Ceramide AP

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  • Identifiers

    CAS number
    212070-45-6

    Molecular formula
    C36H73NO5

    SMILES
    CCCCCCCCCCCCCCCCC(C(=O)N[C@@H](CO)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 51.65%
    Odorless 38.48%
    Oily 37.07%
    Fatty 36.12%
    Woody 23.71%
    Savory 22.98%
    Fishy 22.38%
    Fresh 21.71%
    Milky 20.86%
    Amber 19.81%

     

    Flavor
    Bland 40.19%
    Odorless 35.25%
    Mild 34.67%
    Waxy 27.22%
    Faint 26.05%
    Fatty 22.51%
    Slightly waxy 21.86%
    Delicate 21.02%
    Bay oil 20.42%
    Sweet-like 19.81%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    12.6

    pKa est.
    8.4 (weak base)

    Molecular weight
    600.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1134°C

    Flash point

    • 272.93 ˚C est.

  • Synonyms

    • Ceramide AP
    • ceramide 6
    • Ceramide VI
    • Cytomide VI
    • Biomide 6
    • Ceramide 6 II
    • N-2-Hydroxystearoyl-phytosphingosine
    • F1X8L2B00J
    • phytosphingosine-2-hydroxy-18:0
    • 212070-45-6
    • N-(2-hydroxyoctadecanoyl)phytoceramide
    • PHC-C 18:0/18:0
    • N-(2-hydroxyoctadecanoyl)phytosphingosine
    • alpha-Hydroxystearoyl-4-hydroxysphinganine
    • alpha-Hydroxystearoyl-C18-phytosphingosine
    • Octadecanamide, N-((1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl)-2-hydroxy-
    • 2-(2'-hydroxyoctadecanoylamino)-1,3,4-octadecanetriol
    • RefChem:575145
    • N-(alpha-hydroxyoctadecanoyl)phytosphingosine
    • N-(2-hydroxyoctadecanoyl)-hydroxysphinganine
    • N-(2-hydroxyoctadecanoyl)-4R-hydroxysphinganine
    • Cer(t18:0/18:0(2OH))
    • N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine
    • Ceramide AP [INCI]
    • DL-CER6
    • Ceramide 6 II [INCI]
    • UNII-F1X8L2B00J
    • SCHEMBL4133281
    • CHEBI:67041
    • LMSP02030016
    • 2-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadecanamide
    • DB14705
    • N-(2-hydroxyoctadecanoyl)-phytosphingosine
    • phytosphingosine-2-hydroxy-18:0, ceramide
    • N-(2-(R,S)-hydroxyoctadecanoyl) phytosphingosine
    • .ALPHA.-HYDROXYSTEAROYL-4-HYDROXYSPHINGANINE
    • .ALPHA.-HYDROXYSTEAROYL-C18-PHYTOSPHINGOSINE
    • Q27135599
    • 212070-45-6

  • Applications

    Ceramide AP (CAS 212070-45-6) is a skin-identical lipid widely used in cosmetics and personal care as an emollient and barrier-supporting ingredient in creams, lotions, and serums to help restore lipid balance and reduce transepidermal water loss; it is also used in hair care formulations to improve conditioning and moisture retention; in topical pharmaceutical formulations it serves as a lipid excipient and part of lipid-based delivery systems (liposomes, stable emulsions) to enhance skin compatibility and occlusion; and in research and development contexts it is employed as a model ceramide for lipid-based delivery systems and barrier-performance studies.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.54
    methanol 7.24
    isopropanol 2.78
    water 0.58
    ethyl acetate 14.78
    n-propanol 5.07
    acetone 12.34
    n-butanol 4.33
    acetonitrile 2.72
    DMF 43.86
    toluene 6.29
    isobutanol 3.82
    1,4-dioxane 20.61
    methyl acetate 12.28
    THF 63.57
    2-butanone 16.84
    n-pentanol 5.06
    sec-butanol 5.08
    n-hexane 1.2
    ethylene glycol 1.48
    NMP 178.2
    cyclohexane 3.4
    DMSO 65.39
    n-butyl acetate 14.23
    n-octanol 8.66
    chloroform 27.82
    n-propyl acetate 14.74
    acetic acid 21.9
    dichloromethane 23.59
    cyclohexanone 52.85
    propylene glycol 3.37
    isopropyl acetate 14.3
    DMAc 116.88
    2-ethoxyethanol 16.2
    isopentanol 4.35
    n-heptane 1.56
    ethyl formate 10.44
    1,2-dichloroethane 16.19
    n-hexanol 4.39
    2-methoxyethanol 18.31
    isobutyl acetate 9.86
    tetrachloromethane 9.33
    n-pentyl acetate 32.13
    transcutol 90.47
    n-heptanol 8.64
    ethylbenzene 5.46
    MIBK 11.63
    2-propoxyethanol 15.95
    tert-butanol 4.7
    MTBE 8.77
    2-butoxyethanol 29.24
    propionic acid 14.9
    o-xylene 8.97
    formic acid 10.89
    diethyl ether 5.71
    m-xylene 5.94
    p-xylene 6.88
    chlorobenzene 9.49
    dimethyl carbonate 15.6
    n-octane 1.21
    formamide 16.29
    cyclopentanone 68.82
    2-pentanone 14.66
    anisole 10.06
    cyclopentyl methyl ether 33.51
    gamma-butyrolactone 82.3
    1-methoxy-2-propanol 18.3
    pyridine 19.4
    3-pentanone 16.89
    furfural 57.08
    n-dodecane 0.61
    diethylene glycol 9.09
    diisopropyl ether 3.65
    tert-amyl alcohol 8.55
    acetylacetone 28.58
    n-hexadecane 0.7
    acetophenone 20.62
    methyl propionate 19.56
    isopentyl acetate 15.93
    trichloroethylene 37.84
    n-nonanol 9.26
    cyclohexanol 12.22
    benzyl alcohol 8.77
    2-ethylhexanol 5.34
    isooctanol 8.17
    dipropyl ether 9.12
    1,2-dichlorobenzene 14.22
    ethyl lactate 15.2
    propylene carbonate 49.48
    n-methylformamide 17.28
    2-pentanol 4.03
    n-pentane 0.84
    1-propoxy-2-propanol 17.96
    1-methoxy-2-propyl acetate 26.69
    2-(2-methoxypropoxy) propanol 27.99
    mesitylene 4.47
    ε-caprolactone 65.42
    p-cymene 5.22
    epichlorohydrin 49.19
    1,1,1-trichloroethane 20.56
    2-aminoethanol 3.97
    morpholine-4-carbaldehyde 80.9
    sulfolane 212.77
    2,2,4-trimethylpentane 1.42
    2-methyltetrahydrofuran 35.38
    n-hexyl acetate 29.35
    isooctane 0.54
    2-(2-butoxyethoxy)ethanol 36.85
    sec-butyl acetate 13.72
    tert-butyl acetate 23.62
    decalin 2.3
    glycerin 8.9
    diglyme 77.72
    acrylic acid 14.09
    isopropyl myristate 8.24
    n-butyric acid 21.53
    acetyl acetate 15.15
    di(2-ethylhexyl) phthalate 11.27
    ethyl propionate 15.94
    nitromethane 35.32
    1,2-diethoxyethane 23.99
    benzonitrile 7.54
    trioctyl phosphate 8.87
    1-bromopropane 7.43
    gamma-valerolactone 103.85
    n-decanol 5.41
    triethyl phosphate 18.22
    4-methyl-2-pentanol 3.21
    propionitrile 3.63
    vinylene carbonate 36.48
    1,1,2-trichlorotrifluoroethane 67.31
    DMS 23.97
    cumene 4.65
    2-octanol 7.57
    2-hexanone 13.7
    octyl acetate 12.49
    limonene 8.75
    1,2-dimethoxyethane 27.78
    ethyl orthosilicate 17.27
    tributyl phosphate 11.8
    diacetone alcohol 27.07
    N,N-dimethylaniline 12.7
    acrylonitrile 5.12
    aniline 8.23
    1,3-propanediol 5.93
    bromobenzene 9.65
    dibromomethane 13.47
    1,1,2,2-tetrachloroethane 42.12
    2-methyl-cyclohexyl acetate 20.0
    tetrabutyl urea 18.14
    diisobutyl methanol 4.15
    2-phenylethanol 8.03
    styrene 5.01
    dioctyl adipate 18.31
    dimethyl sulfate 56.35
    ethyl butyrate 17.18
    methyl lactate 20.41
    butyl lactate 33.28
    diethyl carbonate 11.53
    propanediol butyl ether 26.71
    triethyl orthoformate 21.06
    p-tert-butyltoluene 5.57
    methyl 4-tert-butylbenzoate 40.69
    morpholine 29.5
    tert-butylamine 2.92
    n-dodecanol 3.38
    dimethoxymethane 22.54
    ethylene carbonate 30.42
    cyrene 39.84
    2-ethoxyethyl acetate 42.92
    2-ethylhexyl acetate 14.63
    1,2,4-trichlorobenzene 21.99
    4-methylpyridine 16.2
    dibutyl ether 11.19
    2,6-dimethyl-4-heptanol 4.15
    DEF 31.89
    dimethyl isosorbide 61.79
    tetrachloroethylene 30.8
    eugenol 30.36
    triacetin 49.73
    span 80 26.99
    1,4-butanediol 3.48
    1,1-dichloroethane 11.62
    2-methyl-1-pentanol 5.97
    methyl formate 14.61
    2-methyl-1-butanol 5.79
    n-decane 1.56
    butyronitrile 3.75
    3,7-dimethyl-1-octanol 7.17
    1-chlorooctane 6.89
    1-chlorotetradecane 1.87
    n-nonane 1.43
    undecane 0.89
    tert-butylcyclohexane 1.67
    cyclooctane 1.62
    cyclopentanol 14.76
    tetrahydropyran 22.15
    tert-amyl methyl ether 12.97
    2,5,8-trioxanonane 45.68
    1-hexene 2.84
    2-isopropoxyethanol 12.46
    2,2,2-trifluoroethanol 18.9
    methyl butyrate 21.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction