(-)-Clerosterol

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  • Identifiers

    CAS number
    2364-23-0

    Molecular formula
    C29H48O

    SMILES
    CC[C@@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(=C)C

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  • Odor profile

    Fragrance
    Woody 81.8%
    Sandalwood 54.42%
    Amber 42.51%
    Balsamic 42.36%
    Sweet 42.34%
    Waxy 37.2%
    Dry 36.32%
    Vetiver 31.38%
    Powdery 31.31%
    Cedar 30.81%

     

    Flavor
    Woody 52.12%
    Wood 41.5%
    Herb 36.63%
    Herbal 33.55%
    Spice 31.45%
    Waxy 26.13%
    Balsam 24.04%
    Fir needle 23.16%
    Balsamic 22.34%
    Sandalwood 21.94%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    9.3

    pKa est.
    7.53 (neutral)

    Molecular weight
    412.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    516°C

    Flash point

    • 216.23 ˚C est.

  • Synonyms

    • Clerosterol
    • 2364-23-0
    • (-)-Clerosterol
    • Poriferasta-5,25-dien-3beta-ol
    • (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-ethyl-6-methylhept-6-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
    • (3S,8S,9S,10R,13R,14S,17R)-17-((2R,5S)-5-ethyl-6-methylhept-6-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3-ol
    • RefChem:905543
    • Stigmasta-5,25-dien-3-ol, (3beta,24S)-
    • 5,25-Stigmastadienol
    • NSC144945
    • NSC 144945
    • SCHEMBL598225
    • CHEMBL252365
    • orb1984211
    • CHEBI:166817
    • (24s)stigmasta-5,25-dien-3b-ol
    • EX-A15133
    • LMST01040124
    • MFCD28139307
    • MSK001403
    • AKOS040761517
    • FS-7119
    • 17-(5-Ethyl-6-methylhept-6-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3-ol
    • HY-129159
    • CS-0103809
    • Stigmasta-5,25-dien-3-ol, (3|A,24S)-
    • (3S,8S,9S,10R,13R,14S,17R)-17-[(1R,4S)-4-ethyl-1,5-dimethyl-hex-5-enyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
    • 1H-cyclopenta(a)phenanthren-3-ol, 2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-17-(5-ethyl-6-methylhept-6-en-2-yl)-10,13-dimethyl-
    • 2364-23-0

  • Applications

    (-)-Clerosterol (CAS 2364-23-0) is a sterol primarily used as an intermediate and a chiral building block in the synthesis of steroidal compounds within pharmaceutical and fine-chemical manufacturing. It can serve as a scaffold for preparing complex sterol derivatives and as a source of chirality in asymmetric syntheses. In cosmetics and personal care, clerosterol may function as a skin-conditioning agent and emollient, contributing to barrier-supporting formulations and helping to stabilize lipid phases in emulsions. In analytical chemistry and research, it is often used as a reference standard or as a starting material for method development and stereochemical studies. Depending on formulation and local regulations, it may be employed for other research or process-development purposes related to sterol chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 44.86
    methanol 7.77
    isopropanol 43.61
    water 0.04
    ethyl acetate 44.92
    n-propanol 51.24
    acetone 38.87
    n-butanol 65.54
    acetonitrile 4.76
    DMF 26.48
    toluene 100.56
    isobutanol 37.24
    1,4-dioxane 110.44
    methyl acetate 18.66
    THF 236.96
    2-butanone 44.06
    n-pentanol 27.86
    sec-butanol 23.55
    n-hexane 3.37
    ethylene glycol 0.67
    NMP 31.67
    cyclohexane 9.22
    DMSO 11.29
    n-butyl acetate 56.12
    n-octanol 19.25
    chloroform 106.2
    n-propyl acetate 28.18
    acetic acid 9.93
    dichloromethane 60.19
    cyclohexanone 76.66
    propylene glycol 2.01
    isopropyl acetate 60.21
    DMAc 44.16
    2-ethoxyethanol 37.78
    isopentanol 59.6
    n-heptane 5.71
    ethyl formate 10.85
    1,2-dichloroethane 40.42
    n-hexanol 42.35
    2-methoxyethanol 46.81
    isobutyl acetate 32.94
    tetrachloromethane 18.85
    n-pentyl acetate 55.07
    transcutol 298.54
    n-heptanol 31.12
    ethylbenzene 25.79
    MIBK 62.93
    2-propoxyethanol 102.1
    tert-butanol 35.11
    MTBE 58.93
    2-butoxyethanol 74.23
    propionic acid 9.5
    o-xylene 38.72
    formic acid 2.03
    diethyl ether 89.69
    m-xylene 63.93
    p-xylene 25.22
    chlorobenzene 48.77
    dimethyl carbonate 13.23
    n-octane 1.44
    formamide 3.32
    cyclopentanone 73.74
    2-pentanone 64.16
    anisole 53.31
    cyclopentyl methyl ether 93.02
    gamma-butyrolactone 48.25
    1-methoxy-2-propanol 64.02
    pyridine 79.31
    3-pentanone 38.3
    furfural 39.41
    n-dodecane 0.76
    diethylene glycol 25.42
    diisopropyl ether 29.18
    tert-amyl alcohol 19.7
    acetylacetone 63.21
    n-hexadecane 0.95
    acetophenone 38.16
    methyl propionate 31.85
    isopentyl acetate 76.69
    trichloroethylene 78.88
    n-nonanol 23.15
    cyclohexanol 34.93
    benzyl alcohol 29.74
    2-ethylhexanol 30.38
    isooctanol 29.5
    dipropyl ether 59.11
    1,2-dichlorobenzene 40.64
    ethyl lactate 12.86
    propylene carbonate 27.16
    n-methylformamide 7.29
    2-pentanol 35.91
    n-pentane 6.45
    1-propoxy-2-propanol 87.79
    1-methoxy-2-propyl acetate 109.6
    2-(2-methoxypropoxy) propanol 61.6
    mesitylene 34.31
    ε-caprolactone 66.27
    p-cymene 24.32
    epichlorohydrin 78.46
    1,1,1-trichloroethane 41.91
    2-aminoethanol 4.61
    morpholine-4-carbaldehyde 60.1
    sulfolane 36.89
    2,2,4-trimethylpentane 3.1
    2-methyltetrahydrofuran 95.79
    n-hexyl acetate 53.88
    isooctane 3.95
    2-(2-butoxyethoxy)ethanol 100.87
    sec-butyl acetate 32.33
    tert-butyl acetate 76.24
    decalin 4.07
    glycerin 4.34
    diglyme 179.34
    acrylic acid 5.6
    isopropyl myristate 23.44
    n-butyric acid 40.08
    acetyl acetate 29.94
    di(2-ethylhexyl) phthalate 25.28
    ethyl propionate 27.86
    nitromethane 13.0
    1,2-diethoxyethane 99.15
    benzonitrile 24.94
    trioctyl phosphate 16.88
    1-bromopropane 39.42
    gamma-valerolactone 117.35
    n-decanol 14.48
    triethyl phosphate 23.33
    4-methyl-2-pentanol 33.1
    propionitrile 15.0
    vinylene carbonate 25.47
    1,1,2-trichlorotrifluoroethane 33.23
    DMS 27.02
    cumene 18.02
    2-octanol 16.55
    2-hexanone 30.83
    octyl acetate 25.85
    limonene 28.43
    1,2-dimethoxyethane 79.03
    ethyl orthosilicate 30.09
    tributyl phosphate 17.14
    diacetone alcohol 56.34
    N,N-dimethylaniline 35.77
    acrylonitrile 10.13
    aniline 55.57
    1,3-propanediol 22.96
    bromobenzene 59.44
    dibromomethane 47.88
    1,1,2,2-tetrachloroethane 63.97
    2-methyl-cyclohexyl acetate 46.15
    tetrabutyl urea 25.04
    diisobutyl methanol 25.8
    2-phenylethanol 51.01
    styrene 27.75
    dioctyl adipate 33.17
    dimethyl sulfate 15.99
    ethyl butyrate 46.67
    methyl lactate 12.84
    butyl lactate 39.38
    diethyl carbonate 25.69
    propanediol butyl ether 37.98
    triethyl orthoformate 52.49
    p-tert-butyltoluene 24.46
    methyl 4-tert-butylbenzoate 61.26
    morpholine 121.15
    tert-butylamine 26.17
    n-dodecanol 8.98
    dimethoxymethane 79.19
    ethylene carbonate 26.03
    cyrene 39.01
    2-ethoxyethyl acetate 88.27
    2-ethylhexyl acetate 58.96
    1,2,4-trichlorobenzene 48.78
    4-methylpyridine 78.33
    dibutyl ether 30.28
    2,6-dimethyl-4-heptanol 25.8
    DEF 42.61
    dimethyl isosorbide 100.12
    tetrachloroethylene 44.22
    eugenol 55.42
    triacetin 52.08
    span 80 48.94
    1,4-butanediol 5.13
    1,1-dichloroethane 40.4
    2-methyl-1-pentanol 28.09
    methyl formate 5.09
    2-methyl-1-butanol 42.03
    n-decane 2.1
    butyronitrile 27.39
    3,7-dimethyl-1-octanol 26.3
    1-chlorooctane 11.15
    1-chlorotetradecane 3.08
    n-nonane 1.76
    undecane 1.17
    tert-butylcyclohexane 3.71
    cyclooctane 3.71
    cyclopentanol 23.48
    tetrahydropyran 147.75
    tert-amyl methyl ether 33.31
    2,5,8-trioxanonane 101.17
    1-hexene 11.79
    2-isopropoxyethanol 35.82
    2,2,2-trifluoroethanol 4.18
    methyl butyrate 28.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction