Chelidonine

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  • Identifiers

    CAS number
    476-32-4

    Molecular formula
    C20H19NO5

    SMILES
    CN1CC2=C(C=CC3=C2OCO3)[C@@H]4[C@H]1C5=CC6=C(C=C5C[C@@H]4O)OCO6

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 44.67%
    Sweet 30.35%
    Vanilla 27.74%
    Phenolic 26.39%
    Animal 26.21%
    Spicy 25.15%
    Powdery 19.37%
    Floral 19.09%
    Smoky 18.07%
    Creamy 17.35%

     

    Flavor
    Bitter 96.0%
    Bland 20.29%
    Sweet-like 19.54%
    Cedarleaf 18.72%
    Cereal 17.44%
    Indole 17.21%
    Very strong 17.13%
    Alkaline 17.09%
    Parsley 17.05%
    Naphthalic 16.75%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    5.4 (weak acid)

    Molecular weight
    353.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    734°C

    Flash point

    • 235.18 ˚C est.

  • Synonyms

    • CHELIDONINE
    • Stylophorin
    • Chelidonin
    • Khelidonin
    • Helidonine
    • CHEBI:31389
    • 8K7EK8446J
    • DTXSID10878474
    • (1S,12S,13R)-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol
    • (1S,12S,13R)-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo(11.11.0.02,10.04,8.014,22.017,21)tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol
    • RefChem:32153
    • DTXCID501016520
    • 207-504-1
    • 476-32-4
    • (+)-Chelidonine
    • MFCD00069660
    • 4UDG3LY0GT
    • (+/-)-chelidonine
    • Chelidoniny
    • 20267-87-2
    • (5bR,6S,12bS)-13-Methyl-5b,6,7,12b,13,14-hexahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol
    • Stylophorine
    • Chelidonin [German]
    • Chelidoniny [Polish]
    • UNII-8K7EK8446J
    • NSC646661
    • (1)-Chelidonine
    • (1,3)BENZODIOXOLO(5,6-C)-1,3-DIOXOLO(4,5-I)PHENANTHRIDIN-6-OL, 5B,6,7,12B,13,14-HEXAHYDRO-13-METHYL-, (5BR,6S,12BS)-
    • (1,3)BENZODIOXOLO(5,6-C)-1,3-DIOXOLO(4,5-I)PHENANTHRIDIN-6-OL, 5B,6,7,12B,13,14-HEXAHYDRO-13-METHYL-, (5BR,6S,12BS)-REL-
    • [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-13-methyl-, (5bR,6S,12bS)-
    • [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-13-methyl-, (5bR,6S,12bS)-rel-
    • EINECS 207-504-1
    • Chelidonine (+-)-
    • Chelidonine (Standard)
    • Prestwick0_000587
    • Prestwick1_000587
    • Prestwick2_000587
    • Prestwick3_000587
    • UNII-4UDG3LY0GT
    • BSPBio_000434
    • CHELIDONINE [WHO-DD]
    • DIPHYLLINE (ALKALOID)
    • CHELIDONINE (+)-FORM
    • SCHEMBL563820
    • SPBio_002653
    • BPBio1_000478
    • CHEMBL496867
    • MEGxp0_001421
    • orb1301354
    • Chelidonine ((+)-Chelidonine)
    • SCHEMBL29387014
    • ACon1_000007
    • CHELIDONINE, (+/-)-
    • HY-N2369R
    • WLZ4634
    • HMS3886N18
    • HY-N2369
    • CHELIDONINE (+)-FORM [MI]
    • Chelidonine, >=97.0% (HPLC)
    • EINECS 243-662-8
    • BDBM50480259
    • MSK168746
    • s9154
    • AKOS016010202
    • CCG-208430
    • EBC-578241
    • FS66040
    • CHELIDONINE (+/-)-FORM [MI]
    • NCGC00167959-01
    • NCGC00167959-02
    • NCGC00167959-03
    • NCGC00167959-05
    • NCGC00167959-08
    • NCGC00167959-12
    • AC-34033
    • MS-25483
    • CS-0022550
    • NS00003894
    • 476C324
    • SR-05000002251
    • Q1069066
    • SR-05000002251-2
    • BRD-K32828673-001-01-5
    • BRD-K32828673-002-03-9
    • (5BR-(5B.ALPHA.,6.BETA.,12B.ALPHA.))-5B,6,7,12B,13,14-HEXAHYDRO-13-METHYL(1,3)BENZODIOXOLO(5,6-C)-1,3-DIOXOLO(4,5-I)PHENANTHRIDIN-6-OL
    • 5b,6,7,12b,13,14-Hexahydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenan-thridin-6-ol
    • Rel-(5bR,6R,12bS)-13-methyl-5b,6,7,12b,13,14-hexahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol
    • 476-32-4

  • Applications

    Chelidonine is a benzophenanthridine alkaloid isolated from Chelidonium majus, primarily of interest in natural product research and chemical synthesis. In industrial contexts, it is often viewed as a building-block intermediate for the synthesis of other benzophenanthridine alkaloids and for structure-activity relationship studies; it is also commonly used as a reference compound or analytical standard in the analysis and quality control of plant extracts containing Chelidonium. Additionally, chelidonine may be employed as a reagent in synthetic and analytical research in academic or contract laboratories, with use subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.86
    methanol 2.12
    isopropanol 0.78
    water 0.14
    ethyl acetate 4.22
    n-propanol 0.78
    acetone 4.55
    n-butanol 1.03
    acetonitrile 4.02
    DMF 14.24
    toluene 0.76
    isobutanol 0.73
    1,4-dioxane 4.99
    methyl acetate 3.43
    THF 6.52
    2-butanone 3.28
    n-pentanol 0.77
    sec-butanol 0.36
    n-hexane 0.01
    ethylene glycol 1.99
    NMP 9.71
    cyclohexane 0.04
    DMSO 18.51
    n-butyl acetate 5.82
    n-octanol 1.89
    chloroform 11.77
    n-propyl acetate 4.14
    acetic acid 12.31
    dichloromethane 8.36
    cyclohexanone 8.48
    propylene glycol 0.5
    isopropyl acetate 4.19
    DMAc 21.3
    2-ethoxyethanol 6.71
    isopentanol 1.7
    n-heptane 0.06
    ethyl formate 5.76
    1,2-dichloroethane 4.89
    n-hexanol 1.59
    2-methoxyethanol 11.36
    isobutyl acetate 3.97
    tetrachloromethane 1.76
    n-pentyl acetate 6.81
    transcutol 17.84
    n-heptanol 2.62
    ethylbenzene 0.42
    MIBK 4.38
    2-propoxyethanol 14.53
    tert-butanol 1.18
    MTBE 0.52
    2-butoxyethanol 12.27
    propionic acid 2.75
    o-xylene 0.72
    formic acid 12.91
    diethyl ether 0.81
    m-xylene 0.84
    p-xylene 0.72
    chlorobenzene 2.26
    dimethyl carbonate 8.37
    n-octane 0.05
    formamide 16.13
    cyclopentanone 9.24
    2-pentanone 3.93
    anisole 1.74
    cyclopentyl methyl ether 1.98
    gamma-butyrolactone 12.91
    1-methoxy-2-propanol 7.0
    pyridine 5.02
    3-pentanone 2.61
    furfural 20.74
    n-dodecane 0.08
    diethylene glycol 19.71
    diisopropyl ether 0.43
    tert-amyl alcohol 0.58
    acetylacetone 10.23
    n-hexadecane 0.1
    acetophenone 4.87
    methyl propionate 4.26
    isopentyl acetate 6.76
    trichloroethylene 14.97
    n-nonanol 2.42
    cyclohexanol 1.01
    benzyl alcohol 3.47
    2-ethylhexanol 1.57
    isooctanol 2.58
    dipropyl ether 1.39
    1,2-dichlorobenzene 3.68
    ethyl lactate 5.5
    propylene carbonate 9.4
    n-methylformamide 8.49
    2-pentanol 0.52
    n-pentane 0.02
    1-propoxy-2-propanol 8.4
    1-methoxy-2-propyl acetate 12.18
    2-(2-methoxypropoxy) propanol 11.01
    mesitylene 0.58
    ε-caprolactone 8.13
    p-cymene 1.15
    epichlorohydrin 13.7
    1,1,1-trichloroethane 4.12
    2-aminoethanol 1.53
    morpholine-4-carbaldehyde 20.27
    sulfolane 17.03
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 1.8
    n-hexyl acetate 5.83
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 12.18
    sec-butyl acetate 2.69
    tert-butyl acetate 4.37
    decalin 0.06
    glycerin 4.71
    diglyme 24.83
    acrylic acid 5.15
    isopropyl myristate 2.86
    n-butyric acid 6.02
    acetyl acetate 7.57
    di(2-ethylhexyl) phthalate 5.11
    ethyl propionate 3.73
    nitromethane 28.27
    1,2-diethoxyethane 4.73
    benzonitrile 6.28
    trioctyl phosphate 3.76
    1-bromopropane 0.94
    gamma-valerolactone 24.54
    n-decanol 1.7
    triethyl phosphate 5.17
    4-methyl-2-pentanol 0.92
    propionitrile 3.43
    vinylene carbonate 14.25
    1,1,2-trichlorotrifluoroethane 25.39
    DMS 6.94
    cumene 0.48
    2-octanol 1.28
    2-hexanone 3.19
    octyl acetate 3.81
    limonene 1.05
    1,2-dimethoxyethane 11.32
    ethyl orthosilicate 4.3
    tributyl phosphate 4.03
    diacetone alcohol 7.5
    N,N-dimethylaniline 1.63
    acrylonitrile 7.61
    aniline 2.19
    1,3-propanediol 4.35
    bromobenzene 2.06
    dibromomethane 3.69
    1,1,2,2-tetrachloroethane 10.13
    2-methyl-cyclohexyl acetate 5.65
    tetrabutyl urea 5.86
    diisobutyl methanol 1.23
    2-phenylethanol 5.98
    styrene 0.49
    dioctyl adipate 5.08
    dimethyl sulfate 13.99
    ethyl butyrate 4.87
    methyl lactate 6.98
    butyl lactate 7.92
    diethyl carbonate 5.06
    propanediol butyl ether 6.38
    triethyl orthoformate 5.18
    p-tert-butyltoluene 1.0
    methyl 4-tert-butylbenzoate 9.7
    morpholine 4.69
    tert-butylamine 0.38
    n-dodecanol 1.23
    dimethoxymethane 11.4
    ethylene carbonate 11.96
    cyrene 12.42
    2-ethoxyethyl acetate 11.34
    2-ethylhexyl acetate 5.0
    1,2,4-trichlorobenzene 4.58
    4-methylpyridine 4.34
    dibutyl ether 1.41
    2,6-dimethyl-4-heptanol 1.23
    DEF 6.09
    dimethyl isosorbide 18.52
    tetrachloroethylene 8.78
    eugenol 11.27
    triacetin 9.85
    span 80 6.9
    1,4-butanediol 1.74
    1,1-dichloroethane 2.82
    2-methyl-1-pentanol 1.07
    methyl formate 8.96
    2-methyl-1-butanol 0.88
    n-decane 0.13
    butyronitrile 2.99
    3,7-dimethyl-1-octanol 2.06
    1-chlorooctane 0.79
    1-chlorotetradecane 0.38
    n-nonane 0.09
    undecane 0.1
    tert-butylcyclohexane 0.05
    cyclooctane 0.03
    cyclopentanol 0.99
    tetrahydropyran 1.62
    tert-amyl methyl ether 0.55
    2,5,8-trioxanonane 18.68
    1-hexene 0.08
    2-isopropoxyethanol 4.72
    2,2,2-trifluoroethanol 12.28
    methyl butyrate 4.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction