Chlortetracycline

Overview IFRA Request a quote

  • Identifiers

    CAS number
    57-62-5

    Molecular formula
    C22H23ClN2O8

    SMILES
    C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 72.4%
    Sweet 29.35%
    Cooling 21.32%
    Savory 21.0%
    Bitter 20.44%
    Milky 18.67%
    Burnt 16.8%
    Spicy 16.4%
    Dry 15.59%
    Phenolic 15.17%

     

    Flavor
    Bitter 87.5%
    Odorless 37.71%
    Bland 25.68%
    Sweet-like 21.6%
    Very mild 20.74%
    Cedarleaf 20.04%
    Nitrile 19.09%
    Lovage 18.56%
    Basil 18.3%
    Leaves 18.29%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -1.3

    pKa est.
    6.19 (neutral)

    Molecular weight
    478.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1353°C

    Flash point

    • 293.38 ˚C est.

  • Synonyms

    • chlortetracycline
    • 57-62-5
    • 7-Chlorotetracycline
    • AUREOMYCIN
    • Chlorotetracycline
    • Clortetraciclina
    • (4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
    • Chlortetracyclinum
    • Chrysomykine
    • Acronize
    • Aureocina
    • Biomitsin
    • Biomycin
    • Duomycin
    • WCK1KIQ23Q
    • PIG KIDNEY (CTC free)
    • PIG MUSCLE (CTC free)
    • Aureomykoin
    • Flamycin
    • Uromycin
    • Biomycin a
    • CTC (abtibiotic)
    • Tri-chlortetracycline
    • MFCD00864876
    • Aureomycin A-377
    • Aureomycin (TN)
    • Chlortetracycline (INN)
    • CHLORTETRACYCLINE [INN]
    • Chlormax
    • (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
    • Caswell No. 219B
    • UNII-WCK1KIQ23Q
    • Aueromycin
    • Chlortetracycline [INN:BAN]
    • Chlortetracyclinum [INN-Latin]
    • Clortetraciclina [INN-Spanish]
    • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
    • EINECS 200-341-7
    • EPA Pesticide Chemical Code 006301
    • Spectrum_000727
    • Spectrum_001315
    • Prestwick0_000145
    • Prestwick1_000145
    • Prestwick2_000145
    • Spectrum2_000802
    • Spectrum3_000348
    • Spectrum4_001001
    • Spectrum4_001791
    • Spectrum5_000461
    • Spectrum5_001870
    • Pig liver-Chlortetracycline
    • SCHEMBL3110
    • SCHEMBL62861
    • BSPBio_002015
    • KBioGR_001461
    • KBioGR_002364
    • KBioSS_001207
    • KBioSS_001795
    • CHLORTETRACYCLINE [MI]
    • DivK1c_000253
    • SPBio_000663
    • SPBio_002189
    • 722 - Tetracyclines in pork
    • CHEMBL404520
    • orb1705248
    • SCHEMBL4099094
    • CHEMBL1622557
    • DTXSID9022811
    • SCHEMBL19981439
    • SCHEMBL27323552
    • CHEBI:27644
    • CHLORTETRACYCLINE [VANDF]
    • GTPL13537
    • HMS500M15
    • HY-B1327A
    • KBio1_000253
    • KBio2_001207
    • KBio2_001795
    • KBio2_003775
    • KBio2_004363
    • KBio2_006343
    • KBio2_006931
    • KBio3_001235
    • CHLORTETRACYCLINE [MART.]
    • DHPRQBPJLMKORJ-XRNKAMNCSA-N
    • NINDS_000253
    • CHLORTETRACYCLINE [WHO-DD]
    • RKL10090
    • EBC-27205
    • LMPK07000004
    • CHLORTETRACYCLINE [GREEN BOOK]
    • AKOS027381845
    • Pig liver - Chlortetracycline (blank)
    • CCG-269531
    • CHLORTETRACYCLINE [EP IMPURITY]
    • DB09093
    • IDI1_000253
    • NCGC00178862-01
    • NCGC00178862-04
    • E702
    • FC153179
    • SBI-0051312.P003
    • CS-0013541
    • Lymecycline EP Impurity G(Chlortetracycline)
    • LYMECYCLINE IMPURITY G [EP IMPURITY]
    • NS00001931
    • C06571
    • D07689
    • H10649
    • AB00643434_03
    • 864C876
    • EN300-19651945
    • Q417948
    • 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
    • 57-62-5

  • Applications

    Chlortetracycline is a tetracycline antibiotic used primarily in veterinary medicine to control bacterial infections in livestock and poultry; it has historically been used as a growth-promoting feed additive in some regions, though such use is restricted or banned in many markets. In the pharmaceutical industry it may serve as an active pharmaceutical ingredient or a chemical intermediate in the synthesis of other tetracycline antibiotics. It is also employed in microbiology research as a selective antibiotic for culture media. In industrial manufacturing, chlortetracycline can function as an intermediate in the synthesis of tetracycline-related compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.76
    methanol 2.72
    isopropanol 0.17
    water 0.02
    ethyl acetate 0.27
    n-propanol 0.44
    acetone 0.27
    n-butanol 0.24
    acetonitrile 0.34
    DMF 5.96
    toluene 0.09
    isobutanol 0.16
    1,4-dioxane 1.43
    methyl acetate 0.46
    THF 3.52
    2-butanone 0.45
    n-pentanol 0.25
    sec-butanol 0.13
    n-hexane 0.02
    ethylene glycol 1.84
    NMP 11.72
    cyclohexane 0.02
    DMSO 7.89
    n-butyl acetate 0.29
    n-octanol 0.08
    chloroform 0.42
    n-propyl acetate 0.32
    acetic acid 1.81
    dichloromethane 0.51
    cyclohexanone 1.07
    propylene glycol 0.85
    isopropyl acetate 0.11
    DMAc 6.02
    2-ethoxyethanol 2.72
    isopentanol 0.12
    n-heptane 0.01
    ethyl formate 0.69
    1,2-dichloroethane 0.34
    n-hexanol 0.21
    2-methoxyethanol 6.05
    isobutyl acetate 0.12
    tetrachloromethane 0.08
    n-pentyl acetate 0.22
    transcutol 0.93
    n-heptanol 0.19
    ethylbenzene 0.07
    MIBK 0.13
    2-propoxyethanol 2.95
    tert-butanol 0.09
    MTBE 0.04
    2-butoxyethanol 1.47
    propionic acid 0.69
    o-xylene 0.06
    formic acid 7.77
    diethyl ether 0.15
    m-xylene 0.05
    p-xylene 0.09
    chlorobenzene 0.09
    dimethyl carbonate 0.98
    n-octane 0.01
    formamide 7.24
    cyclopentanone 2.48
    2-pentanone 0.27
    anisole 0.19
    cyclopentyl methyl ether 0.47
    gamma-butyrolactone 4.29
    1-methoxy-2-propanol 2.12
    pyridine 1.51
    3-pentanone 0.27
    furfural 3.83
    n-dodecane 0.0
    diethylene glycol 4.77
    diisopropyl ether 0.02
    tert-amyl alcohol 0.09
    acetylacetone 0.38
    n-hexadecane 0.0
    acetophenone 0.41
    methyl propionate 0.66
    isopentyl acetate 0.18
    trichloroethylene 0.78
    n-nonanol 0.09
    cyclohexanol 0.17
    benzyl alcohol 0.46
    2-ethylhexanol 0.1
    isooctanol 0.11
    dipropyl ether 0.17
    1,2-dichlorobenzene 0.11
    ethyl lactate 0.71
    propylene carbonate 1.07
    n-methylformamide 4.62
    2-pentanol 0.07
    n-pentane 0.01
    1-propoxy-2-propanol 0.95
    1-methoxy-2-propyl acetate 0.65
    2-(2-methoxypropoxy) propanol 0.71
    mesitylene 0.03
    ε-caprolactone 1.22
    p-cymene 0.04
    epichlorohydrin 3.21
    1,1,1-trichloroethane 0.09
    2-aminoethanol 1.96
    morpholine-4-carbaldehyde 8.0
    sulfolane 8.33
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.68
    n-hexyl acetate 0.15
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.91
    sec-butyl acetate 0.11
    tert-butyl acetate 0.1
    decalin 0.01
    glycerin 3.98
    diglyme 1.93
    acrylic acid 1.45
    isopropyl myristate 0.05
    n-butyric acid 0.49
    acetyl acetate 0.18
    di(2-ethylhexyl) phthalate 0.19
    ethyl propionate 0.32
    nitromethane 3.17
    1,2-diethoxyethane 0.24
    benzonitrile 0.34
    trioctyl phosphate 0.13
    1-bromopropane 0.11
    gamma-valerolactone 6.79
    n-decanol 0.06
    triethyl phosphate 0.23
    4-methyl-2-pentanol 0.04
    propionitrile 0.41
    vinylene carbonate 1.22
    1,1,2-trichlorotrifluoroethane 6.16
    DMS 0.34
    cumene 0.04
    2-octanol 0.07
    2-hexanone 0.35
    octyl acetate 0.1
    limonene 0.04
    1,2-dimethoxyethane 3.08
    ethyl orthosilicate 0.17
    tributyl phosphate 0.12
    diacetone alcohol 0.5
    N,N-dimethylaniline 0.2
    acrylonitrile 1.04
    aniline 0.26
    1,3-propanediol 1.67
    bromobenzene 0.06
    dibromomethane 0.24
    1,1,2,2-tetrachloroethane 0.61
    2-methyl-cyclohexyl acetate 0.23
    tetrabutyl urea 0.26
    diisobutyl methanol 0.03
    2-phenylethanol 0.45
    styrene 0.07
    dioctyl adipate 0.13
    dimethyl sulfate 2.18
    ethyl butyrate 0.25
    methyl lactate 1.7
    butyl lactate 0.45
    diethyl carbonate 0.21
    propanediol butyl ether 0.83
    triethyl orthoformate 0.25
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 0.43
    morpholine 2.44
    tert-butylamine 0.03
    n-dodecanol 0.04
    dimethoxymethane 2.87
    ethylene carbonate 0.86
    cyrene 2.79
    2-ethoxyethyl acetate 0.49
    2-ethylhexyl acetate 0.16
    1,2,4-trichlorobenzene 0.18
    4-methylpyridine 0.61
    dibutyl ether 0.05
    2,6-dimethyl-4-heptanol 0.03
    DEF 0.99
    dimethyl isosorbide 1.85
    tetrachloroethylene 0.61
    eugenol 0.77
    triacetin 0.31
    span 80 0.57
    1,4-butanediol 0.76
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.14
    methyl formate 2.96
    2-methyl-1-butanol 0.14
    n-decane 0.01
    butyronitrile 0.28
    3,7-dimethyl-1-octanol 0.04
    1-chlorooctane 0.03
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.01
    cyclopentanol 0.43
    tetrahydropyran 0.46
    tert-amyl methyl ether 0.06
    2,5,8-trioxanonane 1.29
    1-hexene 0.06
    2-isopropoxyethanol 0.86
    2,2,2-trifluoroethanol 1.48
    methyl butyrate 0.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction