Chloramine-T

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  • Identifiers

    CAS number
    127-65-1

    Molecular formula
    C7H7ClNNaO2S

    SMILES
    CC1=CC=C(C=C1)S(=O)(=O)[N-]Cl.[Na+]

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 69.34%
    Sulfurous 28.48%
    Cooked 25.46%
    Roasted 22.57%
    Savory 22.05%
    Pungent 19.81%
    Bitter 19.79%
    Meaty 18.98%
    Burnt 18.38%
    Onion 16.59%

     

    Flavor
    Bitter 69.75%
    Odorless 26.8%
    Nitrile 21.85%
    Taco 19.57%
    Mild 19.42%
    Roasted peanuts 19.27%
    Very strong 19.24%
    Bread crust 19.17%
    Urine 19.08%
    Indole 19.07%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.01 (neutral)

    Molecular weight
    227.64 g/mol

    Melting point expt.

    • 170-177 °C decomposes

    Flash point

    • 146.46 ˚C est.
    • 192 °C c.c. (trihydrate)

    Solubility expt.

    • Insoluble in benzene, chloroform, and ether; decomposed by alcohol
    • Soluble in water.
    • Solubility in water, g/100ml at 25 °C: (good, trihydrate)

  • Synonyms

    • Chloramine-T
    • CHLORAMINE T
    • 127-65-1
    • Chlorazene
    • Chloralone
    • Chlorasan
    • Chlorazone
    • Tochlorine
    • Tolamine
    • Tosylchloramide sodium
    • Acti-chlore
    • Chlorazan
    • Chlorosol
    • Chlorozone
    • Chlorseptol
    • Heliogen
    • Mannolite
    • Multichlor
    • Tampules
    • Aktivin
    • Sodium chloramine T
    • Chlorina Aktivin
    • Monochloramine T
    • Sodium tosylchloramide
    • Tosylchloramide sodique
    • Gyneclorina
    • Berkendyl
    • Mianine
    • Anexol
    • Gansil
    • Euclorina
    • Clorina
    • Tosilcloramida sodica
    • Cloramine T
    • Sodium p-toluenesulfonchloramide
    • Tosylchloramidum natricum
    • Aseptoclean
    • Clorosan
    • Desinfect
    • Kloramin
    • Tosylchloramid-natrium
    • Chloramin Heyden
    • Kloramine-T
    • (N-Chloro-p-toluenesulfonamido)sodium
    • Sodium p-toluenesulfonylchloramide
    • N-Chloro-p-toluenesulfonamide sodium
    • Sodium N-chloro-p-toluenesulfonamide
    • chloramine-T anhydrous
    • Chloramin Dr. Fahlberg
    • N-Chlorotoluenesulfonamide sodium salt
    • N-Chloro-4-methylbenzylsulfonamide sodium salt
    • CHEBI:53767
    • Tosilcloramida de sodio
    • 328AS34YM6
    • p-Toluenesulfonamide, N-chloro-, sodium salt
    • NSC-36959
    • DTXSID6040321
    • sodium;chloro-(4-methylphenyl)sulfonylazanide
    • chloraminum
    • tosilcloramide sodica
    • (N-chloro-p-toluenesulfonamide)sodium
    • RefChem:54770
    • DTXCID4020321
    • D08AX04
    • N05CA19
    • 204-854-7
    • Chloraseptine
    • Sodium chloro(tosyl)amide
    • Chloramine-T hydrate
    • Tosylchloramide sodium [INN]
    • MFCD00000522
    • [chloro(p-tolylsulfonyl)amino]sodium
    • sodium chloro(4-methylbenzenesulfonyl)azanide
    • p-Toluenesulfonchloramide Sodium Salt
    • 149358-73-6
    • Tosylchloramide sodium (INN)
    • n-chloro-4-toluenesulfonamide sodium salt
    • Caswell No. 170
    • Benzenesulfonamide, N-chloro-4-methyl-, sodium salt (1:1)
    • Chloramine-t [NF]
    • HSDB 4303
    • SR-01000872612
    • N-Chloro-p-toluenesulfonamide sodium salt
    • EINECS 204-854-7
    • Tosilcloramida sodica [INN-Spanish]
    • N-Chloro-4-methylbenzenesulfonamide sodium salt
    • NSC 36959
    • Tosylchloramide sodique [INN-French]
    • Tosylchloramidum natricum [INN-Latin]
    • AI3-18426C
    • EPA Pesticide Chemical Code 076502
    • UNII-328AS34YM6
    • Chloramin T
    • Sodiumchloro(tosyl)amide
    • CHLORAMINE-T [MI]
    • Epitope ID:116223
    • CHLORAMINE-T [HSDB]
    • SCHEMBL19335
    • MSK166467Na
    • CHEMBL1697734
    • HMS3264N19
    • HMS5085E18
    • HY-B0959
    • N-Chloro-4-toluenesulfonamide sodium
    • s6403
    • sodium;chloro(p-tolylsulfonyl)azanide
    • AKOS015890257
    • CCG-213937
    • CS-4435
    • EBC-152228
    • FN71895
    • TOSYLCHLORAMIDE SODIUM [WHO-DD]
    • DA-72163
    • TOSYLCHLORAMIDE SODIUM [EP IMPURITY]
    • NS00066780
    • TOSYLCHLORAMIDE SODIUM [EP MONOGRAPH]
    • Chloramine-T 1000 microg/mL in Acetonitrile
    • EN300-75322
    • sodium chloro[(4-methylphenyl)sulfonyl]azanide
    • D02445
    • D88065
    • Sodium chloro(4-methylbenzene-1-sulfonyl)azanide
    • Q420695
    • SR-01000872612-2
    • SR-01000872612-3
    • Chloramine (T) N-Chloro-4-toluenesulfonamide,sodium salt
    • Z1172235461
    • 127-65-1

  • Applications

    Chloramine-T, N-chloro-p-toluenesulfonamide (CAS 127-65-1), is widely used as a disinfectant and sanitizer for water, surfaces, and equipment in healthcare, food processing, and dairy operations; it also functions as a mild oxidizing agent and chlorinating reagent in organic synthesis. In biochemical research, Chloramine-T is employed in protein iodination to label proteins with radioactive iodine for immunoassays, and it can participate in other oxidation-type steps in synthetic routes. Depending on conditions, it may be used in cleaning and water-treatment formulations under local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 35.5
    methanol 37.34
    isopropanol 21.8
    water 0.2
    ethyl acetate 190.89
    n-propanol 29.75
    acetone 371.94
    n-butanol 22.84
    acetonitrile 236.53
    DMF 867.08
    toluene 50.22
    isobutanol 19.09
    1,4-dioxane 181.08
    methyl acetate 334.29
    THF 433.85
    2-butanone 371.81
    n-pentanol 17.8
    sec-butanol 30.01
    n-hexane 0.77
    ethylene glycol 19.99
    NMP 1193.97
    cyclohexane 2.67
    DMSO 409.16
    n-butyl acetate 90.48
    n-octanol 11.22
    chloroform 225.68
    n-propyl acetate 98.94
    acetic acid 103.09
    dichloromethane 278.8
    cyclohexanone 365.76
    propylene glycol 27.41
    isopropyl acetate 96.7
    DMAc 773.97
    2-ethoxyethanol 75.22
    isopentanol 20.06
    n-heptane 1.52
    ethyl formate 124.49
    1,2-dichloroethane 213.92
    n-hexanol 25.08
    2-methoxyethanol 150.31
    isobutyl acetate 41.72
    tetrachloromethane 19.39
    n-pentyl acetate 48.15
    transcutol 200.05
    n-heptanol 13.67
    ethylbenzene 21.79
    MIBK 76.62
    2-propoxyethanol 86.2
    tert-butanol 32.15
    MTBE 59.09
    2-butoxyethanol 46.3
    propionic acid 82.34
    o-xylene 34.26
    formic acid 63.65
    diethyl ether 48.73
    m-xylene 26.91
    p-xylene 32.61
    chlorobenzene 110.37
    dimethyl carbonate 156.11
    n-octane 0.58
    formamide 264.82
    cyclopentanone 760.52
    2-pentanone 180.23
    anisole 111.02
    cyclopentyl methyl ether 123.9
    gamma-butyrolactone 731.32
    1-methoxy-2-propanol 105.81
    pyridine 355.74
    3-pentanone 181.79
    furfural 653.43
    n-dodecane 0.57
    diethylene glycol 71.76
    diisopropyl ether 13.27
    tert-amyl alcohol 39.7
    acetylacetone 343.18
    n-hexadecane 0.7
    acetophenone 160.68
    methyl propionate 220.49
    isopentyl acetate 73.58
    trichloroethylene 666.81
    n-nonanol 11.38
    cyclohexanol 32.2
    benzyl alcohol 70.71
    2-ethylhexanol 18.39
    isooctanol 11.03
    dipropyl ether 23.99
    1,2-dichlorobenzene 114.67
    ethyl lactate 50.95
    propylene carbonate 285.83
    n-methylformamide 344.89
    2-pentanol 18.19
    n-pentane 1.07
    1-propoxy-2-propanol 59.35
    1-methoxy-2-propyl acetate 127.65
    2-(2-methoxypropoxy) propanol 65.57
    mesitylene 14.78
    ε-caprolactone 270.12
    p-cymene 16.76
    epichlorohydrin 653.6
    1,1,1-trichloroethane 162.49
    2-aminoethanol 31.48
    morpholine-4-carbaldehyde 565.44
    sulfolane 723.04
    2,2,4-trimethylpentane 1.28
    2-methyltetrahydrofuran 248.82
    n-hexyl acetate 57.04
    isooctane 0.77
    2-(2-butoxyethoxy)ethanol 71.05
    sec-butyl acetate 62.52
    tert-butyl acetate 110.25
    decalin 1.82
    glycerin 50.02
    diglyme 178.36
    acrylic acid 122.58
    isopropyl myristate 21.16
    n-butyric acid 73.96
    acetyl acetate 165.5
    di(2-ethylhexyl) phthalate 28.33
    ethyl propionate 97.08
    nitromethane 784.29
    1,2-diethoxyethane 59.76
    benzonitrile 129.66
    trioctyl phosphate 17.68
    1-bromopropane 48.04
    gamma-valerolactone 713.86
    n-decanol 8.5
    triethyl phosphate 36.29
    4-methyl-2-pentanol 11.99
    propionitrile 111.81
    vinylene carbonate 253.93
    1,1,2-trichlorotrifluoroethane 316.3
    DMS 127.92
    cumene 12.83
    2-octanol 9.38
    2-hexanone 103.56
    octyl acetate 29.59
    limonene 24.92
    1,2-dimethoxyethane 161.8
    ethyl orthosilicate 27.78
    tributyl phosphate 23.33
    diacetone alcohol 136.89
    N,N-dimethylaniline 62.23
    acrylonitrile 256.28
    aniline 89.22
    1,3-propanediol 39.36
    bromobenzene 105.59
    dibromomethane 113.98
    1,1,2,2-tetrachloroethane 343.57
    2-methyl-cyclohexyl acetate 58.95
    tetrabutyl urea 35.0
    diisobutyl methanol 11.6
    2-phenylethanol 66.36
    styrene 34.98
    dioctyl adipate 42.4
    dimethyl sulfate 328.34
    ethyl butyrate 68.66
    methyl lactate 110.81
    butyl lactate 41.19
    diethyl carbonate 49.24
    propanediol butyl ether 43.99
    triethyl orthoformate 38.05
    p-tert-butyltoluene 16.39
    methyl 4-tert-butylbenzoate 77.91
    morpholine 237.97
    tert-butylamine 14.95
    n-dodecanol 6.14
    dimethoxymethane 219.18
    ethylene carbonate 157.11
    cyrene 122.14
    2-ethoxyethyl acetate 109.47
    2-ethylhexyl acetate 59.9
    1,2,4-trichlorobenzene 172.81
    4-methylpyridine 307.32
    dibutyl ether 13.73
    2,6-dimethyl-4-heptanol 11.6
    DEF 281.23
    dimethyl isosorbide 167.51
    tetrachloroethylene 173.78
    eugenol 71.2
    triacetin 102.46
    span 80 45.63
    1,4-butanediol 15.93
    1,1-dichloroethane 150.24
    2-methyl-1-pentanol 19.14
    methyl formate 305.81
    2-methyl-1-butanol 22.46
    n-decane 0.88
    butyronitrile 72.42
    3,7-dimethyl-1-octanol 13.59
    1-chlorooctane 6.81
    1-chlorotetradecane 3.06
    n-nonane 0.73
    undecane 0.69
    tert-butylcyclohexane 1.55
    cyclooctane 0.93
    cyclopentanol 64.38
    tetrahydropyran 118.6
    tert-amyl methyl ether 57.57
    2,5,8-trioxanonane 116.29
    1-hexene 6.16
    2-isopropoxyethanol 49.95
    2,2,2-trifluoroethanol 83.49
    methyl butyrate 129.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction