Carbamic acid, ethyl-, ethyl ester

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  • Identifiers

    CAS number
    623-78-9

    Molecular formula
    C5H11NO2

    SMILES
    CCNC(=O)OCC

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fruity 75.55%
    Grape 40.72%
    Tropical 40.55%
    Cheesy 38.83%
    Sulfurous 37.83%
    Meaty 28.95%
    Ripe 27.22%
    Sweet 23.19%
    Roasted 22.47%
    Savory 22.32%

     

    Flavor
    Fruity 82.07%
    Pineapple 48.28%
    Fruit 40.86%
    Sweet 39.88%
    Tropical 37.69%
    Grape 37.26%
    Berry 35.25%
    Cheese 33.64%
    Apple 30.06%
    Fatty 28.09%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    8.34 (weak base)

    Molecular weight
    117.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point

    • 176 °C AT 760 MM HG

    Flash point

    • 63.23 ˚C est.

    Solubility expt.

    • SOL IN WATER; VERY SOL IN ALCOHOL, ETHER

  • Synonyms

    • Ethyl N-ethylcarbamate
    • Ethyl ethylcarbamate
    • 623-78-9
    • N-Ethylurethane
    • Ethyl-N-ethyl carbamate
    • Ethylcarbamic acid, ethyl ester
    • CARBAMIC ACID, ETHYL-, ETHYL ESTER
    • ethyl-N-ethylcarbamate
    • HSDB 5506
    • NSC 440
    • UNII-P1WCG74L8I
    • EINECS 210-812-9
    • BRN 1744742
    • NSC-440
    • Carbamic acid, N-ethyl-, ethyl ester
    • P1WCG74L8I
    • ethyl-carbamic acid ethyl ester
    • DTXSID0060775
    • GZXSDYYWLZERLF-UHFFFAOYSA-
    • 4-04-00-00365 (Beilstein Handbook Reference)
    • CARBAMIC ACID, ETHYL-, ETHYL ESTER [HSDB]
    • NEthylurethane
    • Ethyl Nethylcarbamate
    • EthylNethyl carbamate
    • ethyl-carbamic ethyl ester
    • WLN: 2OVM2
    • SCHEMBL149187
    • NSC440
    • DTXCID4043307
    • N-ethyl-carbamic acid ethyl ester
    • Carbamic acid, Nethyl, ethyl ester
    • MFCD00009102
    • AKOS003862635
    • DB-054148
    • NS00035025
    • Q27286016

  • Applications

    Carbamic acid, ethyl-, ethyl ester, CAS 623-78-9 is primarily used as an organic synthesis intermediate to introduce carbamate (urethane) functionality, commonly enabling the preparation of urethane derivatives and related pharmaceutical compounds. It also serves as a solvent/reaction medium in certain specialty organic processes. In polymer chemistry, it can act as a feedstock or precursor for carbamate-containing polymers and polyurethane formulations under controlled conditions. It is used in protective group chemistry to install an ethoxycarbonyl (EtOCO) carbamate protection on amines during multi-step syntheses. Depending on formulation and regulatory constraints, it may be used in research and development settings across chemical, pharmaceutical, and materials industries.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1188.67
    methanol 2063.14
    isopropanol 841.96
    water 22.65
    ethyl acetate 391.57
    n-propanol 855.16
    acetone 780.28
    n-butanol 635.26
    acetonitrile 821.16
    DMF 1787.57
    toluene 156.47
    isobutanol 548.57
    1,4-dioxane 735.1
    methyl acetate 446.59
    THF 937.71
    2-butanone 495.08
    n-pentanol 499.75
    sec-butanol 660.98
    n-hexane 66.3
    ethylene glycol 419.98
    NMP 1285.22
    cyclohexane 92.38
    DMSO 1542.81
    n-butyl acetate 264.41
    n-octanol 251.55
    chloroform 1344.06
    n-propyl acetate 259.47
    acetic acid 2081.86
    dichloromethane 1440.23
    cyclohexanone 718.39
    propylene glycol 508.61
    isopropyl acetate 226.98
    DMAc 1060.48
    2-ethoxyethanol 591.06
    isopentanol 377.68
    n-heptane 32.2
    ethyl formate 478.59
    1,2-dichloroethane 685.07
    n-hexanol 309.65
    2-methoxyethanol 1088.94
    isobutyl acetate 150.85
    tetrachloromethane 139.44
    n-pentyl acetate 244.07
    transcutol 738.54
    n-heptanol 176.56
    ethylbenzene 118.29
    MIBK 197.93
    2-propoxyethanol 472.4
    tert-butanol 662.52
    MTBE 292.38
    2-butoxyethanol 285.25
    propionic acid 947.51
    o-xylene 122.43
    formic acid 871.09
    diethyl ether 337.77
    m-xylene 104.05
    p-xylene 175.67
    chlorobenzene 407.48
    dimethyl carbonate 188.09
    n-octane 21.94
    formamide 770.44
    cyclopentanone 876.05
    2-pentanone 367.04
    anisole 250.26
    cyclopentyl methyl ether 323.61
    gamma-butyrolactone 1145.75
    1-methoxy-2-propanol 685.54
    pyridine 818.13
    3-pentanone 280.7
    furfural 1129.48
    n-dodecane 24.84
    diethylene glycol 413.54
    diisopropyl ether 78.35
    tert-amyl alcohol 521.47
    acetylacetone 376.76
    n-hexadecane 27.03
    acetophenone 292.32
    methyl propionate 361.55
    isopentyl acetate 198.1
    trichloroethylene 1255.64
    n-nonanol 200.0
    cyclohexanol 483.25
    benzyl alcohol 324.79
    2-ethylhexanol 161.21
    isooctanol 136.76
    dipropyl ether 144.09
    1,2-dichlorobenzene 363.43
    ethyl lactate 205.37
    propylene carbonate 618.77
    n-methylformamide 1062.36
    2-pentanol 348.37
    n-pentane 62.74
    1-propoxy-2-propanol 316.26
    1-methoxy-2-propyl acetate 220.21
    2-(2-methoxypropoxy) propanol 255.31
    mesitylene 71.88
    ε-caprolactone 628.12
    p-cymene 73.24
    epichlorohydrin 904.85
    1,1,1-trichloroethane 453.93
    2-aminoethanol 669.37
    morpholine-4-carbaldehyde 961.92
    sulfolane 1364.14
    2,2,4-trimethylpentane 33.24
    2-methyltetrahydrofuran 617.1
    n-hexyl acetate 388.22
    isooctane 20.76
    2-(2-butoxyethoxy)ethanol 351.88
    sec-butyl acetate 151.62
    tert-butyl acetate 206.38
    decalin 43.59
    glycerin 631.23
    diglyme 559.11
    acrylic acid 1032.28
    isopropyl myristate 125.26
    n-butyric acid 889.79
    acetyl acetate 286.1
    di(2-ethylhexyl) phthalate 161.94
    ethyl propionate 244.83
    nitromethane 1760.58
    1,2-diethoxyethane 250.53
    benzonitrile 514.25
    trioctyl phosphate 120.18
    1-bromopropane 423.13
    gamma-valerolactone 1084.19
    n-decanol 141.66
    triethyl phosphate 114.36
    4-methyl-2-pentanol 161.87
    propionitrile 604.71
    vinylene carbonate 716.86
    1,1,2-trichlorotrifluoroethane 863.13
    DMS 250.31
    cumene 89.91
    2-octanol 158.61
    2-hexanone 279.63
    octyl acetate 190.46
    limonene 106.75
    1,2-dimethoxyethane 762.43
    ethyl orthosilicate 101.57
    tributyl phosphate 142.63
    diacetone alcohol 300.19
    N,N-dimethylaniline 206.78
    acrylonitrile 915.96
    aniline 335.37
    1,3-propanediol 718.58
    bromobenzene 365.82
    dibromomethane 876.49
    1,1,2,2-tetrachloroethane 973.96
    2-methyl-cyclohexyl acetate 163.69
    tetrabutyl urea 189.73
    diisobutyl methanol 84.89
    2-phenylethanol 230.82
    styrene 170.63
    dioctyl adipate 191.25
    dimethyl sulfate 368.68
    ethyl butyrate 195.7
    methyl lactate 309.71
    butyl lactate 228.79
    diethyl carbonate 149.26
    propanediol butyl ether 366.89
    triethyl orthoformate 137.15
    p-tert-butyltoluene 68.85
    methyl 4-tert-butylbenzoate 265.32
    morpholine 906.66
    tert-butylamine 386.56
    n-dodecanol 109.58
    dimethoxymethane 556.3
    ethylene carbonate 515.56
    cyrene 280.3
    2-ethoxyethyl acetate 261.51
    2-ethylhexyl acetate 151.12
    1,2,4-trichlorobenzene 420.24
    4-methylpyridine 718.52
    dibutyl ether 195.54
    2,6-dimethyl-4-heptanol 84.89
    DEF 560.73
    dimethyl isosorbide 348.12
    tetrachloroethylene 596.51
    eugenol 283.66
    triacetin 314.67
    span 80 302.45
    1,4-butanediol 360.95
    1,1-dichloroethane 646.42
    2-methyl-1-pentanol 340.24
    methyl formate 720.14
    2-methyl-1-butanol 416.28
    n-decane 36.19
    butyronitrile 598.72
    3,7-dimethyl-1-octanol 186.13
    1-chlorooctane 137.92
    1-chlorotetradecane 59.08
    n-nonane 36.05
    undecane 28.68
    tert-butylcyclohexane 40.06
    cyclooctane 24.16
    cyclopentanol 656.88
    tetrahydropyran 656.45
    tert-amyl methyl ether 230.49
    2,5,8-trioxanonane 405.59
    1-hexene 227.07
    2-isopropoxyethanol 325.91
    2,2,2-trifluoroethanol 468.7
    methyl butyrate 380.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction