Cetylhydroxyproline palmitamide

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  • Identifiers

    CAS number
    791838-11-4

    Molecular formula
    C37H71NO4

    SMILES
    CCCCCCCCCCCCCCCCOC(=O)[C@@H]1C[C@H](CN1C(=O)CCCCCCCCCCCCCCC)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 59.22%
    Fatty 44.59%
    Oily 39.91%
    Odorless 34.98%
    Woody 24.52%
    Milky 23.72%
    Fresh 22.49%
    Savory 20.94%
    Animal 20.88%
    Sweet 20.21%

     

    Flavor
    Bland 38.57%
    Waxy 35.61%
    Mild 35.29%
    Fatty 32.68%
    Odorless 29.16%
    Faint 28.37%
    Oily 26.62%
    Slightly waxy 23.36%
    Bay oil 21.46%
    Delicate 21.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    14.3

    pKa est.
    7.75 (neutral)

    Molecular weight
    594.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    760°C

    Flash point

    • 254.65 ˚C est.

  • Synonyms

    • Cetylhydroxyproline palmitamide
    • Pseudoceramide 391
    • Bio 391
    • UNII-74ONU0S62G
    • 74ONU0S62G
    • 791838-11-4
    • L-Proline, 4-hydroxy-1-(1-oxohexadecyl)-, hexadecyl ester, (4R)-
    • DTXSID80229575
    • RefChem:124723
    • Bio391
    • Bio-391
    • DTXCID30152066
    • CETYLHYDROXYPROLINE PALMITAMIDE [INCI]
    • SCHEMBL22898048
    • GOVINWHEYOSPAK-GPOMZPHUSA-N
    • Hexadecyl (4R)-1-hexadecanoyl-4-hydroxy-L-prolinate
    • Q27266295
    • 791838-11-4

  • Applications

    Chemical name: Cetylhydroxyproline palmitamide; CAS number: 791838-11-4 is a fatty amide derivative often considered a specialty ingredient for cosmetics and personal care, where it can act as a skin-conditioning emollient and a conditioning additive in creams, lotions, and hair-care formulations. In household products, it may function as a surfactant or lubricating additive to improve texture, spread, and feel in cleaners and surface-care products. In polymer and coating applications, it can serve as a plasticizer or texture modifier, helping to tune flexibility, film formation, and slip in formulations such as polymer blends and coatings. It is also evaluated as a functional additive in specialty coatings and inks to influence rheology and film properties, with use governed by formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 21.94
    methanol 27.08
    isopropanol 22.03
    water 1.0
    ethyl acetate 290.74
    n-propanol 35.91
    acetone 159.38
    n-butanol 37.71
    acetonitrile 76.92
    DMF 269.78
    toluene 106.8
    isobutanol 33.08
    1,4-dioxane 190.89
    methyl acetate 211.06
    THF 496.44
    2-butanone 234.62
    n-pentanol 38.72
    sec-butanol 45.87
    n-hexane 13.14
    ethylene glycol 4.27
    NMP 980.08
    cyclohexane 46.11
    DMSO 249.35
    n-butyl acetate 202.18
    n-octanol 53.25
    chloroform 716.04
    n-propyl acetate 249.76
    acetic acid 164.57
    dichloromethane 788.54
    cyclohexanone 624.99
    propylene glycol 9.73
    isopropyl acetate 240.86
    DMAc 802.23
    2-ethoxyethanol 96.8
    isopentanol 41.97
    n-heptane 11.41
    ethyl formate 138.29
    1,2-dichloroethane 425.81
    n-hexanol 30.78
    2-methoxyethanol 86.18
    isobutyl acetate 141.23
    tetrachloromethane 168.08
    n-pentyl acetate 355.04
    transcutol 414.43
    n-heptanol 48.11
    ethylbenzene 68.68
    MIBK 145.84
    2-propoxyethanol 93.51
    tert-butanol 36.86
    MTBE 98.08
    2-butoxyethanol 152.94
    propionic acid 123.79
    o-xylene 95.42
    formic acid 42.92
    diethyl ether 88.38
    m-xylene 70.12
    p-xylene 103.6
    chlorobenzene 251.53
    dimethyl carbonate 139.68
    n-octane 7.88
    formamide 81.84
    cyclopentanone 663.53
    2-pentanone 213.3
    anisole 142.39
    cyclopentyl methyl ether 269.53
    gamma-butyrolactone 827.8
    1-methoxy-2-propanol 91.48
    pyridine 327.64
    3-pentanone 227.84
    furfural 545.82
    n-dodecane 4.89
    diethylene glycol 34.68
    diisopropyl ether 42.3
    tert-amyl alcohol 69.11
    acetylacetone 360.33
    n-hexadecane 5.9
    acetophenone 251.15
    methyl propionate 243.74
    isopentyl acetate 195.71
    trichloroethylene 920.46
    n-nonanol 57.22
    cyclohexanol 99.44
    benzyl alcohol 82.61
    2-ethylhexanol 39.78
    isooctanol 49.27
    dipropyl ether 82.03
    1,2-dichlorobenzene 315.21
    ethyl lactate 110.0
    propylene carbonate 537.03
    n-methylformamide 120.78
    2-pentanol 38.47
    n-pentane 10.16
    1-propoxy-2-propanol 100.36
    1-methoxy-2-propyl acetate 231.08
    2-(2-methoxypropoxy) propanol 137.21
    mesitylene 48.13
    ε-caprolactone 699.92
    p-cymene 47.6
    epichlorohydrin 661.24
    1,1,1-trichloroethane 571.92
    2-aminoethanol 14.83
    morpholine-4-carbaldehyde 492.26
    sulfolane 1135.56
    2,2,4-trimethylpentane 12.77
    2-methyltetrahydrofuran 408.81
    n-hexyl acetate 293.3
    isooctane 4.77
    2-(2-butoxyethoxy)ethanol 168.0
    sec-butyl acetate 206.82
    tert-butyl acetate 251.2
    decalin 22.48
    glycerin 19.93
    diglyme 428.0
    acrylic acid 109.94
    isopropyl myristate 81.16
    n-butyric acid 226.48
    acetyl acetate 276.28
    di(2-ethylhexyl) phthalate 84.09
    ethyl propionate 253.36
    nitromethane 377.06
    1,2-diethoxyethane 204.62
    benzonitrile 143.55
    trioctyl phosphate 58.02
    1-bromopropane 199.65
    gamma-valerolactone 862.78
    n-decanol 33.98
    triethyl phosphate 149.11
    4-methyl-2-pentanol 28.05
    propionitrile 79.05
    vinylene carbonate 451.46
    1,1,2-trichlorotrifluoroethane 455.81
    DMS 230.06
    cumene 47.74
    2-octanol 47.61
    2-hexanone 181.85
    octyl acetate 116.4
    limonene 75.16
    1,2-dimethoxyethane 217.59
    ethyl orthosilicate 132.39
    tributyl phosphate 87.18
    diacetone alcohol 179.09
    N,N-dimethylaniline 109.87
    acrylonitrile 98.0
    aniline 107.45
    1,3-propanediol 27.35
    bromobenzene 297.62
    dibromomethane 420.81
    1,1,2,2-tetrachloroethane 770.4
    2-methyl-cyclohexyl acetate 179.29
    tetrabutyl urea 124.32
    diisobutyl methanol 27.26
    2-phenylethanol 66.51
    styrene 84.5
    dioctyl adipate 156.77
    dimethyl sulfate 356.34
    ethyl butyrate 218.17
    methyl lactate 111.58
    butyl lactate 219.99
    diethyl carbonate 146.88
    propanediol butyl ether 96.91
    triethyl orthoformate 178.61
    p-tert-butyltoluene 41.64
    methyl 4-tert-butylbenzoate 265.27
    morpholine 244.08
    tert-butylamine 25.53
    n-dodecanol 22.38
    dimethoxymethane 160.06
    ethylene carbonate 388.1
    cyrene 188.09
    2-ethoxyethyl acetate 411.35
    2-ethylhexyl acetate 176.23
    1,2,4-trichlorobenzene 421.65
    4-methylpyridine 321.87
    dibutyl ether 104.98
    2,6-dimethyl-4-heptanol 27.26
    DEF 340.01
    dimethyl isosorbide 325.69
    tetrachloroethylene 495.99
    eugenol 184.59
    triacetin 397.7
    span 80 123.24
    1,4-butanediol 16.62
    1,1-dichloroethane 360.12
    2-methyl-1-pentanol 52.26
    methyl formate 109.0
    2-methyl-1-butanol 51.34
    n-decane 11.62
    butyronitrile 80.91
    3,7-dimethyl-1-octanol 49.34
    1-chlorooctane 62.96
    1-chlorotetradecane 18.7
    n-nonane 10.35
    undecane 7.01
    tert-butylcyclohexane 14.39
    cyclooctane 14.28
    cyclopentanol 111.79
    tetrahydropyran 266.51
    tert-amyl methyl ether 126.05
    2,5,8-trioxanonane 228.51
    1-hexene 40.57
    2-isopropoxyethanol 82.96
    2,2,2-trifluoroethanol 130.22
    methyl butyrate 344.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction