Carmustine

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  • Identifiers

    CAS number
    154-93-8

    Molecular formula
    C5H9Cl2N3O2

    SMILES
    C(CCl)NC(=O)N(CCCl)N=O

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 55.22%
    Fishy 44.99%
    Savory 32.55%
    Meaty 25.15%
    Cooling 24.85%
    Cheesy 21.05%
    Sweet 19.56%
    Ripe 18.83%
    Pungent 18.49%
    Cooked 18.27%

     

    Flavor
    Odorless 46.73%
    Bitter 42.21%
    Bland 27.16%
    Mild 23.66%
    Roasted 22.83%
    Cooked 22.31%
    Sweet-like 20.49%
    Nitrile 19.77%
    Yeast 19.36%
    Scallion 19.12%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    6.82 (neutral)

    Molecular weight
    214.05 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    250°C

    Melting point expt.

    • 86 to 90 °F (NTP, 1992)
    • 31 °C

    Flash point

    • 149.13 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 64 °F (NTP, 1992)
    • 4000 mg/L (at 25 °C)
    • Very soluble in ethanol
    • Soluble in 50% ethanol up to 150 mg/mL
    • Highly soluble in alcohol and poorly soluble in water. It is also highly soluble in lipids
    • In water, 4.0X10+3 mg/L at 25 °C
    • 1.53e+00 g/L

  • Synonyms

    • carmustine
    • 154-93-8
    • 1,3-Bis(2-chloroethyl)-1-nitrosourea
    • BCNU
    • Carmustin
    • Nitrumon
    • Carmubris
    • BiCNU
    • Becenun
    • Bischloroethyl nitrosourea
    • Carmustina
    • Carmustinum
    • Bischlorethylnitrosurea
    • Bischlorethylnitrosourea
    • Becenum
    • N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA
    • NSC-409962
    • Urea, N,N'-bis(2-chloroethyl)-N-nitroso-
    • Bischloroethylnitrosourea
    • FDA 0345
    • SRI 1720
    • SK 27702
    • NCI-C04773
    • Camustine
    • Carustine
    • NSC 409962
    • DTXSID8022743
    • 1,3-Bis(beta-chloroethyl)-1-nitrosourea
    • NSC409962
    • 1,3-bis(2-chloroethyl)-3-nitrosourea
    • SK-27702
    • DTI-015
    • Urea, 1,3-bis(2-chloroethyl)-1-nitroso-
    • U68WG3173Y
    • bis-chloroethylnitrosourea
    • FDA-0345
    • SRI-1720
    • CHEBI:3423
    • DTXCID002743
    • FIVB
    • Nitrourean
    • RefChem:57681
    • bis(chloroethyl) nitrosourea
    • L01AD01
    • WR-139021
    • 205-838-2
    • Bis-Chloronitrosourea
    • Gliadel
    • 1,3-Bis(2-chloroethyl)nitrosourea
    • Bi CNU
    • Bis(2-chloroethyl)nitrosourea
    • BiCNU (TN)
    • DTI 015
    • Carmustine (98%)
    • Bis(chloroethyl)nitrosourea
    • MFCD00057706
    • CHEMBL513
    • 1,3-bis(2-chloroethyl)-1-nitroso-urea
    • NCGC00015204-05
    • 1,3-Bis(.beta.-chloroethyl)-1-nitrosourea
    • Gliadel Wafer
    • Carmustinum [INN-Latin]
    • Carmustina [INN-Spanish]
    • Bis(2-chloroethyl)1-nitrosourea
    • Bis-N,N'-(chloroethyl)nitrosourea
    • CAS-154-93-8
    • CCRIS 810
    • BCNU [Chloroethyl nitrosoureas]
    • Carmustine; 1,3-bis(2-chloroethyl)-1-nitrosourea
    • SR-01000075736
    • EINECS 205-838-2
    • BRN 2049744
    • UNII-U68WG3173Y
    • Carmustine?
    • AI3-52216
    • Carmubris;
    • Becenum;
    • Carmustine CRS
    • HSDB 7761
    • Carmustine [USAN:USP:INN:BAN]
    • Prestwick_997
    • Gliadel (TN)
    • Bischloroethyl nitrosourea [Chloroethyl nitrosoureas]
    • Carmustine (Standard)
    • Gliadel (MGI Pharm)
    • Spectrum_000265
    • Carmustine, >=98%
    • CARMUSTINE [MI]
    • CARMUSTINE [INN]
    • CARMUSTINE [JAN]
    • Spectrum4_000888
    • Spectrum5_000920
    • CAMUSTINE [VANDF]
    • CARMUSTINE [HSDB]
    • CARMUSTINE [USAN]
    • Lopac-C-0400
    • WLN: ONN2GVM2G
    • C 0400
    • CARMUSTINE [MART.]
    • SCHEMBL4503
    • CARMUSTINE [USP-RS]
    • CARMUSTINE [WHO-DD]
    • Lopac0_000188
    • Carmustine (JAN/USP/INN)
    • KBioGR_001296
    • KBioSS_000745
    • MLS001333962
    • DivK1c_000835
    • Carmustine - Bio-X trade mark
    • GTPL6800
    • orb1304551
    • CARMUSTINE [EP IMPURITY]
    • CARMUSTINE [ORANGE BOOK]
    • HMS502J17
    • KBio1_000835
    • KBio2_000745
    • KBio2_003313
    • KBio2_005881
    • CARMUSTINE [EP MONOGRAPH]
    • NINDS_000835
    • CARMUSTINE [USP MONOGRAPH]
    • GLXC-05943
    • HMS2092J22
    • HMS2230I05
    • HMS3260F17
    • HMS3369D17
    • HMS5081L16
    • 154-93-8

  • Applications

    Carmustine is a nitrosourea alkylating agent used in pharmaceutical applications as an active component in drug formulations and in specialized delivery systems, including implantable local-delivery devices (such as Gliadel wafers) for targeted exposure. In research and development, it serves as a chemical reagent and a reference compound for nitrosourea chemistry and as an intermediate in the synthesis of related alkylating agents. It is also encountered as a specialty pharmaceutical intermediate in supplier catalogs and formulation workflows, supporting preclinical studies and medicinal chemistry exploration.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 43.16
    methanol 92.07
    isopropanol 27.18
    water 9.71
    ethyl acetate 50.36
    n-propanol 29.5
    acetone 236.93
    n-butanol 22.86
    acetonitrile 157.65
    DMF 734.77
    toluene 33.75
    isobutanol 22.12
    1,4-dioxane 92.11
    methyl acetate 83.41
    THF 135.12
    2-butanone 115.56
    n-pentanol 26.9
    sec-butanol 24.33
    n-hexane 2.17
    ethylene glycol 29.16
    NMP 601.07
    cyclohexane 4.56
    DMSO 954.71
    n-butyl acetate 40.1
    n-octanol 12.03
    chloroform 183.22
    n-propyl acetate 45.32
    acetic acid 235.03
    dichloromethane 294.57
    cyclohexanone 187.91
    propylene glycol 19.21
    isopropyl acetate 29.01
    DMAc 661.38
    2-ethoxyethanol 73.6
    isopentanol 22.15
    n-heptane 2.4
    ethyl formate 75.98
    1,2-dichloroethane 184.74
    n-hexanol 17.63
    2-methoxyethanol 109.48
    isobutyl acetate 23.64
    tetrachloromethane 16.35
    n-pentyl acetate 29.48
    transcutol 129.25
    n-heptanol 11.86
    ethylbenzene 20.01
    MIBK 36.55
    2-propoxyethanol 51.03
    tert-butanol 31.57
    MTBE 24.47
    2-butoxyethanol 35.49
    propionic acid 67.15
    o-xylene 32.3
    formic acid 173.33
    diethyl ether 23.1
    m-xylene 23.09
    p-xylene 36.24
    chlorobenzene 76.26
    dimethyl carbonate 46.7
    n-octane 1.23
    formamide 262.24
    cyclopentanone 228.55
    2-pentanone 64.5
    anisole 52.99
    cyclopentyl methyl ether 43.47
    gamma-butyrolactone 264.68
    1-methoxy-2-propanol 65.41
    pyridine 216.24
    3-pentanone 63.78
    furfural 357.43
    n-dodecane 1.08
    diethylene glycol 62.02
    diisopropyl ether 6.66
    tert-amyl alcohol 28.13
    acetylacetone 118.14
    n-hexadecane 1.27
    acetophenone 99.77
    methyl propionate 62.34
    isopentyl acetate 31.88
    trichloroethylene 399.73
    n-nonanol 11.49
    cyclohexanol 32.8
    benzyl alcohol 66.91
    2-ethylhexanol 13.73
    isooctanol 10.57
    dipropyl ether 16.07
    1,2-dichlorobenzene 77.26
    ethyl lactate 37.09
    propylene carbonate 115.59
    n-methylformamide 229.9
    2-pentanol 14.39
    n-pentane 2.11
    1-propoxy-2-propanol 35.65
    1-methoxy-2-propyl acetate 44.3
    2-(2-methoxypropoxy) propanol 48.89
    mesitylene 14.72
    ε-caprolactone 123.03
    p-cymene 14.18
    epichlorohydrin 213.54
    1,1,1-trichloroethane 75.95
    2-aminoethanol 37.3
    morpholine-4-carbaldehyde 302.92
    sulfolane 438.23
    2,2,4-trimethylpentane 1.73
    2-methyltetrahydrofuran 74.52
    n-hexyl acetate 31.04
    isooctane 0.96
    2-(2-butoxyethoxy)ethanol 52.01
    sec-butyl acetate 24.82
    tert-butyl acetate 30.29
    decalin 2.92
    glycerin 43.34
    diglyme 119.57
    acrylic acid 112.65
    isopropyl myristate 13.69
    n-butyric acid 58.91
    acetyl acetate 50.29
    di(2-ethylhexyl) phthalate 25.16
    ethyl propionate 39.76
    nitromethane 509.58
    1,2-diethoxyethane 37.79
    benzonitrile 113.94
    trioctyl phosphate 15.82
    1-bromopropane 48.84
    gamma-valerolactone 292.59
    n-decanol 9.07
    triethyl phosphate 28.01
    4-methyl-2-pentanol 10.37
    propionitrile 70.19
    vinylene carbonate 141.01
    1,1,2-trichlorotrifluoroethane 221.68
    DMS 47.69
    cumene 14.29
    2-octanol 8.97
    2-hexanone 51.61
    octyl acetate 18.62
    limonene 18.84
    1,2-dimethoxyethane 143.39
    ethyl orthosilicate 21.49
    tributyl phosphate 20.65
    diacetone alcohol 52.35
    N,N-dimethylaniline 55.91
    acrylonitrile 148.37
    aniline 59.03
    1,3-propanediol 40.49
    bromobenzene 72.19
    dibromomethane 143.79
    1,1,2,2-tetrachloroethane 222.21
    2-methyl-cyclohexyl acetate 32.65
    tetrabutyl urea 38.79
    diisobutyl methanol 9.79
    2-phenylethanol 41.13
    styrene 31.31
    dioctyl adipate 30.2
    dimethyl sulfate 146.18
    ethyl butyrate 35.57
    methyl lactate 53.42
    butyl lactate 32.64
    diethyl carbonate 30.53
    propanediol butyl ether 37.67
    triethyl orthoformate 26.16
    p-tert-butyltoluene 12.2
    methyl 4-tert-butylbenzoate 53.1
    morpholine 111.64
    tert-butylamine 16.48
    n-dodecanol 7.56
    dimethoxymethane 116.46
    ethylene carbonate 90.58
    cyrene 88.73
    2-ethoxyethyl acetate 44.25
    2-ethylhexyl acetate 26.06
    1,2,4-trichlorobenzene 98.53
    4-methylpyridine 192.91
    dibutyl ether 13.88
    2,6-dimethyl-4-heptanol 9.79
    DEF 139.6
    dimethyl isosorbide 90.1
    tetrachloroethylene 137.16
    eugenol 57.43
    triacetin 52.44
    span 80 38.68
    1,4-butanediol 27.98
    1,1-dichloroethane 97.01
    2-methyl-1-pentanol 25.95
    methyl formate 191.66
    2-methyl-1-butanol 21.8
    n-decane 1.63
    butyronitrile 59.68
    3,7-dimethyl-1-octanol 13.08
    1-chlorooctane 8.24
    1-chlorotetradecane 3.87
    n-nonane 1.51
    undecane 1.27
    tert-butylcyclohexane 2.1
    cyclooctane 1.53
    cyclopentanol 44.72
    tetrahydropyran 59.45
    tert-amyl methyl ether 22.4
    2,5,8-trioxanonane 86.95
    1-hexene 9.97
    2-isopropoxyethanol 44.95
    2,2,2-trifluoroethanol 117.73
    methyl butyrate 65.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction