Carvacrol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    499-75-2

    Molecular formula
    C10H14O

    SMILES
    CC1=C(C=C(C=C1)C(C)C)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Phenolic 83.66%
    Spicy 79.05%
    Medicinal 65.82%
    Herbal 63.72%
    Woody 63.14%
    Smoky 60.0%
    Leathery 54.28%
    Camphoreous 39.17%
    Burnt 36.99%
    Musty 33.37%

    Scent© AI

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    10.49 (weak base)

    Molecular weight
    150.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 1 °C
    • 3.5 °C

    Boiling point

    • 237-238 °C @ 760 MM HG
    • 237.70 °C. @ 760.00 mm Hg

    Flash point est.
    102.1 ˚C

    Flash point expt.

    • 100 °C

    Solubility expt.

    • SLIGHTLY SOL IN WATER; SOL IN ETHANOL, ETHER, ALKALIS; VERY SOLUBLE IN ACETONE
    • 1.25 mg/mL at 25 °C
    • insoluble in water; miscible in oils
    • miscible (in ethanol)

  • Synonyms

    • CARVACROL
    • 5-Isopropyl-2-methylphenol
    • 499-75-2
    • Isopropyl-o-cresol
    • Antioxine
    • 2-p-Cymenol
    • 5-Isopropyl-o-cresol
    • o-Thymol
    • Isothymol
    • Karvakrol
    • 2-Hydroxy-p-cymene
    • p-Cymen-2-ol
    • Phenol, 2-methyl-5-(1-methylethyl)-
    • 2-Methyl-5-isopropylphenol
    • 2-methyl-5-propan-2-ylphenol
    • 3-Isopropyl-6-methylphenol
    • p-Cymene, 2-hydroxy-
    • o-Cresol, 5-isopropyl-
    • 2-Methyl-5-(1-methylethyl)phenol
    • 2-Methyl-5-(Propan-2-Yl)Phenol
    • 6-Methyl-3-isopropylphenol
    • 1-Hydroxy-2-methyl-5-isopropylbenzene
    • 5-Isopropyl-2-methyl-phenol
    • FEMA No. 2245
    • Phenol, 5-isopropyl-2-methyl-
    • Cymene-2-ol, p-
    • Caswell No. 511
    • Phenol, 3-isopropyl-6-methyl-
    • 1-Methyl-2-hydroxy-4-isopropylbenzene
    • DENTOL
    • NSC 6188
    • CCRIS 7450
    • HSDB 906
    • Oxycymol
    • NSC-6188
    • EINECS 207-889-6
    • EPA Pesticide Chemical Code 022104
    • UNII-9B1J4V995Q
    • BRN 1860514
    • CHEBI:3440
    • AI3-03438
    • 9B1J4V995Q
    • MFCD00002236
    • CHEMBL281202
    • DTXSID6042074
    • 2-methyl-5-propan-2-yl-phenol
    • 4-06-00-03331 (Beilstein Handbook Reference)
    • 2-Methyl-5-(1-methylethyl)-Phenol
    • Cymenol
    • 2-Hydroxycymene
    • CYMOPHENOL
    • Hydroxy-p-cymene
    • p-Cymene-2-ol
    • Carvacrol, 98%
    • Carvacrol (Standard)
    • CARVACROL [FCC]
    • CARVACROL [MI]
    • CARVACROL [FHFI]
    • CARVACROL [HSDB]
    • CARVACROL [WHO-DD]
    • SCHEMBL24734
    • 3-Isopropyl-6-methyl phenol
    • 3-Isopropyl-6-methyl-Phenol
    • BIDD:ER0492
    • Carvacrol, analytical standard
    • O-CRESOL, 5-ISOPROPYL
    • GTPL2497
    • Carvacrol, natural, 99%, FG
    • DTXCID4022074
    • Methyl-5-(1-methylethyl)phenol
    • p-Mentha-1,3,5-trien-2-ol
    • WLN: QR B1 EY1&1
    • FEMA 2245
    • HY-N0711R
    • NSC6188
    • Carvacrol, >=98%, FCC, FG
    • HY-N0711
    • Tox21_301378
    • BDBM50240433
    • s3788
    • STL453136
    • AKOS000120828
    • AC-2688
    • CCG-266210
    • FS-4199
    • LMPR0102090017
    • MB00118
    • NCGC00256001-01
    • 1ST40100
    • CAS-499-75-2
    • DA-49857
    • Isothymol (=2-Isopropyl-4-methyl phenol)
    • Carvacrol Cymenol 5-Isopropyl-2-methylphenol
    • CS-0009729
    • NS00004666
    • 2-HYDROXY-4-ISOPROPYL-1-METHYLBENZENE
    • EN300-21426
    • C09840
    • F17722
    • Q225543
    • Carvacrol, primary pharmaceutical reference standard
    • BRD-K15541734-001-01-2
    • BRD-K15541734-001-02-0
    • BENZENE,2-HYDROXY,4-ISOPROPYL,1-METHYL CARVACROL
    • F8889-1978
    • Z104496566
    • BENZENE,2-HYDROXY,4-ISOPROPYL,1-METHYL CARVACROL
    • InChI=1/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H
    • 207-889-6
    • S5V

  • Applications

    Carvacrol (CAS 499-75-2) is a natural phenolic compound responsible for the characteristic aroma of thyme and oregano, valued for its broad-spectrum antibacterial, antifungal, antioxidant, and anti-inflammatory activities; in the food industry it serves as a clean-label preservative to extend the shelf life of meats, seafood, dairy and bakery products while enhancing flavor; in pharmaceuticals it is explored in mouthwashes, lozenges, topical gels and nano-formulations to help manage respiratory infections, skin wounds and gastrointestinal inflammations; in agriculture it is incorporated into seed coatings or foliar sprays to protect crops from pathogenic fungi and insect pests without harmful residues; cosmetic formulators add it for deodorizing effects and to shield skin from oxidative stress; it is also embedded in smart packaging materials, eco-friendly household cleaners and livestock disinfectants, where its ability to suppress microbes and neutralize odors offers a natural, sustainable alternative to synthetic chemicals.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 897.28
    methanol 402.08
    isopropanol 917.95
    water 0.64
    ethyl acetate 622.67
    n-propanol 858.29
    acetone 725.54
    n-butanol 733.68
    acetonitrile 1006.04
    DMF 797.01
    toluene 248.92
    isobutanol 598.06
    1,4-dioxane 1201.86
    methyl acetate 677.59
    THF 1310.65
    2-butanone 854.8
    n-pentanol 411.79
    sec-butanol 699.83
    n-hexane 79.06
    ethylene glycol 71.02
    NMP 305.74
    cyclohexane 88.08
    DMSO 431.57
    n-butyl acetate 676.97
    n-octanol 258.49
    chloroform 1089.26
    n-propyl acetate 327.6
    acetic acid 255.98
    dichloromethane 1022.84
    cyclohexanone 643.66
    propylene glycol 171.16
    isopropyl acetate 274.3
    DMAc 490.09
    2-ethoxyethanol 358.68
    isopentanol 472.49
    n-heptane 92.52
    ethyl formate 459.35
    1,2-dichloroethane 618.91
    n-hexanol 801.71
    2-methoxyethanol 634.89
    isobutyl acetate 210.72
    tetrachloromethane 175.57
    n-pentyl acetate 253.18
    transcutol 610.93
    n-heptanol 293.05
    ethylbenzene 173.28
    MIBK 264.41
    2-propoxyethanol 687.27
    tert-butanol 910.91
    MTBE 732.75
    2-butoxyethanol 355.7
    propionic acid 350.89
    o-xylene 144.3
    formic acid 56.4
    diethyl ether 725.8
    m-xylene 157.39
    p-xylene 214.38
    chlorobenzene 276.37
    dimethyl carbonate 122.6
    n-octane 38.82
    formamide 150.73
    cyclopentanone 710.56
    2-pentanone 567.96
    anisole 279.51
    cyclopentyl methyl ether 355.0
    gamma-butyrolactone 665.14
    1-methoxy-2-propanol 516.42
    pyridine 728.22
    3-pentanone 376.96
    furfural 451.28
    n-dodecane 29.28
    diethylene glycol 291.74
    diisopropyl ether 144.41
    tert-amyl alcohol 618.69
    acetylacetone 317.07
    n-hexadecane 33.21
    acetophenone 209.57
    methyl propionate 407.97
    isopentyl acetate 466.16
    trichloroethylene 972.21
    n-nonanol 213.31
    cyclohexanol 337.47
    benzyl alcohol 216.06
    2-ethylhexanol 363.38
    isooctanol 209.76
    dipropyl ether 458.6
    1,2-dichlorobenzene 209.51
    ethyl lactate 114.0
    propylene carbonate 346.61
    n-methylformamide 419.35
    2-pentanol 436.68
    n-pentane 72.67
    1-propoxy-2-propanol 539.55
    1-methoxy-2-propyl acetate 352.03
    2-(2-methoxypropoxy) propanol 222.16
    mesitylene 96.18
    ε-caprolactone 466.61
    p-cymene 128.8
    epichlorohydrin 859.3
    1,1,1-trichloroethane 602.04
    2-aminoethanol 229.26
    morpholine-4-carbaldehyde 461.71
    sulfolane 428.4
    2,2,4-trimethylpentane 37.03
    2-methyltetrahydrofuran 839.46
    n-hexyl acetate 325.24
    isooctane 35.43
    2-(2-butoxyethoxy)ethanol 328.82
    sec-butyl acetate 202.29
    tert-butyl acetate 261.7
    decalin 47.01
    glycerin 147.22
    diglyme 565.01
    acrylic acid 199.77
    isopropyl myristate 124.97
    n-butyric acid 516.88
    acetyl acetate 200.21
    di(2-ethylhexyl) phthalate 103.45
    ethyl propionate 255.01
    nitromethane 497.12
    1,2-diethoxyethane 421.98
    benzonitrile 319.49
    trioctyl phosphate 89.04
    1-bromopropane 561.38
    gamma-valerolactone 783.74
    n-decanol 163.25
    triethyl phosphate 108.93
    4-methyl-2-pentanol 217.89
    propionitrile 869.09
    vinylene carbonate 319.8
    1,1,2-trichlorotrifluoroethane 298.0
    DMS 156.29
    cumene 116.8
    2-octanol 195.52
    2-hexanone 388.83
    octyl acetate 167.87
    limonene 176.69
    1,2-dimethoxyethane 665.22
    ethyl orthosilicate 112.06
    tributyl phosphate 97.18
    diacetone alcohol 317.71
    N,N-dimethylaniline 172.17
    acrylonitrile 699.7
    aniline 273.2
    1,3-propanediol 410.91
    bromobenzene 280.55
    dibromomethane 786.95
    1,1,2,2-tetrachloroethane 672.71
    2-methyl-cyclohexyl acetate 202.97
    tetrabutyl urea 124.87
    diisobutyl methanol 174.61
    2-phenylethanol 313.02
    styrene 182.22
    dioctyl adipate 143.92
    dimethyl sulfate 128.41
    ethyl butyrate 353.41
    methyl lactate 136.79
    butyl lactate 159.12
    diethyl carbonate 198.43
    propanediol butyl ether 240.45
    triethyl orthoformate 187.13
    p-tert-butyltoluene 131.31
    methyl 4-tert-butylbenzoate 202.08
    morpholine 1290.01
    tert-butylamine 546.58
    n-dodecanol 126.21
    dimethoxymethane 470.26
    ethylene carbonate 292.08
    cyrene 171.07
    2-ethoxyethyl acetate 283.02
    2-ethylhexyl acetate 351.08
    1,2,4-trichlorobenzene 219.75
    4-methylpyridine 646.41
    dibutyl ether 264.15
    2,6-dimethyl-4-heptanol 174.61
    DEF 402.46
    dimethyl isosorbide 326.68
    tetrachloroethylene 361.14
    eugenol 190.43
    triacetin 177.74
    span 80 208.01
    1,4-butanediol 134.21
    1,1-dichloroethane 847.07
    2-methyl-1-pentanol 320.79
    methyl formate 278.1
    2-methyl-1-butanol 439.04
    n-decane 50.72
    butyronitrile 898.01
    3,7-dimethyl-1-octanol 216.73
    1-chlorooctane 166.47
    1-chlorotetradecane 64.54
    n-nonane 49.27
    undecane 37.84
    tert-butylcyclohexane 53.08
    cyclooctane 31.49
    cyclopentanol 398.7
    tetrahydropyran 1127.13
    tert-amyl methyl ether 354.36
    2,5,8-trioxanonane 336.37
    1-hexene 319.89
    2-isopropoxyethanol 272.7
    2,2,2-trifluoroethanol 82.63
    methyl butyrate 355.16

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Eucalyptus camaldulensis (USA-Florida) Eucalyptus camaldulensis Dehn., fam. Myrtaceae 0.47%