Carbonic acid, 2-methoxy-4-methylphenyl methyl ester

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  • Identifiers

    CAS number
    132638-45-0

    Molecular formula
    C10H12O4

    SMILES
    CC1=CC(=C(C=C1)OC(=O)OC)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 58.45%
    Phenolic 45.75%
    Spicy 44.23%
    Woody 36.3%
    Green 35.65%
    Sweet 33.85%
    Balsamic 32.12%
    Fresh 31.65%
    Fruity 31.22%
    Powdery 31.06%

     

    Flavor
    Woody 48.96%
    Sweet 42.71%
    Spice 36.89%
    Bitter 35.2%
    Floral 33.08%
    Herbal 31.98%
    Fruity 31.46%
    Powdery 31.08%
    Flower 27.9%
    Smoky 27.86%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    7.2 (neutral)

    Molecular weight
    196.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    268°C

    Flash point

    • 104.4 ˚C est.

  • Synonyms

    • 132638-45-0
    • CARBONIC ACID, 2-METHOXY-4-METHYLPHENYL METHYL ESTER
    • 2-methoxy-4-methylphenyl methyl carbonate
    • DTXSID50888951
    • RefChem:574373
    • DTXCID801028221
    • 700-673-7
    • 2-methoxy-4-methyl-phenyl methyl carbonate
    • 2-methoxy-4-methylphenylmethylcarbonate
    • SCHEMBL2565359
    • SCHEMBL30474574
    • (2-methoxy-4-methylphenyl) methyl carbonate
    • 132638-45-0

  • Applications

    Chemical name: Carbonic acid, 2-methoxy-4-methylphenyl methyl ester; CAS 132638-45-0 is primarily used as an intermediate in organic synthesis, enabling introduction of carbonate functionality and acting as a protecting group for phenolic substrates during multi-step sequences. It is evaluated as a reactive carbonate donor in polymer chemistry, including routes to polycarbonates or functionalized polymers, and as a precursor for specialty monomers or crosslinking agents. It may serve as a solvent or co-solvent in formulation work and as a fragrance-related intermediate in perfumery. It also appears in discussions of agrochemical and pharmaceutical synthesis as an intermediate, and in coatings/inks for surface modification or adhesive formulations. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 438.54
    methanol 516.58
    isopropanol 329.21
    water 0.56
    ethyl acetate 623.81
    n-propanol 344.64
    acetone 935.79
    n-butanol 280.27
    acetonitrile 715.56
    DMF 1639.65
    toluene 208.84
    isobutanol 240.77
    1,4-dioxane 710.0
    methyl acetate 723.15
    THF 877.91
    2-butanone 740.45
    n-pentanol 197.02
    sec-butanol 382.06
    n-hexane 11.16
    ethylene glycol 122.2
    NMP 794.53
    cyclohexane 20.62
    DMSO 1263.55
    n-butyl acetate 290.41
    n-octanol 79.75
    chloroform 1127.1
    n-propyl acetate 328.49
    acetic acid 525.41
    dichloromethane 1354.83
    cyclohexanone 567.35
    propylene glycol 115.31
    isopropyl acetate 282.67
    DMAc 943.67
    2-ethoxyethanol 479.4
    isopentanol 270.08
    n-heptane 7.53
    ethyl formate 372.23
    1,2-dichloroethane 1059.63
    n-hexanol 172.49
    2-methoxyethanol 839.66
    isobutyl acetate 161.6
    tetrachloromethane 119.29
    n-pentyl acetate 148.45
    transcutol 604.87
    n-heptanol 83.76
    ethylbenzene 135.8
    MIBK 248.41
    2-propoxyethanol 330.42
    tert-butanol 604.46
    MTBE 517.89
    2-butoxyethanol 187.7
    propionic acid 342.63
    o-xylene 156.19
    formic acid 249.21
    diethyl ether 453.51
    m-xylene 145.79
    p-xylene 167.28
    chlorobenzene 311.85
    dimethyl carbonate 334.64
    n-octane 5.33
    formamide 702.28
    cyclopentanone 838.57
    2-pentanone 498.98
    anisole 374.37
    cyclopentyl methyl ether 377.12
    gamma-butyrolactone 970.27
    1-methoxy-2-propanol 506.91
    pyridine 637.12
    3-pentanone 381.23
    furfural 766.36
    n-dodecane 5.91
    diethylene glycol 286.57
    diisopropyl ether 101.67
    tert-amyl alcohol 558.16
    acetylacetone 581.01
    n-hexadecane 6.98
    acetophenone 313.83
    methyl propionate 565.51
    isopentyl acetate 248.3
    trichloroethylene 1743.44
    n-nonanol 70.92
    cyclohexanol 244.09
    benzyl alcohol 274.32
    2-ethylhexanol 105.51
    isooctanol 72.92
    dipropyl ether 98.11
    1,2-dichlorobenzene 287.22
    ethyl lactate 146.32
    propylene carbonate 447.12
    n-methylformamide 767.77
    2-pentanol 227.92
    n-pentane 11.43
    1-propoxy-2-propanol 201.34
    1-methoxy-2-propyl acetate 247.41
    2-(2-methoxypropoxy) propanol 179.54
    mesitylene 85.52
    ε-caprolactone 493.29
    p-cymene 63.83
    epichlorohydrin 1324.75
    1,1,1-trichloroethane 704.17
    2-aminoethanol 212.17
    morpholine-4-carbaldehyde 728.72
    sulfolane 940.65
    2,2,4-trimethylpentane 15.95
    2-methyltetrahydrofuran 672.65
    n-hexyl acetate 203.1
    isooctane 9.49
    2-(2-butoxyethoxy)ethanol 216.85
    sec-butyl acetate 206.14
    tert-butyl acetate 357.52
    decalin 22.06
    glycerin 189.27
    diglyme 496.66
    acrylic acid 326.1
    isopropyl myristate 69.99
    n-butyric acid 368.66
    acetyl acetate 364.51
    di(2-ethylhexyl) phthalate 75.58
    ethyl propionate 280.65
    nitromethane 1310.71
    1,2-diethoxyethane 208.99
    benzonitrile 283.52
    trioctyl phosphate 54.54
    1-bromopropane 365.76
    gamma-valerolactone 843.03
    n-decanol 53.31
    triethyl phosphate 101.7
    4-methyl-2-pentanol 120.4
    propionitrile 427.78
    vinylene carbonate 436.04
    1,1,2-trichlorotrifluoroethane 677.21
    DMS 233.48
    cumene 85.3
    2-octanol 65.91
    2-hexanone 284.84
    octyl acetate 95.7
    limonene 87.16
    1,2-dimethoxyethane 673.9
    ethyl orthosilicate 93.11
    tributyl phosphate 70.75
    diacetone alcohol 401.5
    N,N-dimethylaniline 211.37
    acrylonitrile 602.17
    aniline 330.47
    1,3-propanediol 328.61
    bromobenzene 320.36
    dibromomethane 764.51
    1,1,2,2-tetrachloroethane 1221.05
    2-methyl-cyclohexyl acetate 149.25
    tetrabutyl urea 89.57
    diisobutyl methanol 64.06
    2-phenylethanol 209.15
    styrene 175.72
    dioctyl adipate 109.31
    dimethyl sulfate 478.37
    ethyl butyrate 184.19
    methyl lactate 214.2
    butyl lactate 108.4
    diethyl carbonate 150.21
    propanediol butyl ether 148.16
    triethyl orthoformate 117.49
    p-tert-butyltoluene 65.44
    methyl 4-tert-butylbenzoate 189.45
    morpholine 806.5
    tert-butylamine 280.27
    n-dodecanol 40.64
    dimethoxymethane 783.13
    ethylene carbonate 350.28
    cyrene 226.25
    2-ethoxyethyl acetate 217.32
    2-ethylhexyl acetate 184.96
    1,2,4-trichlorobenzene 359.2
    4-methylpyridine 606.11
    dibutyl ether 87.65
    2,6-dimethyl-4-heptanol 64.06
    DEF 581.78
    dimethyl isosorbide 303.73
    tetrachloroethylene 713.49
    eugenol 188.99
    triacetin 180.8
    span 80 119.94
    1,4-butanediol 119.91
    1,1-dichloroethane 824.44
    2-methyl-1-pentanol 211.67
    methyl formate 640.01
    2-methyl-1-butanol 264.74
    n-decane 8.92
    butyronitrile 364.85
    3,7-dimethyl-1-octanol 83.14
    1-chlorooctane 56.36
    1-chlorotetradecane 24.35
    n-nonane 7.75
    undecane 7.09
    tert-butylcyclohexane 20.49
    cyclooctane 7.28
    cyclopentanol 268.3
    tetrahydropyran 518.31
    tert-amyl methyl ether 390.76
    2,5,8-trioxanonane 298.59
    1-hexene 79.13
    2-isopropoxyethanol 302.7
    2,2,2-trifluoroethanol 257.12
    methyl butyrate 398.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction