Carnosic acid

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    3650-09-7

    Molecular formula
    C20H28O4

    SMILES
    CC(C)C1=C(C(=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C(=O)O)O)O

  • Odor profile

    Woody 44.04%
    Phenolic 38.96%
    Spicy 38.42%
    Balsamic 35.84%
    Dry 35.06%
    Odorless 34.52%
    Musk 28.25%
    Amber 27.27%
    Animal 24.93%
    Herbal 23.43%

    Scent© AI

  • Properties

    XLogP3-AA
    4.9

    pKa est.
    7.72 (neutral)

    Molecular weight
    332.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    549°C

    Flash point est.
    247.6 ˚C

  • Synonyms

    • Carnosic acid
    • 3650-09-7
    • Salvin
    • LI791SXT24
    • 139236-75-2
    • CHEBI:65585
    • MFCD02259459
    • UNII-LI791SXT24
    • 11,12-dihydroxyabieta-8,11,13-trien-20-oic acid
    • NSC694080
    • (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
    • 11,12-dihydroxy-13-isopropylpodocarpa-8,11,13-trien-17-oic acid
    • (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthrene-4a(2H)-carboxylic acid
    • (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid
    • 4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)-rel-
    • 4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR-trans)-
    • RoseOx
    • CARNOSIC ACID (USP-RS)
    • CARNOSIC ACID [USP-RS]
    • Podocarpa-8,11,13-trien-17-oic acid, 11,12-dihydroxy-13-isopropyl-
    • (4AR,10AS)-1,3,4,9,10,10A-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-(1-METHYLETHYL)-4A(2H)-PHENANTHRENECARBOXYLIC ACID
    • Rosamox
    • Carnosic-acid
    • Carsonic acid
    • Carnosic acid (Standard)
    • UPCMLD-DP056
    • CARNOSIC ACID [MI]
    • CHEMBL484853
    • SCHEMBL9923661
    • UPCMLD-DP056:001
    • HY-N0644R
    • DTXSID20904450
    • BCPP000299
    • Carnosic acid, analytical standard
    • HY-N0644
    • BDBM50371232
    • s3838
    • AKOS015901362
    • AC-6030
    • BCP9000491
    • CCG-207954
    • FC32525
    • NSC-694080
    • SMP2_000204
    • NCGC00161623-01
    • 1ST40209
    • AS-31052
    • NCI60_033653
    • BCP0726000155
    • C2488
    • C3477
    • CS-0009671
    • NS00124779
    • C21818
    • CARNOSIC ACID (CONSTITUENT OF ROSEMARY)
    • A918580
    • Q412827
    • SR-05000002202
    • SR-05000002202-2
    • CARNOSIC ACID (CONSTITUENT OF ROSEMARY) [DSC]
    • Carnosic acid, primary pharmaceutical reference standard
    • Carnosic acid from Rosmarinus officinalis, >=91%, powder
    • Carnosic acid, United States Pharmacopeia (USP) Reference Standard
    • (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylicacid

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 81.52
    methanol 95.3
    isopropanol 69.27
    water 0.12
    ethyl acetate 34.1
    n-propanol 79.05
    acetone 52.9
    n-butanol 64.22
    acetonitrile 13.01
    DMF 173.62
    toluene 17.77
    isobutanol 48.72
    1,4-dioxane 80.0
    methyl acetate 29.04
    THF 267.32
    2-butanone 54.01
    n-pentanol 35.27
    sec-butanol 38.98
    n-hexane 0.97
    ethylene glycol 22.78
    NMP 108.23
    cyclohexane 1.51
    DMSO 151.39
    n-butyl acetate 41.52
    n-octanol 14.82
    chloroform 44.56
    n-propyl acetate 20.94
    acetic acid 37.67
    dichloromethane 35.29
    cyclohexanone 84.43
    propylene glycol 25.93
    isopropyl acetate 34.43
    DMAc 127.41
    2-ethoxyethanol 62.61
    isopentanol 48.69
    n-heptane 0.81
    ethyl formate 23.24
    1,2-dichloroethane 41.47
    n-hexanol 57.59
    2-methoxyethanol 140.3
    isobutyl acetate 19.08
    tetrachloromethane 7.69
    n-pentyl acetate 37.59
    transcutol 53.27
    n-heptanol 31.25
    ethylbenzene 10.57
    MIBK 41.4
    2-propoxyethanol 126.15
    tert-butanol 73.31
    MTBE 31.22
    2-butoxyethanol 65.41
    propionic acid 26.02
    o-xylene 13.15
    formic acid 25.7
    diethyl ether 32.02
    m-xylene 17.7
    p-xylene 12.07
    chlorobenzene 21.21
    dimethyl carbonate 29.91
    n-octane 0.67
    formamide 40.95
    cyclopentanone 132.36
    2-pentanone 55.22
    anisole 22.52
    cyclopentyl methyl ether 57.77
    gamma-butyrolactone 103.81
    1-methoxy-2-propanol 112.05
    pyridine 60.58
    3-pentanone 33.06
    furfural 69.28
    n-dodecane 0.52
    diethylene glycol 92.43
    diisopropyl ether 10.32
    tert-amyl alcohol 39.81
    acetylacetone 53.1
    n-hexadecane 0.63
    acetophenone 28.89
    methyl propionate 39.33
    isopentyl acetate 46.18
    trichloroethylene 69.64
    n-nonanol 15.6
    cyclohexanol 35.03
    benzyl alcohol 33.04
    2-ethylhexanol 20.44
    isooctanol 24.18
    dipropyl ether 14.04
    1,2-dichlorobenzene 21.36
    ethyl lactate 20.1
    propylene carbonate 43.05
    n-methylformamide 76.28
    2-pentanol 32.95
    n-pentane 1.23
    1-propoxy-2-propanol 67.24
    1-methoxy-2-propyl acetate 61.39
    2-(2-methoxypropoxy) propanol 34.62
    mesitylene 9.82
    ε-caprolactone 62.88
    p-cymene 9.94
    epichlorohydrin 131.89
    1,1,1-trichloroethane 27.06
    2-aminoethanol 49.11
    morpholine-4-carbaldehyde 120.71
    sulfolane 134.36
    2,2,4-trimethylpentane 1.05
    2-methyltetrahydrofuran 72.68
    n-hexyl acetate 33.75
    isooctane 1.05
    2-(2-butoxyethoxy)ethanol 47.73
    sec-butyl acetate 18.73
    tert-butyl acetate 45.57
    decalin 1.47
    glycerin 46.3
    diglyme 74.8
    acrylic acid 25.4
    isopropyl myristate 12.59
    n-butyric acid 45.57
    acetyl acetate 21.33
    di(2-ethylhexyl) phthalate 18.11
    ethyl propionate 20.06
    nitromethane 48.42
    1,2-diethoxyethane 27.48
    benzonitrile 25.79
    trioctyl phosphate 15.79
    1-bromopropane 18.78
    gamma-valerolactone 154.06
    n-decanol 11.02
    triethyl phosphate 14.38
    4-methyl-2-pentanol 21.69
    propionitrile 24.34
    vinylene carbonate 40.36
    1,1,2-trichlorotrifluoroethane 73.71
    DMS 29.3
    cumene 8.52
    2-octanol 18.05
    2-hexanone 28.27
    octyl acetate 17.39
    limonene 10.83
    1,2-dimethoxyethane 76.36
    ethyl orthosilicate 14.51
    tributyl phosphate 13.73
    diacetone alcohol 66.88
    N,N-dimethylaniline 20.08
    acrylonitrile 33.91
    aniline 32.63
    1,3-propanediol 82.15
    bromobenzene 17.9
    dibromomethane 23.92
    1,1,2,2-tetrachloroethane 60.29
    2-methyl-cyclohexyl acetate 25.28
    tetrabutyl urea 21.64
    diisobutyl methanol 12.37
    2-phenylethanol 48.32
    styrene 9.89
    dioctyl adipate 17.32
    dimethyl sulfate 49.87
    ethyl butyrate 20.27
    methyl lactate 35.52
    butyl lactate 31.71
    diethyl carbonate 14.08
    propanediol butyl ether 36.82
    triethyl orthoformate 18.14
    p-tert-butyltoluene 10.16
    methyl 4-tert-butylbenzoate 38.74
    morpholine 114.04
    tert-butylamine 27.26
    n-dodecanol 7.52
    dimethoxymethane 123.52
    ethylene carbonate 35.96
    cyrene 47.06
    2-ethoxyethyl acetate 46.96
    2-ethylhexyl acetate 32.52
    1,2,4-trichlorobenzene 26.88
    4-methylpyridine 50.89
    dibutyl ether 8.74
    2,6-dimethyl-4-heptanol 12.37
    DEF 48.19
    dimethyl isosorbide 65.8
    tetrachloroethylene 40.9
    eugenol 40.39
    triacetin 24.57
    span 80 31.06
    1,4-butanediol 27.03
    1,1-dichloroethane 28.22
    2-methyl-1-pentanol 28.83
    methyl formate 51.93
    2-methyl-1-butanol 39.58
    n-decane 0.93
    butyronitrile 26.6
    3,7-dimethyl-1-octanol 14.74
    1-chlorooctane 6.15
    1-chlorotetradecane 2.42
    n-nonane 0.71
    undecane 0.68
    tert-butylcyclohexane 1.35
    cyclooctane 0.79
    cyclopentanol 48.37
    tetrahydropyran 64.32
    tert-amyl methyl ether 22.86
    2,5,8-trioxanonane 49.34
    1-hexene 5.51
    2-isopropoxyethanol 42.26
    2,2,2-trifluoroethanol 17.67
    methyl butyrate 25.49

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Sage, spanish 2 8016-65-7 Salvia lavandulaefolia Vahl., fam. Lamiaceae (Labiatae) 2.7%