Ceramide 1 A

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  • Identifiers

    CAS number
    179186-48-2

    Molecular formula
    C63H121NO6

    SMILES
    CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC/C=C\C/C=C\CCCCC)O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 60.57%
    Fatty 51.18%
    Oily 41.41%
    Odorless 33.87%
    Savory 22.07%
    Fishy 21.64%
    Woody 20.39%
    Meaty 19.1%
    Milky 17.85%
    Sweet 17.44%

     

    Flavor
    Bland 36.44%
    Mild 32.18%
    Faint 31.97%
    Waxy 30.62%
    Fatty 26.86%
    Odorless 26.55%
    Slightly waxy 22.51%
    Delicate 21.42%
    Bay oil 20.36%
    Beer 19.61%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    24.0

    pKa est.
    -100100.49 (strong acid)

    Molecular weight
    988.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2185°C

    Flash point

    • -649826.21 ˚C est.

  • Synonyms

    • Ceramide 1 A
    • Ceramide 1 A [INCI]
    • UNII-9GJK960DEY
    • 9GJK960DEY
    • 179186-48-2
    • Linoleoyloxyheptacosanoyl-C18-phytosphingosine
    • 1,3,4-Octadecanetriol, 2-linolenoylheptacosamide
    • 9,12-Octadecadienoic acid, 27-((2,3-dihydroxy-1-(hydroxymethyl)heptadecyl)amino)-27-oxoheptacosyl ester, (1S-(1R*(9Z,12Z),2R*,3S*))-
    • RefChem:124456
    • CERAMIDE 1 A (RETIRED)
    • CERAMIDE 1 A (RETIRED) [INCI]
    • orb1697915
    • SCHEMBL18323048
    • DTXSID701021284
    • AKOS040751076
    • N-(27-linoleovloxyheptacosanoyl)-phytosphingosine
    • N-(27-linoleoyloxyheptacosanoyl)-phytosphingosine
    • Q27272531
    • 179186-48-2

  • Applications

    Ceramide 1 A (CAS number: 179186-48-2) is a skin-identical lipid used in cosmetics and personal care to support the integrity of the stratum corneum, providing moisturization and barrier repair in creams, lotions, and serums. It is commonly employed as a lipid component in topical pharmaceutical formulations and in lipid-based delivery systems (liposomes, nanoemulsions) to improve skin compatibility and enable more sustained release of actives. In research and development, Ceramide 1 A is evaluated as a model ceramide for skin-barrier studies and for formulation design with other ceramides and fatty acids. It may also function as a structural lipid in specialized oleochemical blends or advanced emulsion systems where skin-relevant lipids are desired. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.4
    methanol 5.63
    isopropanol 4.25
    water 0.1
    ethyl acetate 36.08
    n-propanol 7.43
    acetone 24.79
    n-butanol 7.69
    acetonitrile 5.97
    DMF 62.99
    toluene 22.92
    isobutanol 6.54
    1,4-dioxane 43.62
    methyl acetate 26.53
    THF 130.61
    2-butanone 38.56
    n-pentanol 8.99
    sec-butanol 9.47
    n-hexane 4.13
    ethylene glycol 0.98
    NMP 287.58
    cyclohexane 10.64
    DMSO 69.07
    n-butyl acetate 27.77
    n-octanol 14.83
    chloroform 96.18
    n-propyl acetate 29.55
    acetic acid 25.71
    dichloromethane 84.0
    cyclohexanone 120.7
    propylene glycol 2.99
    isopropyl acetate 32.53
    DMAc 202.54
    2-ethoxyethanol 22.16
    isopentanol 8.49
    n-heptane 4.02
    ethyl formate 18.42
    1,2-dichloroethane 48.97
    n-hexanol 7.91
    2-methoxyethanol 20.0
    isobutyl acetate 19.63
    tetrachloromethane 24.21
    n-pentyl acetate 59.18
    transcutol 116.12
    n-heptanol 12.4
    ethylbenzene 17.26
    MIBK 26.84
    2-propoxyethanol 24.61
    tert-butanol 7.63
    MTBE 21.88
    2-butoxyethanol 36.93
    propionic acid 20.01
    o-xylene 24.94
    formic acid 7.46
    diethyl ether 16.06
    m-xylene 17.66
    p-xylene 20.19
    chlorobenzene 33.09
    dimethyl carbonate 28.81
    n-octane 2.74
    formamide 11.95
    cyclopentanone 136.86
    2-pentanone 36.57
    anisole 27.81
    cyclopentyl methyl ether 76.9
    gamma-butyrolactone 148.69
    1-methoxy-2-propanol 24.99
    pyridine 51.57
    3-pentanone 44.13
    furfural 100.96
    n-dodecane 1.52
    diethylene glycol 9.15
    diisopropyl ether 9.2
    tert-amyl alcohol 16.51
    acetylacetone 57.51
    n-hexadecane 1.79
    acetophenone 47.39
    methyl propionate 43.09
    isopentyl acetate 30.03
    trichloroethylene 114.84
    n-nonanol 16.46
    cyclohexanol 24.14
    benzyl alcohol 17.62
    2-ethylhexanol 10.37
    isooctanol 12.34
    dipropyl ether 21.18
    1,2-dichlorobenzene 43.87
    ethyl lactate 22.81
    propylene carbonate 87.64
    n-methylformamide 21.35
    2-pentanol 8.39
    n-pentane 2.77
    1-propoxy-2-propanol 28.39
    1-methoxy-2-propyl acetate 45.3
    2-(2-methoxypropoxy) propanol 41.56
    mesitylene 12.62
    ε-caprolactone 133.29
    p-cymene 11.99
    epichlorohydrin 115.39
    1,1,1-trichloroethane 68.26
    2-aminoethanol 3.39
    morpholine-4-carbaldehyde 126.42
    sulfolane 298.29
    2,2,4-trimethylpentane 4.49
    2-methyltetrahydrofuran 85.93
    n-hexyl acetate 58.51
    isooctane 1.61
    2-(2-butoxyethoxy)ethanol 48.68
    sec-butyl acetate 29.74
    tert-butyl acetate 46.0
    decalin 7.16
    glycerin 6.33
    diglyme 104.44
    acrylic acid 17.97
    isopropyl myristate 17.36
    n-butyric acid 35.69
    acetyl acetate 32.9
    di(2-ethylhexyl) phthalate 19.91
    ethyl propionate 35.36
    nitromethane 51.33
    1,2-diethoxyethane 43.57
    benzonitrile 18.28
    trioctyl phosphate 14.42
    1-bromopropane 28.68
    gamma-valerolactone 188.06
    n-decanol 9.81
    triethyl phosphate 29.82
    4-methyl-2-pentanol 6.78
    propionitrile 9.13
    vinylene carbonate 66.83
    1,1,2-trichlorotrifluoroethane 104.97
    DMS 40.28
    cumene 12.14
    2-octanol 12.2
    2-hexanone 32.31
    octyl acetate 24.42
    limonene 22.32
    1,2-dimethoxyethane 46.98
    ethyl orthosilicate 29.13
    tributyl phosphate 19.36
    diacetone alcohol 41.32
    N,N-dimethylaniline 30.41
    acrylonitrile 11.19
    aniline 21.04
    1,3-propanediol 5.97
    bromobenzene 38.46
    dibromomethane 50.05
    1,1,2,2-tetrachloroethane 124.0
    2-methyl-cyclohexyl acetate 37.74
    tetrabutyl urea 31.91
    diisobutyl methanol 7.74
    2-phenylethanol 15.08
    styrene 16.71
    dioctyl adipate 32.59
    dimethyl sulfate 80.65
    ethyl butyrate 34.24
    methyl lactate 28.72
    butyl lactate 47.89
    diethyl carbonate 20.19
    propanediol butyl ether 31.41
    triethyl orthoformate 38.04
    p-tert-butyltoluene 12.48
    methyl 4-tert-butylbenzoate 65.54
    morpholine 56.49
    tert-butylamine 5.63
    n-dodecanol 6.25
    dimethoxymethane 38.51
    ethylene carbonate 56.58
    cyrene 63.25
    2-ethoxyethyl acetate 73.02
    2-ethylhexyl acetate 29.81
    1,2,4-trichlorobenzene 61.7
    4-methylpyridine 47.89
    dibutyl ether 26.29
    2,6-dimethyl-4-heptanol 7.74
    DEF 68.54
    dimethyl isosorbide 94.42
    tetrachloroethylene 75.21
    eugenol 44.77
    triacetin 80.01
    span 80 40.64
    1,4-butanediol 3.77
    1,1-dichloroethane 41.09
    2-methyl-1-pentanol 11.82
    methyl formate 19.27
    2-methyl-1-butanol 10.85
    n-decane 3.8
    butyronitrile 9.62
    3,7-dimethyl-1-octanol 12.9
    1-chlorooctane 16.51
    1-chlorotetradecane 4.78
    n-nonane 3.42
    undecane 2.24
    tert-butylcyclohexane 5.01
    cyclooctane 5.39
    cyclopentanol 26.66
    tetrahydropyran 59.46
    tert-amyl methyl ether 33.47
    2,5,8-trioxanonane 60.87
    1-hexene 9.95
    2-isopropoxyethanol 19.19
    2,2,2-trifluoroethanol 19.54
    methyl butyrate 45.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction