Ceramide NG

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  • Identifiers

    CAS number
    2304-80-5

    Molecular formula
    C36H73NO3

    SMILES
    CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 58.79%
    Fatty 43.01%
    Oily 36.98%
    Odorless 33.74%
    Fishy 25.47%
    Savory 25.39%
    Woody 24.19%
    Meaty 23.32%
    Animal 22.07%
    Fresh 20.51%

     

    Flavor
    Bland 39.42%
    Mild 33.59%
    Odorless 30.7%
    Faint 28.7%
    Waxy 28.67%
    Fatty 25.44%
    Slightly waxy 22.72%
    Delicate 21.5%
    Bay oil 20.75%
    Beer 19.86%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    14.5

    pKa est.
    9.22 (weak base)

    Molecular weight
    568.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    795°C

    Flash point

    • 270.38 ˚C est.

  • Synonyms

    • CERAMIDE NG
    • Ceramide 2
    • n-stearoyl dihydrosphingosine
    • Ceramide NS
    • Ceramide 2 pure
    • C04977SRJ5
    • (2S,3R)-2-(Octadecanoylamino)octadecane-1,3-diol
    • 1-stearoyl-C18-sphingosine
    • palmitoyl-c16-dihydrosphingosine
    • CERAMIDE TIC-001
    • Octadecanamide, N-((1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl)-
    • Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (R-(R*,S*))-
    • Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, D-erythro-
    • DTXSID50177594
    • Octadecanamide, N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-
    • RefChem:575148
    • CERAMIDE NG [INCI]
    • CERAMIDE NS [INCI]
    • CERAMIDE 2 (RETIRED)
    • DTXCID10100085
    • CERAMIDE 2 (RETIRED) [INCI]
    • C18 Dihydroceramide
    • 2304-80-5
    • N-(octadecanoyl)-sphinganine
    • N-Stearoylsphinganine
    • N-octodecanoylsphinganine
    • Cer(d18:0/18:0)
    • N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]octadecanamide
    • N-(stearoyl)-dihydroceramide
    • C18DH Cer
    • N-(octadecanoyl)-dihydroceramide
    • Ceramide II
    • N-stearoyldihydrosphingosine
    • UNII-8AD8CNQ956
    • UNII-C04977SRJ5
    • 8AD8CNQ956
    • N-stearoyldihydroceramide
    • N-octodecanoyldihydroceramide
    • N-(octodecanoyl)-sphinganine
    • C18 Dihydroceramide (d18:0/18:0)
    • N-octodecanoyldihydrosphingosine
    • MFCD01076443
    • N-stearoyl-D-erythro-sphinganine
    • C18 dihydro Ceramide (d18:0/18:0)
    • Cer(36:0)
    • C36H73NO3
    • C18 Sphinganine
    • C18 dihydrosphingosine
    • N-stearoyl-sphinganine
    • N-(stearoyl)-sphinganine
    • (2S,3R)-2-octadecanoylaminooctadecane-1,3-diol
    • N-[(2S,3R)-1,3-Dihydroxy-2-octadecyl]stearamide
    • orb1694297
    • SCHEMBL1478975
    • CHEBI:67033
    • Cer(36:00)
    • N-[(1S,2R)-2-Hydroxy-1-(hydroxymethyl)heptadecyl]octadecanamide
    • C18-dihydro-Ceramide (N-stearoyl)
    • LMSP02020008
    • AKOS040754846
    • DB14706
    • N-Stearoyldihydro-D-erythro-Sphingosine
    • DHC-A 18:0/18:0
    • BP-28818
    • SY350293
    • HY-141580
    • G91426
    • (2S,3R)-2-octadecanoylaminooctadecane-1 ,3-diol
    • Q27135592
    • C18 Dihydroceramide (d18:0/18:0), N-stearoyl-D-erythro-sphinganine, powder
    • 2304-80-5

  • Applications

    Ceramide NG (CAS 2304-80-5) is a synthetic ceramide commonly used in cosmetics and personal care as a skin-identical lipid and conditioning/emollient ingredient, helping to restore and maintain the stratum corneum lipid barrier when formulated in moisturizers, serums, cleansers, or hair-care products. It is also used in pharmaceutical topical formulations and lipid-based delivery systems (e.g., liposomes) to improve hydration, formulation stability, and skin delivery potential. In hair care, it can be added to conditioners and treatments to enhance moisture retention and fiber conditioning. Additionally, ceramide NG may serve as an intermediate or structural lipid in the preparation of ceramide- or lipid blends for topical formulations. Applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.01
    methanol 4.87
    isopropanol 2.74
    water 0.18
    ethyl acetate 24.77
    n-propanol 4.82
    acetone 15.65
    n-butanol 5.0
    acetonitrile 4.2
    DMF 40.71
    toluene 11.1
    isobutanol 4.54
    1,4-dioxane 29.67
    methyl acetate 17.69
    THF 99.64
    2-butanone 25.51
    n-pentanol 5.86
    sec-butanol 5.92
    n-hexane 2.75
    ethylene glycol 0.74
    NMP 201.21
    cyclohexane 10.26
    DMSO 56.71
    n-butyl acetate 31.18
    n-octanol 13.41
    chloroform 81.79
    n-propyl acetate 30.52
    acetic acid 17.94
    dichloromethane 70.73
    cyclohexanone 99.74
    propylene glycol 2.06
    isopropyl acetate 26.61
    DMAc 133.87
    2-ethoxyethanol 16.02
    isopentanol 6.3
    n-heptane 3.46
    ethyl formate 14.25
    1,2-dichloroethane 43.04
    n-hexanol 5.83
    2-methoxyethanol 14.62
    isobutyl acetate 22.19
    tetrachloromethane 24.46
    n-pentyl acetate 68.31
    transcutol 111.61
    n-heptanol 11.99
    ethylbenzene 10.57
    MIBK 23.55
    2-propoxyethanol 18.57
    tert-butanol 6.08
    MTBE 15.0
    2-butoxyethanol 36.7
    propionic acid 14.54
    o-xylene 13.93
    formic acid 5.77
    diethyl ether 9.39
    m-xylene 9.95
    p-xylene 14.94
    chlorobenzene 23.38
    dimethyl carbonate 16.7
    n-octane 2.39
    formamide 9.57
    cyclopentanone 111.14
    2-pentanone 24.29
    anisole 19.19
    cyclopentyl methyl ether 50.89
    gamma-butyrolactone 122.09
    1-methoxy-2-propanol 16.74
    pyridine 36.44
    3-pentanone 27.99
    furfural 85.16
    n-dodecane 1.24
    diethylene glycol 7.87
    diisopropyl ether 7.35
    tert-amyl alcohol 11.94
    acetylacetone 45.08
    n-hexadecane 1.48
    acetophenone 37.68
    methyl propionate 26.95
    isopentyl acetate 36.26
    trichloroethylene 95.23
    n-nonanol 14.95
    cyclohexanol 17.05
    benzyl alcohol 11.72
    2-ethylhexanol 9.63
    isooctanol 13.51
    dipropyl ether 19.57
    1,2-dichlorobenzene 33.82
    ethyl lactate 20.53
    propylene carbonate 80.33
    n-methylformamide 13.98
    2-pentanol 5.09
    n-pentane 1.68
    1-propoxy-2-propanol 24.25
    1-methoxy-2-propyl acetate 43.65
    2-(2-methoxypropoxy) propanol 39.55
    mesitylene 8.73
    ε-caprolactone 108.56
    p-cymene 11.0
    epichlorohydrin 83.92
    1,1,1-trichloroethane 62.19
    2-aminoethanol 2.56
    morpholine-4-carbaldehyde 86.36
    sulfolane 273.0
    2,2,4-trimethylpentane 3.22
    2-methyltetrahydrofuran 63.6
    n-hexyl acetate 60.2
    isooctane 1.22
    2-(2-butoxyethoxy)ethanol 45.98
    sec-butyl acetate 29.57
    tert-butyl acetate 43.81
    decalin 5.61
    glycerin 5.05
    diglyme 110.99
    acrylic acid 12.29
    isopropyl myristate 18.14
    n-butyric acid 27.32
    acetyl acetate 25.73
    di(2-ethylhexyl) phthalate 20.21
    ethyl propionate 31.96
    nitromethane 35.76
    1,2-diethoxyethane 43.48
    benzonitrile 15.75
    trioctyl phosphate 14.78
    1-bromopropane 21.3
    gamma-valerolactone 147.53
    n-decanol 8.83
    triethyl phosphate 34.75
    4-methyl-2-pentanol 5.19
    propionitrile 6.15
    vinylene carbonate 58.57
    1,1,2-trichlorotrifluoroethane 85.36
    DMS 35.19
    cumene 9.06
    2-octanol 12.43
    2-hexanone 28.45
    octyl acetate 23.98
    limonene 17.89
    1,2-dimethoxyethane 43.78
    ethyl orthosilicate 33.14
    tributyl phosphate 20.99
    diacetone alcohol 38.41
    N,N-dimethylaniline 20.66
    acrylonitrile 7.4
    aniline 11.47
    1,3-propanediol 4.53
    bromobenzene 27.61
    dibromomethane 42.0
    1,1,2,2-tetrachloroethane 101.24
    2-methyl-cyclohexyl acetate 42.63
    tetrabutyl urea 33.39
    diisobutyl methanol 8.41
    2-phenylethanol 11.99
    styrene 10.53
    dioctyl adipate 37.32
    dimethyl sulfate 56.63
    ethyl butyrate 39.2
    methyl lactate 18.29
    butyl lactate 52.17
    diethyl carbonate 25.19
    propanediol butyl ether 29.73
    triethyl orthoformate 43.1
    p-tert-butyltoluene 10.64
    methyl 4-tert-butylbenzoate 63.76
    morpholine 39.14
    tert-butylamine 4.44
    n-dodecanol 5.72
    dimethoxymethane 23.4
    ethylene carbonate 50.71
    cyrene 50.86
    2-ethoxyethyl acetate 75.07
    2-ethylhexyl acetate 34.58
    1,2,4-trichlorobenzene 48.59
    4-methylpyridine 31.22
    dibutyl ether 27.04
    2,6-dimethyl-4-heptanol 8.41
    DEF 45.78
    dimethyl isosorbide 99.77
    tetrachloroethylene 68.04
    eugenol 46.02
    triacetin 79.58
    span 80 36.91
    1,4-butanediol 2.81
    1,1-dichloroethane 31.2
    2-methyl-1-pentanol 8.44
    methyl formate 12.75
    2-methyl-1-butanol 7.52
    n-decane 3.21
    butyronitrile 7.03
    3,7-dimethyl-1-octanol 13.49
    1-chlorooctane 14.77
    1-chlorotetradecane 4.13
    n-nonane 2.96
    undecane 1.83
    tert-butylcyclohexane 3.96
    cyclooctane 3.77
    cyclopentanol 18.7
    tetrahydropyran 42.4
    tert-amyl methyl ether 22.09
    2,5,8-trioxanonane 63.84
    1-hexene 6.22
    2-isopropoxyethanol 14.75
    2,2,2-trifluoroethanol 15.36
    methyl butyrate 43.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction