Cinchophen

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  • Identifiers

    CAS number
    132-60-5

    Molecular formula
    C16H11NO2

    SMILES
    C1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 60.55%
    Honey 43.06%
    Balsamic 41.61%
    Neroli 40.98%
    Grape 38.03%
    Animal 37.43%
    Phenolic 35.41%
    Fruity 34.27%
    Sweet 32.87%
    Orange 32.59%

     

    Flavor
    Bitter 68.23%
    Odorless 34.86%
    Balsam 28.57%
    Honey 28.14%
    Mild 28.12%
    Faint 23.51%
    Nitrile 23.32%
    Urine 23.31%
    Very strong 23.24%
    Moth ball 23.06%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    6.42 (neutral)

    Molecular weight
    249.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    489°C

    Melting point expt.

    • 218 °C

    Flash point

    • 223.33 ˚C est.

    Solubility expt.

    • RAPIDLY LOSES WATER OF CRYSTALLIZATION ON EXPOSURE TO AIR; SOL IN WATER, ALC; PRACTICALLY INSOL IN ETHER /LITHIUM SALT OCTAHYDRATE/
    • SOLUBLE IN HOT ALCOHOL, ALKALI; SLIGHTLY SOL IN HOT ACETONE, HOT BENZENE; INSOLUBLE IN PETROLEUM ETHER, WATER
    • 1 G DISSOLVES IN ABOUT: 400 ML CHLOROFORM, 100 ML ETHER, 120 ML ALCOHOL

  • Synonyms

    • Cinchophen
    • 132-60-5
    • 2-Phenylquinoline-4-carboxylic acid
    • 2-Phenyl-4-quinolinecarboxylic acid
    • Cinchopen
    • 2-Phenylcinchoninic acid
    • Cinchophene
    • Atophan
    • Tervalon
    • Cinconal
    • Phenoquin
    • Quinofen
    • Quinophan
    • Quinophen
    • Atofan
    • Cinchophenic acid
    • Aciphenochinolinium
    • Aminophan
    • Cincosal
    • Ikterosan
    • Mylofanol
    • Phenophan
    • Rhematan
    • Tophosan
    • Traubofan
    • Agotan
    • Alutyl
    • Artexin
    • Atigoa
    • Atocin
    • Rheumin
    • Tophol
    • Vantyl
    • Viophan
    • Artam
    • Aciphenochinoline
    • CINCOPHEN
    • 2-Phenylcinchonic acid
    • Acifenokinolin
    • Cincofeno
    • Artamin
    • 4-Quinolinecarboxylic acid, 2-phenyl-
    • Aciphenochinolinum
    • Cinchoninic acid, 2-phenyl-
    • Cincofene [DCIT]
    • Cinchophenum
    • Cincofene
    • Phenylcinchoninic Acid
    • 2-Phenyl-quinoline-4-carboxylic acid
    • Cincofeno [INN-Spanish]
    • Cinchophene [INN-French]
    • Cinchophenum [INN-Latin]
    • NSC 2617
    • Rheumatan
    • Alutyo
    • HSDB 2085
    • 2-Phenylquinoline-4-carboxlic acid
    • NSC-2617
    • Cinchophen [INN:BAN:NF]
    • EINECS 205-067-1
    • MFCD00006750
    • Cinchophen (BAN)
    • BRN 0192803
    • DTXSID0040705
    • UNII-39Y533Z02M
    • AI3-15400
    • CINCHOPHEN [MI]
    • CINCHOPHEN [INN]
    • CINCHOPHEN [HSDB]
    • 39Y533Z02M
    • CINCHOPHEN [MART.]
    • CINCHOPHEN [WHO-DD]
    • MLS000053018
    • N-Cyclohexyl-2-phenyl-4-chinolincarboxamid
    • CHEMBL348000
    • DTXCID8020705
    • 5-22-03-00484 (Beilstein Handbook Reference)
    • 2-Phenylquinolinecarboxylic acid-(4)
    • NCGC00018221-06
    • NCGC00018221-08
    • SMR000059017
    • Cincofeno (INN-Spanish)
    • Cinchophene (INN-French)
    • Cinchophenum (INN-Latin)
    • CINCHOPHEN (MART.)
    • WLN: T66 BNJ CR & EVQ
    • aciphenochinolium
    • CAS-132-60-5
    • SR-01000000141
    • aciphenocholinum
    • Cincain (TN)
    • Cinchophen (Standard)
    • 2-Phenylquinoline acid
    • Opera_ID_819
    • Cambridge id 5117240
    • TimTec1_001239
    • Oprea1_652483
    • SCHEMBL25519
    • MLS000069591
    • MLS001074296
    • HY-B0972R
    • M04AC02
    • NSC2617
    • CHEBI:114195
    • HMS1537I07
    • HMS2236H09
    • HMS3264N13
    • HMS3369G13
    • HMS3652D09
    • Pharmakon1600-01504508
    • ALBB-035149
    • HY-B0972
    • NSC70178
    • Tox21_110841
    • Tox21_400022
    • BBL011719
    • BDBM50097100
    • CCG-34161
    • NSC-70178
    • NSC758887
    • STK076256
    • 2-phenyl-4-quinoline-carboxylic acid
    • AKOS000264299
    • Tox21_110841_1
    • CS-4461
    • DB13551
    • FP44219
    • NSC-758887

  • Applications

    Cinchophen (CAS 132-60-5) is primarily used as an organic synthesis intermediate across multiple industries. It serves as a building block in the production of dyes and pigments, and as a precursor in the synthesis of pharmaceuticals and specialty chemicals. In the polymer and coatings sector, it can be used as a precursor to functional intermediates for materials technology. It is also used in research and development as a reagent and reference standard to support method development and characterization. Additionally, it may appear in synthetic routes for related fine chemicals in agrochemical and other industrial applications, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.71
    methanol 4.7
    isopropanol 1.45
    water 0.01
    ethyl acetate 1.97
    n-propanol 3.24
    acetone 2.41
    n-butanol 2.75
    acetonitrile 0.93
    DMF 52.93
    toluene 2.25
    isobutanol 1.87
    1,4-dioxane 7.3
    methyl acetate 3.02
    THF 23.96
    2-butanone 5.75
    n-pentanol 2.39
    sec-butanol 1.99
    n-hexane 0.0
    ethylene glycol 1.88
    NMP 28.09
    cyclohexane 0.01
    DMSO 26.01
    n-butyl acetate 3.77
    n-octanol 1.22
    chloroform 0.21
    n-propyl acetate 2.85
    acetic acid 3.94
    dichloromethane 0.98
    cyclohexanone 7.85
    propylene glycol 1.74
    isopropyl acetate 2.52
    DMAc 80.16
    2-ethoxyethanol 10.5
    isopentanol 3.32
    n-heptane 0.03
    ethyl formate 1.81
    1,2-dichloroethane 2.97
    n-hexanol 2.8
    2-methoxyethanol 21.76
    isobutyl acetate 2.18
    tetrachloromethane 0.05
    n-pentyl acetate 3.99
    transcutol 52.51
    n-heptanol 2.55
    ethylbenzene 1.52
    MIBK 3.72
    2-propoxyethanol 14.81
    tert-butanol 2.01
    MTBE 1.58
    2-butoxyethanol 11.07
    propionic acid 2.68
    o-xylene 1.72
    formic acid 3.65
    diethyl ether 1.19
    m-xylene 1.51
    p-xylene 1.5
    chlorobenzene 1.55
    dimethyl carbonate 4.54
    n-octane 0.02
    formamide 10.84
    cyclopentanone 14.22
    2-pentanone 3.37
    anisole 6.52
    cyclopentyl methyl ether 4.52
    gamma-butyrolactone 14.21
    1-methoxy-2-propanol 12.59
    pyridine 18.47
    3-pentanone 2.58
    furfural 21.7
    n-dodecane 0.05
    diethylene glycol 13.87
    diisopropyl ether 0.45
    tert-amyl alcohol 2.65
    acetylacetone 5.85
    n-hexadecane 0.06
    acetophenone 8.78
    methyl propionate 3.61
    isopentyl acetate 5.48
    trichloroethylene 6.53
    n-nonanol 1.71
    cyclohexanol 1.7
    benzyl alcohol 7.79
    2-ethylhexanol 2.47
    isooctanol 2.6
    dipropyl ether 2.18
    1,2-dichlorobenzene 2.42
    ethyl lactate 3.54
    propylene carbonate 5.16
    n-methylformamide 9.73
    2-pentanol 1.26
    n-pentane 0.01
    1-propoxy-2-propanol 8.67
    1-methoxy-2-propyl acetate 10.0
    2-(2-methoxypropoxy) propanol 12.54
    mesitylene 0.78
    ε-caprolactone 8.81
    p-cymene 1.86
    epichlorohydrin 30.47
    1,1,1-trichloroethane 0.39
    2-aminoethanol 4.51
    morpholine-4-carbaldehyde 30.81
    sulfolane 25.55
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 7.22
    n-hexyl acetate 4.08
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 17.76
    sec-butyl acetate 2.83
    tert-butyl acetate 4.52
    decalin 0.06
    glycerin 6.16
    diglyme 37.39
    acrylic acid 3.99
    isopropyl myristate 2.34
    n-butyric acid 3.41
    acetyl acetate 1.75
    di(2-ethylhexyl) phthalate 4.06
    ethyl propionate 3.02
    nitromethane 7.52
    1,2-diethoxyethane 8.87
    benzonitrile 5.03
    trioctyl phosphate 2.34
    1-bromopropane 0.44
    gamma-valerolactone 27.9
    n-decanol 1.41
    triethyl phosphate 3.86
    4-methyl-2-pentanol 1.47
    propionitrile 1.9
    vinylene carbonate 5.86
    1,1,2-trichlorotrifluoroethane 17.36
    DMS 6.26
    cumene 1.34
    2-octanol 1.24
    2-hexanone 3.65
    octyl acetate 2.82
    limonene 1.58
    1,2-dimethoxyethane 20.28
    ethyl orthosilicate 3.76
    tributyl phosphate 2.54
    diacetone alcohol 10.32
    N,N-dimethylaniline 5.68
    acrylonitrile 4.5
    aniline 6.12
    1,3-propanediol 6.93
    bromobenzene 1.2
    dibromomethane 0.25
    1,1,2,2-tetrachloroethane 4.47
    2-methyl-cyclohexyl acetate 5.07
    tetrabutyl urea 4.69
    diisobutyl methanol 1.94
    2-phenylethanol 8.47
    styrene 1.68
    dioctyl adipate 4.49
    dimethyl sulfate 9.91
    ethyl butyrate 3.74
    methyl lactate 5.44
    butyl lactate 5.21
    diethyl carbonate 3.0
    propanediol butyl ether 7.02
    triethyl orthoformate 3.99
    p-tert-butyltoluene 1.66
    methyl 4-tert-butylbenzoate 10.24
    morpholine 13.83
    tert-butylamine 0.8
    n-dodecanol 1.1
    dimethoxymethane 17.81
    ethylene carbonate 3.37
    cyrene 12.29
    2-ethoxyethyl acetate 8.83
    2-ethylhexyl acetate 4.04
    1,2,4-trichlorobenzene 4.26
    4-methylpyridine 11.07
    dibutyl ether 1.91
    2,6-dimethyl-4-heptanol 1.94
    DEF 9.95
    dimethyl isosorbide 24.73
    tetrachloroethylene 2.93
    eugenol 12.48
    triacetin 6.72
    span 80 7.89
    1,4-butanediol 2.02
    1,1-dichloroethane 0.34
    2-methyl-1-pentanol 3.71
    methyl formate 5.19
    2-methyl-1-butanol 3.22
    n-decane 0.06
    butyronitrile 1.72
    3,7-dimethyl-1-octanol 2.09
    1-chlorooctane 0.51
    1-chlorotetradecane 0.32
    n-nonane 0.03
    undecane 0.05
    tert-butylcyclohexane 0.07
    cyclooctane 0.0
    cyclopentanol 2.06
    tetrahydropyran 3.4
    tert-amyl methyl ether 2.32
    2,5,8-trioxanonane 25.9
    1-hexene 0.1
    2-isopropoxyethanol 7.45
    2,2,2-trifluoroethanol 1.55
    methyl butyrate 3.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction