Ceramide NP

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  • Identifiers

    CAS number
    178436-06-1

    Molecular formula
    C36H71NO4

    SMILES
    CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)NC(=O)CCCCCCC/C=C\CCCCCCCC)O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 52.83%
    Fatty 41.65%
    Oily 38.23%
    Odorless 33.98%
    Savory 26.96%
    Fishy 24.52%
    Meaty 23.58%
    Woody 22.91%
    Milky 20.74%
    Fresh 20.74%

     

    Flavor
    Bland 36.82%
    Mild 31.72%
    Odorless 30.18%
    Faint 28.73%
    Waxy 24.94%
    Fatty 22.7%
    Slightly waxy 22.02%
    Delicate 21.25%
    Bay oil 20.25%
    Diterpene 19.48%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    12.4

    pKa est.
    8.43 (weak base)

    Molecular weight
    582.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    871°C

    Flash point

    • 265.36 ˚C est.

  • Synonyms

    • ceramide np
    • Ceramide 3B
    • 178436-06-1
    • Cytomide IIIa
    • Cytomide IIIb
    • Ceramide IIIB
    • N-octadecanoylphytosphingosine
    • DTXSID201319096
    • 9-Octadecenamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-, (9Z)-
    • N-(9Z-octadecenoyl)-4-hydroxysphinganine
    • 9-Octadecenamide, N-((1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl)-, (9Z)-
    • RefChem:575149
    • CERAMIDE NP [INCI]
    • DTXCID301748052
    • 812-963-1
    • OCTADECANAMIDE, N-(1,3,4-TRIHYDROXY-2-OCTADECYL)-
    • CERAMIDE III
    • Ceramides Mixture
    • N-oleoylphytosphingosine
    • N-oleoyl phytosphingosine
    • N-oloeoyl-4-hydroxysphinganine
    • N-((2S,3S,4R)-1,3,4-Trihydroxyoctadecan-2-yl)oleamide
    • N-(9Z-octadecenoyl)phytosphingosine
    • Cer(t18:0/18:1n-9)
    • (9Z)-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadec-9-enamide
    • UNII-4370DF050B
    • EINECS 309-560-3
    • Ceramide GL(3)
    • N-oleoyl-phytosphingosine
    • LG42Y89AJF
    • PHCer C18:1(n-9)
    • SCHEMBL29350530
    • CHEBI:85204
    • N-[(2S,3S,4R)-1,3,4-Trihydroxy-2-octadecyl]oleamide
    • AKOS040732785
    • 4370DF050B
    • DB14111
    • DA-62214
    • SY343426
    • TS-07726
    • HY-160410
    • CS-0928939
    • NS00073596
    • N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine
    • Burkitt's Lymphoma associated glycolipid antigen
    • C18:1 Phytoceramide (t18:0/18:1(9Z))
    • H36913
    • Q27158397
    • (9Z)-N-[(1S,2S,3R)-2,3-Dihydroxy-1-(hydroxymethyl)heptadecyl]-9-octadecenamide
    • (Z)-N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]octadec-9-enamide
    • 178436-06-1

  • Applications

    Ceramide NP (CAS 178436-06-1) is used primarily in cosmetics and personal care as a skin-identical lipid that supports the stratum corneum and enhances moisturization in moisturizers, serums, cleansers, and body care products; it is also employed in hair care formulations to help retain moisture and improve conditioning; in topical pharmaceutical formulations it serves as an excipient and lipid component in creams and gels and is being explored in lipid-based drug-delivery systems, including lipid nanoparticles; it can be used in emulsions to influence texture and compatibility with other lipids. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.11
    methanol 7.17
    isopropanol 3.44
    water 0.16
    ethyl acetate 21.35
    n-propanol 6.07
    acetone 17.15
    n-butanol 6.35
    acetonitrile 3.49
    DMF 43.53
    toluene 10.71
    isobutanol 5.26
    1,4-dioxane 30.1
    methyl acetate 15.95
    THF 92.99
    2-butanone 24.52
    n-pentanol 7.45
    sec-butanol 6.83
    n-hexane 2.25
    ethylene glycol 0.95
    NMP 180.61
    cyclohexane 7.11
    DMSO 65.11
    n-butyl acetate 21.03
    n-octanol 13.36
    chloroform 48.62
    n-propyl acetate 22.09
    acetic acid 19.7
    dichloromethane 42.96
    cyclohexanone 82.3
    propylene glycol 2.55
    isopropyl acetate 21.47
    DMAc 140.62
    2-ethoxyethanol 19.43
    isopentanol 7.34
    n-heptane 2.78
    ethyl formate 12.36
    1,2-dichloroethane 30.17
    n-hexanol 6.71
    2-methoxyethanol 18.65
    isobutyl acetate 16.25
    tetrachloromethane 14.98
    n-pentyl acetate 48.79
    transcutol 119.3
    n-heptanol 12.51
    ethylbenzene 9.98
    MIBK 20.72
    2-propoxyethanol 20.39
    tert-butanol 6.8
    MTBE 15.19
    2-butoxyethanol 37.8
    propionic acid 13.93
    o-xylene 13.75
    formic acid 7.1
    diethyl ether 9.93
    m-xylene 9.39
    p-xylene 11.98
    chlorobenzene 16.01
    dimethyl carbonate 16.99
    n-octane 2.03
    formamide 10.8
    cyclopentanone 90.44
    2-pentanone 24.0
    anisole 17.55
    cyclopentyl methyl ether 49.38
    gamma-butyrolactone 94.43
    1-methoxy-2-propanol 20.74
    pyridine 29.31
    3-pentanone 26.33
    furfural 62.5
    n-dodecane 1.1
    diethylene glycol 9.14
    diisopropyl ether 6.44
    tert-amyl alcohol 12.38
    acetylacetone 38.99
    n-hexadecane 1.3
    acetophenone 31.34
    methyl propionate 25.17
    isopentyl acetate 25.57
    trichloroethylene 60.4
    n-nonanol 14.7
    cyclohexanol 17.66
    benzyl alcohol 12.67
    2-ethylhexanol 8.72
    isooctanol 12.81
    dipropyl ether 15.91
    1,2-dichlorobenzene 22.4
    ethyl lactate 17.41
    propylene carbonate 56.0
    n-methylformamide 14.77
    2-pentanol 6.01
    n-pentane 1.53
    1-propoxy-2-propanol 23.49
    1-methoxy-2-propyl acetate 34.82
    2-(2-methoxypropoxy) propanol 37.54
    mesitylene 7.23
    ε-caprolactone 89.69
    p-cymene 8.43
    epichlorohydrin 69.2
    1,1,1-trichloroethane 37.32
    2-aminoethanol 3.25
    morpholine-4-carbaldehyde 84.55
    sulfolane 216.05
    2,2,4-trimethylpentane 2.86
    2-methyltetrahydrofuran 57.66
    n-hexyl acetate 47.03
    isooctane 1.07
    2-(2-butoxyethoxy)ethanol 47.09
    sec-butyl acetate 22.31
    tert-butyl acetate 35.03
    decalin 4.68
    glycerin 6.2
    diglyme 99.35
    acrylic acid 12.05
    isopropyl myristate 14.14
    n-butyric acid 25.84
    acetyl acetate 19.58
    di(2-ethylhexyl) phthalate 17.03
    ethyl propionate 23.3
    nitromethane 33.2
    1,2-diethoxyethane 36.99
    benzonitrile 11.39
    trioctyl phosphate 12.75
    1-bromopropane 14.81
    gamma-valerolactone 124.7
    n-decanol 8.72
    triethyl phosphate 23.71
    4-methyl-2-pentanol 5.58
    propionitrile 5.21
    vinylene carbonate 40.92
    1,1,2-trichlorotrifluoroethane 74.43
    DMS 27.21
    cumene 8.19
    2-octanol 11.49
    2-hexanone 23.39
    octyl acetate 20.21
    limonene 14.72
    1,2-dimethoxyethane 40.06
    ethyl orthosilicate 23.53
    tributyl phosphate 16.19
    diacetone alcohol 36.93
    N,N-dimethylaniline 19.55
    acrylonitrile 6.3
    aniline 11.57
    1,3-propanediol 5.79
    bromobenzene 17.25
    dibromomethane 25.07
    1,1,2,2-tetrachloroethane 70.89
    2-methyl-cyclohexyl acetate 30.84
    tetrabutyl urea 27.03
    diisobutyl methanol 7.23
    2-phenylethanol 11.77
    styrene 9.24
    dioctyl adipate 28.77
    dimethyl sulfate 52.94
    ethyl butyrate 25.9
    methyl lactate 19.67
    butyl lactate 41.82
    diethyl carbonate 15.87
    propanediol butyl ether 31.38
    triethyl orthoformate 30.18
    p-tert-butyltoluene 8.54
    methyl 4-tert-butylbenzoate 52.78
    morpholine 40.62
    tert-butylamine 4.64
    n-dodecanol 5.7
    dimethoxymethane 28.78
    ethylene carbonate 35.59
    cyrene 49.3
    2-ethoxyethyl acetate 59.95
    2-ethylhexyl acetate 23.79
    1,2,4-trichlorobenzene 33.07
    4-methylpyridine 25.16
    dibutyl ether 20.75
    2,6-dimethyl-4-heptanol 7.23
    DEF 43.33
    dimethyl isosorbide 80.26
    tetrachloroethylene 48.41
    eugenol 38.89
    triacetin 62.65
    span 80 36.48
    1,4-butanediol 3.44
    1,1-dichloroethane 20.68
    2-methyl-1-pentanol 10.1
    methyl formate 12.6
    2-methyl-1-butanol 8.99
    n-decane 2.79
    butyronitrile 5.99
    3,7-dimethyl-1-octanol 12.13
    1-chlorooctane 12.04
    1-chlorotetradecane 3.5
    n-nonane 2.51
    undecane 1.62
    tert-butylcyclohexane 3.31
    cyclooctane 3.05
    cyclopentanol 19.07
    tetrahydropyran 40.28
    tert-amyl methyl ether 22.22
    2,5,8-trioxanonane 59.07
    1-hexene 5.59
    2-isopropoxyethanol 16.79
    2,2,2-trifluoroethanol 14.72
    methyl butyrate 31.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction