Chlorpyrifos

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  • Identifiers

    CAS number
    2921-88-2

    Molecular formula
    C9H11Cl3NO3PS

    SMILES
    CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 60.02%
    Grape 24.49%
    Meaty 20.21%
    Savory 19.83%
    Fresh 19.48%
    Floral 19.03%
    Roasted 17.92%
    Cooked 17.85%
    Milky 17.38%
    Fruity 16.16%

     

    Flavor
    Bitter 53.94%
    Odorless 36.67%
    Mild 28.43%
    Bland 25.96%
    Fruity 23.22%
    Roasted 21.57%
    Sweet-like 20.78%
    Scallion 20.29%
    Taco 19.86%
    Bouillon 19.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.3

    pKa est.
    5.37 (weak acid)

    Molecular weight
    350.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 108 to 110 °F (NTP, 1992)
    • 41-42 °C
    • 42 °C
    • 108 °F

    Boiling point

    • 320 °F at 760 mmHg (Decomposes) (NIOSH, 2024)
    • 320 °F (decomp)
    • No boiling point at normal pressure; decomposes at 160 °C
    • 320 °F (decomposes)
    • 320 °F (Decomposes)

    Flash point

    • 142.87 ˚C est.
    • 82 °F (CLOSED CUP) /DURSBAN 4E/
    • 87 °F (CLOSED CUP) /LORSBAN 4E/

    Solubility expt.

    • approximately 2 mg/L at 77 °F (NTP, 1992)
    • In water, 1.4 mg/L at 25 °C
    • In water, 1.12 mg/L at 24 °C
    • In water, 0.39 mg/L at 19.5 °C /OECD 105 method/
    • Solubility at 25 °C: isooctane 79% wt/wt; methanol 43% wt/wt
    • Solubility (g/100 g): acetone 650, benzene 790, carbon disulfide 590, carbon tetrachloride 310, chloroform 630, diethyl ether 510, ethanol 63, ethyl acetate >200, isooctane 79, kerosene 60, methanol 45, methylene chloride 400, propylene glycol 4, toluene 150, 1,1,1-trichloroethane 400, triethylene glycol 5, xylene 400. Readily soluble in other organic solvents.
    • 0.00112 mg/mL at 24 °C
    • Solubility in water, mg/l at 25 °C: 1.4 (very poor)
    • 0.0002%

  • Synonyms

    • chlorpyrifos
    • 2921-88-2
    • Dursban
    • Chlorpyriphos
    • Lorsban
    • Trichlorpyrphos
    • Coroban
    • Brodan
    • Chloropyrifos
    • Chlorpyrifos-ethyl
    • Piridane
    • Equity
    • Lentrek
    • Pyrinex
    • Stipend
    • Dowco 179
    • Chlorpyrifos ethyl
    • Lock-On
    • Danusban
    • Geodinfos
    • Killmaster
    • Bonidel
    • Durmet
    • Spannit
    • Tafaban
    • Terial
    • Radar
    • Zidil
    • Suscon green
    • Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester
    • suSCon
    • Suscon blue
    • Dursban F
    • Dursban R
    • Dursban 4E
    • Chlorpyriphos-ethyl
    • Ethyl chlorpyriphos
    • Dursban 10CR
    • O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
    • Dhanusban
    • Grofo
    • Detmol U.A.
    • Detmol ua
    • Radar (fungicide)
    • Dursban 44
    • Lorsban 50SL
    • Terial 40L
    • Chloropyriphos
    • Empire
    • m-Chlorpyrifos
    • ENT 27311
    • XRM 429
    • OMS-0971
    • XRM 5160
    • ENT-27311
    • DTXSID4020458
    • NSC-755891
    • O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl)phosphorothioate
    • JCS58I644W
    • Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) ester
    • O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat
    • O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) thiophosphate
    • 2-Pyridinol, 3,5,6-trichloro-, O-ester with O,O-diethyl phosphorothioate
    • DTXCID80458
    • o,o-Diethyl-o-(3,5,6-trichloro-2-pyridyl)phosphorothioate
    • CHEBI:34631
    • O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate
    • O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate
    • ethyl 3,5,6-trichloropyridin-2-yl ethoxy(sulfanylidene)phosphonite
    • Ethion, dry
    • RefChem:5677
    • O,O-DIETHYL O-3,5,6-TRICHLOROPYRIDIN-2-YL PHOSPHOROTHIOATE
    • PHOSPHOROTHIOIC ACID, O,O-DIETHYL O-(3,5,6-TRICHLORO-2-PYRIDINYL)ESTER
    • 220-864-4
    • Eradex
    • Chlorpyrifos (Dursban)
    • C9H11Cl3NO3PS
    • Empire 20
    • Chlorpyrifos [BAN]
    • Chlorpyrofos
    • Chlorpyrophos
    • Pageant
    • Silrifos
    • Dursban 2E
    • MFCD00041800
    • Bonidel; CPF Zamba; Chlora;
    • MLS001065609
    • Chlorpyrifos (BAN)
    • SMR000568474
    • O,O-Diethyl O-(3,5,6-Trichloro-2-pyridyl) phosphorothioate
    • Caswell No. 219AA
    • diethoxy-sulfanylidene-[(3,5,6-trichloro-2-pyridinyl)oxy]phosphorane
    • Chlorpyriphos [ISO-French]
    • CAS-2921-88-2
    • CCRIS 7144
    • HSDB 389
    • Chlorpyrifos [ANSI:BSI:ISO]
    • EINECS 220-864-4
    • EPA Pesticide Chemical Code 059101
    • BRN 1545756
    • pridane
    • UNII-JCS58I644W
    • Warhawk
    • Bolton
    • Detmol
    • Tricel
    • Nufos
    • AI3-27311
    • Zodiac (TN)
    • Chlorpyrifos (ethyl)
    • Spectrum_001897
    • O,O-Diethyl O-(3,5,6-trichloro-2-pyridyl) phsophorothioate
    • Chlorpyrifos (Standard)
    • SpecPlus_000518
    • O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat [German]
    • Spectrum2_001230
    • Spectrum3_000849
    • Spectrum4_000689
    • Spectrum5_002014
    • CHLORPYRIFOS [MI]
    • CHLORPYRIFOS [ISO]
    • CHLORPYRIFOS [HSDB]
    • cid_2730
    • Dursban, analytical standard
    • BIDD:PXR0044
    • SCHEMBL21680
    • BSPBio_002437
    • 2921-88-2

  • Applications

    Chlorpyrifos (CAS 2921-88-2) is primarily used as a broad-spectrum organophosphate insecticide in agriculture, protecting field and horticultural crops such as cereals, corn, cotton, fruits, and vegetables from a range of pests. It is also employed in limited stored-product protection to deter pests in grain and processed commodities where permitted, and in some structural pest control formulations under regulatory oversight. In addition, chlorpyrifos has historically been evaluated for seed treatments and soil applications to disrupt pest life cycles prior to emergence, and may be used in greenhouses or nursery settings to protect ornamental crops. Its use is governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 31.72
    methanol 31.3
    isopropanol 23.71
    water 0.32
    ethyl acetate 101.23
    n-propanol 29.52
    acetone 146.9
    n-butanol 30.42
    acetonitrile 81.11
    DMF 384.57
    toluene 40.36
    isobutanol 23.98
    1,4-dioxane 111.5
    methyl acetate 112.04
    THF 238.02
    2-butanone 127.11
    n-pentanol 29.87
    sec-butanol 29.74
    n-hexane 2.29
    ethylene glycol 11.92
    NMP 462.42
    cyclohexane 6.69
    DMSO 303.39
    n-butyl acetate 90.0
    n-octanol 17.64
    chloroform 274.81
    n-propyl acetate 84.96
    acetic acid 98.43
    dichloromethane 296.12
    cyclohexanone 197.85
    propylene glycol 13.8
    isopropyl acetate 68.37
    DMAc 433.02
    2-ethoxyethanol 80.75
    isopentanol 29.93
    n-heptane 4.81
    ethyl formate 94.4
    1,2-dichloroethane 172.96
    n-hexanol 32.69
    2-methoxyethanol 107.43
    isobutyl acetate 49.97
    tetrachloromethane 34.13
    n-pentyl acetate 66.76
    transcutol 99.45
    n-heptanol 23.23
    ethylbenzene 24.37
    MIBK 58.08
    2-propoxyethanol 87.27
    tert-butanol 31.26
    MTBE 47.68
    2-butoxyethanol 58.37
    propionic acid 52.23
    o-xylene 34.14
    formic acid 47.34
    diethyl ether 50.88
    m-xylene 26.33
    p-xylene 35.97
    chlorobenzene 94.18
    dimethyl carbonate 83.72
    n-octane 2.35
    formamide 86.15
    cyclopentanone 241.69
    2-pentanone 95.27
    anisole 77.27
    cyclopentyl methyl ether 90.65
    gamma-butyrolactone 277.37
    1-methoxy-2-propanol 77.81
    pyridine 181.33
    3-pentanone 97.58
    furfural 315.69
    n-dodecane 2.41
    diethylene glycol 68.06
    diisopropyl ether 16.93
    tert-amyl alcohol 37.71
    acetylacetone 153.28
    n-hexadecane 2.76
    acetophenone 110.64
    methyl propionate 99.54
    isopentyl acetate 71.38
    trichloroethylene 374.06
    n-nonanol 18.95
    cyclohexanol 46.85
    benzyl alcohol 72.42
    2-ethylhexanol 30.34
    isooctanol 21.05
    dipropyl ether 41.11
    1,2-dichlorobenzene 104.39
    ethyl lactate 53.45
    propylene carbonate 172.42
    n-methylformamide 121.0
    2-pentanol 23.32
    n-pentane 3.47
    1-propoxy-2-propanol 65.96
    1-methoxy-2-propyl acetate 97.31
    2-(2-methoxypropoxy) propanol 64.69
    mesitylene 17.5
    ε-caprolactone 173.9
    p-cymene 27.73
    epichlorohydrin 265.32
    1,1,1-trichloroethane 130.62
    2-aminoethanol 21.65
    morpholine-4-carbaldehyde 296.48
    sulfolane 363.35
    2,2,4-trimethylpentane 3.29
    2-methyltetrahydrofuran 145.79
    n-hexyl acetate 55.5
    isooctane 1.69
    2-(2-butoxyethoxy)ethanol 65.75
    sec-butyl acetate 56.82
    tert-butyl acetate 66.56
    decalin 4.24
    glycerin 31.9
    diglyme 125.31
    acrylic acid 67.47
    isopropyl myristate 29.28
    n-butyric acid 71.0
    acetyl acetate 97.33
    di(2-ethylhexyl) phthalate 41.33
    ethyl propionate 78.98
    nitromethane 250.71
    1,2-diethoxyethane 67.28
    benzonitrile 103.74
    trioctyl phosphate 28.86
    1-bromopropane 69.06
    gamma-valerolactone 324.41
    n-decanol 16.15
    triethyl phosphate 57.97
    4-methyl-2-pentanol 17.3
    propionitrile 63.35
    vinylene carbonate 176.64
    1,1,2-trichlorotrifluoroethane 211.25
    DMS 73.72
    cumene 18.07
    2-octanol 17.12
    2-hexanone 82.11
    octyl acetate 38.64
    limonene 37.84
    1,2-dimethoxyethane 151.24
    ethyl orthosilicate 51.38
    tributyl phosphate 35.09
    diacetone alcohol 73.6
    N,N-dimethylaniline 69.06
    acrylonitrile 101.33
    aniline 69.75
    1,3-propanediol 35.59
    bromobenzene 92.39
    dibromomethane 164.75
    1,1,2,2-tetrachloroethane 254.28
    2-methyl-cyclohexyl acetate 69.96
    tetrabutyl urea 56.15
    diisobutyl methanol 19.68
    2-phenylethanol 70.42
    styrene 35.9
    dioctyl adipate 50.04
    dimethyl sulfate 158.12
    ethyl butyrate 83.19
    methyl lactate 71.5
    butyl lactate 54.42
    diethyl carbonate 68.02
    propanediol butyl ether 43.33
    triethyl orthoformate 63.35
    p-tert-butyltoluene 25.86
    methyl 4-tert-butylbenzoate 77.11
    morpholine 146.87
    tert-butylamine 19.09
    n-dodecanol 13.71
    dimethoxymethane 153.06
    ethylene carbonate 134.25
    cyrene 120.72
    2-ethoxyethyl acetate 92.37
    2-ethylhexyl acetate 65.3
    1,2,4-trichlorobenzene 129.61
    4-methylpyridine 171.42
    dibutyl ether 25.15
    2,6-dimethyl-4-heptanol 19.68
    DEF 162.08
    dimethyl isosorbide 137.9
    tetrachloroethylene 156.98
    eugenol 77.95
    triacetin 75.63
    span 80 54.83
    1,4-butanediol 19.95
    1,1-dichloroethane 120.13
    2-methyl-1-pentanol 33.02
    methyl formate 121.66
    2-methyl-1-butanol 31.31
    n-decane 3.18
    butyronitrile 64.08
    3,7-dimethyl-1-octanol 20.45
    1-chlorooctane 15.53
    1-chlorotetradecane 8.7
    n-nonane 2.62
    undecane 2.72
    tert-butylcyclohexane 3.34
    cyclooctane 2.44
    cyclopentanol 57.4
    tetrahydropyran 99.13
    tert-amyl methyl ether 52.06
    2,5,8-trioxanonane 100.7
    1-hexene 11.85
    2-isopropoxyethanol 58.32
    2,2,2-trifluoroethanol 67.07
    methyl butyrate 102.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction