Cetyl trimethoxysilane

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  • Identifiers

    CAS number
    16415-12-6

    Molecular formula
    C19H42O3Si

    SMILES
    CCCCCCCCCCCCCCCC[Si](OC)(OC)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Waxy 64.84%
    Fatty 48.24%
    Oily 44.13%
    Fresh 43.71%
    Citrus 39.6%
    Fruity 34.13%
    Clean 29.72%
    Woody 29.38%
    Green 28.75%
    Floral 28.01%

     

    Flavor
    Waxy 59.85%
    Oily 37.74%
    Mild 36.43%
    Fatty 35.43%
    Soapy 30.02%
    Fat 27.23%
    Bland 25.79%
    Floral 25.75%
    Slightly waxy 24.17%
    Mushroom 23.85%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    9.69 (weak base)

    Molecular weight
    346.6 g/mol

    Flash point

    • 151.7 ˚C est.

  • Synonyms

    • Hexadecyltrimethoxysilane
    • 16415-12-6
    • Silane, hexadecyltrimethoxy-
    • Cetyl trimethoxysilane
    • n-Hexadecyltrimethoxysilane
    • 975S1VH3IB
    • EINECS 240-464-3
    • DYNASYLAN 9116
    • DYNASYLAN-9116
    • SILANE 116
    • DTXSID9066047
    • VP-SI 116
    • EC 240-464-3
    • AY 43-216MC
    • RefChem:575403
    • DTXCID2035271
    • CETYL TRIMETHOXYSILANE [INCI]
    • 240-464-3
    • hexadecyl(trimethoxy)silane
    • Trimethoxyhexadecylsilane
    • C19H42O3Si
    • MFCD00069149
    • S09425
    • UNII-975S1VH3IB
    • Hexadecyltri(methoxy)silane
    • SCHEMBL114003
    • RSKGMYDENCAJEN-UHFFFAOYSA-N
    • AKOS015903991
    • DS-3394
    • FH62928
    • SY057415
    • CS-0152216
    • H1376
    • NS00053804
    • D70291
    • Hexadecyltrimethoxysilane, technical, >=85% (GC)
    • Q27271967
    • Hexadecyltrimethoxysilane, Vetec(TM) reagent grade, 85%
    • 224052-41-9
    • 16415-12-6

  • Applications

    Cetyl trimethoxysilane (CAS 16415-12-6) is a long-chain organosilane typically used as a silane coupling agent and surface modifier. In practice, it is employed to treat inorganic fillers such as silica and mineral pigments and to size glass fibers, improving compatibility with organic polymers, enhancing adhesion, and imparting hydrophobic, moisture-resistant surfaces. It is widely used in coatings, paints, and inks to form hydrophobic siloxane networks and reduce surface energy; in polymer composites and plastics formulations to compatibilize fillers and improve mechanical properties and weather resistance; as a reactive intermediate to build siloxane or hybrid organic–inorganic networks in coatings and sealants; and in electronic protective coatings or encapsulants where surface modification and adhesion promotion are beneficial.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 651.7
    methanol 572.61
    isopropanol 718.77
    water 1.01
    ethyl acetate 1626.1
    n-propanol 895.09
    acetone 1090.14
    n-butanol 970.25
    acetonitrile 490.32
    DMF 1514.18
    toluene 586.19
    isobutanol 829.03
    1,4-dioxane 2023.44
    methyl acetate 1120.03
    THF 3303.84
    2-butanone 1312.58
    n-pentanol 693.82
    sec-butanol 982.18
    n-hexane 297.23
    ethylene glycol 43.62
    NMP 1841.26
    cyclohexane 1369.26
    DMSO 1405.27
    n-butyl acetate 1783.79
    n-octanol 679.26
    chloroform 4782.36
    n-propyl acetate 1708.22
    acetic acid 687.12
    dichloromethane 4178.13
    cyclohexanone 3056.14
    propylene glycol 123.33
    isopropyl acetate 1371.11
    DMAc 1745.95
    2-ethoxyethanol 1048.25
    isopentanol 944.33
    n-heptane 466.1
    ethyl formate 924.83
    1,2-dichloroethane 2553.14
    n-hexanol 654.11
    2-methoxyethanol 1166.5
    isobutyl acetate 1140.6
    tetrachloromethane 1402.36
    n-pentyl acetate 2323.8
    transcutol 2222.85
    n-heptanol 829.36
    ethylbenzene 376.99
    MIBK 1118.51
    2-propoxyethanol 949.36
    tert-butanol 1144.93
    MTBE 1667.73
    2-butoxyethanol 1395.08
    propionic acid 801.74
    o-xylene 525.9
    formic acid 149.48
    diethyl ether 1728.62
    m-xylene 428.77
    p-xylene 542.72
    chlorobenzene 863.89
    dimethyl carbonate 404.4
    n-octane 198.61
    formamide 342.05
    cyclopentanone 2524.53
    2-pentanone 1388.86
    anisole 682.36
    cyclopentyl methyl ether 2256.22
    gamma-butyrolactone 2366.77
    1-methoxy-2-propanol 1066.78
    pyridine 1369.79
    3-pentanone 1250.79
    furfural 1414.09
    n-dodecane 71.62
    diethylene glycol 315.39
    diisopropyl ether 779.55
    tert-amyl alcohol 1210.83
    acetylacetone 1276.21
    n-hexadecane 87.06
    acetophenone 792.79
    methyl propionate 1104.44
    isopentyl acetate 1605.41
    trichloroethylene 3869.15
    n-nonanol 616.99
    cyclohexanol 1601.18
    benzyl alcohol 465.4
    2-ethylhexanol 663.54
    isooctanol 793.93
    dipropyl ether 1612.14
    1,2-dichlorobenzene 991.45
    ethyl lactate 506.91
    propylene carbonate 1495.52
    n-methylformamide 715.05
    2-pentanol 868.2
    n-pentane 341.53
    1-propoxy-2-propanol 1131.49
    1-methoxy-2-propyl acetate 1145.53
    2-(2-methoxypropoxy) propanol 500.04
    mesitylene 364.09
    ε-caprolactone 2764.22
    p-cymene 438.7
    epichlorohydrin 2543.92
    1,1,1-trichloroethane 3028.16
    2-aminoethanol 213.35
    morpholine-4-carbaldehyde 1739.79
    sulfolane 2785.01
    2,2,4-trimethylpentane 247.64
    2-methyltetrahydrofuran 2782.74
    n-hexyl acetate 1673.1
    isooctane 147.97
    2-(2-butoxyethoxy)ethanol 884.41
    sec-butyl acetate 1221.59
    tert-butyl acetate 1721.49
    decalin 282.2
    glycerin 178.22
    diglyme 2634.96
    acrylic acid 471.45
    isopropyl myristate 530.68
    n-butyric acid 1731.23
    acetyl acetate 843.92
    di(2-ethylhexyl) phthalate 320.24
    ethyl propionate 1253.39
    nitromethane 1342.93
    1,2-diethoxyethane 1617.93
    benzonitrile 716.54
    trioctyl phosphate 351.05
    1-bromopropane 1720.38
    gamma-valerolactone 3005.68
    n-decanol 360.48
    triethyl phosphate 647.26
    4-methyl-2-pentanol 556.57
    propionitrile 788.46
    vinylene carbonate 1273.22
    1,1,2-trichlorotrifluoroethane 1702.11
    DMS 651.17
    cumene 310.09
    2-octanol 732.7
    2-hexanone 1273.47
    octyl acetate 649.68
    limonene 854.57
    1,2-dimethoxyethane 2168.41
    ethyl orthosilicate 764.78
    tributyl phosphate 420.29
    diacetone alcohol 1089.16
    N,N-dimethylaniline 527.52
    acrylonitrile 621.44
    aniline 645.35
    1,3-propanediol 517.41
    bromobenzene 1034.9
    dibromomethane 2882.28
    1,1,2,2-tetrachloroethane 4128.42
    2-methyl-cyclohexyl acetate 1048.13
    tetrabutyl urea 561.97
    diisobutyl methanol 555.57
    2-phenylethanol 468.24
    styrene 426.81
    dioctyl adipate 633.64
    dimethyl sulfate 709.47
    ethyl butyrate 1564.36
    methyl lactate 384.24
    butyl lactate 1196.08
    diethyl carbonate 837.29
    propanediol butyl ether 725.82
    triethyl orthoformate 1377.71
    p-tert-butyltoluene 415.93
    methyl 4-tert-butylbenzoate 894.65
    morpholine 2604.69
    tert-butylamine 934.3
    n-dodecanol 242.83
    dimethoxymethane 1222.75
    ethylene carbonate 1442.81
    cyrene 617.43
    2-ethoxyethyl acetate 1794.28
    2-ethylhexyl acetate 1420.81
    1,2,4-trichlorobenzene 1065.26
    4-methylpyridine 1360.78
    dibutyl ether 1325.47
    2,6-dimethyl-4-heptanol 555.57
    DEF 1854.47
    dimethyl isosorbide 1042.15
    tetrachloroethylene 2648.54
    eugenol 641.58
    triacetin 1139.24
    span 80 631.39
    1,4-butanediol 225.83
    1,1-dichloroethane 2321.39
    2-methyl-1-pentanol 713.11
    methyl formate 496.84
    2-methyl-1-butanol 931.75
    n-decane 200.78
    butyronitrile 1119.95
    3,7-dimethyl-1-octanol 606.13
    1-chlorooctane 719.54
    1-chlorotetradecane 180.72
    n-nonane 214.81
    undecane 107.39
    tert-butylcyclohexane 233.69
    cyclooctane 389.58
    cyclopentanol 1482.21
    tetrahydropyran 3234.69
    tert-amyl methyl ether 1418.79
    2,5,8-trioxanonane 987.56
    1-hexene 579.82
    2-isopropoxyethanol 841.23
    2,2,2-trifluoroethanol 383.97
    methyl butyrate 1788.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction