Carbamol

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  • Identifiers

    CAS number
    140-95-4

    Molecular formula
    C3H8N2O3

    SMILES
    C(NC(=O)NCO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 54.93%
    Savory 35.67%
    Meaty 35.67%
    Fishy 30.02%
    Sulfurous 29.86%
    Cheesy 27.17%
    Ripe 22.32%
    Cooked 20.44%
    Pungent 19.44%
    Cooling 18.16%

     

    Flavor
    Odorless 70.29%
    Mild 28.27%
    Very mild 26.82%
    Sweet-like 25.3%
    Yeast 23.73%
    Sour 23.21%
    Bland 22.51%
    Faint 21.42%
    Very slight 21.06%
    Formyl 20.34%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.8

    pKa est.
    7.9 (neutral)

    Molecular weight
    120.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    455°C

    Flash point

    • 211.93 ˚C est.

  • Synonyms

    • 1,3-Bis(hydroxymethyl)urea
    • N,N'-Bis(hydroxymethyl)urea
    • Carbamol
    • RefChem:857848
    • Dimethylolurea
    • 140-95-4
    • Oxymethurea
    • Methural
    • N,N'-Dimethylolurea
    • Urea, N,N'-bis(hydroxymethyl)-
    • Metural
    • 1,3-Dimethylolurea
    • Protesine DMU
    • Finish EN
    • Knittex ASL
    • Ureol P
    • CSI Paste
    • Caurite
    • Urofix
    • Kaurit S
    • Permafresh 477
    • DIMETHYLOL UREA
    • N,N'-Dihydroxymethylurea
    • Dimethanol urea
    • Papirol J 001
    • Urea, 1,3-bis(hydroxymethyl)-
    • NSC 41819
    • MFCD00014414
    • N68H97CAWG
    • DTXSID6025141
    • NSC-41819
    • 1,3-Bis(hydroxymethyl)harnstoff
    • N-(hydroxymethyl)[(hydroxymethyl)amino]carboxamide
    • EINECS 205-444-0
    • UNII-N68H97CAWG
    • OXYMETHUREA [MI]
    • 1,3-Bis-hydroxymethyl-urea
    • OXYMETHUREA [MART.]
    • Urea,3-bis(hydroxymethyl)-
    • SCHEMBL27834
    • OXYMETHUREA [WHO-DD]
    • Urea,N'-bis(hydroxymethyl)-
    • DIHYDROXYMETHYL CARBAMIDE
    • DTXCID305141
    • CHEMBL3185052
    • CHEBI:134755
    • NSC41819
    • Tox21_300714
    • BBL000676
    • SBB071713
    • STK366820
    • AKOS005444079
    • FD33309
    • N,N'-Bis(hydroxymethyl)urea, >=95%
    • NCGC00248149-01
    • NCGC00254620-01
    • CAS-140-95-4
    • VS-00664
    • CS-0064471
    • D0767
    • NS00009508
    • ST45026868
    • EN300-134864
    • H11231
    • N,N inverted exclamation marka-Bis(hydroxymethyl)urea
    • Q27284611
    • 140-95-4

  • Applications

    Carbamol is typically used as an intermediate and reactive reagent that introduces the carbamoyl group in organic synthesis. In industry, it serves as a building block for carbamate derivatives and as a feedstock to attach the carbamoyl moiety to molecules, supporting the production of polymers and plastics with carbamate linkages. In coatings and inks, it can function as a reactive component to form carbamate bonds and improve coating performance and chemical resistance. It is also used in adhesives and sealants as a functional linking component. Additionally, carbamol may appear in cleaning formulations as a reactive ingredient or intermediate and is evaluated for pharmaceutical applications at the intermediate level, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 38.79
    methanol 124.45
    isopropanol 21.88
    water 630.97
    ethyl acetate 5.98
    n-propanol 25.81
    acetone 13.75
    n-butanol 14.78
    acetonitrile 12.23
    DMF 656.14
    toluene 0.94
    isobutanol 14.8
    1,4-dioxane 25.27
    methyl acetate 10.69
    THF 31.31
    2-butanone 9.37
    n-pentanol 7.24
    sec-butanol 13.46
    n-hexane 0.55
    ethylene glycol 204.08
    NMP 382.33
    cyclohexane 1.02
    DMSO 354.43
    n-butyl acetate 3.2
    n-octanol 3.0
    chloroform 4.03
    n-propyl acetate 3.16
    acetic acid 92.4
    dichloromethane 6.6
    cyclohexanone 17.17
    propylene glycol 124.51
    isopropyl acetate 3.18
    DMAc 361.45
    2-ethoxyethanol 42.03
    isopentanol 7.75
    n-heptane 0.76
    ethyl formate 19.07
    1,2-dichloroethane 5.69
    n-hexanol 5.59
    2-methoxyethanol 143.54
    isobutyl acetate 1.69
    tetrachloromethane 1.46
    n-pentyl acetate 2.31
    transcutol 20.75
    n-heptanol 3.8
    ethylbenzene 0.64
    MIBK 3.23
    2-propoxyethanol 30.02
    tert-butanol 16.81
    MTBE 3.82
    2-butoxyethanol 14.65
    propionic acid 57.5
    o-xylene 1.85
    formic acid 305.19
    diethyl ether 3.99
    m-xylene 1.3
    p-xylene 0.99
    chlorobenzene 1.38
    dimethyl carbonate 17.06
    n-octane 0.3
    formamide 244.05
    cyclopentanone 31.39
    2-pentanone 5.93
    anisole 2.37
    cyclopentyl methyl ether 8.54
    gamma-butyrolactone 69.46
    1-methoxy-2-propanol 70.81
    pyridine 11.52
    3-pentanone 6.53
    furfural 68.6
    n-dodecane 0.2
    diethylene glycol 63.4
    diisopropyl ether 1.1
    tert-amyl alcohol 11.9
    acetylacetone 7.85
    n-hexadecane 0.22
    acetophenone 4.81
    methyl propionate 15.62
    isopentyl acetate 2.41
    trichloroethylene 7.48
    n-nonanol 2.73
    cyclohexanol 11.41
    benzyl alcohol 7.17
    2-ethylhexanol 2.77
    isooctanol 2.81
    dipropyl ether 3.17
    1,2-dichlorobenzene 1.98
    ethyl lactate 12.54
    propylene carbonate 27.4
    n-methylformamide 235.82
    2-pentanol 6.19
    n-pentane 0.82
    1-propoxy-2-propanol 14.99
    1-methoxy-2-propyl acetate 7.11
    2-(2-methoxypropoxy) propanol 13.16
    mesitylene 1.15
    ε-caprolactone 21.97
    p-cymene 1.06
    epichlorohydrin 27.2
    1,1,1-trichloroethane 2.08
    2-aminoethanol 153.49
    morpholine-4-carbaldehyde 197.55
    sulfolane 140.71
    2,2,4-trimethylpentane 0.45
    2-methyltetrahydrofuran 11.57
    n-hexyl acetate 2.96
    isooctane 0.26
    2-(2-butoxyethoxy)ethanol 13.87
    sec-butyl acetate 1.72
    tert-butyl acetate 3.0
    decalin 0.39
    glycerin 263.25
    diglyme 26.01
    acrylic acid 91.85
    isopropyl myristate 1.27
    n-butyric acid 29.39
    acetyl acetate 3.81
    di(2-ethylhexyl) phthalate 3.9
    ethyl propionate 4.18
    nitromethane 103.96
    1,2-diethoxyethane 3.08
    benzonitrile 5.32
    trioctyl phosphate 3.07
    1-bromopropane 2.39
    gamma-valerolactone 74.34
    n-decanol 2.03
    triethyl phosphate 4.07
    4-methyl-2-pentanol 2.99
    propionitrile 10.09
    vinylene carbonate 30.06
    1,1,2-trichlorotrifluoroethane 75.97
    DMS 5.44
    cumene 0.71
    2-octanol 1.99
    2-hexanone 2.81
    octyl acetate 2.15
    limonene 1.71
    1,2-dimethoxyethane 33.54
    ethyl orthosilicate 3.23
    tributyl phosphate 2.89
    diacetone alcohol 11.53
    N,N-dimethylaniline 4.31
    acrylonitrile 22.36
    aniline 5.51
    1,3-propanediol 81.78
    bromobenzene 0.84
    dibromomethane 3.37
    1,1,2,2-tetrachloroethane 8.78
    2-methyl-cyclohexyl acetate 3.12
    tetrabutyl urea 6.14
    diisobutyl methanol 1.83
    2-phenylethanol 4.5
    styrene 0.72
    dioctyl adipate 3.16
    dimethyl sulfate 58.87
    ethyl butyrate 3.68
    methyl lactate 52.64
    butyl lactate 7.35
    diethyl carbonate 3.19
    propanediol butyl ether 17.63
    triethyl orthoformate 3.6
    p-tert-butyltoluene 1.04
    methyl 4-tert-butylbenzoate 8.49
    morpholine 47.83
    tert-butylamine 6.57
    n-dodecanol 1.57
    dimethoxymethane 59.84
    ethylene carbonate 21.56
    cyrene 33.97
    2-ethoxyethyl acetate 3.88
    2-ethylhexyl acetate 2.07
    1,2,4-trichlorobenzene 2.65
    4-methylpyridine 8.36
    dibutyl ether 1.34
    2,6-dimethyl-4-heptanol 1.83
    DEF 42.97
    dimethyl isosorbide 17.04
    tetrachloroethylene 5.64
    eugenol 11.08
    triacetin 6.48
    span 80 13.14
    1,4-butanediol 38.83
    1,1-dichloroethane 2.65
    2-methyl-1-pentanol 4.32
    methyl formate 112.97
    2-methyl-1-butanol 9.83
    n-decane 0.3
    butyronitrile 7.89
    3,7-dimethyl-1-octanol 2.29
    1-chlorooctane 0.77
    1-chlorotetradecane 0.41
    n-nonane 0.3
    undecane 0.23
    tert-butylcyclohexane 0.31
    cyclooctane 0.5
    cyclopentanol 24.46
    tetrahydropyran 9.11
    tert-amyl methyl ether 4.3
    2,5,8-trioxanonane 20.44
    1-hexene 0.99
    2-isopropoxyethanol 15.31
    2,2,2-trifluoroethanol 81.1
    methyl butyrate 6.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction