Chlorpropamide

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  • Identifiers

    CAS number
    94-20-2

    Molecular formula
    C10H13ClN2O3S

    SMILES
    CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 65.44%
    Savory 34.55%
    Meaty 29.95%
    Cooked 29.09%
    Roasted 24.26%
    Pungent 19.27%
    Cheesy 18.89%
    Cooling 18.54%
    Sulfurous 17.41%
    Bitter 16.58%

     

    Flavor
    Bitter 69.74%
    Odorless 38.91%
    Bland 24.82%
    Mild 24.16%
    Nitrile 21.17%
    Taco 19.54%
    Roasted peanuts 19.31%
    Yeast 19.2%
    Bread crust 18.91%
    Cedarleaf 18.82%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    6.16 (neutral)

    Molecular weight
    276.74 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    555°C

    Melting point expt.

    • 261 to 264 °F (NTP, 1992)
    • 129.2-129.8
    • 127-129 °C
    • 127 - 129 °C

    Flash point

    • 206.82 ˚C est.

    Solubility expt.

    • >41.5 [ug/mL] (The mean of the results at pH 7.4)
    • less than 1 mg/mL at 57 °F (NTP, 1992)
    • 258 mg/L (at 37 °C)
    • 2.2 mg/ml in water @ pH 6; practically insol in water @ pH 7.3; sol in alcohol; moderately sol in chloroform; sparingly sol in ether, benzene
    • In water, 258 mg/l @ 37 °C
    • 1.57e-01 g/L

  • Synonyms

    • chlorpropamide
    • 94-20-2
    • Chloropropamide
    • Diabinese
    • Chlorpropamid
    • Diabenese
    • Glucamide
    • Meldian
    • Chlorodiabina
    • Chloronase
    • Diabeneza
    • Diabetoral
    • Adiaben
    • Catanil
    • Diabaril
    • Dynalase
    • Insulase
    • Melitase
    • Diabechlor
    • Diabenal
    • Mellinese
    • Millinese
    • Asucrol
    • Glisema
    • Oradian
    • Diabet-Pages
    • Diamel Ex
    • Clorpropamida
    • Prodiaben
    • 1-(4-Chlorophenylsulfonyl)-3-propylurea
    • 4-chloro-N-(propylcarbamoyl)benzenesulfonamide
    • Chlorpropamidum
    • Clorpropamide
    • Diabexan
    • 1-(p-Chlorobenzenesulfonyl)-3-propylurea
    • 1-Propyl-3-(p-chlorobenzenesulfonyl)urea
    • N-(4-Chlorophenylsulfonyl)-N'-propylurea
    • N-(p-Chlorobenzenesulfonyl)-N'-propylurea
    • N-Propyl-N'-(p-chlorobenzenesulfonyl)urea
    • 1-(4-chlorophenyl)sulfonyl-3-propylurea
    • 1-(p-Chlorophenylsulfonyl)-3-propylurea
    • 4-Chloro-N-((propylamino)carbonyl)benzenesulfonamide
    • 1-p-Chlorophenyl-3-(propylsulfonyl)urea
    • NCI-C01752
    • n-Propyl-N'-p-chlorophenylsulfonylcarbamide
    • 1-[(4-chlorobenzene)sulfonyl]-3-propylurea
    • 4-chloro-N-[(propylamino)carbonyl]benzenesulfonamide
    • Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)-
    • WTM2C3IL2X
    • N-Propyl-N'-p-chlorphenylsulfonylcarbamide
    • 1-((p-Chlorophenyl)sulfonyl)-3-propylurea
    • 4-Chloro-4-((propylamino)carbonyl)benzenesulfonamide
    • P 607
    • MFCD00079004
    • NSC 44634
    • NSC-44634
    • U-9818
    • NSC-626720
    • CHEBI:3650
    • 1-(4-chlorobenzenesulfonyl)-3-propylurea
    • DTXSID9020322
    • Benzenesulfonamide, 4-chloro-N-[(propylamino)carbonyl]-
    • Clorpropamid
    • Urea, 1-((p-chlorophenyl)sulfonyl)-3-propyl-
    • CHEMBL498
    • DTXCID30322
    • MLS000028395
    • Bioglumin
    • Insogen
    • NSC44634
    • NSC626720
    • CAS-94-20-2
    • NCGC00015216-11
    • Chlorporpamide
    • SMR000058364
    • Clorpropamide [DCIT]
    • chlorpropamide, alpha-form
    • Clorpropamide [Italian]
    • Urea, 1-[(p-chlorophenyl)sulfonyl]-3-propyl-
    • chlorpropamide, epsilon-form
    • chlorpropamide, epsilon`-form
    • CHLORPROPAMIDE (MART.)
    • CHLORPROPAMIDE [MART.]
    • CHLORPROPAMIDE (USP-RS)
    • CHLORPROPAMIDE [USP-RS]
    • Chlorpropamidum [INN-Latin]
    • Clorpropamida [INN-Spanish]
    • CHLORPROPAMIDE (EP IMPURITY)
    • CHLORPROPAMIDE [EP IMPURITY]
    • CHLORPROPAMIDE (USP MONOGRAPH)
    • CHLORPROPAMIDE [USP MONOGRAPH]
    • Diabinese (TN)
    • CCRIS 155
    • 1-(p-Chlorobenzensulfonyl)-3-propylurea
    • HSDB 2051
    • 4-chloro-n-(propylaminocarbonyl)benzenesulfonamide
    • SR-01000000060
    • 4-chloro-N-((propylaminocarbonyl)benzenesulfonamide
    • EINECS 202-314-5
    • UNII-WTM2C3IL2X
    • U-3818
    • NSC 626720
    • BRN 2218363
    • Diabinase
    • Urea, 1-((p-chloropenyl)sulfonyl)-3-propyl-
    • Prestwick_684
    • Chlorpropamide [USP:INN:BAN:JAN]
    • Spectrum_000144
    • 1-(4-chlorophenyl)sulfonyl-3-propyl-urea
    • Opera_ID_359
    • Prestwick0_000323
    • Prestwick1_000323
    • Prestwick2_000323
    • Prestwick3_000323
    • Spectrum2_000089
    • Spectrum3_000347
    • Spectrum4_000284
    • Spectrum5_000719
    • WLN: GR DSWMVM3
    • Chlorpropamide (Standard)
    • Lopac-C-1290
    • chlorpropamide, delta-form
    • 1-(4-chloro-benzenesulfonyl)-3-n-propyl-urea
    • C 1290
    • CHLORPROPAMIDE [MI]
    • CHLORPROPAMIDE [INN]
    • CHLORPROPAMIDE [JAN]
    • Lopac0_000229

  • Applications

    Chlorpropamide (CAS 94-20-2) is primarily used as an oral antidiabetic agent, a sulfonylurea that stimulates insulin release and improves glycemic control in type 2 diabetes; in pharmaceutical development it serves as an active pharmaceutical ingredient (API) and is used in medicinal chemistry research to study structure-activity relationships within the sulfonylurea class; in analytical chemistry and quality control it may be used as a reference compound for method development and assay validation of related APIs; and in pharmacokinetic and formulation research it may be employed in preclinical or clinical studies to evaluate absorption, metabolism, and formulation performance of sulfonylurea drugs.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.68
    methanol 33.0
    isopropanol 10.87
    water 0.08
    ethyl acetate 22.08
    n-propanol 14.21
    acetone 94.36
    n-butanol 13.19
    acetonitrile 22.89
    DMF 778.94
    toluene 3.05
    isobutanol 7.37
    1,4-dioxane 37.49
    methyl acetate 27.63
    THF 183.43
    2-butanone 74.68
    n-pentanol 9.38
    sec-butanol 10.57
    n-hexane 0.06
    ethylene glycol 7.41
    NMP 518.15
    cyclohexane 0.18
    DMSO 411.92
    n-butyl acetate 20.16
    n-octanol 2.04
    chloroform 22.92
    n-propyl acetate 18.93
    acetic acid 39.01
    dichloromethane 25.41
    cyclohexanone 105.02
    propylene glycol 17.54
    isopropyl acetate 16.95
    DMAc 645.14
    2-ethoxyethanol 43.92
    isopentanol 10.9
    n-heptane 0.1
    ethyl formate 27.05
    1,2-dichloroethane 24.5
    n-hexanol 7.74
    2-methoxyethanol 117.62
    isobutyl acetate 9.82
    tetrachloromethane 0.98
    n-pentyl acetate 9.69
    transcutol 68.19
    n-heptanol 3.95
    ethylbenzene 2.01
    MIBK 21.86
    2-propoxyethanol 46.9
    tert-butanol 13.14
    MTBE 5.97
    2-butoxyethanol 21.85
    propionic acid 18.55
    o-xylene 2.73
    formic acid 27.82
    diethyl ether 4.65
    m-xylene 2.54
    p-xylene 3.6
    chlorobenzene 9.18
    dimethyl carbonate 26.46
    n-octane 0.05
    formamide 75.39
    cyclopentanone 204.82
    2-pentanone 45.93
    anisole 16.87
    cyclopentyl methyl ether 20.02
    gamma-butyrolactone 161.2
    1-methoxy-2-propanol 81.73
    pyridine 54.7
    3-pentanone 27.29
    furfural 140.82
    n-dodecane 0.08
    diethylene glycol 43.63
    diisopropyl ether 1.2
    tert-amyl alcohol 11.61
    acetylacetone 78.43
    n-hexadecane 0.1
    acetophenone 33.27
    methyl propionate 31.67
    isopentyl acetate 17.97
    trichloroethylene 63.84
    n-nonanol 2.26
    cyclohexanol 9.23
    benzyl alcohol 23.0
    2-ethylhexanol 4.46
    isooctanol 3.32
    dipropyl ether 4.36
    1,2-dichlorobenzene 10.9
    ethyl lactate 23.25
    propylene carbonate 71.59
    n-methylformamide 124.93
    2-pentanol 5.32
    n-pentane 0.06
    1-propoxy-2-propanol 30.84
    1-methoxy-2-propyl acetate 40.84
    2-(2-methoxypropoxy) propanol 35.87
    mesitylene 1.66
    ε-caprolactone 67.98
    p-cymene 2.56
    epichlorohydrin 143.97
    1,1,1-trichloroethane 10.05
    2-aminoethanol 18.21
    morpholine-4-carbaldehyde 217.79
    sulfolane 274.2
    2,2,4-trimethylpentane 0.12
    2-methyltetrahydrofuran 47.45
    n-hexyl acetate 8.83
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 34.42
    sec-butyl acetate 11.69
    tert-butyl acetate 21.68
    decalin 0.19
    glycerin 38.35
    diglyme 67.73
    acrylic acid 25.32
    isopropyl myristate 4.65
    n-butyric acid 30.32
    acetyl acetate 19.57
    di(2-ethylhexyl) phthalate 12.03
    ethyl propionate 17.25
    nitromethane 126.4
    1,2-diethoxyethane 14.46
    benzonitrile 27.28
    trioctyl phosphate 6.53
    1-bromopropane 4.86
    gamma-valerolactone 239.1
    n-decanol 1.85
    triethyl phosphate 12.69
    4-methyl-2-pentanol 3.83
    propionitrile 15.75
    vinylene carbonate 53.21
    1,1,2-trichlorotrifluoroethane 99.6
    DMS 18.04
    cumene 1.77
    2-octanol 1.97
    2-hexanone 27.57
    octyl acetate 6.46
    limonene 3.43
    1,2-dimethoxyethane 84.79
    ethyl orthosilicate 9.51
    tributyl phosphate 8.55
    diacetone alcohol 52.34
    N,N-dimethylaniline 14.53
    acrylonitrile 32.51
    aniline 14.29
    1,3-propanediol 30.24
    bromobenzene 6.68
    dibromomethane 11.46
    1,1,2,2-tetrachloroethane 47.58
    2-methyl-cyclohexyl acetate 18.99
    tetrabutyl urea 17.99
    diisobutyl methanol 2.94
    2-phenylethanol 20.99
    styrene 3.2
    dioctyl adipate 13.56
    dimethyl sulfate 79.33
    ethyl butyrate 17.98
    methyl lactate 45.38
    butyl lactate 17.19
    diethyl carbonate 13.82
    propanediol butyl ether 22.46
    triethyl orthoformate 13.08
    p-tert-butyltoluene 2.36
    methyl 4-tert-butylbenzoate 25.43
    morpholine 70.25
    tert-butylamine 3.4
    n-dodecanol 1.46
    dimethoxymethane 112.29
    ethylene carbonate 37.18
    cyrene 65.5
    2-ethoxyethyl acetate 19.76
    2-ethylhexyl acetate 13.03
    1,2,4-trichlorobenzene 19.61
    4-methylpyridine 50.96
    dibutyl ether 2.25
    2,6-dimethyl-4-heptanol 2.94
    DEF 84.58
    dimethyl isosorbide 72.97
    tetrachloroethylene 17.24
    eugenol 29.73
    triacetin 21.36
    span 80 23.85
    1,4-butanediol 10.43
    1,1-dichloroethane 12.77
    2-methyl-1-pentanol 9.01
    methyl formate 77.4
    2-methyl-1-butanol 9.45
    n-decane 0.1
    butyronitrile 18.42
    3,7-dimethyl-1-octanol 2.96
    1-chlorooctane 0.75
    1-chlorotetradecane 0.45
    n-nonane 0.07
    undecane 0.09
    tert-butylcyclohexane 0.14
    cyclooctane 0.06
    cyclopentanol 20.87
    tetrahydropyran 19.82
    tert-amyl methyl ether 6.7
    2,5,8-trioxanonane 57.99
    1-hexene 0.68
    2-isopropoxyethanol 22.68
    2,2,2-trifluoroethanol 18.25
    methyl butyrate 32.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction