Cholesteryl isostearate

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  • Identifiers

    CAS number
    83615-24-1

    Molecular formula
    C45H80O2

    SMILES
    C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)CCCCCCCCCCCCCCC(C)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Waxy 65.51%
    Woody 59.93%
    Oily 39.93%
    Fatty 38.13%
    Balsamic 38.05%
    Sandalwood 37.19%
    Amber 30.67%
    Floral 27.38%
    Green 25.57%
    Dry 24.52%

     

    Flavor
    Waxy 32.05%
    Mild 28.66%
    Bland 26.31%
    Woody 23.0%
    Faint 22.8%
    Oily 22.4%
    Slightly waxy 21.75%
    Delicate 21.29%
    Diterpene 20.61%
    Sandalwood 20.58%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    17.2

    pKa est.
    -42.38 (strong acid)

    Molecular weight
    653.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    613°C

    Flash point

    • -55.31 ˚C est.

  • Synonyms

    • Cholesteryl isostearate
    • Cholesterol isostearate
    • IS-CE
    • 83615-24-1
    • JD5KDN9464
    • Isostearic acid, cholesterol ester
    • UNII-JD5KDN9464
    • Cholest-5-en-3-ol, isooctadecanoate
    • Cholest-5-en-3-ol (3beta-, isostearate
    • CHOLEST-5-EN-3-OL (3-BETA)-, ISOSTEARATE
    • RefChem:125709
    • DTXSID401019745
    • CHOLESTERYL ISOSTEARATE [INCI]
    • [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 16-methylheptadecanoate
    • SCHEMBL29356325
    • JBBRZDLNVILTDL-XNTGVSEISA-N
    • Q27281449
    • 83615-24-1

  • Applications

    Cholesteryl isostearate (CAS 83615-24-1) is a lipophilic cholesterol ester widely used in cosmetics and personal care as an emollient, conditioning agent, and texture enhancer, contributing a smooth feel and slip in creams, lotions, and lip products. It can serve as a wax-like structuring component to improve rheology, stabilize emulsions, and enhance product texture. In polymer and plastics-related formulations, it is sometimes evaluated as a lubricant or processing aid to improve slip and compatibility with lipophilic matrices. In coatings and inks, cholesteryl isostearate may be used as a rheology modifier or surface additive to adjust application properties and feel of the coated surface. In household products, it may be used as an emollient or conditioning additive in cleaners, laundry formulations, or related care products. Its use is formulation- and regulation-dependent, and may be subject to local restrictions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 16.54
    methanol 6.33
    isopropanol 13.22
    water 0.06
    ethyl acetate 78.45
    n-propanol 29.31
    acetone 38.88
    n-butanol 35.86
    acetonitrile 9.82
    DMF 43.83
    toluene 105.77
    isobutanol 25.49
    1,4-dioxane 83.23
    methyl acetate 40.72
    THF 191.72
    2-butanone 75.21
    n-pentanol 32.59
    sec-butanol 23.03
    n-hexane 12.49
    ethylene glycol 0.77
    NMP 165.66
    cyclohexane 22.18
    DMSO 23.07
    n-butyl acetate 97.38
    n-octanol 25.73
    chloroform 239.31
    n-propyl acetate 70.5
    acetic acid 24.21
    dichloromethane 188.35
    cyclohexanone 184.49
    propylene glycol 2.35
    isopropyl acetate 83.16
    DMAc 130.84
    2-ethoxyethanol 39.94
    isopentanol 35.4
    n-heptane 11.48
    ethyl formate 25.82
    1,2-dichloroethane 100.39
    n-hexanol 38.49
    2-methoxyethanol 29.41
    isobutyl acetate 66.49
    tetrachloromethane 51.21
    n-pentyl acetate 121.66
    transcutol 169.59
    n-heptanol 36.27
    ethylbenzene 55.89
    MIBK 74.11
    2-propoxyethanol 80.1
    tert-butanol 13.53
    MTBE 44.92
    2-butoxyethanol 81.76
    propionic acid 25.66
    o-xylene 65.03
    formic acid 5.11
    diethyl ether 67.45
    m-xylene 68.65
    p-xylene 58.27
    chlorobenzene 127.35
    dimethyl carbonate 30.53
    n-octane 3.82
    formamide 7.17
    cyclopentanone 170.34
    2-pentanone 86.96
    anisole 82.22
    cyclopentyl methyl ether 144.98
    gamma-butyrolactone 155.39
    1-methoxy-2-propanol 40.95
    pyridine 122.74
    3-pentanone 87.99
    furfural 101.01
    n-dodecane 2.07
    diethylene glycol 17.26
    diisopropyl ether 29.86
    tert-amyl alcohol 22.55
    acetylacetone 89.52
    n-hexadecane 2.57
    acetophenone 86.61
    methyl propionate 70.12
    isopentyl acetate 105.63
    trichloroethylene 212.28
    n-nonanol 31.35
    cyclohexanol 50.78
    benzyl alcohol 48.01
    2-ethylhexanol 40.36
    isooctanol 35.64
    dipropyl ether 71.29
    1,2-dichlorobenzene 120.05
    ethyl lactate 31.91
    propylene carbonate 94.04
    n-methylformamide 18.36
    2-pentanol 27.67
    n-pentane 11.38
    1-propoxy-2-propanol 73.71
    1-methoxy-2-propyl acetate 123.56
    2-(2-methoxypropoxy) propanol 71.4
    mesitylene 41.69
    ε-caprolactone 201.79
    p-cymene 39.0
    epichlorohydrin 166.93
    1,1,1-trichloroethane 120.63
    2-aminoethanol 4.57
    morpholine-4-carbaldehyde 121.54
    sulfolane 160.65
    2,2,4-trimethylpentane 7.94
    2-methyltetrahydrofuran 163.81
    n-hexyl acetate 109.85
    isooctane 5.01
    2-(2-butoxyethoxy)ethanol 82.89
    sec-butyl acetate 71.75
    tert-butyl acetate 90.01
    decalin 13.44
    glycerin 4.6
    diglyme 165.73
    acrylic acid 17.61
    isopropyl myristate 40.43
    n-butyric acid 69.86
    acetyl acetate 60.88
    di(2-ethylhexyl) phthalate 45.44
    ethyl propionate 76.29
    nitromethane 36.07
    1,2-diethoxyethane 88.35
    benzonitrile 44.94
    trioctyl phosphate 30.07
    1-bromopropane 93.57
    gamma-valerolactone 226.88
    n-decanol 19.31
    triethyl phosphate 53.06
    4-methyl-2-pentanol 24.24
    propionitrile 22.36
    vinylene carbonate 85.0
    1,1,2-trichlorotrifluoroethane 82.68
    DMS 65.15
    cumene 37.28
    2-octanol 23.61
    2-hexanone 75.99
    octyl acetate 49.57
    limonene 50.71
    1,2-dimethoxyethane 70.86
    ethyl orthosilicate 59.47
    tributyl phosphate 34.81
    diacetone alcohol 61.99
    N,N-dimethylaniline 60.55
    acrylonitrile 18.45
    aniline 67.92
    1,3-propanediol 13.63
    bromobenzene 157.87
    dibromomethane 139.91
    1,1,2,2-tetrachloroethane 179.02
    2-methyl-cyclohexyl acetate 89.67
    tetrabutyl urea 48.77
    diisobutyl methanol 25.87
    2-phenylethanol 60.28
    styrene 59.29
    dioctyl adipate 63.71
    dimethyl sulfate 54.43
    ethyl butyrate 91.01
    methyl lactate 25.55
    butyl lactate 75.83
    diethyl carbonate 52.98
    propanediol butyl ether 37.8
    triethyl orthoformate 86.64
    p-tert-butyltoluene 35.7
    methyl 4-tert-butylbenzoate 105.89
    morpholine 105.86
    tert-butylamine 12.16
    n-dodecanol 12.33
    dimethoxymethane 57.85
    ethylene carbonate 81.55
    cyrene 77.1
    2-ethoxyethyl acetate 145.27
    2-ethylhexyl acetate 103.42
    1,2,4-trichlorobenzene 147.96
    4-methylpyridine 128.73
    dibutyl ether 45.33
    2,6-dimethyl-4-heptanol 25.87
    DEF 101.71
    dimethyl isosorbide 145.05
    tetrachloroethylene 117.78
    eugenol 80.4
    triacetin 115.13
    span 80 67.97
    1,4-butanediol 5.74
    1,1-dichloroethane 94.98
    2-methyl-1-pentanol 37.82
    methyl formate 13.54
    2-methyl-1-butanol 39.67
    n-decane 5.51
    butyronitrile 30.73
    3,7-dimethyl-1-octanol 29.77
    1-chlorooctane 27.32
    1-chlorotetradecane 7.83
    n-nonane 4.59
    undecane 3.12
    tert-butylcyclohexane 10.1
    cyclooctane 10.13
    cyclopentanol 42.62
    tetrahydropyran 149.9
    tert-amyl methyl ether 54.8
    2,5,8-trioxanonane 95.84
    1-hexene 37.01
    2-isopropoxyethanol 40.72
    2,2,2-trifluoroethanol 15.14
    methyl butyrate 86.99

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction