.45
    cyclohexane 0.55
    DMSO 8.13
    n-butyl acetate 17.82
    n-octanol 10.67
    chloroform 9.88
    n-propyl acetate 13.35
    acetic acid 4.21
    dichloromethane 9.55
    cyclohexanone 12.5
    propylene glycol 0.98
    isopropyl acetate 7.85
    DMAc 30.57
    2-ethoxyethanol 15.85
    isopentanol 3.57
    n-heptane 2.95
    ethyl formate 5.13
    1,2-dichloroethane 7.74
    n-hexanol 10.11
    2-methoxyethanol 12.58
    isobutyl acetate 12.73
    tetrachloromethane 2.1
    n-pentyl acetate 22.05
    transcutol 61.38
    n-heptanol 12.05
    ethylbenzene 6.72
    MIBK 9.89
    2-propoxyethanol 26.28
    tert-butanol 4.07
    MTBE 7.12
    2-butoxyethanol 24.23
    propionic acid 2.38
    o-xylene 6.48
    formic acid 2.04
    diethyl ether 5.02
    m-xylene 6.82
    p-xylene 8.74
    chlorobenzene 6.6
    dimethyl carbonate 8.39
    n-octane 1.91
    formamide 4.55
    cyclopentanone 18.54
    2-pentanone 6.69
    anisole 17.97
    cyclopentyl methyl ether 15.97
    gamma-butyrolactone 19.0
    1-methoxy-2-propanol 11.11
    pyridine 18.79
    3-pentanone 5.72
    furfural 29.52
    n-dodecane 1.86
    diethylene glycol 15.92
    diisopropyl ether 4.11
    tert-amyl alcohol 5.05
    acetylacetone 13.66
    n-hexadecane 2.14
    acetophenone 19.97
    methyl propionate 7.43
    isopentyl acetate 19.21
    trichloroethylene 18.85
    n-nonanol 12.1
    cyclohexanol 3.69
    benzyl alcohol 12.05
    2-ethylhexanol 12.01
    isooctanol 11.9
    dipropyl ether 15.52
    1,2-dichlorobenzene 8.5
    ethyl lactate 8.76
    propylene carbonate 11.92
    n-methylformamide 7.38
    2-pentanol 2.44
    n-pentane 0.45
    1-propoxy-2-propanol 21.64
    1-methoxy-2-propyl acetate 24.4
    2-(2-methoxypropoxy) propanol 27.74
    mesitylene 4.94
    ε-caprolactone 15.72
    p-cymene 10.55
    epichlorohydrin 29.32
    1,1,1-trichloroethane 6.59
    2-aminoethanol 2.09
    morpholine-4-carbaldehyde 40.35
    sulfolane 20.71
    2,2,4-trimethylpentane 0.9
    2-methyltetrahydrofuran 17.39
    n-hexyl acetate 20.35
    isooctane 0.81
    2-(2-butoxyethoxy)ethanol 34.15
    sec-butyl acetate 11.13
    tert-butyl acetate 13.41
    decalin 1.47
    glycerin 2.99
    diglyme 63.95
    acrylic acid 3.32
    isopropyl myristate 13.25
    n-butyric acid 3.92
    acetyl acetate 5.91
    di(2-ethylhexyl) phthalate 13.87
    ethyl propionate 10.79
    nitromethane 9.19
    1,2-diethoxyethane 32.43
    benzonitrile 12.87
    trioctyl phosphate 10.85
    1-bromopropane 4.26
    gamma-valerolactone 32.33
    n-decanol 10.19
    triethyl phosphate 10.66
    4-methyl-2-pentanol 3.7
    propionitrile 3.15
    vinylene carbonate 12.67
    1,1,2-trichlorotrifluoroethane 26.01
    DMS 15.61
    cumene 6.68
    2-octanol 10.24
    2-hexanone 15.72
    octyl acetate 15.19
    limonene 12.47
    1,2-dimethoxyethane 39.76
    ethyl orthosilicate 11.63
    tributyl phosphate 10.91
    diacetone alcohol 15.22
    N,N-dimethylaniline 19.32
    acrylonitrile 5.49
    aniline 7.6
    1,3-propanediol 2.96
    bromobenzene 6.48
    dibromomethane 5.61
    1,1,2,2-tetrachloroethane 15.23
    2-methyl-cyclohexyl acetate 19.34
    tetrabutyl urea 19.84
    diisobutyl methanol 9.0
    2-phenylethanol 18.92
    styrene 6.88
    dioctyl adipate 17.31
    dimethyl sulfate 11.86
    ethyl butyrate 15.77
    methyl lactate 6.48
    butyl lactate 16.69
    diethyl carbonate 9.98
    propanediol butyl ether 17.13
    triethyl orthoformate 14.98
    p-tert-butyltoluene 10.63
    methyl 4-tert-butylbenzoate 27.38
    morpholine 20.06
    tert-butylamine 3.28
    n-dodecanol 8.45
    dimethoxymethane 23.88
    ethylene carbonate 8.61
    cyrene 26.94
    2-ethoxyethyl acetate 29.05
    2-ethylhexyl acetate 17.76
    1,2,4-trichlorobenzene 11.38
    4-methylpyridine 16.13
    dibutyl ether 15.39
    2,6-dimethyl-4-heptanol 9.0
    DEF 15.77
    dimethyl isosorbide 54.41
    tetrachloroethylene 10.77
    eugenol 33.22
    triacetin 21.54
    span 80 23.07
    1,4-butanediol 2.71
    1,1-dichloroethane 4.66
    2-methyl-1-pentanol 7.04
    methyl formate 7.81
    2-methyl-1-butanol 3.04
    n-decane 2.96
    butyronitrile 3.66
    3,7-dimethyl-1-octanol 11.16
    1-chlorooctane 9.16
    1-chlorotetradecane 4.85
    n-nonane 2.45
    undecane 2.3
    tert-butylcyclohexane 1.73
    cyclooctane 0.56
    cyclopentanol 4.97
    tetrahydropyran 11.01
    tert-amyl methyl ether 9.0
    2,5,8-trioxanonane 49.1
    1-hexene 3.37
    2-isopropoxyethanol 15.25
    2,2,2-trifluoroethanol 3.74
    methyl butyrate 13.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction