Cholesterol

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  • Identifiers

    CAS number
    57-88-5

    Molecular formula
    C27H46O

    SMILES
    C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

  • Odor profile

    Fragrance
    Woody 78.73%
    Sandalwood 52.13%
    Balsamic 44.18%
    Amber 41.68%
    Waxy 39.84%
    Sweet 38.09%
    Dry 37.62%
    Spicy 36.89%
    Floral 33.11%
    Vetiver 31.77%

     

    Flavor
    Woody 41.31%
    Wood 35.98%
    Herb 34.08%
    Spice 31.98%
    Waxy 26.82%
    Herbal 26.45%
    Fir needle 23.73%
    Pine 23.34%
    Sandalwood 22.11%
    Terpentine 21.81%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.7

    pKa est.
    7.94 (neutral)

    Molecular weight
    386.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 148.5 °C
    • MP: 145.5 °C (the melt becomes clear at 180 °C); optical rotation (25 °C/D) = -13.7 deg (c = 0.9 in chloroform) /Benzoate/
    • 148 °C

    Boiling point

    • 360 °C
    • 360 °C (decomposes)

    Flash point

    • 213.22 ˚C est.

    Solubility expt.

    • 0.095 mg/L (at 30 °C)
    • Moderately soluble in hot alcohol; soluble in benzene, oils, fats and aq solns of bile salts
    • In water, 0.095 mg/l @ 30 °C.
    • 9.5e-05 mg/mL

  • Synonyms

    • cholesterol
    • 57-88-5
    • Cholesterin
    • Cholest-5-en-3beta-ol
    • Cholesteryl alcohol
    • Dythol
    • Cholestrin
    • Cordulan
    • Dusoline
    • Dusoran
    • Cholesterine
    • Cholestrol
    • Hydrocerin
    • Lidinite
    • Kathro
    • Lanol
    • Super hartolan
    • Lidinit
    • Cholesterol base H
    • Provitamin D
    • Nimco cholesterol base H
    • (-)-Cholesterol
    • Cholesterinum
    • Tegolan
    • 5:6-Cholesten-3beta-ol
    • 3beta-Hydroxycholest-5-ene
    • Tegolan (VAN)
    • Cholest-5-en-3-beta-ol
    • 5-Cholesten-3beta-ol
    • (3beta)-cholest-5-en-3-ol
    • CCRIS 2834
    • (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
    • Cholest-5-en-3-ol (3beta)-
    • HSDB 7106
    • Cholest-5-en-3-ol
    • 3beta-Hydroxy-5-cholestene
    • NSC 8798
    • 3-beta-Hydroxycholest-5-ene
    • 5-Cholesten-3B-ol
    • Cholest-5-en-3-ol (3.beta.)-
    • Dastar
    • CHEBI:16113
    • Provitamin-d
    • Cholest-5-en-3-ol, (3beta)-
    • AI3-03112
    • delta(sup 5)-Cholesten-3-beta-ol
    • Fancol CH
    • NSC-8798
    • 3h-cholesterol
    • EINECS 200-353-2
    • UNII-97C5T2UQ7J
    • 97C5T2UQ7J
    • DTXSID3022401
    • Nimco cholesterol base No. 712
    • NSC8798
    • 5-cholestene-3beta-ol
    • Cholesterol (Excipient)
    • 5:6-Cholesten-3-ol
    • (3beta,14beta,17alpha)-cholest-5-en-3-ol
    • MFCD00003646
    • 5-Cholesten-3.beta.-ol
    • Cholest-5-en-3.beta.-ol
    • 5,6-Cholesten-3.beta.-ol
    • 3.beta.-Hydroxycholest-5-ene
    • DTXCID402401
    • EC 200-353-2
    • 129111-15-5
    • NCGC00159351-02
    • CHOLESTEROL (II)
    • CHOLESTEROL [II]
    • CHOLESTEROL (IARC)
    • CHOLESTEROL [IARC]
    • CHOLESTEROL (MART.)
    • CHOLESTEROL [MART.]
    • CHOLESTEROL (USP-RS)
    • CHOLESTEROL [USP-RS]
    • CHOLESTEROL (EP MONOGRAPH)
    • CHOLESTEROL [EP MONOGRAPH]
    • Cholesterol-t
    • (3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
    • (3H)-Cholesterol
    • epicholesterin
    • Cholesterol [BAN:JAN:NF]
    • Cholesterol?
    • .DELTA.5-Cholesten-3-.beta.-ol
    • 80356-14-5
    • 1zhy
    • Cholest-5-en-3-ol, (3.beta.)- #
    • Cholesterol1551
    • Cholesterol (TN)
    • 20-epi-cholesterol
    • 20-iso-cholesterol
    • Cholesterol, 94%
    • Liquid crystal CN/9
    • (+)-ent-Cholesterol
    • cholest-5-en-3b-ol
    • 5-Cholesten-3ss--ol
    • Cholesterol (Standard)
    • Cholesterol (>99%)
    • Cholesterol, 99.0%
    • CHOLESTEROL [MI]
    • ALF component cholesterol
    • CHOLESTEROL [JAN]
    • ALFQ component cholesterol
    • Cholesterol (JP18/NF)
    • CHOLESTEROL [HSDB]
    • Phospholipon & Cholesterol
    • Delta5-Cholesten-3beta-ol
    • Epitope ID:150761
    • CHOLESTEROL [VANDF]
    • 3beta-cholest-5-en-3-ol
    • 3ss--Hydroxy-5-cholestene
    • ALF43 component cholesterol
    • CHOLESTERINUM [HPUS]
    • BIDD:PXR0095
    • (3b)-cholest-5-en-3-ol
    • CHOLESTEROL [WHO-DD]
    • 5:6-Cholesten-3.beta.-ol
    • 20bFH-cholest-5-en-3b-ol
    • BIDD:ER0548
    • Cholest-5-en-3-ol (3beta)-, labeled with tritium
    • CHEMBL112570
    • Cholest-5-en-3-ol (3beta)
    • GTPL2718
    • BDBM20192
    • HY-N0322B
    • HY-N0322R
    • (20bFH)-cholest-5-en-3b-ol

  • Applications

    Cholesterol (57-88-5) is used in cosmetics and personal care as an emollient, occlusive agent, and stabilizer in creams, lotions, and lip care products; in pharmaceuticals and biotech, it serves as a starting material for steroid synthesis and as a key component of lipid-based drug delivery systems such as liposomes and lipid nanoparticles; in industrial manufacturing, it is an important precursor for steroid hormones and related pharmaceutical intermediates; in research and analytical laboratories, it is used as a reference standard for lipid analysis and as a model component for membrane studies.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 30.48
    methanol 5.15
    isopropanol 30.03
    water 0.06
    ethyl acetate 50.35
    n-propanol 38.92
    acetone 51.09
    n-butanol 53.86
    acetonitrile 7.08
    DMF 25.84
    toluene 120.96
    isobutanol 32.71
    1,4-dioxane 123.74
    methyl acetate 24.2
    THF 232.74
    2-butanone 54.4
    n-pentanol 27.77
    sec-butanol 18.54
    n-hexane 6.25
    ethylene glycol 0.72
    NMP 41.12
    cyclohexane 17.05
    DMSO 13.0
    n-butyl acetate 73.21
    n-octanol 25.11
    chloroform 121.14
    n-propyl acetate 38.47
    acetic acid 9.67
    dichloromethane 72.41
    cyclohexanone 103.43
    propylene glycol 1.96
    isopropyl acetate 69.5
    DMAc 48.32
    2-ethoxyethanol 33.83
    isopentanol 55.94
    n-heptane 11.1
    ethyl formate 12.93
    1,2-dichloroethane 51.53
    n-hexanol 48.43
    2-methoxyethanol 36.26
    isobutyl acetate 47.83
    tetrachloromethane 24.96
    n-pentyl acetate 71.03
    transcutol 279.54
    n-heptanol 38.14
    ethylbenzene 37.87
    MIBK 74.45
    2-propoxyethanol 95.8
    tert-butanol 29.29
    MTBE 63.44
    2-butoxyethanol 76.47
    propionic acid 10.62
    o-xylene 53.49
    formic acid 1.83
    diethyl ether 96.61
    m-xylene 80.23
    p-xylene 40.62
    chlorobenzene 63.34
    dimethyl carbonate 16.09
    n-octane 2.94
    formamide 3.11
    cyclopentanone 94.75
    2-pentanone 73.93
    anisole 68.53
    cyclopentyl methyl ether 106.17
    gamma-butyrolactone 58.28
    1-methoxy-2-propanol 48.14
    pyridine 89.53
    3-pentanone 52.62
    furfural 46.11
    n-dodecane 1.65
    diethylene glycol 24.84
    diisopropyl ether 39.21
    tert-amyl alcohol 18.51
    acetylacetone 75.65
    n-hexadecane 2.07
    acetophenone 52.54
    methyl propionate 37.57
    isopentyl acetate 95.55
    trichloroethylene 93.06
    n-nonanol 30.3
    cyclohexanol 38.51
    benzyl alcohol 34.59
    2-ethylhexanol 41.74
    isooctanol 37.45
    dipropyl ether 78.74
    1,2-dichlorobenzene 55.69
    ethyl lactate 16.48
    propylene carbonate 35.67
    n-methylformamide 7.29
    2-pentanol 31.98
    n-pentane 9.99
    1-propoxy-2-propanol 87.55
    1-methoxy-2-propyl acetate 116.54
    2-(2-methoxypropoxy) propanol 69.81
    mesitylene 48.95
    ε-caprolactone 85.0
    p-cymene 37.05
    epichlorohydrin 86.3
    1,1,1-trichloroethane 57.52
    2-aminoethanol 3.84
    morpholine-4-carbaldehyde 67.98
    sulfolane 47.41
    2,2,4-trimethylpentane 5.01
    2-methyltetrahydrofuran 109.71
    n-hexyl acetate 72.49
    isooctane 6.28
    2-(2-butoxyethoxy)ethanol 102.91
    sec-butyl acetate 43.34
    tert-butyl acetate 86.88
    decalin 8.09
    glycerin 4.28
    diglyme 180.07
    acrylic acid 6.57
    isopropyl myristate 33.66
    n-butyric acid 40.44
    acetyl acetate 38.98
    di(2-ethylhexyl) phthalate 32.93
    ethyl propionate 37.67
    nitromethane 14.99
    1,2-diethoxyethane 111.43
    benzonitrile 34.21
    trioctyl phosphate 23.33
    1-bromopropane 51.13
    gamma-valerolactone 132.82
    n-decanol 20.52
    triethyl phosphate 32.37
    4-methyl-2-pentanol 34.03
    propionitrile 17.8
    vinylene carbonate 32.35
    1,1,2-trichlorotrifluoroethane 35.63
    DMS 38.33
    cumene 28.25
    2-octanol 21.74
    2-hexanone 42.94
    octyl acetate 37.04
    limonene 42.24
    1,2-dimethoxyethane 80.72
    ethyl orthosilicate 39.9
    tributyl phosphate 23.78
    diacetone alcohol 59.56
    N,N-dimethylaniline 47.18
    acrylonitrile 12.47
    aniline 62.47
    1,3-propanediol 17.67
    bromobenzene 79.66
    dibromomethane 59.93
    1,1,2,2-tetrachloroethane 76.33
    2-methyl-cyclohexyl acetate 63.47
    tetrabutyl urea 33.67
    diisobutyl methanol 33.42
    2-phenylethanol 61.11
    styrene 40.78
    dioctyl adipate 45.91
    dimethyl sulfate 19.25
    ethyl butyrate 63.02
    methyl lactate 13.85
    butyl lactate 46.97
    diethyl carbonate 36.58
    propanediol butyl ether 38.88
    triethyl orthoformate 65.45
    p-tert-butyltoluene 36.82
    methyl 4-tert-butylbenzoate 74.61
    morpholine 118.41
    tert-butylamine 25.24
    n-dodecanol 14.01
    dimethoxymethane 76.19
    ethylene carbonate 33.18
    cyrene 46.72
    2-ethoxyethyl acetate 103.29
    2-ethylhexyl acetate 78.84
    1,2,4-trichlorobenzene 66.21
    4-methylpyridine 91.67
    dibutyl ether 42.99
    2,6-dimethyl-4-heptanol 33.42
    DEF 50.05
    dimethyl isosorbide 110.87
    tetrachloroethylene 52.77
    eugenol 65.66
    triacetin 70.03
    span 80 55.45
    1,4-butanediol 5.03
    1,1-dichloroethane 50.35
    2-methyl-1-pentanol 31.69
    methyl formate 5.49
    2-methyl-1-butanol 41.02
    n-decane 4.34
    butyronitrile 30.25
    3,7-dimethyl-1-octanol 33.86
    1-chlorooctane 18.91
    1-chlorotetradecane 6.11
    n-nonane 3.61
    undecane 2.49
    tert-butylcyclohexane 6.96
    cyclooctane 7.27
    cyclopentanol 24.93
    tetrahydropyran 159.62
    tert-amyl methyl ether 38.49
    2,5,8-trioxanonane 104.44
    1-hexene 18.69
    2-isopropoxyethanol 36.56
    2,2,2-trifluoroethanol 4.93
    methyl butyrate 39.38

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction