Cholesteryl hydroxystearate

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  • Identifiers

    CAS number
    40445-72-5

    Molecular formula
    C45H80O3

    SMILES
    CCCCCCC(CCCCCCCCCCC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC[C@@H]4[C@H](C)CCCC(C)C)C)C)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 62.22%
    Waxy 53.76%
    Sandalwood 46.93%
    Floral 43.65%
    Balsamic 40.69%
    Oily 38.62%
    Amber 35.75%
    Fatty 28.87%
    Sweet 27.62%
    Animal 26.1%

     

    Flavor
    Waxy 32.87%
    Mild 32.26%
    Bland 26.35%
    Woody 25.88%
    Fatty 25.83%
    Oily 25.5%
    Faint 23.14%
    Odorless 23.05%
    Slightly waxy 22.11%
    Delicate 21.52%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    15.6

    pKa est.
    -57.69 (strong acid)

    Molecular weight
    669.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    718°C

    Flash point

    • -125.68 ˚C est.

  • Synonyms

    • Cholesteryl hydroxystearate
    • Salacos HS
    • Estemol CHS
    • O6K1LG6N4D
    • Cholesterol 12-hydroxystearate
    • Cholesteryl 12-hydroxystearate
    • UNII-O6K1LG6N4D
    • DTXSID60193462
    • Cholest-5-en-3-ol (3beta)-, 12-hydroxyoctadecanoate
    • Cholest-5-en-3-ol (3beta)-, 3-(12-hydroxyoctadecanoate)
    • CHOLEST-5-EN-3-OL (3.BETA.)-, 12-HYDROXYOCTADECANOATE
    • CHOLEST-5-EN-3-OL (3.BETA.)-, 3-(12-HYDROXYOCTADECANOATE)
    • RefChem:125706
    • DTXCID70115953
    • CHOLESTERYL HYDROXYSTEARATE [INCI]
    • CHOLESTERYL HYDROXYSTEARATE, (+-)-
    • 680-603-9
    • 40445-72-5
    • Cholesteryl hydroxystearate, (+/-)-
    • [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 12-hydroxyoctadecanoate
    • SCHEMBL296396
    • XKMYWNHZAQUEPY-YZGJEOKZSA-N
    • Cholest-5-en-3beta-yl 12-hydroxyoctadecanoate
    • Q27285408
    • 40445-72-5

  • Applications

    Cholesteryl hydroxystearate (CAS 40445-72-5) is a wax‑like cholesterol ester used across several industries as a texture and performance modifier. In cosmetics and personal care, it acts as a conditioning emollient, thickener and texture enhancer in creams, lotions and hair care products. In coatings and inks, it functions as a wax additive and rheology modifier to improve gloss, slip and film stability. In polymers and plastics, it may serve as a crystallization modifier or lubricant additive to influence processing behavior and the tactile feel of finished parts. It can also be used in household products and cleaning formulations as a wax‑like component to adjust consistency and gloss, subject to formulation limits and regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 16.16
    methanol 7.77
    isopropanol 9.97
    water 0.04
    ethyl acetate 40.45
    n-propanol 23.71
    acetone 24.12
    n-butanol 26.68
    acetonitrile 6.01
    DMF 33.6
    toluene 55.55
    isobutanol 17.74
    1,4-dioxane 59.06
    methyl acetate 23.67
    THF 139.73
    2-butanone 46.05
    n-pentanol 24.02
    sec-butanol 14.89
    n-hexane 4.49
    ethylene glycol 0.76
    NMP 115.05
    cyclohexane 8.25
    DMSO 20.87
    n-butyl acetate 52.82
    n-octanol 17.22
    chloroform 131.61
    n-propyl acetate 37.14
    acetic acid 21.25
    dichloromethane 101.47
    cyclohexanone 116.78
    propylene glycol 2.17
    isopropyl acetate 41.6
    DMAc 94.59
    2-ethoxyethanol 33.34
    isopentanol 22.98
    n-heptane 4.53
    ethyl formate 17.13
    1,2-dichloroethane 54.3
    n-hexanol 26.19
    2-methoxyethanol 27.56
    isobutyl acetate 34.03
    tetrachloromethane 24.84
    n-pentyl acetate 68.86
    transcutol 138.36
    n-heptanol 24.64
    ethylbenzene 28.13
    MIBK 39.7
    2-propoxyethanol 64.13
    tert-butanol 8.66
    MTBE 23.41
    2-butoxyethanol 62.12
    propionic acid 18.43
    o-xylene 31.84
    formic acid 5.38
    diethyl ether 36.37
    m-xylene 33.19
    p-xylene 28.22
    chlorobenzene 64.21
    dimethyl carbonate 18.65
    n-octane 1.5
    formamide 6.68
    cyclopentanone 110.72
    2-pentanone 49.39
    anisole 46.61
    cyclopentyl methyl ether 79.29
    gamma-butyrolactone 100.4
    1-methoxy-2-propanol 33.7
    pyridine 81.9
    3-pentanone 47.78
    furfural 67.83
    n-dodecane 0.9
    diethylene glycol 16.04
    diisopropyl ether 12.68
    tert-amyl alcohol 13.36
    acetylacetone 51.82
    n-hexadecane 1.12
    acetophenone 51.04
    methyl propionate 39.69
    isopentyl acetate 59.61
    trichloroethylene 117.62
    n-nonanol 20.78
    cyclohexanol 30.54
    benzyl alcohol 32.11
    2-ethylhexanol 23.64
    isooctanol 22.1
    dipropyl ether 36.53
    1,2-dichlorobenzene 58.82
    ethyl lactate 20.36
    propylene carbonate 53.96
    n-methylformamide 14.91
    2-pentanol 15.99
    n-pentane 4.13
    1-propoxy-2-propanol 52.65
    1-methoxy-2-propyl acetate 75.27
    2-(2-methoxypropoxy) propanol 51.54
    mesitylene 18.47
    ε-caprolactone 124.9
    p-cymene 19.71
    epichlorohydrin 108.13
    1,1,1-trichloroethane 54.88
    2-aminoethanol 4.49
    morpholine-4-carbaldehyde 87.78
    sulfolane 108.63
    2,2,4-trimethylpentane 3.03
    2-methyltetrahydrofuran 96.96
    n-hexyl acetate 64.67
    isooctane 1.85
    2-(2-butoxyethoxy)ethanol 64.6
    sec-butyl acetate 35.54
    tert-butyl acetate 45.67
    decalin 5.5
    glycerin 4.55
    diglyme 120.73
    acrylic acid 13.74
    isopropyl myristate 21.93
    n-butyric acid 47.77
    acetyl acetate 33.17
    di(2-ethylhexyl) phthalate 28.16
    ethyl propionate 38.15
    nitromethane 26.07
    1,2-diethoxyethane 53.4
    benzonitrile 25.34
    trioctyl phosphate 18.43
    1-bromopropane 45.55
    gamma-valerolactone 166.34
    n-decanol 12.16
    triethyl phosphate 28.7
    4-methyl-2-pentanol 13.19
    propionitrile 13.51
    vinylene carbonate 51.58
    1,1,2-trichlorotrifluoroethane 59.49
    DMS 37.85
    cumene 18.47
    2-octanol 14.47
    2-hexanone 43.83
    octyl acetate 28.48
    limonene 25.79
    1,2-dimethoxyethane 50.87
    ethyl orthosilicate 32.38
    tributyl phosphate 20.44
    diacetone alcohol 38.55
    N,N-dimethylaniline 34.25
    acrylonitrile 11.97
    aniline 41.1
    1,3-propanediol 12.27
    bromobenzene 74.61
    dibromomethane 73.54
    1,1,2,2-tetrachloroethane 97.77
    2-methyl-cyclohexyl acetate 49.71
    tetrabutyl urea 29.55
    diisobutyl methanol 13.95
    2-phenylethanol 41.09
    styrene 29.86
    dioctyl adipate 36.87
    dimethyl sulfate 33.3
    ethyl butyrate 48.75
    methyl lactate 18.67
    butyl lactate 49.3
    diethyl carbonate 27.86
    propanediol butyl ether 30.51
    triethyl orthoformate 47.82
    p-tert-butyltoluene 17.83
    methyl 4-tert-butylbenzoate 64.32
    morpholine 79.34
    tert-butylamine 6.83
    n-dodecanol 7.43
    dimethoxymethane 42.81
    ethylene carbonate 47.9
    cyrene 55.61
    2-ethoxyethyl acetate 90.94
    2-ethylhexyl acetate 54.14
    1,2,4-trichlorobenzene 75.56
    4-methylpyridine 75.09
    dibutyl ether 23.38
    2,6-dimethyl-4-heptanol 13.95
    DEF 61.12
    dimethyl isosorbide 95.32
    tetrachloroethylene 67.94
    eugenol 53.81
    triacetin 69.16
    span 80 48.67
    1,4-butanediol 4.94
    1,1-dichloroethane 46.25
    2-methyl-1-pentanol 24.35
    methyl formate 10.53
    2-methyl-1-butanol 25.8
    n-decane 2.41
    butyronitrile 18.11
    3,7-dimethyl-1-octanol 17.66
    1-chlorooctane 13.51
    1-chlorotetradecane 3.72
    n-nonane 1.93
    undecane 1.36
    tert-butylcyclohexane 3.92
    cyclooctane 3.62
    cyclopentanol 26.81
    tetrahydropyran 93.13
    tert-amyl methyl ether 26.81
    2,5,8-trioxanonane 69.53
    1-hexene 16.41
    2-isopropoxyethanol 29.01
    2,2,2-trifluoroethanol 10.97
    methyl butyrate 45.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction