Cholesteryl palmitate

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  • Identifiers

    CAS number
    601-34-3

    Molecular formula
    C43H76O2

    SMILES
    CCCCCCCCCCCCCCCC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC[C@@H]4[C@H](C)CCCC(C)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Waxy 65.42%
    Woody 55.13%
    Fatty 41.83%
    Oily 41.55%
    Balsamic 37.11%
    Sandalwood 35.67%
    Amber 29.87%
    Floral 27.0%
    Sweet 23.32%
    Animal 23.27%

     

    Flavor
    Waxy 35.47%
    Mild 29.93%
    Bland 25.8%
    Fatty 24.4%
    Oily 24.13%
    Faint 23.21%
    Slightly waxy 22.11%
    Woody 21.54%
    Delicate 21.11%
    Sandalwood 20.8%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    16.4

    pKa est.
    -9.96 (strong acid)

    Molecular weight
    625.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    607°C

    Melting point expt.

    • 75 - 77 °C

    Flash point

    • 108.7 ˚C est.

  • Synonyms

    • Cholesteryl palmitate
    • 601-34-3
    • Cholesterol palmitate
    • Cholesteryl hexadecanoate
    • Hexadecanoic acid, cholesteryl ester
    • ZR4D53AD57
    • DTXSID40889356
    • NSC-59692
    • CHEBI:3663
    • Cholest-5-en-3-ol (3beta)-, 3-hexadecanoate
    • Cholest-5-en-3-ol (3beta)-, hexadecanoate
    • [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] hexadecanoate
    • ((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((2R)-6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3-yl) hexadecanoate
    • RefChem:576071
    • DTXCID101028618
    • 210-002-5
    • Cholesterol, palmitate
    • MFCD00003638
    • Cholest-5-en-3-ol (3.beta.)-, hexadecanoate
    • 16:0 Cholesteryl ester
    • CE(16:0)
    • cholest-5-en-3beta-yl hexadecanoate
    • Cholest-5-ene-3-beta-yl palmitate
    • 16:0 Cholesterol ester
    • Palmitic acid cholesteryl ester
    • 16:0(CE)
    • (3beta)-cholest-5-en-3-ol hexadecanoate
    • (3beta)-cholest-5-en-3-yl hexadecanoate
    • C43H76O2
    • Cholesterol hexadecanoate
    • (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl palmitate
    • cholest-5-en-3-yl palmitate
    • UNII-ZR4D53AD57
    • Hexadecanoic acid cholesteryl ester; 5-Cholesten-3ss-ol stearate
    • cholesterylpalmitate
    • EINECS 210-002-5
    • NSC 59692
    • 1-palmitoyl-cholesterol
    • cholesterol 1-palmitoate
    • cholesteryl 1-palmitoate
    • Cholesteryl palmitic acid
    • bmse000544
    • cholesterol 1-hexadecanoate
    • cholesteryl 1-hexadecanoate
    • Cholesterol Ester(16:0)
    • cholesterol 1-palmitoic acid
    • cholesteryl 1-palmitoic acid
    • Cholesteryl hexadecanoic acid
    • Cholesteryl palmitate, 97%
    • SCHEMBL295637
    • cholesterol 1-hexadecanoic acid
    • cholesteryl 1-hexadecanoic acid
    • orb1302116
    • Palmitic Acid Cholesterol Ester
    • Cholesteryl palmitate (Standard)
    • Cholesterol Palmitate, >/=97%
    • Cholest-5-en-3b-yl hexadecanoate
    • Cholesterol Ester(16:0/0:0)
    • Hexadecanoic acid cholesteryl ester
    • HY-W010708R
    • NSC59692
    • LMST01020005
    • 3.beta.-Hexadecanoyloxycholest-5-ene
    • AKOS015839810
    • AKOS015915569
    • CS-W011424
    • DS-4666
    • EBC-616191
    • FC46042
    • HY-W010708
    • (1R,3aS,3bS,7S,9aR,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl hexadecanoate
    • SY059901
    • NS00043878
    • ST50411407
    • D95354
    • OP0201 COMPONENT CHOLESTERYL PALMITATE
    • Cholest-5-en-3-ol (3.beta.)-, 3-hexadecanoate
    • Q27068156
    • Cholesteryl palmitate, >=98% (HPLC; detection at 205 nm)
    • [(3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] hexadecanoate
    • 14-((1R)-1,5-dimethylhexyl)(1S,5S,10S,11S,2R,14R,15R)-2,15-dimethyltetracyclo[ 8.7.0.0<2,7>.0<11,15>]heptadec-7-en-5-yl hexadecanoate
    • 601-34-3

  • Applications

    Cholesteryl palmitate (CAS 601-34-3) is a wax ester of cholesterol and palmitic acid, used primarily as a structuring agent and emollient in cosmetics and personal care products, imparting occlusion and a smooth feel in creams, lotions, and lip products. In pharmaceutical contexts, it may serve as a lipid-based excipient or lipid phase in topical formulations and lipid-based drug delivery systems. In coatings, inks, and polymers, it can function as a wax-like additive to modify rheology, gloss, and water resistance, and to help structure polymer blends. It is also used in household products as a waxy thickener/texture modifier in polishing and surface-care formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 19.06
    methanol 7.57
    isopropanol 15.25
    water 0.07
    ethyl acetate 79.51
    n-propanol 32.57
    acetone 41.51
    n-butanol 40.06
    acetonitrile 11.4
    DMF 44.59
    toluene 109.37
    isobutanol 28.02
    1,4-dioxane 89.69
    methyl acetate 43.06
    THF 191.83
    2-butanone 77.53
    n-pentanol 34.44
    sec-butanol 24.38
    n-hexane 12.07
    ethylene glycol 0.93
    NMP 165.74
    cyclohexane 24.33
    DMSO 24.21
    n-butyl acetate 96.0
    n-octanol 25.16
    chloroform 248.16
    n-propyl acetate 70.63
    acetic acid 26.39
    dichloromethane 203.79
    cyclohexanone 193.44
    propylene glycol 2.63
    isopropyl acetate 83.08
    DMAc 129.77
    2-ethoxyethanol 41.73
    isopentanol 38.7
    n-heptane 10.9
    ethyl formate 27.04
    1,2-dichloroethane 109.94
    n-hexanol 40.08
    2-methoxyethanol 32.11
    isobutyl acetate 64.05
    tetrachloromethane 54.42
    n-pentyl acetate 119.85
    transcutol 172.48
    n-heptanol 36.39
    ethylbenzene 55.35
    MIBK 74.17
    2-propoxyethanol 81.91
    tert-butanol 14.6
    MTBE 44.6
    2-butoxyethanol 81.8
    propionic acid 27.38
    o-xylene 66.45
    formic acid 5.79
    diethyl ether 70.09
    m-xylene 68.76
    p-xylene 58.18
    chlorobenzene 132.05
    dimethyl carbonate 31.05
    n-octane 3.6
    formamide 8.06
    cyclopentanone 173.27
    2-pentanone 89.48
    anisole 82.33
    cyclopentyl methyl ether 143.42
    gamma-butyrolactone 154.8
    1-methoxy-2-propanol 43.28
    pyridine 129.05
    3-pentanone 89.33
    furfural 103.98
    n-dodecane 2.07
    diethylene glycol 19.25
    diisopropyl ether 29.15
    tert-amyl alcohol 23.0
    acetylacetone 91.61
    n-hexadecane 2.55
    acetophenone 86.89
    methyl propionate 70.2
    isopentyl acetate 104.33
    trichloroethylene 221.8
    n-nonanol 30.55
    cyclohexanol 54.98
    benzyl alcohol 50.36
    2-ethylhexanol 40.14
    isooctanol 35.16
    dipropyl ether 68.17
    1,2-dichlorobenzene 123.82
    ethyl lactate 31.71
    propylene carbonate 93.05
    n-methylformamide 19.52
    2-pentanol 29.57
    n-pentane 11.62
    1-propoxy-2-propanol 72.43
    1-methoxy-2-propyl acetate 120.75
    2-(2-methoxypropoxy) propanol 69.66
    mesitylene 41.65
    ε-caprolactone 205.04
    p-cymene 38.65
    epichlorohydrin 167.5
    1,1,1-trichloroethane 125.14
    2-aminoethanol 5.2
    morpholine-4-carbaldehyde 120.9
    sulfolane 159.67
    2,2,4-trimethylpentane 7.67
    2-methyltetrahydrofuran 164.31
    n-hexyl acetate 106.76
    isooctane 4.8
    2-(2-butoxyethoxy)ethanol 82.94
    sec-butyl acetate 70.2
    tert-butyl acetate 87.92
    decalin 13.56
    glycerin 5.14
    diglyme 164.39
    acrylic acid 19.29
    isopropyl myristate 39.06
    n-butyric acid 73.4
    acetyl acetate 61.98
    di(2-ethylhexyl) phthalate 45.96
    ethyl propionate 75.12
    nitromethane 37.88
    1,2-diethoxyethane 87.63
    benzonitrile 47.77
    trioctyl phosphate 29.8
    1-bromopropane 98.0
    gamma-valerolactone 228.2
    n-decanol 18.87
    triethyl phosphate 52.32
    4-methyl-2-pentanol 24.91
    propionitrile 24.51
    vinylene carbonate 83.97
    1,1,2-trichlorotrifluoroethane 84.97
    DMS 65.59
    cumene 36.57
    2-octanol 22.97
    2-hexanone 75.84
    octyl acetate 48.54
    limonene 50.62
    1,2-dimethoxyethane 71.72
    ethyl orthosilicate 57.86
    tributyl phosphate 35.21
    diacetone alcohol 62.15
    N,N-dimethylaniline 58.88
    acrylonitrile 20.35
    aniline 72.7
    1,3-propanediol 15.44
    bromobenzene 161.6
    dibromomethane 149.6
    1,1,2,2-tetrachloroethane 186.76
    2-methyl-cyclohexyl acetate 88.46
    tetrabutyl urea 48.99
    diisobutyl methanol 25.84
    2-phenylethanol 62.82
    styrene 60.57
    dioctyl adipate 63.87
    dimethyl sulfate 53.38
    ethyl butyrate 89.47
    methyl lactate 26.24
    butyl lactate 73.58
    diethyl carbonate 53.36
    propanediol butyl ether 37.6
    triethyl orthoformate 82.91
    p-tert-butyltoluene 34.66
    methyl 4-tert-butylbenzoate 103.55
    morpholine 112.23
    tert-butylamine 13.24
    n-dodecanol 12.17
    dimethoxymethane 59.96
    ethylene carbonate 82.71
    cyrene 77.18
    2-ethoxyethyl acetate 147.26
    2-ethylhexyl acetate 101.59
    1,2,4-trichlorobenzene 151.79
    4-methylpyridine 131.33
    dibutyl ether 43.15
    2,6-dimethyl-4-heptanol 25.84
    DEF 102.55
    dimethyl isosorbide 142.79
    tetrachloroethylene 125.59
    eugenol 80.27
    triacetin 113.3
    span 80 66.61
    1,4-butanediol 6.49
    1,1-dichloroethane 99.79
    2-methyl-1-pentanol 38.84
    methyl formate 14.34
    2-methyl-1-butanol 43.04
    n-decane 5.27
    butyronitrile 33.32
    3,7-dimethyl-1-octanol 29.14
    1-chlorooctane 26.05
    1-chlorotetradecane 7.76
    n-nonane 4.36
    undecane 3.05
    tert-butylcyclohexane 9.55
    cyclooctane 10.35
    cyclopentanol 45.14
    tetrahydropyran 156.91
    tert-amyl methyl ether 52.64
    2,5,8-trioxanonane 96.94
    1-hexene 35.93
    2-isopropoxyethanol 41.07
    2,2,2-trifluoroethanol 16.3
    methyl butyrate 85.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction