Cholesteryl Oleate

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  • Identifiers

    CAS number
    303-43-5

    Molecular formula
    C45H78O2

    SMILES
    CCCCCCCC/C=C\CCCCCCCC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC[C@@H]4[C@H](C)CCCC(C)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Waxy 62.76%
    Woody 51.99%
    Oily 45.77%
    Fatty 45.28%
    Balsamic 36.79%
    Sandalwood 33.2%
    Floral 28.31%
    Green 27.6%
    Sweet 26.33%
    Amber 26.24%

     

    Flavor
    Waxy 30.94%
    Mild 25.08%
    Faint 24.49%
    Bland 23.13%
    Fatty 21.73%
    Woody 21.65%
    Slightly waxy 21.35%
    Oily 21.07%
    Delicate 20.85%
    Diterpene 20.62%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    16.6

    pKa est.
    -77.97 (strong acid)

    Molecular weight
    651.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    631°C

    Flash point

    • -238.15 ˚C est.

  • Synonyms

    • Cholesteryl oleate
    • 303-43-5
    • Oleoylcholesterol
    • Cholesterol Oleate
    • Cholesteryl cis-9-octadecenoate
    • Oleic acid cholesteryl ester
    • Cholest-5-en-3-beta-yl oleate
    • Cholesterol, oleate
    • 3DPK9KFN2M
    • Cholest-5-en-3-ol (3beta)-, 3-[(9Z)-9-octadecenoate]
    • DTXSID901014621
    • YOFCO LC-CO-D
    • [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (Z)-octadec-9-enoate
    • CHEBI:46898
    • NSC-18186
    • Cholest-5-en-3-ol (3beta)-, (9Z)-9-octadecenoate
    • Cholest-5-en-3-ol (3beta)-, 3-((9Z)-9-octadecenoate)
    • ((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((2R)-6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3-yl) (Z)-octadec-9-enoate
    • RefChem:125721
    • DTXCID601437167
    • 206-142-1
    • Cholesteroyl-oleate
    • cholesteryloleate
    • 18:1 Cholesteryl ester
    • MFCD00003645
    • CE(18:1)
    • Cholesteryl oleic ester
    • Oleic Acid Cholesterol Ester
    • Cholesteryl oleate-9,10-t2
    • (3beta)-cholest-5-en-3-yl (9E)-octadec-9-enoate
    • cholest-5-en-3b-yl (9Z-octadecenoate)
    • CE(18:1(9Z))
    • C45H78O2
    • CE 18:1
    • Cholesterol 3beta-oleate
    • 5-Cholesten-3b-ol 3-oleate
    • Cholesteryl oleate-9,10-3H
    • UNII-3DPK9KFN2M
    • Cholesteryl [9,10-3H]oleate
    • Cholest-5-en-3-ol (3.beta.)-, (9Z)-9-octadecenoate
    • Cholest-5-en-3-ol (3.beta.)-, 9-octadecenoate, (Z)-
    • 3beta-Hydroxy-5-cholestene 3-oleate
    • 2OB
    • Cholest-5-en-3-ss-yl oleate; Chloesteryl cis-9-octadecanoate; Cholesteryl oleic ester; Oleoylcholesterol
    • EINECS 206-142-1
    • NSC 18186
    • Cholesterol, oleate (8CI)
    • SCHEMBL132003
    • cholesteryl (9Z-octadecenoate)
    • orb1307096
    • 5-Cholesten-3beta-ol 3-oleate
    • CHEMBL1097567
    • Cholesterol, oleate (6CI,8CI)
    • CHOLESTEROL 3.BETA.-OLEATE
    • LMST01020003
    • OLEIC ACID, CHOLESTERYL ESTER
    • Oleic acid, cholesteryl ester (6CI)
    • AKOS025311525
    • MSK1893-1000S
    • FC61961
    • BP-29625
    • BS-42184
    • SY059899
    • CHOLEST-5-EN-3-.BETA.-YL OLEATE
    • Cholest-5-en-3-yl (9Z)-9-octadecenoate
    • HY-113217
    • CS-0059332
    • NS00013460
    • Cholest-5-en-3-yl (9Z)-9-octadecenoate #
    • Cholest-5-en-3beta-yl (9Z)-octadec-9-enoate
    • F82232
    • (3beta)-cholest-5-en-3-ol, (Z)-9-octadecenoate
    • 303C435
    • (3beta)-cholest-5-en-3-yl (9Z)-octadec-9-enoate
    • Cholesteryl oleate Solution in Chloroform, 1000ug/mL
    • Q27104577
    • Cholest-5-en-3-ol (3beta)-, 9-octadecenoate, (Z)-
    • Cholesteryl oleate, >=98% (HPLC; detection at 205 nm)
    • Cholesteryl oleate-13C18, 99 atom % 13C, 95% (CP)
    • 9-octadecenoic acid, (3beta)-cholest-5-en-3-yl ester, (9Z)-
    • Cholest-5-en-3-ol (3beta)-, (9Z)-9-octadecenoate (9CI)
    • CHOLEST-5-EN-3-OL (3.BETA.)-, 3-((9Z)-9-OCTADECENOATE)
    • (3beta,9beta,14beta,17alpha)-cholest-5-en-3-yl (9Z)-octadec-9-enoate
    • Cholest-5-en-3-ol (3beta)-, 9-octadecenoate-9,10-t2, (Z)- (9CI)
    • [(3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (Z)-octadec-9-enoate
    • 303-43-5

  • Applications

    Cholesteryl Oleate (CAS 303-43-5) is primarily used as a waxy lipid component in cosmetic and personal-care formulations, functioning as an emollient, thickener and structuring agent in creams, lotions and solid sticks. It serves as a wax-like additive in coatings and inks to modify hardness, gloss and melting behavior. In polymer and plastics formulations, it is employed as a waxy additive or crystallinity modifier to adjust rheology in wax blends and PVC compounds. It also finds use in household products as a conditioning lipid or wax component in polishes and cleaners to impart slip and shine. Additionally, it can act as a wax-like additive in adhesives to improve glide and water resistance of bonds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 17.53
    methanol 7.04
    isopropanol 13.07
    water 0.05
    ethyl acetate 66.66
    n-propanol 28.9
    acetone 31.78
    n-butanol 37.45
    acetonitrile 8.47
    DMF 34.24
    toluene 103.77
    isobutanol 24.74
    1,4-dioxane 76.64
    methyl acetate 34.28
    THF 158.29
    2-butanone 67.53
    n-pentanol 32.47
    sec-butanol 22.05
    n-hexane 10.75
    ethylene glycol 0.72
    NMP 134.08
    cyclohexane 21.13
    DMSO 19.44
    n-butyl acetate 81.06
    n-octanol 22.07
    chloroform 220.24
    n-propyl acetate 58.61
    acetic acid 21.95
    dichloromethane 177.27
    cyclohexanone 168.18
    propylene glycol 2.16
    isopropyl acetate 69.12
    DMAc 109.88
    2-ethoxyethanol 36.24
    isopentanol 35.39
    n-heptane 9.75
    ethyl formate 22.03
    1,2-dichloroethane 94.25
    n-hexanol 37.48
    2-methoxyethanol 27.69
    isobutyl acetate 53.54
    tetrachloromethane 44.07
    n-pentyl acetate 97.13
    transcutol 153.29
    n-heptanol 31.98
    ethylbenzene 51.52
    MIBK 63.99
    2-propoxyethanol 74.84
    tert-butanol 11.92
    MTBE 38.29
    2-butoxyethanol 71.35
    propionic acid 22.59
    o-xylene 59.49
    formic acid 4.91
    diethyl ether 62.05
    m-xylene 62.34
    p-xylene 51.87
    chlorobenzene 114.59
    dimethyl carbonate 24.41
    n-octane 3.14
    formamide 6.6
    cyclopentanone 141.37
    2-pentanone 76.98
    anisole 73.89
    cyclopentyl methyl ether 122.85
    gamma-butyrolactone 122.77
    1-methoxy-2-propanol 37.13
    pyridine 112.52
    3-pentanone 78.9
    furfural 84.62
    n-dodecane 1.85
    diethylene glycol 16.51
    diisopropyl ether 25.09
    tert-amyl alcohol 20.44
    acetylacetone 73.52
    n-hexadecane 2.29
    acetophenone 76.09
    methyl propionate 58.37
    isopentyl acetate 91.16
    trichloroethylene 195.07
    n-nonanol 27.03
    cyclohexanol 50.78
    benzyl alcohol 45.03
    2-ethylhexanol 37.43
    isooctanol 30.58
    dipropyl ether 59.25
    1,2-dichlorobenzene 107.65
    ethyl lactate 26.67
    propylene carbonate 73.54
    n-methylformamide 15.54
    2-pentanol 26.81
    n-pentane 10.27
    1-propoxy-2-propanol 64.34
    1-methoxy-2-propyl acetate 103.95
    2-(2-methoxypropoxy) propanol 62.97
    mesitylene 36.72
    ε-caprolactone 177.2
    p-cymene 34.57
    epichlorohydrin 140.67
    1,1,1-trichloroethane 101.59
    2-aminoethanol 4.31
    morpholine-4-carbaldehyde 99.39
    sulfolane 126.2
    2,2,4-trimethylpentane 6.88
    2-methyltetrahydrofuran 141.84
    n-hexyl acetate 90.28
    isooctane 4.27
    2-(2-butoxyethoxy)ethanol 73.9
    sec-butyl acetate 59.94
    tert-butyl acetate 73.13
    decalin 12.28
    glycerin 4.21
    diglyme 139.64
    acrylic acid 15.77
    isopropyl myristate 33.66
    n-butyric acid 62.74
    acetyl acetate 49.83
    di(2-ethylhexyl) phthalate 39.68
    ethyl propionate 63.34
    nitromethane 29.07
    1,2-diethoxyethane 74.99
    benzonitrile 38.98
    trioctyl phosphate 25.41
    1-bromopropane 91.06
    gamma-valerolactone 191.85
    n-decanol 16.78
    triethyl phosphate 45.49
    4-methyl-2-pentanol 22.48
    propionitrile 20.12
    vinylene carbonate 66.79
    1,1,2-trichlorotrifluoroethane 71.09
    DMS 53.18
    cumene 33.46
    2-octanol 19.8
    2-hexanone 66.4
    octyl acetate 41.47
    limonene 46.11
    1,2-dimethoxyethane 61.16
    ethyl orthosilicate 50.88
    tributyl phosphate 29.76
    diacetone alcohol 52.97
    N,N-dimethylaniline 53.72
    acrylonitrile 16.48
    aniline 66.16
    1,3-propanediol 13.3
    bromobenzene 142.44
    dibromomethane 133.95
    1,1,2,2-tetrachloroethane 162.2
    2-methyl-cyclohexyl acetate 77.37
    tetrabutyl urea 42.3
    diisobutyl methanol 23.41
    2-phenylethanol 57.8
    styrene 55.96
    dioctyl adipate 54.48
    dimethyl sulfate 40.56
    ethyl butyrate 77.04
    methyl lactate 21.65
    butyl lactate 60.55
    diethyl carbonate 44.83
    propanediol butyl ether 32.03
    triethyl orthoformate 71.63
    p-tert-butyltoluene 30.32
    methyl 4-tert-butylbenzoate 88.44
    morpholine 98.38
    tert-butylamine 10.99
    n-dodecanol 10.84
    dimethoxymethane 50.3
    ethylene carbonate 65.77
    cyrene 67.39
    2-ethoxyethyl acetate 120.22
    2-ethylhexyl acetate 88.2
    1,2,4-trichlorobenzene 130.14
    4-methylpyridine 117.27
    dibutyl ether 37.2
    2,6-dimethyl-4-heptanol 23.41
    DEF 89.34
    dimethyl isosorbide 123.18
    tetrachloroethylene 109.16
    eugenol 70.68
    triacetin 91.22
    span 80 58.76
    1,4-butanediol 5.43
    1,1-dichloroethane 84.65
    2-methyl-1-pentanol 36.51
    methyl formate 11.05
    2-methyl-1-butanol 39.49
    n-decane 4.65
    butyronitrile 28.44
    3,7-dimethyl-1-octanol 26.03
    1-chlorooctane 22.79
    1-chlorotetradecane 6.87
    n-nonane 3.77
    undecane 2.74
    tert-butylcyclohexane 8.51
    cyclooctane 9.14
    cyclopentanol 37.73
    tetrahydropyran 142.54
    tert-amyl methyl ether 46.6
    2,5,8-trioxanonane 83.18
    1-hexene 32.87
    2-isopropoxyethanol 35.74
    2,2,2-trifluoroethanol 12.13
    methyl butyrate 70.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction