Chromium Picolinate

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  • Identifiers

    CAS number
    14639-25-9

    Molecular formula
    C18H12CrN3O6

    SMILES
    C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Cr+3]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 61.8%
    Nutty 39.06%
    Burnt 29.75%
    Roasted 29.58%
    Popcorn 28.06%
    Caramellic 27.15%
    Musty 22.6%
    Bitter 22.12%
    Almond 19.87%
    Cooked 19.15%

     

    Flavor
    Nutty 51.0%
    Odorless 43.14%
    Popcorn 38.28%
    Bitter 32.19%
    Roast 27.99%
    Corn 27.39%
    Chip 26.62%
    Mild 26.46%
    Musty 25.88%
    Bread crust 25.05%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.2 (weak acid)

    Molecular weight
    418.3 g/mol

    Flash point

    • 92.43 ˚C est.

  • Synonyms

    • Chromium picolinate
    • 14639-25-9
    • Chromium(III) Picolinate
    • Chromium(III) Pyridine-2-carboxylate
    • chromiumpicolinate
    • chromium(3+);pyridine-2-carboxylate
    • 15713-60-7
    • Chromium(III) trispicolinate
    • Chromax
    • Divista
    • CCRIS 8310
    • DTXSID1024831
    • CHROMIUM GTF
    • GTF CHROMIUM
    • Chromium, tris(picolinato)-
    • Chromium 2-pyridinecarboxylate
    • tris(picolinato)chromium
    • DTXCID304831
    • S71T8B8Z6P
    • UNII-S71T8B8Z6P
    • Chromium (III) picolinate;Cr(Pic)3
    • CrPic
    • chromium(3+) tripyridine-2-carboxylate
    • Chromium, tris(2-pyridinecarboxylato-N(1),O(2))-
    • Cr(pic)3
    • 2-Pyridinecarboxylic acid, chromium salt
    • CHROMIUM PICOLINATE (USP-RS)
    • CHROMIUM PICOLINATE [USP-RS]
    • CHROMIUM TRIPICOLINATE (MART.)
    • CHROMIUM TRIPICOLINATE [MART.]
    • CHEBI:50369
    • MFCD00068715
    • Pyridine-2-carboxylic Acid Chromium(III) Salt
    • tris(2-pyridinecarboxylato-N(1),O(2))chromium
    • tris(pyridine-2-carboxylato-kappa(2)N,O)chromium
    • tris(pyridine-2-carboxylato-kappa(2)N,O)chromium(III)
    • bis[(pyridin-2-yl)carbonyloxy]chromio pyridine-2-carboxylate
    • chromium tris-picolinate
    • CHROMIUM PICOLINATE [MI]
    • Chromium, tris(2-pyridinecarboxylato-.kappa.N1,.kappa.O2)-
    • CHROMIUM PICOLINATE [VANDF]
    • BCP21370
    • Tox21_200574
    • BBL033863
    • CHROMIUM PICOLINATE [WHO-DD]
    • chromium; pyridine-2-carboxylic acid
    • STL146656
    • AKOS005720870
    • AC-9849
    • DB11255
    • FC45823
    • NCGC00248744-01
    • NCGC00258128-01
    • SY037125
    • CAS-14639-25-9
    • DB-042842
    • NS00120616
    • P1347
    • A808500
    • Q2329715
    • CCRIS 8310; CCRIS-8310; CCRIS8310; Chromax
    • chromium; pyridine-2-carboxylic acid;Chromium picolinate

  • Applications

    Chromium picolinate (CAS 14639-25-9) is primarily used as a chromium source in human dietary supplements and in animal nutrition as a feed additive; it is also employed in laboratory coordination chemistry as a chromium(III) chelate ligand and as a reagent or precursor for preparing chromium complexes in chemical synthesis; in research settings it may be used as a reference chromium compound for analytical development, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 94.57
    methanol 220.19
    isopropanol 46.34
    water 7.94
    ethyl acetate 75.92
    n-propanol 67.85
    acetone 126.51
    n-butanol 66.32
    acetonitrile 110.45
    DMF 1027.13
    toluene 26.29
    isobutanol 38.91
    1,4-dioxane 99.35
    methyl acetate 128.87
    THF 150.54
    2-butanone 102.44
    n-pentanol 48.73
    sec-butanol 51.8
    n-hexane 3.09
    ethylene glycol 117.5
    NMP 489.71
    cyclohexane 3.04
    DMSO 683.39
    n-butyl acetate 51.46
    n-octanol 52.23
    chloroform 53.65
    n-propyl acetate 43.67
    acetic acid 101.84
    dichloromethane 81.89
    cyclohexanone 94.97
    propylene glycol 60.21
    isopropyl acetate 35.08
    DMAc 594.55
    2-ethoxyethanol 152.42
    isopentanol 51.75
    n-heptane 3.81
    ethyl formate 89.03
    1,2-dichloroethane 108.72
    n-hexanol 51.74
    2-methoxyethanol 391.82
    isobutyl acetate 17.71
    tetrachloromethane 7.15
    n-pentyl acetate 45.8
    transcutol 894.01
    n-heptanol 35.16
    ethylbenzene 19.74
    MIBK 40.18
    2-propoxyethanol 137.49
    tert-butanol 54.49
    MTBE 37.79
    2-butoxyethanol 100.06
    propionic acid 85.65
    o-xylene 30.08
    formic acid 163.33
    diethyl ether 48.36
    m-xylene 25.57
    p-xylene 20.96
    chlorobenzene 46.43
    dimethyl carbonate 79.48
    n-octane 2.78
    formamide 327.88
    cyclopentanone 115.87
    2-pentanone 76.02
    anisole 49.46
    cyclopentyl methyl ether 54.39
    gamma-butyrolactone 166.68
    1-methoxy-2-propanol 200.72
    pyridine 107.2
    3-pentanone 62.86
    furfural 248.77
    n-dodecane 3.28
    diethylene glycol 211.9
    diisopropyl ether 10.72
    tert-amyl alcohol 59.02
    acetylacetone 95.88
    n-hexadecane 3.59
    acetophenone 63.4
    methyl propionate 108.76
    isopentyl acetate 38.09
    trichloroethylene 154.96
    n-nonanol 46.46
    cyclohexanol 42.3
    benzyl alcohol 61.78
    2-ethylhexanol 28.43
    isooctanol 24.82
    dipropyl ether 25.5
    1,2-dichlorobenzene 56.19
    ethyl lactate 53.96
    propylene carbonate 84.8
    n-methylformamide 438.48
    2-pentanol 42.73
    n-pentane 3.49
    1-propoxy-2-propanol 86.57
    1-methoxy-2-propyl acetate 74.37
    2-(2-methoxypropoxy) propanol 125.87
    mesitylene 16.17
    ε-caprolactone 91.8
    p-cymene 15.5
    epichlorohydrin 196.88
    1,1,1-trichloroethane 38.04
    2-aminoethanol 111.87
    morpholine-4-carbaldehyde 384.49
    sulfolane 262.85
    2,2,4-trimethylpentane 2.65
    2-methyltetrahydrofuran 71.26
    n-hexyl acetate 71.15
    isooctane 2.05
    2-(2-butoxyethoxy)ethanol 224.7
    sec-butyl acetate 23.6
    tert-butyl acetate 38.53
    decalin 3.61
    glycerin 140.5
    diglyme 343.76
    acrylic acid 111.21
    isopropyl myristate 26.55
    n-butyric acid 77.97
    acetyl acetate 41.46
    di(2-ethylhexyl) phthalate 30.33
    ethyl propionate 46.03
    nitromethane 362.11
    1,2-diethoxyethane 111.72
    benzonitrile 74.15
    trioctyl phosphate 25.45
    1-bromopropane 39.16
    gamma-valerolactone 203.44
    n-decanol 35.92
    triethyl phosphate 27.51
    4-methyl-2-pentanol 23.78
    propionitrile 80.05
    vinylene carbonate 95.59
    1,1,2-trichlorotrifluoroethane 166.33
    DMS 77.63
    cumene 14.91
    2-octanol 28.56
    2-hexanone 46.05
    octyl acetate 39.35
    limonene 18.95
    1,2-dimethoxyethane 213.94
    ethyl orthosilicate 22.92
    tributyl phosphate 30.94
    diacetone alcohol 84.64
    N,N-dimethylaniline 47.2
    acrylonitrile 164.27
    aniline 48.62
    1,3-propanediol 133.85
    bromobenzene 38.56
    dibromomethane 48.72
    1,1,2,2-tetrachloroethane 123.26
    2-methyl-cyclohexyl acetate 27.15
    tetrabutyl urea 54.3
    diisobutyl methanol 19.56
    2-phenylethanol 55.95
    styrene 22.99
    dioctyl adipate 37.71
    dimethyl sulfate 151.93
    ethyl butyrate 35.87
    methyl lactate 119.09
    butyl lactate 60.97
    diethyl carbonate 30.68
    propanediol butyl ether 138.25
    triethyl orthoformate 28.59
    p-tert-butyltoluene 14.3
    methyl 4-tert-butylbenzoate 61.8
    morpholine 145.82
    tert-butylamine 26.91
    n-dodecanol 26.59
    dimethoxymethane 262.27
    ethylene carbonate 66.03
    cyrene 83.59
    2-ethoxyethyl acetate 84.53
    2-ethylhexyl acetate 28.27
    1,2,4-trichlorobenzene 62.76
    4-methylpyridine 102.26
    dibutyl ether 42.31
    2,6-dimethyl-4-heptanol 19.56
    DEF 210.07
    dimethyl isosorbide 143.37
    tetrachloroethylene 81.78
    eugenol 91.66
    triacetin 71.45
    span 80 80.73
    1,4-butanediol 56.95
    1,1-dichloroethane 50.62
    2-methyl-1-pentanol 42.63
    methyl formate 279.08
    2-methyl-1-butanol 50.82
    n-decane 4.58
    butyronitrile 64.65
    3,7-dimethyl-1-octanol 37.64
    1-chlorooctane 21.09
    1-chlorotetradecane 9.82
    n-nonane 4.0
    undecane 3.87
    tert-butylcyclohexane 3.24
    cyclooctane 1.9
    cyclopentanol 43.44
    tetrahydropyran 50.17
    tert-amyl methyl ether 42.31
    2,5,8-trioxanonane 243.16
    1-hexene 13.25
    2-isopropoxyethanol 78.08
    2,2,2-trifluoroethanol 61.78
    methyl butyrate 65.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction