Cefazolin Sodium

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  • Identifiers

    CAS number
    27164-46-1

    Molecular formula
    C14H13N8NaO4S3

    SMILES
    CC1=NN=C(S1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 58.27%
    Roasted 41.98%
    Meaty 41.62%
    Nutty 35.39%
    Savory 34.27%
    Cooked 34.2%
    Popcorn 26.78%
    Beefy 18.34%
    Burnt 17.33%
    Cocoa 15.49%

     

    Flavor
    Bitter 87.59%
    Odorless 32.55%
    Bland 24.21%
    Roasted 23.66%
    Taco 18.13%
    Sweet-like 18.1%
    Bread crust 17.83%
    Roasted peanuts 17.78%
    Nitrile 17.64%
    Scallion 17.63%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    3.44 (weak acid)

    Molecular weight
    476.5 g/mol

    Flash point

    • 367.61 ˚C est.

  • Synonyms

    • CEFAZOLIN SODIUM
    • 27164-46-1
    • Cefazolin sodium salt
    • Cefazoline sodium
    • Ancef
    • Totacef
    • Cefacidal
    • Cefamedin
    • Gramaxin
    • Zolicef
    • Cefazil
    • Kefzol
    • Sodium cefazolin
    • Sodium cephazolin
    • Cephazolin Sodium
    • Monosodium cefazolin
    • Cefazolin injection
    • SK&F 41558
    • CEFAZOLIN AND DEXTROSE
    • ANCEF IN PLASTIC CONTAINER
    • SKF 41558
    • NSC-291561
    • P380M0454Z
    • CHEBI:3483
    • DTXSID901015786
    • ANCEF IN DEXTROSE 5% IN PLASTIC CONTAINER
    • ANCEF IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER
    • NSC291561
    • Sodium, Cefazolin
    • Cephazolin, Sodium
    • Sodium, Cephazolin
    • RefChem:54732
    • DTXCID001473947
    • CEFAZOLIN IN PLASTIC CONTAINER
    • (6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Sodium Salt
    • Monosodium (6R,7R)-3-(5-methyl-1,3,4-thiadiazol-2-ylsulfanylmethyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetylamino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
    • Cefazolin (sodium)
    • Cefazina
    • Firmacef
    • Liviclina
    • Atirin
    • Acef
    • MFCD00056883
    • MLS000028706
    • Biazolina
    • SMR000058708
    • Sodium CEZ
    • 7-epi-Cefazolin Sodium Salt
    • Cefazolin sodium 100 microg/mL in Acetonitrile/Water
    • Cefabiozim
    • Cefalomicina
    • Lampocef
    • Neofazol
    • Zolisint
    • Recef
    • Zolin
    • Bor-Cefazol
    • CEZ sodium
    • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-, monosodium salt (6R-trans)-
    • Sodium (6R,7R)-7-(2-(1H-tetrazol-1-yl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    • Sodium (6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    • sodium;(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    • Lilly 46083
    • UNII-P380M0454Z
    • Cefazolin sodium [USAN:USP:JAN]
    • Monosodium (6R,7R)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
    • Monosodium (6R,7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    • Sodium (6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
    • Prestwick_975
    • EINECS 248-278-4
    • monosodium cephazolin
    • Ancef (TN)
    • NSC 291561
    • Opera_ID_1323
    • Cefazolin Sodium (sterile)
    • MSK7014Na
    • SCHEMBL40735
    • SPECTRUM1500164
    • Cefazolin (sodium) (Standard)
    • CEFAZOLIN SODIUM [JAN]
    • Cefazolin sodium (JP18/USP)
    • orb1310135
    • Sodium CEZ; SKF-41558
    • CEFAZOLIN SODIUM [USAN]
    • CEFAZOLIN SODIUM [VANDF]
    • CHEMBL1200523
    • HMS500A16
    • HY-B1078R
    • CEFAZOLIN SODIUM [MART.]
    • CEFAZOLIN SODIUM [WHO-DD]
    • HMS1570C14
    • HMS1920K07
    • HMS2091A10
    • HMS2097C14
    • HMS2230I22
    • HMS3260H10
    • HMS3714C14
    • CEFAZOLIN SODIUM SALT [MI]
    • HY-B1078
    • sodium (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[2-(1H-1,2,3,4-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    • Tox21_500274
    • CCG-40011
    • EBC-08481
    • s4595
    • AKOS015895533
    • CEFAZOLIN SODIUM [ORANGE BOOK]
    • AC19848
    • CEFAZOLIN SODIUM [EP MONOGRAPH]
    • CS-4634
    • LP00274
    • CEFAZOLIN SODIUM [USP MONOGRAPH]
    • Cefazolin sodium salt, 89.1-110.1%
    • NCGC00093731-01
    • NCGC00260959-01
    • 3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-7-(2-(1H-tetrazol-1-yl)acetamido)-3-cephem-4-carboxylate
    • AC-13166
    • AC-31729
    • AS-12230
    • DA-62213
    • Sodium (6R,7R)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
    • ST024775
    • EU-0100274
    • C 5020
    • C08098
    • D00905
    • EN300-6731106
    • Q27106104
    • 27164-46-1

  • Applications

    Cefazolin Sodium (CAS 27164-46-1) is a cephalosporin beta-lactam antibiotic that serves primarily as an active pharmaceutical ingredient in injectable antibiotic products. In pharmaceutical manufacturing it functions as the API for parenteral dosage forms, with the sodium salt improving water solubility for intravenous or intramuscular administration. It is commonly used in formulation development and stability studies, and in analytical quality control for method development and impurity/assay testing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.3
    methanol 1.82
    isopropanol 0.08
    water 0.41
    ethyl acetate 1.16
    n-propanol 0.28
    acetone 2.71
    n-butanol 0.22
    acetonitrile 4.84
    DMF 946.08
    toluene 0.22
    isobutanol 0.18
    1,4-dioxane 3.83
    methyl acetate 3.64
    THF 4.91
    2-butanone 3.58
    n-pentanol 0.29
    sec-butanol 0.14
    n-hexane 0.0
    ethylene glycol 2.34
    NMP 102.37
    cyclohexane 0.01
    DMSO 40.78
    n-butyl acetate 1.87
    n-octanol 0.56
    chloroform 1.53
    n-propyl acetate 1.96
    acetic acid 3.86
    dichloromethane 2.16
    cyclohexanone 7.73
    propylene glycol 1.11
    isopropyl acetate 0.53
    DMAc 244.8
    2-ethoxyethanol 7.36
    isopentanol 0.22
    n-heptane 0.01
    ethyl formate 5.45
    1,2-dichloroethane 1.43
    n-hexanol 0.25
    2-methoxyethanol 16.02
    isobutyl acetate 0.97
    tetrachloromethane 0.11
    n-pentyl acetate 1.89
    transcutol 14.31
    n-heptanol 0.49
    ethylbenzene 0.13
    MIBK 0.87
    2-propoxyethanol 7.77
    tert-butanol 0.11
    MTBE 0.13
    2-butoxyethanol 6.25
    propionic acid 2.73
    o-xylene 0.18
    formic acid 15.85
    diethyl ether 0.16
    m-xylene 0.14
    p-xylene 0.29
    chlorobenzene 0.59
    dimethyl carbonate 8.11
    n-octane 0.01
    formamide 26.66
    cyclopentanone 12.82
    2-pentanone 1.57
    anisole 0.91
    cyclopentyl methyl ether 0.61
    gamma-butyrolactone 21.17
    1-methoxy-2-propanol 6.08
    pyridine 5.73
    3-pentanone 1.77
    furfural 34.43
    n-dodecane 0.02
    diethylene glycol 13.5
    diisopropyl ether 0.03
    tert-amyl alcohol 0.19
    acetylacetone 4.64
    n-hexadecane 0.02
    acetophenone 3.14
    methyl propionate 3.65
    isopentyl acetate 1.35
    trichloroethylene 5.36
    n-nonanol 0.63
    cyclohexanol 0.27
    benzyl alcohol 2.06
    2-ethylhexanol 0.27
    isooctanol 0.39
    dipropyl ether 0.34
    1,2-dichlorobenzene 0.77
    ethyl lactate 4.79
    propylene carbonate 7.6
    n-methylformamide 65.34
    2-pentanol 0.07
    n-pentane 0.0
    1-propoxy-2-propanol 4.14
    1-methoxy-2-propyl acetate 3.54
    2-(2-methoxypropoxy) propanol 7.49
    mesitylene 0.08
    ε-caprolactone 6.79
    p-cymene 0.16
    epichlorohydrin 12.53
    1,1,1-trichloroethane 0.48
    2-aminoethanol 2.36
    morpholine-4-carbaldehyde 92.27
    sulfolane 35.76
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.94
    n-hexyl acetate 1.85
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 9.31
    sec-butyl acetate 0.62
    tert-butyl acetate 0.49
    decalin 0.01
    glycerin 8.33
    diglyme 19.2
    acrylic acid 7.14
    isopropyl myristate 0.64
    n-butyric acid 1.79
    acetyl acetate 1.1
    di(2-ethylhexyl) phthalate 2.14
    ethyl propionate 1.65
    nitromethane 36.43
    1,2-diethoxyethane 2.2
    benzonitrile 4.4
    trioctyl phosphate 1.17
    1-bromopropane 0.19
    gamma-valerolactone 55.4
    n-decanol 0.48
    triethyl phosphate 1.5
    4-methyl-2-pentanol 0.08
    propionitrile 2.95
    vinylene carbonate 12.48
    1,1,2-trichlorotrifluoroethane 23.03
    DMS 3.16
    cumene 0.09
    2-octanol 0.27
    2-hexanone 2.01
    octyl acetate 1.24
    limonene 0.18
    1,2-dimethoxyethane 16.18
    ethyl orthosilicate 0.96
    tributyl phosphate 1.48
    diacetone alcohol 2.14
    N,N-dimethylaniline 0.84
    acrylonitrile 12.36
    aniline 0.81
    1,3-propanediol 1.93
    bromobenzene 0.43
    dibromomethane 0.62
    1,1,2,2-tetrachloroethane 3.11
    2-methyl-cyclohexyl acetate 1.52
    tetrabutyl urea 4.24
    diisobutyl methanol 0.12
    2-phenylethanol 1.82
    styrene 0.21
    dioctyl adipate 2.18
    dimethyl sulfate 20.91
    ethyl butyrate 1.87
    methyl lactate 9.31
    butyl lactate 4.58
    diethyl carbonate 1.66
    propanediol butyl ether 6.21
    triethyl orthoformate 1.49
    p-tert-butyltoluene 0.12
    methyl 4-tert-butylbenzoate 3.71
    morpholine 5.31
    tert-butylamine 0.04
    n-dodecanol 0.34
    dimethoxymethane 25.08
    ethylene carbonate 7.48
    cyrene 15.29
    2-ethoxyethyl acetate 4.2
    2-ethylhexyl acetate 1.09
    1,2,4-trichlorobenzene 1.33
    4-methylpyridine 4.36
    dibutyl ether 0.5
    2,6-dimethyl-4-heptanol 0.12
    DEF 11.44
    dimethyl isosorbide 12.45
    tetrachloroethylene 1.66
    eugenol 7.86
    triacetin 4.73
    span 80 4.83
    1,4-butanediol 1.53
    1,1-dichloroethane 0.47
    2-methyl-1-pentanol 0.31
    methyl formate 48.37
    2-methyl-1-butanol 0.24
    n-decane 0.02
    butyronitrile 1.6
    3,7-dimethyl-1-octanol 0.38
    1-chlorooctane 0.15
    1-chlorotetradecane 0.08
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 0.48
    tetrahydropyran 0.66
    tert-amyl methyl ether 0.19
    2,5,8-trioxanonane 14.5
    1-hexene 0.04
    2-isopropoxyethanol 2.94
    2,2,2-trifluoroethanol 5.8
    methyl butyrate 3.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction