Clausine L

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  • Identifiers

    CAS number
    14501-65-6

    Molecular formula
    C15H13NO3

    SMILES
    COC1=C(C=C2C3=CC=CC=C3NC2=C1)C(=O)OC

    Safety labels

  • Odor profile

    Fragrance
    Floral 66.98%
    Fruity 62.13%
    Grape 55.77%
    Neroli 50.51%
    Sweet 48.15%
    Orange 43.89%
    Powdery 38.25%
    Animal 31.85%
    Phenolic 28.99%
    Berry 28.79%

     

    Flavor
    Bitter 89.57%
    Odorless 25.88%
    Aniseed 19.97%
    Lovage 19.94%
    Bland 19.85%
    Parsley 19.68%
    Indole 19.68%
    Very strong 19.67%
    Tarragon 19.48%
    Sweet-like 19.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    6.96 (neutral)

    Molecular weight
    255.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    455°C

    Melting point expt.

    • 133 - 135 °C

    Flash point

    • 226.8 ˚C est.

  • Synonyms

    • Clausine L
    • methyl 2-methoxy-9H-carbazole-3-carboxylate
    • 9ALK8P8JQ2
    • 14501-65-6
    • DTXSID001318404
    • RefChem:126807
    • DTXCID001748215
    • O-Methylmukonidine
    • UNII-9ALK8P8JQ2
    • 9H-Carbazole-3-carboxylic acid, 2-methoxy-, methyl ester
    • Clausine-L
    • CHEMBL2037029
    • 2-Methoxy-3-carbomethoxycarbazole
    • CHEBI:173802
    • 14501-65-6

  • Applications

    Clausine L, CAS number: 14501-65-6, is used mainly as an intermediate in organic synthesis and as a processing aid in industrial formulations; in perfumery and cosmetics it may be evaluated as an odorant or fixative component; in coatings, inks and adhesives it can function as a solvent or processing diluent; in polymers and plastics manufacturing it may serve as a reactive intermediate for resin systems; in cleaning products it can act as a solvent or fragrance carrier; these applications reflect common roles for small-molecule additives in formulation science, and actual use is subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.25
    methanol 8.56
    isopropanol 5.28
    water 0.06
    ethyl acetate 22.34
    n-propanol 7.21
    acetone 30.25
    n-butanol 7.22
    acetonitrile 8.81
    DMF 115.77
    toluene 3.2
    isobutanol 6.75
    1,4-dioxane 33.98
    methyl acetate 30.61
    THF 75.83
    2-butanone 28.03
    n-pentanol 7.15
    sec-butanol 5.91
    n-hexane 0.16
    ethylene glycol 7.25
    NMP 100.64
    cyclohexane 0.23
    DMSO 75.41
    n-butyl acetate 18.49
    n-octanol 3.17
    chloroform 38.46
    n-propyl acetate 22.3
    acetic acid 29.08
    dichloromethane 44.28
    cyclohexanone 42.04
    propylene glycol 4.89
    isopropyl acetate 15.55
    DMAc 149.17
    2-ethoxyethanol 31.46
    isopentanol 9.8
    n-heptane 0.18
    ethyl formate 15.06
    1,2-dichloroethane 32.89
    n-hexanol 8.09
    2-methoxyethanol 48.31
    isobutyl acetate 16.62
    tetrachloromethane 3.4
    n-pentyl acetate 12.1
    transcutol 63.98
    n-heptanol 5.51
    ethylbenzene 3.48
    MIBK 15.96
    2-propoxyethanol 35.72
    tert-butanol 9.79
    MTBE 7.85
    2-butoxyethanol 20.89
    propionic acid 16.75
    o-xylene 3.89
    formic acid 21.04
    diethyl ether 7.22
    m-xylene 3.36
    p-xylene 5.73
    chlorobenzene 9.97
    dimethyl carbonate 31.33
    n-octane 0.14
    formamide 46.23
    cyclopentanone 64.17
    2-pentanone 20.27
    anisole 16.06
    cyclopentyl methyl ether 20.29
    gamma-butyrolactone 82.25
    1-methoxy-2-propanol 29.96
    pyridine 31.42
    3-pentanone 18.85
    furfural 67.24
    n-dodecane 0.2
    diethylene glycol 41.6
    diisopropyl ether 2.52
    tert-amyl alcohol 10.08
    acetylacetone 37.7
    n-hexadecane 0.24
    acetophenone 24.22
    methyl propionate 27.34
    isopentyl acetate 19.61
    trichloroethylene 73.8
    n-nonanol 3.86
    cyclohexanol 9.33
    benzyl alcohol 18.77
    2-ethylhexanol 6.72
    isooctanol 5.54
    dipropyl ether 5.78
    1,2-dichlorobenzene 12.73
    ethyl lactate 17.59
    propylene carbonate 40.74
    n-methylformamide 36.01
    2-pentanol 4.77
    n-pentane 0.11
    1-propoxy-2-propanol 21.8
    1-methoxy-2-propyl acetate 30.04
    2-(2-methoxypropoxy) propanol 25.61
    mesitylene 2.31
    ε-caprolactone 39.29
    p-cymene 3.82
    epichlorohydrin 90.74
    1,1,1-trichloroethane 16.66
    2-aminoethanol 10.34
    morpholine-4-carbaldehyde 84.76
    sulfolane 93.9
    2,2,4-trimethylpentane 0.33
    2-methyltetrahydrofuran 34.24
    n-hexyl acetate 11.79
    isooctane 0.18
    2-(2-butoxyethoxy)ethanol 26.59
    sec-butyl acetate 15.5
    tert-butyl acetate 17.43
    decalin 0.49
    glycerin 20.61
    diglyme 54.46
    acrylic acid 23.46
    isopropyl myristate 5.76
    n-butyric acid 19.52
    acetyl acetate 20.28
    di(2-ethylhexyl) phthalate 11.13
    ethyl propionate 20.25
    nitromethane 72.01
    1,2-diethoxyethane 17.69
    benzonitrile 16.98
    trioctyl phosphate 6.74
    1-bromopropane 7.85
    gamma-valerolactone 84.3
    n-decanol 3.18
    triethyl phosphate 15.9
    4-methyl-2-pentanol 5.16
    propionitrile 10.57
    vinylene carbonate 38.89
    1,1,2-trichlorotrifluoroethane 70.46
    DMS 27.01
    cumene 3.46
    2-octanol 3.33
    2-hexanone 19.39
    octyl acetate 7.56
    limonene 4.69
    1,2-dimethoxyethane 53.33
    ethyl orthosilicate 13.5
    tributyl phosphate 8.81
    diacetone alcohol 28.85
    N,N-dimethylaniline 12.78
    acrylonitrile 18.92
    aniline 13.26
    1,3-propanediol 16.42
    bromobenzene 8.0
    dibromomethane 18.25
    1,1,2,2-tetrachloroethane 48.58
    2-methyl-cyclohexyl acetate 17.62
    tetrabutyl urea 12.63
    diisobutyl methanol 4.33
    2-phenylethanol 18.74
    styrene 4.06
    dioctyl adipate 11.8
    dimethyl sulfate 62.44
    ethyl butyrate 16.28
    methyl lactate 24.94
    butyl lactate 14.85
    diethyl carbonate 16.18
    propanediol butyl ether 13.65
    triethyl orthoformate 14.79
    p-tert-butyltoluene 3.3
    methyl 4-tert-butylbenzoate 21.66
    morpholine 43.95
    tert-butylamine 4.06
    n-dodecanol 2.51
    dimethoxymethane 56.16
    ethylene carbonate 31.48
    cyrene 36.81
    2-ethoxyethyl acetate 24.99
    2-ethylhexyl acetate 15.31
    1,2,4-trichlorobenzene 18.37
    4-methylpyridine 26.08
    dibutyl ether 4.05
    2,6-dimethyl-4-heptanol 4.33
    DEF 34.26
    dimethyl isosorbide 43.36
    tetrachloroethylene 31.41
    eugenol 25.12
    triacetin 22.2
    span 80 15.93
    1,4-butanediol 7.72
    1,1-dichloroethane 16.89
    2-methyl-1-pentanol 10.3
    methyl formate 34.77
    2-methyl-1-butanol 8.95
    n-decane 0.26
    butyronitrile 9.52
    3,7-dimethyl-1-octanol 4.65
    1-chlorooctane 1.78
    1-chlorotetradecane 1.0
    n-nonane 0.18
    undecane 0.23
    tert-butylcyclohexane 0.45
    cyclooctane 0.11
    cyclopentanol 12.79
    tetrahydropyran 18.08
    tert-amyl methyl ether 8.59
    2,5,8-trioxanonane 41.09
    1-hexene 1.34
    2-isopropoxyethanol 24.34
    2,2,2-trifluoroethanol 26.6
    methyl butyrate 25.57

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction