Cirsilineol

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  • Identifiers

    CAS number
    41365-32-6

    Molecular formula
    C18H16O7

    SMILES
    COC1=C(C=CC(=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC)OC)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 64.62%
    Vanilla 55.27%
    Spicy 52.1%
    Smoky 46.45%
    Sweet 44.83%
    Balsamic 41.6%
    Burnt 41.0%
    Woody 39.23%
    Powdery 34.45%
    Medicinal 30.43%

     

    Flavor
    Bitter 76.53%
    Bland 23.43%
    Eugenol 22.72%
    Parsley 22.24%
    Ham 20.51%
    Sweet-like 20.17%
    Allspice 20.15%
    Vanilla 20.04%
    Odorless 19.85%
    Cedarleaf 19.74%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    8.81 (weak base)

    Molecular weight
    344.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    786°C

    Flash point

    • 212.73 ˚C est.

  • Synonyms

    • Cirsilineol
    • 41365-32-6
    • Eupatrin
    • Fastigenin
    • Anisomelin
    • 4',5-Dihydroxy-3',6,7-trimethoxyflavone
    • 08DZZ529FE
    • DTXSID20194314
    • 5,4'-Dihydroxy-6,7,3'-trimethoxyflavone
    • NSC-633556
    • 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-
    • CHEBI:3718
    • 4',5-dihydroxy-3',6,7-trimethoxy-flavone
    • 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one
    • RefChem:36747
    • DTXCID30116805
    • 2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one
    • 4,5-Dihydroxy-3,6,7-trimethoxyflavone
    • Cirsileneol
    • NSC633556
    • 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one
    • 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one
    • 5-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-chromen-4-one
    • UNII-08DZZ529FE
    • VKOSQMWSWLZQPA-UHFFFAOYSA-N
    • MFCD01083015
    • Cirsilineol (Standard)
    • CHEMBL487213
    • orb1705920
    • SCHEMBL2045672
    • Cirsilineol, analytical standard
    • SCHEMBL29435128
    • BDBM50412272
    • LMPK12111249
    • AKOS040744460
    • HY-119347R
    • DA-62341
    • MS-25276
    • HY-119347
    • CS-0067567
    • C10032
    • G12957
    • Q15634189
    • Cirsilineol (5,4'-dihydroxy-6,7,3'-trimethoxyflavone)
    • 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one #
    • Cirsilineol

  • Applications

    Cirsilineol (CAS 41365-32-6) is a plant-derived compound that may serve as a synthetic scaffold and an intermediate in natural products chemistry. In industry, it may be evaluated as an antioxidant additive for cosmetic and personal care formulations; it can act as a stabilizer in polymer and coating systems; it may be considered a fragrance-related ingredient or a precursor for early-stage pharmaceutical and agrochemical synthesis in research settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.08
    methanol 0.08
    isopropanol 0.13
    water 0.0
    ethyl acetate 0.53
    n-propanol 0.2
    acetone 0.31
    n-butanol 0.18
    acetonitrile 0.25
    DMF 4.45
    toluene 0.05
    isobutanol 0.21
    1,4-dioxane 1.0
    methyl acetate 0.74
    THF 4.96
    2-butanone 0.9
    n-pentanol 0.23
    sec-butanol 0.28
    n-hexane 0.01
    ethylene glycol 0.19
    NMP 10.97
    cyclohexane 0.01
    DMSO 14.47
    n-butyl acetate 0.82
    n-octanol 0.26
    chloroform 0.65
    n-propyl acetate 0.65
    acetic acid 0.87
    dichloromethane 1.01
    cyclohexanone 1.81
    propylene glycol 0.18
    isopropyl acetate 0.46
    DMAc 11.47
    2-ethoxyethanol 1.56
    isopentanol 0.3
    n-heptane 0.03
    ethyl formate 0.3
    1,2-dichloroethane 0.93
    n-hexanol 0.26
    2-methoxyethanol 2.2
    isobutyl acetate 0.42
    tetrachloromethane 0.07
    n-pentyl acetate 0.72
    transcutol 5.82
    n-heptanol 0.35
    ethylbenzene 0.08
    MIBK 0.51
    2-propoxyethanol 2.79
    tert-butanol 0.39
    MTBE 0.36
    2-butoxyethanol 1.83
    propionic acid 0.73
    o-xylene 0.1
    formic acid 0.49
    diethyl ether 0.23
    m-xylene 0.07
    p-xylene 0.13
    chlorobenzene 0.13
    dimethyl carbonate 1.17
    n-octane 0.02
    formamide 1.15
    cyclopentanone 3.37
    2-pentanone 0.46
    anisole 0.38
    cyclopentyl methyl ether 0.95
    gamma-butyrolactone 5.65
    1-methoxy-2-propanol 1.77
    pyridine 1.05
    3-pentanone 0.66
    furfural 4.26
    n-dodecane 0.02
    diethylene glycol 2.74
    diisopropyl ether 0.11
    tert-amyl alcohol 0.57
    acetylacetone 1.11
    n-hexadecane 0.02
    acetophenone 0.85
    methyl propionate 1.03
    isopentyl acetate 1.07
    trichloroethylene 1.99
    n-nonanol 0.37
    cyclohexanol 0.39
    benzyl alcohol 0.46
    2-ethylhexanol 0.42
    isooctanol 0.41
    dipropyl ether 0.69
    1,2-dichlorobenzene 0.32
    ethyl lactate 0.91
    propylene carbonate 1.54
    n-methylformamide 1.0
    2-pentanol 0.17
    n-pentane 0.01
    1-propoxy-2-propanol 2.01
    1-methoxy-2-propyl acetate 2.21
    2-(2-methoxypropoxy) propanol 3.02
    mesitylene 0.06
    ε-caprolactone 2.13
    p-cymene 0.23
    epichlorohydrin 6.21
    1,1,1-trichloroethane 0.35
    2-aminoethanol 0.3
    morpholine-4-carbaldehyde 7.96
    sulfolane 16.85
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 1.59
    n-hexyl acetate 0.81
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 2.82
    sec-butyl acetate 0.5
    tert-butyl acetate 0.91
    decalin 0.03
    glycerin 1.25
    diglyme 7.23
    acrylic acid 1.05
    isopropyl myristate 0.49
    n-butyric acid 0.58
    acetyl acetate 0.48
    di(2-ethylhexyl) phthalate 0.75
    ethyl propionate 0.89
    nitromethane 3.18
    1,2-diethoxyethane 1.42
    benzonitrile 0.43
    trioctyl phosphate 0.55
    1-bromopropane 0.28
    gamma-valerolactone 6.24
    n-decanol 0.28
    triethyl phosphate 1.42
    4-methyl-2-pentanol 0.19
    propionitrile 0.44
    vinylene carbonate 1.27
    1,1,2-trichlorotrifluoroethane 7.79
    DMS 1.58
    cumene 0.1
    2-octanol 0.25
    2-hexanone 0.71
    octyl acetate 0.6
    limonene 0.33
    1,2-dimethoxyethane 3.8
    ethyl orthosilicate 1.24
    tributyl phosphate 0.71
    diacetone alcohol 1.95
    N,N-dimethylaniline 0.58
    acrylonitrile 0.85
    aniline 0.27
    1,3-propanediol 0.52
    bromobenzene 0.11
    dibromomethane 0.39
    1,1,2,2-tetrachloroethane 2.01
    2-methyl-cyclohexyl acetate 1.28
    tetrabutyl urea 1.27
    diisobutyl methanol 0.36
    2-phenylethanol 0.69
    styrene 0.07
    dioctyl adipate 1.06
    dimethyl sulfate 5.13
    ethyl butyrate 1.08
    methyl lactate 1.49
    butyl lactate 1.05
    diethyl carbonate 0.97
    propanediol butyl ether 1.11
    triethyl orthoformate 1.51
    p-tert-butyltoluene 0.22
    methyl 4-tert-butylbenzoate 2.08
    morpholine 1.94
    tert-butylamine 0.16
    n-dodecanol 0.22
    dimethoxymethane 2.33
    ethylene carbonate 0.96
    cyrene 3.86
    2-ethoxyethyl acetate 1.66
    2-ethylhexyl acetate 0.88
    1,2,4-trichlorobenzene 0.59
    4-methylpyridine 0.6
    dibutyl ether 0.51
    2,6-dimethyl-4-heptanol 0.36
    DEF 1.84
    dimethyl isosorbide 7.04
    tetrachloroethylene 1.04
    eugenol 2.07
    triacetin 1.92
    span 80 1.65
    1,4-butanediol 0.22
    1,1-dichloroethane 0.26
    2-methyl-1-pentanol 0.41
    methyl formate 0.76
    2-methyl-1-butanol 0.33
    n-decane 0.03
    butyronitrile 0.24
    3,7-dimethyl-1-octanol 0.37
    1-chlorooctane 0.17
    1-chlorotetradecane 0.09
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.03
    cyclooctane 0.01
    cyclopentanol 0.62
    tetrahydropyran 0.6
    tert-amyl methyl ether 0.61
    2,5,8-trioxanonane 5.41
    1-hexene 0.06
    2-isopropoxyethanol 1.28
    2,2,2-trifluoroethanol 0.85
    methyl butyrate 1.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction