Ciclopirox Olamine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    41621-49-2

    Molecular formula
    C14H24N2O3

    SMILES
    CC1=CC(=O)N(C(=C1)C2CCCCC2)O.C(CO)N

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Animal 33.44%
    Odorless 27.26%
    Phenolic 26.82%
    Spicy 26.14%
    Dry 21.06%
    Leathery 20.84%
    Woody 20.44%
    Fruity 18.66%
    Burnt 18.42%
    Musty 18.07%

     

    Flavor
    Bitter 58.35%
    Fruity 22.8%
    Lovage 20.94%
    Cedarleaf 20.74%
    Very strong 20.56%
    Parsley 20.19%
    Ripe apricot 20.12%
    Indole 20.12%
    Curry 20.11%
    Cereal 20.04%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.25 (neutral)

    Molecular weight
    268.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    437°C

    Flash point

    • 152.67 ˚C est.

  • Synonyms

    • Ciclopirox olamine
    • 41621-49-2
    • Batrafen
    • Micoxolamina
    • Brumixol
    • Mycoster
    • Ciclochem
    • Dafnegin
    • HOE 296
    • Ciclopirox ethanolamine salt (1:1)
    • HOE-296
    • 50MD4SB4AP
    • NSC-336278
    • DTXSID6045583
    • DTXCID4025583
    • cyclopyroxolamine
    • RefChem:58504
    • CICLOPIROX 3%
    • HOE296
    • CHEBI:31398
    • Ciclopirox ethanolamine
    • Ciclopiroxolamin
    • Ciclopirox (olamine)
    • MFCD00078997
    • Ciclobirox Olamine
    • 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one compound with 2-aminoethanol (1:1)
    • MLS003170863
    • 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
    • NSC336278
    • 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone compound with 2-aminoethanol (1:1)
    • NCGC00017112-01
    • CAS-41621-49-2
    • 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one 2-aminoethanol salt
    • Loprox (TN)
    • 2-aminoethan-1-ol; 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one
    • 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-, compound with 2-aminoethanol (1:1)
    • MLS002153867
    • SR-05000001589
    • SMR001233223
    • EINECS 255-464-9
    • UNII-50MD4SB4AP
    • NSC 336278
    • Cyclopirox olamine
    • RV4104A
    • Penlac nail lacquer
    • Prestwick_785
    • Ciclopirox olamine [USAN:USP:JAN]
    • Ciclopirox olamine CRS
    • Spectrum_000150
    • Ciclopirox ethanol amine
    • 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine salt
    • 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt
    • Ciclopirox olamine (GMP)
    • 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridon, 2-aminoethanol-salz [German]
    • 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
    • SCHEMBL66960
    • Ciclopirox (olamine) (GMP)
    • KBioSS_000630
    • DivK1c_000705
    • SPECTRUM1500189
    • Ciclopirox olamine (JAN/USP)
    • CHEMBL242580
    • HY-B0450AG
    • HY-B0450AR
    • orb1309723
    • orb3025780
    • CICLOPIROX OLAMINE [JAN]
    • Ciclopirox (olamine) (Standard)
    • HMS502D07
    • HY-B0450A
    • KBio1_000705
    • KBio2_000630
    • KBio2_003198
    • KBio2_005766
    • CICLOPIROX OLAMINE [USAN]
    • NINDS_000705
    • CICLOPIROX OLAMINE [VANDF]
    • HMS1569N03
    • HMS1920O09
    • HMS2091E16
    • HMS2096N03
    • HMS2232B06
    • HMS3656B16
    • HMS3713N03
    • HMS5081A06
    • Pharmakon1600-01500189
    • CICLOPIROX OLAMINE [MART.]
    • CICLOPIROX OLAMINE [USP-RS]
    • CICLOPIROX OLAMINE [WHO-DD]
    • MSK10154
    • Tox21_110781
    • 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridon, 2-aminoethanol-salz
    • CCG-38945
    • EBC-03767
    • NSC756694
    • s3019
    • AKOS015891685
    • Tox21_110781_1
    • Ciclopirox olamine - Bio-X trade mark
    • Ciclopirox olamine, analytical standard
    • CS-4767
    • FC35446
    • KS-5086
    • NSC-756694
    • CICLOPIROX OLAMINE [EP IMPURITY]
    • IDI1_000705
    • CICLOPIROX OLAMINE [EP MONOGRAPH]
    • NCGC00017112-02
    • NCGC00017112-03
    • NCGC00017112-10
    • NCGC00094623-01
    • NCGC00094623-02
    • AC-14469
    • BC164302
    • CICLOPIROX OLAMINE [USP MONOGRAPH]
    • NCI60_002954
    • SY102087
    • C3545
    • NS00088641
    • ST51039041
    • SW196923-4
    • 42C050
    • D01364
    • EN300-7357052
    • CICLOPIROX ETHANOLAMINE SALT (1:1) [MI]
    • F448710
    • SR-05000001589-1
    • 41621-49-2

  • Applications

    Ciclopirox olamine (CAS 41621-49-2) is primarily used as an antifungal active in topical pharmaceutical formulations. It is commonly formulated in creams, gels, and solutions for the treatment of superficial fungal skin infections; it is also used in nail lacquer to treat onychomycosis, and features in medicated shampoos for scalp fungal conditions such as dandruff and seborrheic dermatitis. In addition, it is included in various dermatological topical dosage forms such as lotions and sprays as an antifungal agent, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 193.91
    methanol 186.27
    isopropanol 185.54
    water 0.33
    ethyl acetate 201.04
    n-propanol 202.34
    acetone 364.35
    n-butanol 171.67
    acetonitrile 177.27
    DMF 670.75
    toluene 127.41
    isobutanol 152.08
    1,4-dioxane 288.16
    methyl acetate 222.7
    THF 450.77
    2-butanone 341.39
    n-pentanol 88.9
    sec-butanol 146.74
    n-hexane 2.44
    ethylene glycol 45.48
    NMP 391.54
    cyclohexane 11.3
    DMSO 395.1
    n-butyl acetate 159.48
    n-octanol 45.47
    chloroform 661.4
    n-propyl acetate 108.27
    acetic acid 178.78
    dichloromethane 675.76
    cyclohexanone 484.35
    propylene glycol 66.5
    isopropyl acetate 122.26
    DMAc 369.05
    2-ethoxyethanol 129.68
    isopentanol 141.78
    n-heptane 2.71
    ethyl formate 195.99
    1,2-dichloroethane 530.09
    n-hexanol 114.09
    2-methoxyethanol 288.12
    isobutyl acetate 68.8
    tetrachloromethane 46.84
    n-pentyl acetate 87.85
    transcutol 318.33
    n-heptanol 58.08
    ethylbenzene 56.42
    MIBK 119.7
    2-propoxyethanol 187.83
    tert-butanol 152.35
    MTBE 96.84
    2-butoxyethanol 109.67
    propionic acid 174.42
    o-xylene 80.42
    formic acid 64.46
    diethyl ether 95.75
    m-xylene 82.41
    p-xylene 76.81
    chlorobenzene 246.08
    dimethyl carbonate 82.24
    n-octane 2.31
    formamide 126.44
    cyclopentanone 573.87
    2-pentanone 224.66
    anisole 96.85
    cyclopentyl methyl ether 148.49
    gamma-butyrolactone 549.91
    1-methoxy-2-propanol 209.23
    pyridine 447.24
    3-pentanone 158.17
    furfural 455.57
    n-dodecane 2.67
    diethylene glycol 148.95
    diisopropyl ether 25.99
    tert-amyl alcohol 109.81
    acetylacetone 231.68
    n-hexadecane 3.19
    acetophenone 129.95
    methyl propionate 175.43
    isopentyl acetate 138.07
    trichloroethylene 1003.34
    n-nonanol 40.05
    cyclohexanol 147.33
    benzyl alcohol 118.43
    2-ethylhexanol 61.32
    isooctanol 48.45
    dipropyl ether 39.78
    1,2-dichlorobenzene 198.56
    ethyl lactate 67.68
    propylene carbonate 292.24
    n-methylformamide 296.21
    2-pentanol 96.87
    n-pentane 3.34
    1-propoxy-2-propanol 129.37
    1-methoxy-2-propyl acetate 140.71
    2-(2-methoxypropoxy) propanol 89.51
    mesitylene 46.22
    ε-caprolactone 317.84
    p-cymene 37.15
    epichlorohydrin 634.3
    1,1,1-trichloroethane 281.33
    2-aminoethanol 96.69
    morpholine-4-carbaldehyde 314.23
    sulfolane 518.6
    2,2,4-trimethylpentane 4.11
    2-methyltetrahydrofuran 262.69
    n-hexyl acetate 108.92
    isooctane 3.63
    2-(2-butoxyethoxy)ethanol 131.85
    sec-butyl acetate 69.98
    tert-butyl acetate 112.46
    decalin 6.79
    glycerin 93.25
    diglyme 230.51
    acrylic acid 167.64
    isopropyl myristate 37.12
    n-butyric acid 249.44
    acetyl acetate 110.1
    di(2-ethylhexyl) phthalate 49.48
    ethyl propionate 91.33
    nitromethane 354.6
    1,2-diethoxyethane 99.73
    benzonitrile 199.33
    trioctyl phosphate 36.5
    1-bromopropane 171.72
    gamma-valerolactone 537.27
    n-decanol 30.41
    triethyl phosphate 44.17
    4-methyl-2-pentanol 57.47
    propionitrile 182.56
    vinylene carbonate 275.27
    1,1,2-trichlorotrifluoroethane 290.12
    DMS 102.86
    cumene 37.93
    2-octanol 38.51
    2-hexanone 108.15
    octyl acetate 51.86
    limonene 44.82
    1,2-dimethoxyethane 200.0
    ethyl orthosilicate 39.54
    tributyl phosphate 41.82
    diacetone alcohol 149.07
    N,N-dimethylaniline 62.08
    acrylonitrile 264.94
    aniline 172.59
    1,3-propanediol 167.95
    bromobenzene 235.04
    dibromomethane 388.47
    1,1,2,2-tetrachloroethane 693.01
    2-methyl-cyclohexyl acetate 72.71
    tetrabutyl urea 54.59
    diisobutyl methanol 36.2
    2-phenylethanol 119.9
    styrene 68.31
    dioctyl adipate 57.58
    dimethyl sulfate 134.99
    ethyl butyrate 85.9
    methyl lactate 101.85
    butyl lactate 80.71
    diethyl carbonate 63.27
    propanediol butyl ether 99.44
    triethyl orthoformate 55.2
    p-tert-butyltoluene 33.48
    methyl 4-tert-butylbenzoate 101.85
    morpholine 363.11
    tert-butylamine 74.44
    n-dodecanol 22.83
    dimethoxymethane 212.9
    ethylene carbonate 216.94
    cyrene 114.09
    2-ethoxyethyl acetate 114.14
    2-ethylhexyl acetate 101.38
    1,2,4-trichlorobenzene 228.7
    4-methylpyridine 345.52
    dibutyl ether 39.55
    2,6-dimethyl-4-heptanol 36.2
    DEF 229.06
    dimethyl isosorbide 165.71
    tetrachloroethylene 379.4
    eugenol 102.72
    triacetin 90.2
    span 80 80.74
    1,4-butanediol 57.71
    1,1-dichloroethane 412.89
    2-methyl-1-pentanol 82.58
    methyl formate 228.66
    2-methyl-1-butanol 124.47
    n-decane 3.79
    butyronitrile 191.37
    3,7-dimethyl-1-octanol 47.15
    1-chlorooctane 29.9
    1-chlorotetradecane 11.35
    n-nonane 3.08
    undecane 3.16
    tert-butylcyclohexane 5.82
    cyclooctane 3.35
    cyclopentanol 184.08
    tetrahydropyran 294.37
    tert-amyl methyl ether 64.81
    2,5,8-trioxanonane 147.2
    1-hexene 20.46
    2-isopropoxyethanol 88.95
    2,2,2-trifluoroethanol 76.54
    methyl butyrate 148.33

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction