Choline Alfoscerate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    28319-77-9

    Molecular formula
    C8H20NO6P

    SMILES
    C[N+](C)(C)CCOP(=O)([O-])OC[C@@H](CO)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 53.28%
    Sweet 26.23%
    Alcoholic 25.47%
    Fruity 23.87%
    Cooling 22.51%
    Oily 20.19%
    Fresh 20.04%
    Mint 19.41%
    Musk 18.45%
    Fatty 17.35%

     

    Flavor
    Odorless 51.0%
    Bland 33.74%
    Mild 30.76%
    Sweet-like 24.37%
    Bitter 21.5%
    Very slight 20.15%
    Stinky 19.86%
    Yeast 19.75%
    Yeasty 19.62%
    Bay oil 19.57%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.3

    pKa est.
    5.23 (weak acid)

    Molecular weight
    257.22 g/mol

    Melting point expt.

    • 142.5 °C

    Flash point

    • -38.78 ˚C est.

  • Synonyms

    • Choline Alfoscerate
    • SN-glycero-3-phosphocholine
    • 28319-77-9
    • Choline glycerophosphate
    • L-alpha-Glycerophosphorylcholine
    • Glycerophosphorylcholine
    • L-alpha-Glycerophosphocholine
    • Choline Alphoscerate
    • Cholini glycerophosphas
    • Cholini alfosceras
    • GPCho
    • Glicerofosfato de colina
    • Glycerophosphate de choline
    • Alfoscerato de colina
    • L-alpha-Glycerylphosphorylcholine
    • Alfoscerate de choline
    • alpha-Glycerophosphorylcholine
    • Glycerol phosphorylcholine
    • Sn-3-GPC
    • (R)-2,3-Dihydroxypropyl (2-(trimethylammonio)ethyl) phosphate
    • L-A-glycerophosphorylcholine
    • alpha-Glycerylphosphorylcholine
    • glycerol-3-phosphocholine
    • Choline alfoscerate [INN]
    • MFCD00063544
    • Glycerol-3-phosphatidylcholine
    • C8H20NO6P
    • (2-{[(2R)-2,3-dihydroxypropyl phosphonato]oxy}ethyl)trimethylazanium
    • MLS000069588
    • (2R)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphate
    • 60M22SGW66
    • Ethanaminium,2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, innersalt
    • SMR000058753
    • L-Choline hydroxide 2,3-dihydroxypropyl hydrogen phosphate inner salt
    • Choline alfoscerate (INN)
    • (R)-2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt
    • (2R)-2,3-dihydroxypropyl 2-(trimethylazaniumyl)ethyl phosphate
    • Choline hydroxide, (R)-2,3-dihydroxypropyl hydrogen phosphate, inner salt
    • Colina glicerofosfato
    • brezal
    • Gliatilin
    • Calcium (glycerophosphate de)
    • UNII-60M22SGW66
    • Cholini glycerophosphas [Latin]
    • Cholini alfosceras [INN-Latin]
    • alpha-Glyceryl phosphoryl choline
    • Gliatilin (TN)
    • Glicerofosfato de colina [Spanish]
    • EINECS 248-962-2
    • Alfoscerate de choline [INN-French]
    • Alfoscerato de colina [INN-Spanish]
    • Glycerophosphate de choline [French]
    • Calcium (glycerophosphate de) [DCF]
    • glycero-phosphocholine
    • BRN 6062450
    • Opera_ID_471
    • Glycerophosphatidylcholine
    • a-Glycerophosphorylcholine
    • Glycerol 3-phosphocholine
    • LysoPC 24:2
    • LysoPC 24:3
    • LysoPC 24:5
    • a-Glycerylphosphorylcholine
    • Epitope ID:150907
    • LysoPC(24:2)
    • LysoPC(24:3)
    • LysoPC(24:4)
    • LysoPC(24:5)
    • sn-glycerol 3-phosphocholine
    • SCHEMBL63754
    • lysophosphatidylcholine 24:2
    • lysophosphatidylcholine 24:3
    • lysophosphatidylcholine 24:4
    • lysophosphatidylcholine 24:5
    • Glyceryl phosphatidyl (alpha)
    • L-1-glycero-phosphorylcholine
    • L-|_-Glycerophosphorylcholine
    • L-1-glycero-3-phosphocholine
    • lysophosphatidylcholine(24:2)
    • lysophosphatidylcholine(24:3)
    • lysophosphatidylcholine(24:4)
    • lysophosphatidylcholine(24:5)
    • orb1302859
    • CHEMBL1567463
    • CHOLINE ALFOSCERATE [MI]
    • hydrogen glycerophosphate Choline
    • CHEBI:16870
    • CHEBI:55397
    • DTXSID70951010
    • EX-A979
    • CHEBI:234527
    • CHEBI:234553
    • CHEBI:234565
    • CHEBI:234566
    • HMS2233P21
    • HMS3887O13
    • [(2R)-2,3-dihydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
    • CHOLINE ALFOSCERATE [MART.]
    • AC7982
    • CHOLINE ALFOSCERATE [WHO-DD]
    • MSK005081
    • AKOS005762883
    • CCG-267031
    • DB04660
    • EBC-616337
    • FG40298
    • 2-{[(2R)-2,3-dihydroxypropoxy](hydroxy)phosphoryloxy}-N,N,N-trimethylethanaminium
    • Choline alfoscerate;L--GPC;L--Lecithin
    • AS-13724
    • HY-17552
    • SY046440
    • Glycerylphosphorylcholine;Cholini alfosceras
    • L-.ALPHA.-GLYCERYLPHOSPHORYLCHOLINE
    • sn-Glycerophosphorylcholine (egg, free base)
    • D07349
    • PC(24:2_0:0)
    • PC(24:3_0:0)
    • PC(24:4_0:0)
    • PC(24:5_0:0)
    • F463337
    • L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE [USP-RS]
    • Q28529699
    • [(2R)-2,3-dihydroxypropyl] 2-(trimethylammonio)ethyl phosphate
    • Choline, hydroxide, 2,3-dihydroxypropyl hydrogen phosphate, inner salt, D-
    • 2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt
    • ETHANAMINIUM, 2-((((2R)-2,3-DIHYDROXYPROPOXXY)HYDROXYPHOSPHINYL)OXY)-N,N,N-TRIMETHYL-, INNER SALT
    • Ethanaminium, 2-(((2,3-dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt, (R)-
    • 28319-77-9

  • Applications

    Choline Alfoscerate (alpha-GPC; CAS 28319-77-9) is primarily used as a choline donor and phospholipid precursor in a range of formulations. In nutraceuticals and dietary supplements, it is marketed as a convenient source of choline to support phospholipid synthesis and related metabolic functions. In the pharmaceutical sector, it serves as an active ingredient or precursor in formulations that rely on choline and lipid-based delivery concepts. It also functions as a chemical intermediate for phospholipid synthesis and as a research reagent in biochemistry and cell culture studies focused on membrane biology and lipid metabolism.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.27
    methanol 16.95
    isopropanol 0.6
    water 737.93
    ethyl acetate 0.3
    n-propanol 1.14
    acetone 0.28
    n-butanol 0.51
    acetonitrile 0.57
    DMF 9.51
    toluene 0.15
    isobutanol 0.46
    1,4-dioxane 0.86
    methyl acetate 0.42
    THF 0.96
    2-butanone 0.21
    n-pentanol 0.3
    sec-butanol 0.51
    n-hexane 0.04
    ethylene glycol 59.63
    NMP 41.92
    cyclohexane 0.21
    DMSO 12.75
    n-butyl acetate 0.45
    n-octanol 0.47
    chloroform 0.74
    n-propyl acetate 0.25
    acetic acid 35.7
    dichloromethane 0.78
    cyclohexanone 1.07
    propylene glycol 24.09
    isopropyl acetate 0.2
    DMAc 10.21
    2-ethoxyethanol 4.44
    isopentanol 0.28
    n-heptane 0.18
    ethyl formate 0.9
    1,2-dichloroethane 0.39
    n-hexanol 0.8
    2-methoxyethanol 14.83
    isobutyl acetate 0.15
    tetrachloromethane 0.31
    n-pentyl acetate 0.34
    transcutol 8.76
    n-heptanol 0.96
    ethylbenzene 0.14
    MIBK 0.15
    2-propoxyethanol 6.01
    tert-butanol 0.66
    MTBE 0.11
    2-butoxyethanol 4.68
    propionic acid 6.29
    o-xylene 0.38
    formic acid 407.11
    diethyl ether 0.11
    m-xylene 0.25
    p-xylene 0.21
    chlorobenzene 0.17
    dimethyl carbonate 1.78
    n-octane 0.07
    formamide 196.95
    cyclopentanone 1.53
    2-pentanone 0.18
    anisole 0.26
    cyclopentyl methyl ether 0.55
    gamma-butyrolactone 5.22
    1-methoxy-2-propanol 5.55
    pyridine 1.0
    3-pentanone 0.25
    furfural 10.24
    n-dodecane 0.04
    diethylene glycol 27.43
    diisopropyl ether 0.07
    tert-amyl alcohol 0.69
    acetylacetone 0.64
    n-hexadecane 0.05
    acetophenone 0.8
    methyl propionate 0.79
    isopentyl acetate 0.4
    trichloroethylene 1.03
    n-nonanol 0.47
    cyclohexanol 1.01
    benzyl alcohol 0.96
    2-ethylhexanol 0.5
    isooctanol 0.62
    dipropyl ether 0.32
    1,2-dichlorobenzene 0.42
    ethyl lactate 2.48
    propylene carbonate 3.46
    n-methylformamide 13.26
    2-pentanol 0.28
    n-pentane 0.06
    1-propoxy-2-propanol 3.29
    1-methoxy-2-propyl acetate 1.55
    2-(2-methoxypropoxy) propanol 4.96
    mesitylene 0.24
    ε-caprolactone 2.04
    p-cymene 0.41
    epichlorohydrin 1.36
    1,1,1-trichloroethane 0.21
    2-aminoethanol 35.76
    morpholine-4-carbaldehyde 19.64
    sulfolane 22.48
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 0.47
    n-hexyl acetate 0.44
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 5.88
    sec-butyl acetate 0.15
    tert-butyl acetate 0.32
    decalin 0.08
    glycerin 116.48
    diglyme 7.03
    acrylic acid 17.68
    isopropyl myristate 0.22
    n-butyric acid 2.43
    acetyl acetate 0.64
    di(2-ethylhexyl) phthalate 1.03
    ethyl propionate 0.3
    nitromethane 13.59
    1,2-diethoxyethane 0.34
    benzonitrile 0.54
    trioctyl phosphate 0.73
    1-bromopropane 0.1
    gamma-valerolactone 5.96
    n-decanol 0.36
    triethyl phosphate 1.04
    4-methyl-2-pentanol 0.19
    propionitrile 0.35
    vinylene carbonate 4.17
    1,1,2-trichlorotrifluoroethane 21.75
    DMS 1.23
    cumene 0.17
    2-octanol 0.36
    2-hexanone 0.14
    octyl acetate 0.38
    limonene 0.45
    1,2-dimethoxyethane 1.49
    ethyl orthosilicate 0.84
    tributyl phosphate 0.68
    diacetone alcohol 1.77
    N,N-dimethylaniline 0.6
    acrylonitrile 1.08
    aniline 0.73
    1,3-propanediol 12.22
    bromobenzene 0.14
    dibromomethane 0.4
    1,1,2,2-tetrachloroethane 1.3
    2-methyl-cyclohexyl acetate 0.84
    tetrabutyl urea 1.34
    diisobutyl methanol 0.34
    2-phenylethanol 1.37
    styrene 0.12
    dioctyl adipate 0.59
    dimethyl sulfate 6.72
    ethyl butyrate 0.42
    methyl lactate 7.96
    butyl lactate 2.18
    diethyl carbonate 0.56
    propanediol butyl ether 7.03
    triethyl orthoformate 0.73
    p-tert-butyltoluene 0.43
    methyl 4-tert-butylbenzoate 2.8
    morpholine 1.96
    tert-butylamine 0.31
    n-dodecanol 0.28
    dimethoxymethane 1.81
    ethylene carbonate 2.14
    cyrene 12.78
    2-ethoxyethyl acetate 0.71
    2-ethylhexyl acetate 0.36
    1,2,4-trichlorobenzene 0.83
    4-methylpyridine 0.47
    dibutyl ether 0.12
    2,6-dimethyl-4-heptanol 0.34
    DEF 1.22
    dimethyl isosorbide 8.3
    tetrachloroethylene 1.54
    eugenol 4.52
    triacetin 2.01
    span 80 5.43
    1,4-butanediol 4.73
    1,1-dichloroethane 0.14
    2-methyl-1-pentanol 0.21
    methyl formate 6.7
    2-methyl-1-butanol 0.37
    n-decane 0.06
    butyronitrile 0.19
    3,7-dimethyl-1-octanol 0.36
    1-chlorooctane 0.12
    1-chlorotetradecane 0.07
    n-nonane 0.06
    undecane 0.05
    tert-butylcyclohexane 0.05
    cyclooctane 0.13
    cyclopentanol 1.67
    tetrahydropyran 0.33
    tert-amyl methyl ether 0.19
    2,5,8-trioxanonane 7.07
    1-hexene 0.05
    2-isopropoxyethanol 1.52
    2,2,2-trifluoroethanol 39.53
    methyl butyrate 0.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction