Ceramide eop

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  • Identifiers

    CAS number
    627881-96-3

    Molecular formula
    C66H127NO6

    SMILES
    CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC/C=C\C/C=C\CCCCC)O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 62.02%
    Fatty 51.83%
    Oily 41.28%
    Odorless 33.82%
    Savory 21.64%
    Fishy 21.6%
    Woody 19.95%
    Meaty 18.74%
    Milky 17.16%
    Sweet 17.14%

     

    Flavor
    Bland 36.51%
    Mild 32.08%
    Faint 31.9%
    Waxy 31.1%
    Fatty 26.64%
    Odorless 26.26%
    Slightly waxy 22.49%
    Delicate 21.39%
    Bay oil 20.29%
    Beer 19.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    25.6

    pKa est.
    -439255.03 (strong acid)

    Molecular weight
    1030.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2302°C

    Flash point

    • -2906699.35 ˚C est.

  • Synonyms

    • Ceramide eop
    • Ceramide I A
    • Ceramide eop [INCI]
    • RefChem:575147
    • Ceramide 9
    • UNII-88KCS7120E
    • 88KCS7120E
    • 627881-96-3
    • 9,12-Octadecadienoic acid (9Z,12Z)-, 30-(((1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl)amino)-30-oxotriacontyl ester
    • SCHEMBL18323053
    • ceramide E(C30:0)OP(C18:0)
    • Q27269935
    • 627881-96-3

  • Applications

    Ceramide eop (CAS 627881-96-3) is a ceramide primarily used in cosmetics and personal care, where it acts as a skin-identical lipid to support the stratum corneum barrier and improve moisture retention, commonly incorporated in moisturizers, serums, and facial oils; it is also employed in lipid-based drug delivery systems for topical pharmaceutical formulations, including liposomes and nanoemulsions; in research and development contexts, it is used as a reference material and building block for the synthesis of related ceramides; and it may serve as a precursor or intermediate in ceramide synthesis for broader lipidome studies, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.23
    methanol 5.34
    isopropanol 4.15
    water 0.09
    ethyl acetate 36.39
    n-propanol 7.24
    acetone 24.39
    n-butanol 7.5
    acetonitrile 5.92
    DMF 62.7
    toluene 23.39
    isobutanol 6.4
    1,4-dioxane 43.57
    methyl acetate 26.5
    THF 131.15
    2-butanone 38.47
    n-pentanol 8.83
    sec-butanol 9.29
    n-hexane 4.22
    ethylene glycol 0.94
    NMP 288.68
    cyclohexane 10.89
    DMSO 67.33
    n-butyl acetate 28.28
    n-octanol 14.69
    chloroform 97.68
    n-propyl acetate 29.98
    acetic acid 25.1
    dichloromethane 85.35
    cyclohexanone 120.84
    propylene glycol 2.91
    isopropyl acetate 32.92
    DMAc 201.33
    2-ethoxyethanol 21.73
    isopentanol 8.35
    n-heptane 4.15
    ethyl formate 18.39
    1,2-dichloroethane 49.36
    n-hexanol 7.83
    2-methoxyethanol 19.51
    isobutyl acetate 19.88
    tetrachloromethane 24.75
    n-pentyl acetate 59.76
    transcutol 114.07
    n-heptanol 12.24
    ethylbenzene 17.57
    MIBK 26.93
    2-propoxyethanol 24.46
    tert-butanol 7.49
    MTBE 21.95
    2-butoxyethanol 36.57
    propionic acid 19.78
    o-xylene 25.34
    formic acid 7.14
    diethyl ether 16.13
    m-xylene 18.09
    p-xylene 20.6
    chlorobenzene 33.87
    dimethyl carbonate 28.92
    n-octane 2.81
    formamide 11.54
    cyclopentanone 137.91
    2-pentanone 36.59
    anisole 28.15
    cyclopentyl methyl ether 77.67
    gamma-butyrolactone 149.97
    1-methoxy-2-propanol 24.65
    pyridine 51.89
    3-pentanone 44.27
    furfural 101.74
    n-dodecane 1.55
    diethylene glycol 8.96
    diisopropyl ether 9.35
    tert-amyl alcohol 16.35
    acetylacetone 57.94
    n-hexadecane 1.83
    acetophenone 47.97
    methyl propionate 43.33
    isopentyl acetate 30.53
    trichloroethylene 116.74
    n-nonanol 16.38
    cyclohexanol 23.96
    benzyl alcohol 17.53
    2-ethylhexanol 10.44
    isooctanol 12.24
    dipropyl ether 21.62
    1,2-dichlorobenzene 45.1
    ethyl lactate 22.97
    propylene carbonate 89.11
    n-methylformamide 21.05
    2-pentanol 8.28
    n-pentane 2.81
    1-propoxy-2-propanol 28.55
    1-methoxy-2-propyl acetate 46.05
    2-(2-methoxypropoxy) propanol 41.68
    mesitylene 12.96
    ε-caprolactone 133.66
    p-cymene 12.3
    epichlorohydrin 116.41
    1,1,1-trichloroethane 70.06
    2-aminoethanol 3.29
    morpholine-4-carbaldehyde 126.57
    sulfolane 300.26
    2,2,4-trimethylpentane 4.58
    2-methyltetrahydrofuran 86.21
    n-hexyl acetate 58.81
    isooctane 1.66
    2-(2-butoxyethoxy)ethanol 48.29
    sec-butyl acetate 30.21
    tert-butyl acetate 46.68
    decalin 7.34
    glycerin 6.18
    diglyme 104.15
    acrylic acid 17.68
    isopropyl myristate 17.63
    n-butyric acid 35.43
    acetyl acetate 33.39
    di(2-ethylhexyl) phthalate 20.03
    ethyl propionate 35.95
    nitromethane 50.87
    1,2-diethoxyethane 43.76
    benzonitrile 18.43
    trioctyl phosphate 14.49
    1-bromopropane 29.19
    gamma-valerolactone 188.56
    n-decanol 9.81
    triethyl phosphate 30.58
    4-methyl-2-pentanol 6.75
    propionitrile 9.08
    vinylene carbonate 67.78
    1,1,2-trichlorotrifluoroethane 105.29
    DMS 40.9
    cumene 12.33
    2-octanol 12.1
    2-hexanone 32.49
    octyl acetate 24.65
    limonene 22.86
    1,2-dimethoxyethane 46.91
    ethyl orthosilicate 29.82
    tributyl phosphate 19.6
    diacetone alcohol 41.27
    N,N-dimethylaniline 30.83
    acrylonitrile 11.17
    aniline 21.18
    1,3-propanediol 5.78
    bromobenzene 39.75
    dibromomethane 50.8
    1,1,2,2-tetrachloroethane 125.93
    2-methyl-cyclohexyl acetate 38.58
    tetrabutyl urea 32.25
    diisobutyl methanol 7.85
    2-phenylethanol 15.04
    styrene 17.01
    dioctyl adipate 33.0
    dimethyl sulfate 81.67
    ethyl butyrate 34.99
    methyl lactate 28.59
    butyl lactate 48.31
    diethyl carbonate 20.61
    propanediol butyl ether 30.97
    triethyl orthoformate 39.02
    p-tert-butyltoluene 12.82
    methyl 4-tert-butylbenzoate 66.25
    morpholine 56.09
    tert-butylamine 5.58
    n-dodecanol 6.26
    dimethoxymethane 38.29
    ethylene carbonate 57.21
    cyrene 63.64
    2-ethoxyethyl acetate 73.62
    2-ethylhexyl acetate 30.41
    1,2,4-trichlorobenzene 63.27
    4-methylpyridine 48.48
    dibutyl ether 26.58
    2,6-dimethyl-4-heptanol 7.85
    DEF 68.57
    dimethyl isosorbide 95.96
    tetrachloroethylene 75.71
    eugenol 45.05
    triacetin 80.63
    span 80 40.61
    1,4-butanediol 3.67
    1,1-dichloroethane 41.76
    2-methyl-1-pentanol 11.63
    methyl formate 19.15
    2-methyl-1-butanol 10.65
    n-decane 3.88
    butyronitrile 9.59
    3,7-dimethyl-1-octanol 12.96
    1-chlorooctane 16.76
    1-chlorotetradecane 4.87
    n-nonane 3.49
    undecane 2.28
    tert-butylcyclohexane 5.15
    cyclooctane 5.56
    cyclopentanol 26.58
    tetrahydropyran 59.55
    tert-amyl methyl ether 33.69
    2,5,8-trioxanonane 60.84
    1-hexene 10.12
    2-isopropoxyethanol 18.96
    2,2,2-trifluoroethanol 19.25
    methyl butyrate 45.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction