Carbenoxolone Sodium

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  • Identifiers

    CAS number
    7421-40-1

    Molecular formula
    C34H48Na2O7

    SMILES
    C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)CCC(=O)[O-])C)(C)C(=O)[O-].[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 65.96%
    Cedar 41.64%
    Dry 41.49%
    Amber 41.46%
    Musk 34.9%
    Balsamic 33.29%
    Odorless 28.68%
    Spicy 27.3%
    Animal 26.81%
    Vetiver 26.73%

     

    Flavor
    Bitter 56.27%
    Woody 26.64%
    Odorless 25.4%
    Camphor 24.62%
    Ripe apricot 22.38%
    Cedarleaf 22.01%
    Red fruit 21.88%
    Fir 21.24%
    Heather 21.2%
    Broom 21.19%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    2.35 (strong acid)

    Molecular weight
    614.7 g/mol

    Flash point

    • 292.22 ˚C est.

  • Synonyms

    • CARBENOXOLONE SODIUM
    • Bioral
    • Sanodin
    • Biogastrone
    • 7421-40-1
    • Neogel
    • Ulcus-tablinen
    • Sodium carbenoxolone
    • Berkobiogastrone
    • Carbenoxolone disodium salt
    • disodium succinoyl glycyrrhetinate
    • Carbenoxolone, disodium salt
    • DTXSID7045572
    • F1MP7242Z5
    • NSC-758146
    • DTXCID5025572
    • Glycyrrhetinic acid hydrogen succinate, disodium salt
    • RefChem:918026
    • Glycyrrhetinic Acid 3 O hemisuccinate
    • Glycyrrhetinic Acid 3-O-hemisuccinate
    • 3-O-hemisuccinate, Glycyrrhetinic Acid
    • Acid 3-O-hemisuccinate, Glycyrrhetinic
    • (3beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic Acid, Disodium Salt
    • 231-044-0
    • Bioplex
    • C34H48Na2O7
    • MFCD03840711
    • 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate disodium salt
    • disodium;(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(3-carboxylatopropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
    • Duogastrone
    • Gastrausil
    • Terulcon tabletten
    • Carbenoxolon dinatrium
    • Carbenoxolon-dinatrium
    • Vampex
    • Disodium glycyrrhetinyl succina
    • UNII-F1MP7242Z5
    • Carbenoxolone sodium [USAN:JAN]
    • Prestwick_19
    • NCGC00017073-01
    • Carbenoxalone sodium
    • CAS-7421-40-1
    • EINECS 231-044-0
    • yp003
    • SCHEMBL57233
    • CHEMBL1697717
    • CHEBI:31351
    • BQENDLAVTKRQMS-SBBGFIFASA-L
    • Carbenoxolone sodium (JAN/USAN)
    • 18-beta-Glycyrrhetinic acid hydrogen succinate, disodium salt
    • 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate
    • CARBENOXOLONE SODIUM [JAN]
    • HMS1570H15
    • HMS2097H15
    • HMS3714H15
    • CARBENOXOLONE SODIUM [USAN]
    • Tox21_110769
    • CARBENOXOLONE SODIUM [MART.]
    • Sodium 3-beta-hydroxy-11-oxo-12-oleanen-30-oate sodium succinate
    • YP-003
    • CARBENOXOLONE SODIUM [WHO-DD]
    • AKOS016036367
    • AKOS024457425
    • Tox21_110769_1
    • CCG-220837
    • FC19690
    • NSC 758146
    • 3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate, disodium salt
    • 3-O-(beta-Carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oic acid, disodium salt
    • CARBENOXOLONE DISODIUM SALT [MI]
    • NCGC00179431-03
    • Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, disodium salt, (3-beta,20-beta)-
    • D01899
    • G13250
    • DISODIUM 3-SUCCINYLOXY-.BETA.-GLYCYRRHETINATE
    • Q27277518
    • 3ss-Hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate
    • (3b,20b)-3-(3-Carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic acid
    • 3b-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate disod ium salt
    • Disodium 3beta-[(3-carboxylatopropanoyl)oxy]-11-oxoolean-12-en-30-oate
    • Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-, hydrogen succinate, disodium salt
    • 20.BETA.-OLEAN-12-EN-29-OIC ACID, 3(.BETA.)-(3-CARBOXY-1-OXOPROPOXY)-11-OXO-, DISODIUM SALT
    • OLEAN-12-EN-29-OIC ACID, 3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO, DISODIUM SALT, (3.BETA.,20.BETA.)-
    • Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo, disodium salt, (3beta,20beta)-
    • OLEAN-12-EN-29-OIC ACID, 3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO-, SODIUM SALT (1:2), (3.BETA.,20.BETA.)-
    • 7421-40-1

  • Applications

    Carbenoxolone Sodium (CAS 7421-40-1) is a glycyrrhetinic acid salt historically used in pharmaceuticals as a gastroprotective agent to promote protective mucus production in the gastric mucosa and support healing of ulcers. In biology and cell research it is widely used as a gap junction inhibitor to probe intercellular communication and connexin function. In cosmetics and personal care, related glycyrrhetinic acid derivatives are evaluated for anti-inflammatory potential and skin-conditioning effects, with carbenoxolone sodium considered as a test ingredient in formulation studies. It also serves as an intermediate in the synthesis of glycyrrhetinic acid derivatives and related compounds for chemical manufacture and process development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 40.16
    methanol 36.12
    isopropanol 24.76
    water 0.01
    ethyl acetate 11.2
    n-propanol 40.31
    acetone 26.13
    n-butanol 18.13
    acetonitrile 6.8
    DMF 177.41
    toluene 6.2
    isobutanol 15.75
    1,4-dioxane 78.42
    methyl acetate 15.02
    THF 175.72
    2-butanone 28.14
    n-pentanol 14.76
    sec-butanol 13.41
    n-hexane 0.2
    ethylene glycol 4.44
    NMP 113.22
    cyclohexane 0.25
    DMSO 72.69
    n-butyl acetate 7.11
    n-octanol 3.39
    chloroform 41.12
    n-propyl acetate 8.62
    acetic acid 29.93
    dichloromethane 28.7
    cyclohexanone 34.83
    propylene glycol 13.51
    isopropyl acetate 7.76
    DMAc 128.63
    2-ethoxyethanol 57.15
    isopentanol 8.35
    n-heptane 0.1
    ethyl formate 11.01
    1,2-dichloroethane 14.83
    n-hexanol 8.79
    2-methoxyethanol 92.9
    isobutyl acetate 4.87
    tetrachloromethane 3.02
    n-pentyl acetate 7.88
    transcutol 50.13
    n-heptanol 5.29
    ethylbenzene 2.79
    MIBK 7.37
    2-propoxyethanol 74.51
    tert-butanol 11.16
    MTBE 7.53
    2-butoxyethanol 29.85
    propionic acid 16.17
    o-xylene 2.9
    formic acid 13.34
    diethyl ether 12.37
    m-xylene 2.84
    p-xylene 3.23
    chlorobenzene 7.2
    dimethyl carbonate 13.44
    n-octane 0.06
    formamide 20.43
    cyclopentanone 66.51
    2-pentanone 16.48
    anisole 12.09
    cyclopentyl methyl ether 21.99
    gamma-butyrolactone 69.2
    1-methoxy-2-propanol 75.35
    pyridine 48.19
    3-pentanone 11.95
    furfural 42.27
    n-dodecane 0.04
    diethylene glycol 40.91
    diisopropyl ether 1.46
    tert-amyl alcohol 8.25
    acetylacetone 18.03
    n-hexadecane 0.05
    acetophenone 11.12
    methyl propionate 17.65
    isopentyl acetate 6.25
    trichloroethylene 38.28
    n-nonanol 3.6
    cyclohexanol 7.11
    benzyl alcohol 16.72
    2-ethylhexanol 2.55
    isooctanol 3.43
    dipropyl ether 4.68
    1,2-dichlorobenzene 5.79
    ethyl lactate 7.28
    propylene carbonate 19.01
    n-methylformamide 54.65
    2-pentanol 5.73
    n-pentane 0.19
    1-propoxy-2-propanol 30.9
    1-methoxy-2-propyl acetate 18.15
    2-(2-methoxypropoxy) propanol 15.68
    mesitylene 1.23
    ε-caprolactone 32.99
    p-cymene 0.98
    epichlorohydrin 90.0
    1,1,1-trichloroethane 9.41
    2-aminoethanol 21.2
    morpholine-4-carbaldehyde 142.83
    sulfolane 72.5
    2,2,4-trimethylpentane 0.11
    2-methyltetrahydrofuran 40.73
    n-hexyl acetate 8.79
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 25.65
    sec-butyl acetate 4.75
    tert-butyl acetate 7.19
    decalin 0.18
    glycerin 19.12
    diglyme 45.96
    acrylic acid 15.34
    isopropyl myristate 1.95
    n-butyric acid 20.4
    acetyl acetate 7.1
    di(2-ethylhexyl) phthalate 4.5
    ethyl propionate 6.84
    nitromethane 40.58
    1,2-diethoxyethane 12.64
    benzonitrile 8.62
    trioctyl phosphate 2.55
    1-bromopropane 6.43
    gamma-valerolactone 134.61
    n-decanol 1.81
    triethyl phosphate 3.04
    4-methyl-2-pentanol 2.64
    propionitrile 9.02
    vinylene carbonate 19.98
    1,1,2-trichlorotrifluoroethane 50.9
    DMS 9.17
    cumene 1.48
    2-octanol 2.27
    2-hexanone 12.21
    octyl acetate 3.42
    limonene 1.19
    1,2-dimethoxyethane 66.78
    ethyl orthosilicate 3.09
    tributyl phosphate 2.41
    diacetone alcohol 15.04
    N,N-dimethylaniline 8.09
    acrylonitrile 13.28
    aniline 13.03
    1,3-propanediol 34.47
    bromobenzene 6.18
    dibromomethane 14.61
    1,1,2,2-tetrachloroethane 31.68
    2-methyl-cyclohexyl acetate 5.57
    tetrabutyl urea 4.52
    diisobutyl methanol 1.17
    2-phenylethanol 14.17
    styrene 3.52
    dioctyl adipate 4.67
    dimethyl sulfate 21.17
    ethyl butyrate 4.88
    methyl lactate 16.57
    butyl lactate 9.89
    diethyl carbonate 3.06
    propanediol butyl ether 21.98
    triethyl orthoformate 5.11
    p-tert-butyltoluene 1.03
    methyl 4-tert-butylbenzoate 11.02
    morpholine 132.24
    tert-butylamine 3.13
    n-dodecanol 0.93
    dimethoxymethane 94.33
    ethylene carbonate 15.52
    cyrene 28.51
    2-ethoxyethyl acetate 17.31
    2-ethylhexyl acetate 4.45
    1,2,4-trichlorobenzene 9.55
    4-methylpyridine 29.78
    dibutyl ether 2.25
    2,6-dimethyl-4-heptanol 1.17
    DEF 26.61
    dimethyl isosorbide 29.15
    tetrachloroethylene 17.82
    eugenol 13.52
    triacetin 10.86
    span 80 13.92
    1,4-butanediol 12.73
    1,1-dichloroethane 13.05
    2-methyl-1-pentanol 7.43
    methyl formate 28.33
    2-methyl-1-butanol 9.18
    n-decane 0.1
    butyronitrile 8.11
    3,7-dimethyl-1-octanol 2.23
    1-chlorooctane 0.87
    1-chlorotetradecane 0.21
    n-nonane 0.09
    undecane 0.06
    tert-butylcyclohexane 0.15
    cyclooctane 0.08
    cyclopentanol 20.08
    tetrahydropyran 39.64
    tert-amyl methyl ether 5.4
    2,5,8-trioxanonane 24.84
    1-hexene 1.51
    2-isopropoxyethanol 28.25
    2,2,2-trifluoroethanol 9.09
    methyl butyrate 9.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction