Cinoxate

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  • Identifiers

    CAS number
    104-28-9

    Molecular formula
    C14H18O4

    SMILES
    CCOCCOC(=O)/C=C/C1=CC=C(C=C1)OC

  • Odor profile

    Fragrance
    Sweet 65.25%
    Balsamic 62.16%
    Spicy 54.74%
    Floral 49.43%
    Fruity 47.06%
    Cinnamon 39.19%
    Vanilla 38.36%
    Powdery 33.62%
    Warm 33.15%
    Honey 33.0%

     

    Flavor
    Fruity 52.91%
    Floral 42.0%
    Balsam 35.58%
    Sweet 30.29%
    Chocolate 25.11%
    Grape 25.01%
    Strawberry 24.6%
    Berry 22.47%
    Rose 21.48%
    Honey 21.33%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    6.05 (neutral)

    Molecular weight
    250.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • Solidifies below -25 °C

    Boiling point

    • 388 °C at 760 mm Hg /Extrapolated from 185 °C at 2 mm Hg/
    • BP: 185 °C at 2 mm Hg

    Flash point

    • 159.34 ˚C est.
    • greater than 212 °F (NTP, 1992)

    Solubility expt.

    • Insoluble (NTP, 1992)
    • Practically insoluble in water with a solubility of approximately 0.05%.
    • Soluble in glycerol 0.5%, propolyene glycol 5%; miscible with alcohols and vegetable oils

  • Synonyms

    • Cinoxate
    • 104-28-9
    • Phiasol
    • Sundare
    • Cinoxato
    • Giv Tan F
    • 2-ETHOXYETHYL P-METHOXYCINNAMATE
    • Give-Tan
    • Cinoxatum
    • Giv Tanf
    • Giv-tan F
    • 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethoxyethyl ester
    • 2-Ethoxyethyl-p-methoxycinnamate
    • 2-ethoxyethyl (E)-3-(4-methoxyphenyl)prop-2-enoate
    • 5437O7N5BH
    • CINOXATE [HSDB]
    • CINOXATE [USAN]
    • 3-(4-Methoxyphenyl)-2-propenoic acid 2-ethoxyethyl ester
    • CINOXATE [INN]
    • CINOXATE [MI]
    • CINOXATE [VANDF]
    • CINOXATE [MART.]
    • CINOXATE [WHO-DD]
    • DTXCID305264
    • DTXSID2025264
    • Cinnamic acid, p-methoxy-, 2-ethoxyethyl ester
    • Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethoxyethyl ester
    • CINOXATE (MART.)
    • 2-ethoxyethyl 3-(4-methoxyphenyl)prop-2-enoate
    • 1322-65-2
    • 2-ethoxyethyl (2E)-3-(4-methoxyphenyl)prop-2-enoate
    • Caswell No. 427E
    • Cinoxatum [INN-Latin]
    • Cinoxato [INN-Spanish]
    • 83834-60-0
    • CCRIS 4813
    • HSDB 7424
    • EINECS 203-191-0
    • EPA Pesticide Chemical Code 076604
    • BRN 2728232
    • Cinoxate [USAN:USP:INN]
    • Cinoxat
    • GiveTan
    • p-Methoxycinnamic acid 2-ethoxyethyl ester
    • UNII-5437O7N5BH
    • GivTan F
    • SUN-DARE
    • CINOXATE [INCI]
    • Cinoxate (USAN/INN)
    • AI Number: 076604
    • SCHEMBL15558
    • 2Ethoxyethyl pmethoxycinnamate
    • Cinoxate, analytical standard
    • CHEMBL2104045
    • 2-ethoxyethyl 4-methoxycinnamate
    • DTXSID101167513
    • Tox21_113675
    • DB15467
    • FC29839
    • NCGC00249899-01
    • CAS-104-28-9
    • p-Methoxycinnamic Acid 2-Ehoxyethyl Ester
    • p-Methoxycinnamic acid 2 ethoxyethyl ester
    • HY-107333
    • p-Methoxycinnamic acid, 2-ethoxyethyl ester
    • Cinnamic acid, p-methoxy-2-ethoxyethyl ester
    • NS00013537
    • D03512
    • ETHANOL, 2-ETHOXY-, P-METHOXYCINNAMATE
    • 2-ethoxyethyl (2E)-3-(4-methoxyphenyl)acrylate
    • EN300-6492977
    • EN300-21043514
    • SR-01000945002
    • 2-Ethoxyethyl 3-(4-methoxyphenyl)-2-propenoate #
    • 2-Propenoic acid, 4-methoxy-, 2-ethoxyethyl ester
    • Q2319112
    • SR-01000945002-1
    • BRD-K17828029-001-01-5
    • Z53833825
    • 3-(-4-Methoxyphenyl)-2-propenoic acid, 2-ethoxyethyl ester
    • 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethoxyethyl ester, (E)-
    • 203-191-0

  • Applications

    Cinoxate (CAS 104-28-9) is a UVB-filtering agent used primarily in cosmetic and personal care formulations, especially sunscreen products and SPF-containing skin care items. It is also employed as a UV absorber in coatings and inks to reduce photodegradation, and as a stabilizer in polymer formulations to improve the light stability of plastics and coatings. It may be considered for inclusion in household and consumer products that require UV protection, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 125.52
    methanol 207.35
    isopropanol 64.71
    water 0.74
    ethyl acetate 303.24
    n-propanol 73.4
    acetone 137.22
    n-butanol 58.42
    acetonitrile 204.74
    DMF 127.94
    toluene 73.53
    isobutanol 39.62
    1,4-dioxane 404.94
    methyl acetate 196.33
    THF 290.3
    2-butanone 116.84
    n-pentanol 47.45
    sec-butanol 52.41
    n-hexane 2.67
    ethylene glycol 46.98
    NMP 98.29
    cyclohexane 11.66
    DMSO 500.02
    n-butyl acetate 56.42
    n-octanol 11.07
    chloroform 543.62
    n-propyl acetate 77.0
    acetic acid 266.0
    dichloromethane 753.85
    cyclohexanone 123.4
    propylene glycol 46.11
    isopropyl acetate 92.38
    DMAc 283.96
    2-ethoxyethanol 226.82
    isopentanol 44.43
    n-heptane 2.97
    ethyl formate 92.3
    1,2-dichloroethane 458.89
    n-hexanol 27.1
    2-methoxyethanol 303.74
    isobutyl acetate 39.89
    tetrachloromethane 35.42
    n-pentyl acetate 22.88
    transcutol 455.27
    n-heptanol 11.95
    ethylbenzene 32.84
    MIBK 45.38
    2-propoxyethanol 99.04
    tert-butanol 103.01
    MTBE 81.98
    2-butoxyethanol 43.24
    propionic acid 98.54
    o-xylene 45.78
    formic acid 143.89
    diethyl ether 132.51
    m-xylene 33.26
    p-xylene 38.49
    chlorobenzene 100.75
    dimethyl carbonate 82.99
    n-octane 1.48
    formamide 265.76
    cyclopentanone 112.68
    2-pentanone 78.05
    anisole 95.99
    cyclopentyl methyl ether 94.61
    gamma-butyrolactone 187.51
    1-methoxy-2-propanol 144.14
    pyridine 272.43
    3-pentanone 85.99
    furfural 212.58
    n-dodecane 1.65
    diethylene glycol 130.6
    diisopropyl ether 21.92
    tert-amyl alcohol 66.02
    acetylacetone 161.54
    n-hexadecane 1.87
    acetophenone 89.93
    methyl propionate 148.44
    isopentyl acetate 51.25
    trichloroethylene 649.44
    n-nonanol 12.41
    cyclohexanol 61.82
    benzyl alcohol 76.72
    2-ethylhexanol 18.02
    isooctanol 11.32
    dipropyl ether 36.16
    1,2-dichlorobenzene 96.76
    ethyl lactate 40.56
    propylene carbonate 98.07
    n-methylformamide 101.85
    2-pentanol 32.49
    n-pentane 2.78
    1-propoxy-2-propanol 52.28
    1-methoxy-2-propyl acetate 91.45
    2-(2-methoxypropoxy) propanol 77.92
    mesitylene 19.89
    ε-caprolactone 122.36
    p-cymene 16.24
    epichlorohydrin 380.41
    1,1,1-trichloroethane 212.97
    2-aminoethanol 76.71
    morpholine-4-carbaldehyde 211.76
    sulfolane 188.96
    2,2,4-trimethylpentane 3.11
    2-methyltetrahydrofuran 163.2
    n-hexyl acetate 31.78
    isooctane 1.69
    2-(2-butoxyethoxy)ethanol 93.94
    sec-butyl acetate 51.06
    tert-butyl acetate 81.1
    decalin 6.27
    glycerin 94.21
    diglyme 235.77
    acrylic acid 99.83
    isopropyl myristate 18.17
    n-butyric acid 119.69
    acetyl acetate 199.6
    di(2-ethylhexyl) phthalate 22.93
    ethyl propionate 84.98
    nitromethane 480.81
    1,2-diethoxyethane 123.94
    benzonitrile 72.6
    trioctyl phosphate 12.25
    1-bromopropane 134.32
    gamma-valerolactone 198.64
    n-decanol 10.17
    triethyl phosphate 44.52
    4-methyl-2-pentanol 17.54
    propionitrile 106.12
    vinylene carbonate 107.37
    1,1,2-trichlorotrifluoroethane 240.04
    DMS 73.68
    cumene 19.4
    2-octanol 7.38
    2-hexanone 52.98
    octyl acetate 20.59
    limonene 21.02
    1,2-dimethoxyethane 283.01
    ethyl orthosilicate 42.39
    tributyl phosphate 21.72
    diacetone alcohol 79.07
    N,N-dimethylaniline 57.24
    acrylonitrile 137.08
    aniline 110.57
    1,3-propanediol 111.57
    bromobenzene 111.27
    dibromomethane 377.18
    1,1,2,2-tetrachloroethane 465.48
    2-methyl-cyclohexyl acetate 48.83
    tetrabutyl urea 29.76
    diisobutyl methanol 13.67
    2-phenylethanol 49.65
    styrene 48.86
    dioctyl adipate 39.32
    dimethyl sulfate 125.42
    ethyl butyrate 61.5
    methyl lactate 64.11
    butyl lactate 24.17
    diethyl carbonate 59.86
    propanediol butyl ether 34.49
    triethyl orthoformate 53.02
    p-tert-butyltoluene 15.2
    methyl 4-tert-butylbenzoate 53.47
    morpholine 398.86
    tert-butylamine 43.53
    n-dodecanol 8.82
    dimethoxymethane 196.32
    ethylene carbonate 91.26
    cyrene 72.58
    2-ethoxyethyl acetate 65.36
    2-ethylhexyl acetate 41.86
    1,2,4-trichlorobenzene 121.13
    4-methylpyridine 147.44
    dibutyl ether 28.0
    2,6-dimethyl-4-heptanol 13.67
    DEF 116.68
    dimethyl isosorbide 135.46
    tetrachloroethylene 275.37
    eugenol 56.95
    triacetin 74.38
    span 80 44.57
    1,4-butanediol 45.19
    1,1-dichloroethane 266.16
    2-methyl-1-pentanol 44.1
    methyl formate 87.83
    2-methyl-1-butanol 41.47
    n-decane 2.35
    butyronitrile 78.15
    3,7-dimethyl-1-octanol 15.34
    1-chlorooctane 10.31
    1-chlorotetradecane 5.65
    n-nonane 2.0
    undecane 1.91
    tert-butylcyclohexane 4.36
    cyclooctane 3.32
    cyclopentanol 53.21
    tetrahydropyran 222.48
    tert-amyl methyl ether 57.24
    2,5,8-trioxanonane 187.37
    1-hexene 14.21
    2-isopropoxyethanol 103.71
    2,2,2-trifluoroethanol 100.3
    methyl butyrate 94.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction