Cholesteryl hemisuccinate

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  • Identifiers

    CAS number
    1510-21-0

    Molecular formula
    C31H50O4

    SMILES
    C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)CCC(=O)O)C)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 69.36%
    Balsamic 45.41%
    Amber 40.58%
    Sandalwood 39.02%
    Dry 34.78%
    Waxy 34.05%
    Cedar 30.08%
    Vetiver 27.84%
    Fatty 27.76%
    Animal 27.3%

     

    Flavor
    Woody 35.66%
    Mild 26.26%
    Waxy 25.54%
    Odorless 25.29%
    Herbal 23.81%
    Fruity 22.25%
    Sandalwood 21.31%
    Bland 20.56%
    Oily 20.35%
    Slightly waxy 20.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.5

    pKa est.
    6.49 (neutral)

    Molecular weight
    486.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    536°C

    Flash point

    • 267.13 ˚C est.

  • Synonyms

    • Cholesteryl hemisuccinate
    • 1510-21-0
    • Cholesteryl succinate
    • monocholesteryl succinate
    • T3J4KS4201
    • CHEBI:138742
    • NSC-628321
    • RefChem:576072
    • 216-148-6
    • Cholesterol Hydrogen Succinate
    • Cholesterol hemisuccinate
    • CHEMS
    • MFCD00037705
    • Cholest-5-en-3-ol (3beta)-, 3-(hydrogen butanedioate)
    • 4-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxobutanoic acid
    • Cholesteryl hydrogen succinate
    • Cholest-5-en-3beta-yl hydrogen succinate
    • Succinic Acid Monocholesterol Ester
    • 3-cholesteryloxycarbonylpropanoic acid
    • Cholest-5-en-3-ol (3.beta.)-, hydrogen butanedioate
    • C31H50O4
    • Cholesterylhemisuccinate
    • UNII-T3J4KS4201
    • 3-(3-Cholesteryloxycarbonyl)propionic Acid; 3-Cholesteryloxycarbonylpropanoic Acid;
    • 3-[(Cholest-5-en-3ss-yl)oxycarbonyl]propionic Acid; Cholesterol Hemisuccinate;
    • DTXSID10934145
    • Y01
    • EINECS 216-148-6
    • NSC 628321
    • SCHEMBL330610
    • orb1745228
    • 4-[(3beta)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid
    • AKOS015839518
    • CHOLESTEROL, HYDROGEN SUCCINATE
    • CS-W011516
    • FC61971
    • HY-W010800
    • AS-46683
    • BP-29634
    • SUCCINIC ACID MONOCHOLESTERYL ESTER
    • SY059918
    • 5-Cholesten-3.beta.-ol hydrogen succinate
    • 3beta-Hydroxy-5-cholestene 3-hemisuccinate
    • NS00045568
    • 3.beta.-(3-Carboxypropanoyloxy)cholest-5-ene
    • E10155
    • 3-(3-CHOLESTERYLOXYCARBONYL)PROPIONIC ACID
    • 4-[(Cholest-5-en-3-yl)oxy]-4-oxobutanoic acid
    • 510C210
    • F556402
    • 4-[(Cholest-5-en-3beta-yl)oxy]-4-oxobutanoic acid
    • Q27289619
    • Cholest-5-en-3-ol (3|A)-, 3-(hydrogen butanedioate)
    • CHOLEST-5-EN-3-OL (3.BETA.)-, 3-(HYDROGEN BUTANEDIOATE)
    • 4-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxo-butanoic acid
    • 1510-21-0

  • Applications

    Cholesteryl hemisuccinate (CAS 1510-21-0) is primarily used as a lipid component in liposome formulations, enabling stable, pH-responsive bilayers (often paired with DOPE) for pharmaceutical and biotech applications such as drug and gene delivery. It is also used in cosmetic and personal care research as a lipid-based carrier for topical actives, supporting liposome-mediated delivery in topical formulations. In laboratory and development settings, CHEMS serves as a membrane-mimetic tool and stabilizer in lipid nanoparticle and model-membrane systems, aiding formulation optimization and performance testing. While its use is formulation-specific and subject to regulatory constraints, cholesteryl hemisuccinate can be included as part of lipid-based systems in manufacturing pipelines where lipid stability and pH responsiveness are desired.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.27
    methanol 6.43
    isopropanol 7.58
    water 0.02
    ethyl acetate 17.65
    n-propanol 16.89
    acetone 8.17
    n-butanol 15.32
    acetonitrile 2.33
    DMF 20.13
    toluene 12.77
    isobutanol 9.41
    1,4-dioxane 29.8
    methyl acetate 9.97
    THF 70.64
    2-butanone 18.68
    n-pentanol 13.95
    sec-butanol 8.57
    n-hexane 0.63
    ethylene glycol 0.57
    NMP 41.15
    cyclohexane 0.91
    DMSO 10.82
    n-butyl acetate 17.1
    n-octanol 5.88
    chloroform 50.14
    n-propyl acetate 13.87
    acetic acid 9.3
    dichloromethane 31.79
    cyclohexanone 34.26
    propylene glycol 1.79
    isopropyl acetate 16.45
    DMAc 56.82
    2-ethoxyethanol 28.82
    isopentanol 11.78
    n-heptane 0.48
    ethyl formate 6.92
    1,2-dichloroethane 16.34
    n-hexanol 13.29
    2-methoxyethanol 24.94
    isobutyl acetate 12.1
    tetrachloromethane 6.2
    n-pentyl acetate 18.05
    transcutol 88.66
    n-heptanol 8.79
    ethylbenzene 6.66
    MIBK 14.03
    2-propoxyethanol 51.09
    tert-butanol 5.35
    MTBE 11.05
    2-butoxyethanol 31.41
    propionic acid 7.8
    o-xylene 7.59
    formic acid 2.98
    diethyl ether 14.16
    m-xylene 8.4
    p-xylene 7.05
    chlorobenzene 14.29
    dimethyl carbonate 7.1
    n-octane 0.2
    formamide 4.18
    cyclopentanone 33.1
    2-pentanone 18.13
    anisole 19.58
    cyclopentyl methyl ether 23.14
    gamma-butyrolactone 32.32
    1-methoxy-2-propanol 28.18
    pyridine 28.39
    3-pentanone 14.7
    furfural 26.52
    n-dodecane 0.14
    diethylene glycol 15.33
    diisopropyl ether 3.69
    tert-amyl alcohol 6.9
    acetylacetone 18.97
    n-hexadecane 0.17
    acetophenone 18.81
    methyl propionate 15.32
    isopentyl acetate 20.1
    trichloroethylene 40.56
    n-nonanol 7.16
    cyclohexanol 10.0
    benzyl alcohol 15.72
    2-ethylhexanol 7.63
    isooctanol 7.45
    dipropyl ether 9.53
    1,2-dichlorobenzene 13.78
    ethyl lactate 9.22
    propylene carbonate 16.6
    n-methylformamide 8.14
    2-pentanol 7.3
    n-pentane 0.59
    1-propoxy-2-propanol 32.23
    1-methoxy-2-propyl acetate 34.41
    2-(2-methoxypropoxy) propanol 25.79
    mesitylene 4.24
    ε-caprolactone 37.14
    p-cymene 4.01
    epichlorohydrin 44.56
    1,1,1-trichloroethane 13.7
    2-aminoethanol 3.69
    morpholine-4-carbaldehyde 48.26
    sulfolane 32.12
    2,2,4-trimethylpentane 0.51
    2-methyltetrahydrofuran 31.38
    n-hexyl acetate 19.05
    isooctane 0.37
    2-(2-butoxyethoxy)ethanol 36.84
    sec-butyl acetate 12.59
    tert-butyl acetate 16.33
    decalin 0.83
    glycerin 3.71
    diglyme 64.25
    acrylic acid 5.61
    isopropyl myristate 5.97
    n-butyric acid 20.26
    acetyl acetate 11.53
    di(2-ethylhexyl) phthalate 9.66
    ethyl propionate 12.71
    nitromethane 11.8
    1,2-diethoxyethane 23.0
    benzonitrile 9.22
    trioctyl phosphate 5.81
    1-bromopropane 11.59
    gamma-valerolactone 66.36
    n-decanol 4.02
    triethyl phosphate 8.87
    4-methyl-2-pentanol 5.66
    propionitrile 4.71
    vinylene carbonate 17.29
    1,1,2-trichlorotrifluoroethane 28.73
    DMS 12.53
    cumene 4.72
    2-octanol 4.31
    2-hexanone 16.45
    octyl acetate 8.52
    limonene 4.8
    1,2-dimethoxyethane 38.66
    ethyl orthosilicate 10.21
    tributyl phosphate 6.19
    diacetone alcohol 17.81
    N,N-dimethylaniline 13.34
    acrylonitrile 5.09
    aniline 14.48
    1,3-propanediol 10.1
    bromobenzene 14.28
    dibromomethane 20.67
    1,1,2,2-tetrachloroethane 33.81
    2-methyl-cyclohexyl acetate 16.31
    tetrabutyl urea 9.27
    diisobutyl methanol 3.81
    2-phenylethanol 19.98
    styrene 7.24
    dioctyl adipate 11.32
    dimethyl sulfate 12.13
    ethyl butyrate 15.12
    methyl lactate 9.73
    butyl lactate 16.52
    diethyl carbonate 8.62
    propanediol butyl ether 17.01
    triethyl orthoformate 14.98
    p-tert-butyltoluene 3.61
    methyl 4-tert-butylbenzoate 22.15
    morpholine 46.41
    tert-butylamine 3.1
    n-dodecanol 2.25
    dimethoxymethane 27.09
    ethylene carbonate 15.02
    cyrene 26.38
    2-ethoxyethyl acetate 30.87
    2-ethylhexyl acetate 16.05
    1,2,4-trichlorobenzene 19.2
    4-methylpyridine 26.94
    dibutyl ether 5.46
    2,6-dimethyl-4-heptanol 3.81
    DEF 22.72
    dimethyl isosorbide 44.49
    tetrachloroethylene 22.0
    eugenol 23.48
    triacetin 22.13
    span 80 20.27
    1,4-butanediol 4.06
    1,1-dichloroethane 14.14
    2-methyl-1-pentanol 11.69
    methyl formate 4.9
    2-methyl-1-butanol 11.71
    n-decane 0.34
    butyronitrile 7.06
    3,7-dimethyl-1-octanol 5.83
    1-chlorooctane 2.45
    1-chlorotetradecane 0.67
    n-nonane 0.27
    undecane 0.21
    tert-butylcyclohexane 0.66
    cyclooctane 0.4
    cyclopentanol 9.49
    tetrahydropyran 31.48
    tert-amyl methyl ether 9.63
    2,5,8-trioxanonane 36.42
    1-hexene 3.42
    2-isopropoxyethanol 21.03
    2,2,2-trifluoroethanol 4.41
    methyl butyrate 15.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction