Cholest-5-en-3-ol (3beta)-, 3-propanoate

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  • Identifiers

    CAS number
    633-31-8

    Molecular formula
    C30H50O2

    SMILES
    CCC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC[C@@H]4[C@H](C)CCCC(C)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 84.07%
    Sandalwood 50.06%
    Amber 47.41%
    Balsamic 44.1%
    Dry 41.14%
    Waxy 40.05%
    Cedar 38.11%
    Vetiver 37.83%
    Oily 35.08%
    Floral 34.08%

     

    Flavor
    Woody 45.27%
    Wood 32.54%
    Herb 29.78%
    Waxy 29.46%
    Herbal 27.83%
    Spice 26.39%
    Balsam 23.93%
    Mild 23.44%
    Fruity 22.73%
    Sandalwood 22.42%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    9.6

    pKa est.
    7.24 (neutral)

    Molecular weight
    442.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    483°C

    Flash point

    • 227.56 ˚C est.

  • Synonyms

    • Cholest-5-en-3-ol (3beta)-, 3-propanoate
    • RefChem:576043
    • Cholest-5-en-3-ol (3.beta.)-, 3-propanoate
    • Cholesterol Propionate
    • 633-31-8
    • Cholesteryl propionate
    • MFCD00021143
    • Cholesterol n-propionate
    • Propionic Acid Cholesterol Ester
    • Cholesterol, propionate
    • Cholest-5-en-3beta-yl propionate
    • Cholest-5-en-3-ol (3|A)-, 3-propanoate
    • [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] propanoate
    • NSC 226871
    • Propionyloxy-3.beta. cholestene-5
    • Cholesterinpropionat
    • cholesteryl propanoate
    • SCHEMBL161165
    • orb2939660
    • Cholest-5-en-3-yl propionate #
    • 3.beta.-Propanoyloxycholest-5-ene
    • AKOS015839618
    • CS-W013844
    • FC61973
    • HY-W013128
    • (3I(2))-cholest-5-en-3-yl propanoate
    • AS-63211
    • SY102614
    • Cholest-5-en-3-ol (3|_)-, 3-propanoate
    • NS00041600
    • D95344
    • [(3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] propanoate
    • 633-31-8

  • Applications

    Cholest-5-en-3-ol (3beta)-, 3-propanoate; CAS number: 633-31-8 is a cholesterol-derived waxy ester used in cosmetics and personal care as a lipid-based component and emollient, improving texture and skin feel in creams, lotions, and lip balms; it also serves as a wax-like processing aid and thickener in lipid-based formulations for coatings and polymer blends; in fragrance applications, cholesteryl esters may act as fragrance carriers or help stabilize scent release; in pharmaceutical contexts, it can function as a lipid-based excipient to support lipid-based drug delivery systems and formulation stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 32.15
    methanol 7.62
    isopropanol 31.4
    water 0.07
    ethyl acetate 76.4
    n-propanol 49.61
    acetone 50.27
    n-butanol 63.42
    acetonitrile 15.21
    DMF 39.85
    toluene 158.33
    isobutanol 42.41
    1,4-dioxane 120.61
    methyl acetate 39.06
    THF 208.54
    2-butanone 73.97
    n-pentanol 45.6
    sec-butanol 30.34
    n-hexane 7.28
    ethylene glycol 1.17
    NMP 99.27
    cyclohexane 20.54
    DMSO 17.33
    n-butyl acetate 82.37
    n-octanol 23.93
    chloroform 232.4
    n-propyl acetate 56.97
    acetic acid 22.54
    dichloromethane 163.72
    cyclohexanone 158.46
    propylene glycol 3.4
    isopropyl acetate 84.59
    DMAc 97.73
    2-ethoxyethanol 52.48
    isopentanol 62.88
    n-heptane 6.56
    ethyl formate 22.2
    1,2-dichloroethane 98.88
    n-hexanol 55.57
    2-methoxyethanol 45.61
    isobutyl acetate 61.19
    tetrachloromethane 38.51
    n-pentyl acetate 82.75
    transcutol 256.2
    n-heptanol 38.8
    ethylbenzene 53.65
    MIBK 81.1
    2-propoxyethanol 117.23
    tert-butanol 24.3
    MTBE 52.48
    2-butoxyethanol 84.62
    propionic acid 23.41
    o-xylene 70.91
    formic acid 4.67
    diethyl ether 90.88
    m-xylene 96.05
    p-xylene 57.19
    chlorobenzene 124.3
    dimethyl carbonate 24.83
    n-octane 1.89
    formamide 6.93
    cyclopentanone 137.96
    2-pentanone 88.88
    anisole 89.02
    cyclopentyl methyl ether 130.44
    gamma-butyrolactone 107.17
    1-methoxy-2-propanol 63.91
    pyridine 135.83
    3-pentanone 77.06
    furfural 89.04
    n-dodecane 1.27
    diethylene glycol 33.37
    diisopropyl ether 33.36
    tert-amyl alcohol 23.66
    acetylacetone 94.32
    n-hexadecane 1.6
    acetophenone 79.38
    methyl propionate 59.13
    isopentyl acetate 101.19
    trichloroethylene 189.66
    n-nonanol 28.68
    cyclohexanol 61.85
    benzyl alcohol 60.35
    2-ethylhexanol 43.01
    isooctanol 35.48
    dipropyl ether 59.85
    1,2-dichlorobenzene 107.29
    ethyl lactate 27.55
    propylene carbonate 65.43
    n-methylformamide 15.11
    2-pentanol 40.34
    n-pentane 9.6
    1-propoxy-2-propanol 90.58
    1-methoxy-2-propyl acetate 127.93
    2-(2-methoxypropoxy) propanol 72.77
    mesitylene 51.45
    ε-caprolactone 149.31
    p-cymene 36.4
    epichlorohydrin 142.8
    1,1,1-trichloroethane 95.96
    2-aminoethanol 6.88
    morpholine-4-carbaldehyde 111.89
    sulfolane 95.72
    2,2,4-trimethylpentane 5.67
    2-methyltetrahydrofuran 143.54
    n-hexyl acetate 81.57
    isooctane 4.8
    2-(2-butoxyethoxy)ethanol 100.79
    sec-butyl acetate 58.17
    tert-butyl acetate 87.56
    decalin 9.92
    glycerin 6.85
    diglyme 179.15
    acrylic acid 16.07
    isopropyl myristate 32.51
    n-butyric acid 65.93
    acetyl acetate 58.83
    di(2-ethylhexyl) phthalate 41.09
    ethyl propionate 55.16
    nitromethane 30.71
    1,2-diethoxyethane 99.45
    benzonitrile 59.13
    trioctyl phosphate 25.78
    1-bromopropane 83.21
    gamma-valerolactone 201.98
    n-decanol 18.37
    triethyl phosphate 39.51
    4-methyl-2-pentanol 35.26
    propionitrile 30.47
    vinylene carbonate 63.97
    1,1,2-trichlorotrifluoroethane 70.95
    DMS 54.77
    cumene 35.13
    2-octanol 20.83
    2-hexanone 64.1
    octyl acetate 39.28
    limonene 43.88
    1,2-dimethoxyethane 86.03
    ethyl orthosilicate 45.67
    tributyl phosphate 29.03
    diacetone alcohol 67.73
    N,N-dimethylaniline 59.59
    acrylonitrile 25.19
    aniline 93.54
    1,3-propanediol 24.71
    bromobenzene 145.81
    dibromomethane 123.84
    1,1,2,2-tetrachloroethane 149.74
    2-methyl-cyclohexyl acetate 72.2
    tetrabutyl urea 39.54
    diisobutyl methanol 26.88
    2-phenylethanol 79.69
    styrene 61.3
    dioctyl adipate 51.34
    dimethyl sulfate 33.29
    ethyl butyrate 69.4
    methyl lactate 23.73
    butyl lactate 58.55
    diethyl carbonate 43.36
    propanediol butyl ether 44.23
    triethyl orthoformate 67.22
    p-tert-butyltoluene 32.22
    methyl 4-tert-butylbenzoate 88.88
    morpholine 138.96
    tert-butylamine 20.83
    n-dodecanol 12.08
    dimethoxymethane 75.29
    ethylene carbonate 61.73
    cyrene 71.55
    2-ethoxyethyl acetate 121.88
    2-ethylhexyl acetate 86.53
    1,2,4-trichlorobenzene 126.93
    4-methylpyridine 141.55
    dibutyl ether 33.52
    2,6-dimethyl-4-heptanol 26.88
    DEF 82.55
    dimethyl isosorbide 131.33
    tetrachloroethylene 101.92
    eugenol 80.44
    triacetin 88.07
    span 80 63.7
    1,4-butanediol 9.62
    1,1-dichloroethane 90.7
    2-methyl-1-pentanol 47.51
    methyl formate 10.55
    2-methyl-1-butanol 55.71
    n-decane 3.13
    butyronitrile 42.57
    3,7-dimethyl-1-octanol 29.86
    1-chlorooctane 17.8
    1-chlorotetradecane 5.63
    n-nonane 2.49
    undecane 1.86
    tert-butylcyclohexane 7.2
    cyclooctane 7.35
    cyclopentanol 41.78
    tetrahydropyran 175.07
    tert-amyl methyl ether 46.21
    2,5,8-trioxanonane 104.47
    1-hexene 27.34
    2-isopropoxyethanol 52.09
    2,2,2-trifluoroethanol 12.4
    methyl butyrate 60.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction