Chondroitinase b

Overview IFRA Request a quote

  • Identifiers

    CAS number
    52227-83-5

    Molecular formula
    C55H88N7O17P3S-4

    SMILES
    CCCCCC=CCC=CCC=CCC=CCC=CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)([O-])OP(=O)([O-])OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)([O-])[O-])O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 45.53%
    Savory 33.74%
    Meaty 30.54%
    Fatty 26.95%
    Oily 22.87%
    Cooling 21.62%
    Herbal 20.89%
    Milky 20.71%
    Fresh 19.58%
    Waxy 19.48%

     

    Flavor
    Odorless 38.0%
    Bland 33.91%
    Mild 27.14%
    Bitter 25.88%
    Faint 23.43%
    Slightly waxy 19.55%
    Oriental 19.27%
    Nitrile 19.24%
    Bay oil 19.13%
    Cedarleaf 18.95%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.4

    pKa est.
    -4589415400.0 (strong acid)

    Molecular weight
    1244.3 g/mol

    Flash point

    • -32109881273.15 ˚C est.

  • Synonyms

    • 52227-83-5
    • 8020-83-5
    • chondroitinase b
    • [5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[[[3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-tetratriaconta-16,19,22,25,28-pentaenoylsulfanylethylamino)propyl]amino]butoxy]-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]oxolan-3-yl] phosphate
    • DB-088283
    • 876516-83-5
    • 8020-83-5

  • Applications

    Chondroitinase b (CAS 52227-83-5) is an enzyme used primarily as a research and analytical tool to depolymerize dermatan sulfate and chondroitin sulfate B in glycosaminoglycan (GAG) studies. In biochemical analysis, it enables structural characterization and compositional analysis of CS/DS by generating defined fragments for downstream chromatography, electrophoresis, NMR, or mass spectrometry workflows. In histology and tissue analysis, it is used to selectively digest DS/CS-B to illuminate the distribution and sulfation patterns of GAGs in connective tissues. In diagnostic and assay development contexts, it supports methods that rely on controlled GAG digestion to quantify or profile CS/DS. In materials characterization and quality control, it serves as a tool for assessing CS/DS content in purified GAG preparations, hydrogels, and dermal matrices used in research and product development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 11.39
    methanol 44.94
    isopropanol 6.09
    water 1.88
    ethyl acetate 6.25
    n-propanol 9.48
    acetone 25.48
    n-butanol 5.99
    acetonitrile 10.35
    DMF 120.36
    toluene 0.97
    isobutanol 4.65
    1,4-dioxane 8.97
    methyl acetate 14.41
    THF 20.17
    2-butanone 20.07
    n-pentanol 4.9
    sec-butanol 5.48
    n-hexane 0.08
    ethylene glycol 16.46
    NMP 166.66
    cyclohexane 0.1
    DMSO 78.2
    n-butyl acetate 3.73
    n-octanol 2.02
    chloroform 17.44
    n-propyl acetate 5.53
    acetic acid 90.92
    dichloromethane 14.96
    cyclohexanone 20.33
    propylene glycol 25.88
    isopropyl acetate 2.95
    DMAc 137.05
    2-ethoxyethanol 24.75
    isopentanol 3.22
    n-heptane 0.08
    ethyl formate 16.72
    1,2-dichloroethane 7.36
    n-hexanol 2.13
    2-methoxyethanol 46.66
    isobutyl acetate 2.5
    tetrachloromethane 2.15
    n-pentyl acetate 5.6
    transcutol 19.07
    n-heptanol 2.89
    ethylbenzene 0.45
    MIBK 3.4
    2-propoxyethanol 15.02
    tert-butanol 3.55
    MTBE 1.37
    2-butoxyethanol 14.76
    propionic acid 27.13
    o-xylene 0.75
    formic acid 108.87
    diethyl ether 2.02
    m-xylene 0.55
    p-xylene 0.83
    chlorobenzene 2.01
    dimethyl carbonate 13.53
    n-octane 0.06
    formamide 88.27
    cyclopentanone 41.16
    2-pentanone 9.4
    anisole 1.97
    cyclopentyl methyl ether 3.21
    gamma-butyrolactone 56.7
    1-methoxy-2-propanol 24.98
    pyridine 13.61
    3-pentanone 7.6
    furfural 58.87
    n-dodecane 0.05
    diethylene glycol 21.01
    diisopropyl ether 0.3
    tert-amyl alcohol 3.56
    acetylacetone 15.8
    n-hexadecane 0.06
    acetophenone 5.93
    methyl propionate 11.34
    isopentyl acetate 2.56
    trichloroethylene 24.45
    n-nonanol 2.0
    cyclohexanol 3.05
    benzyl alcohol 5.99
    2-ethylhexanol 0.95
    isooctanol 1.81
    dipropyl ether 1.12
    1,2-dichlorobenzene 2.09
    ethyl lactate 10.51
    propylene carbonate 24.22
    n-methylformamide 66.59
    2-pentanol 2.29
    n-pentane 0.09
    1-propoxy-2-propanol 8.26
    1-methoxy-2-propyl acetate 5.95
    2-(2-methoxypropoxy) propanol 9.36
    mesitylene 0.28
    ε-caprolactone 20.43
    p-cymene 0.38
    epichlorohydrin 31.19
    1,1,1-trichloroethane 5.44
    2-aminoethanol 22.9
    morpholine-4-carbaldehyde 65.27
    sulfolane 92.99
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 6.76
    n-hexyl acetate 4.56
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 13.18
    sec-butyl acetate 2.29
    tert-butyl acetate 2.27
    decalin 0.05
    glycerin 50.39
    diglyme 19.13
    acrylic acid 44.16
    isopropyl myristate 1.06
    n-butyric acid 18.52
    acetyl acetate 5.96
    di(2-ethylhexyl) phthalate 3.26
    ethyl propionate 4.02
    nitromethane 117.73
    1,2-diethoxyethane 3.28
    benzonitrile 5.62
    trioctyl phosphate 2.22
    1-bromopropane 2.08
    gamma-valerolactone 85.43
    n-decanol 1.26
    triethyl phosphate 1.89
    4-methyl-2-pentanol 0.94
    propionitrile 6.68
    vinylene carbonate 26.97
    1,1,2-trichlorotrifluoroethane 75.03
    DMS 5.56
    cumene 0.33
    2-octanol 1.57
    2-hexanone 6.99
    octyl acetate 2.35
    limonene 0.48
    1,2-dimethoxyethane 19.98
    ethyl orthosilicate 1.45
    tributyl phosphate 2.17
    diacetone alcohol 9.4
    N,N-dimethylaniline 1.75
    acrylonitrile 15.25
    aniline 3.47
    1,3-propanediol 21.94
    bromobenzene 1.43
    dibromomethane 5.69
    1,1,2,2-tetrachloroethane 18.55
    2-methyl-cyclohexyl acetate 2.44
    tetrabutyl urea 4.39
    diisobutyl methanol 0.37
    2-phenylethanol 3.63
    styrene 0.58
    dioctyl adipate 2.92
    dimethyl sulfate 30.64
    ethyl butyrate 2.8
    methyl lactate 26.09
    butyl lactate 10.26
    diethyl carbonate 2.18
    propanediol butyl ether 17.89
    triethyl orthoformate 2.23
    p-tert-butyltoluene 0.31
    methyl 4-tert-butylbenzoate 6.44
    morpholine 14.54
    tert-butylamine 0.92
    n-dodecanol 0.76
    dimethoxymethane 24.57
    ethylene carbonate 15.07
    cyrene 26.61
    2-ethoxyethyl acetate 10.33
    2-ethylhexyl acetate 1.89
    1,2,4-trichlorobenzene 4.07
    4-methylpyridine 8.54
    dibutyl ether 0.88
    2,6-dimethyl-4-heptanol 0.37
    DEF 16.04
    dimethyl isosorbide 11.54
    tetrachloroethylene 11.09
    eugenol 9.61
    triacetin 9.31
    span 80 9.44
    1,4-butanediol 12.02
    1,1-dichloroethane 6.12
    2-methyl-1-pentanol 2.9
    methyl formate 54.47
    2-methyl-1-butanol 4.03
    n-decane 0.09
    butyronitrile 4.76
    3,7-dimethyl-1-octanol 0.97
    1-chlorooctane 0.55
    1-chlorotetradecane 0.19
    n-nonane 0.08
    undecane 0.07
    tert-butylcyclohexane 0.04
    cyclooctane 0.03
    cyclopentanol 7.4
    tetrahydropyran 4.17
    tert-amyl methyl ether 1.46
    2,5,8-trioxanonane 12.55
    1-hexene 0.42
    2-isopropoxyethanol 10.45
    2,2,2-trifluoroethanol 55.33
    methyl butyrate 7.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction