Carbamic Acid

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  • Identifiers

    CAS number
    463-77-4

    Molecular formula
    CH3NO2

    SMILES
    C(=O)(N)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 77.57%
    Sour 39.79%
    Cheesy 31.42%
    Sharp 23.62%
    Sulfurous 22.99%
    Meaty 21.36%
    Savory 19.49%
    Pungent 18.95%
    Sweaty 17.38%
    Cooked 16.74%

     

    Flavor
    Odorless 71.77%
    Sour 48.46%
    Vinegar 40.6%
    Pungent 36.65%
    Acidic 29.41%
    Sharp 25.64%
    Rancid 25.58%
    Formyl 23.76%
    Bland 23.23%
    Soy 22.28%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.8

    pKa est.
    10.44 (weak base)

    Molecular weight
    61.04 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    254°C

    Flash point

    • 143.56 ˚C est.

  • Synonyms

    • CARBAMIC ACID
    • Aminoformic acid
    • 463-77-4
    • O0UC6XOS4H
    • DTXSID5048009
    • CHEBI:28616
    • azaniumylformate
    • hydron;carbamate
    • RefChem:123374
    • carbamic acid, calcium salt
    • carbamic acid, potassium salt
    • DTXCID5027986
    • imidocarbonic acid
    • aminocarboxylic acid
    • Aminoameisensaeure
    • Aminomethanoic Acid
    • UNII-O0UC6XOS4H
    • Aminoformate
    • Carbamidsaeure
    • ammoniocarboxylate
    • Carbonimidic acid
    • ISOCARBAMIC ACID
    • SCHEMBL2
    • azanium carbamate hydrate
    • IMINOCARBONIC ACID
    • FORMIC ACID, AMINO-
    • SCHEMBL28565
    • SCHEMBL43458
    • SCHEMBL316538
    • SCHEMBL992286
    • CHEMBL125278
    • SCHEMBL3754344
    • SCHEMBL29391704
    • BDBM50369454
    • AKOS006223007
    • DB04261
    • NCGC00166327-01
    • NS00003466
    • C01563
    • EN300-379173
    • Q412078
    • VQO
    • 463-77-4

  • Applications

    Carbamic acid (CAS 463-77-4) is primarily used as a reactive intermediate to prepare carbamate derivatives. In the polymer and plastics industries, it provides routes to urethane-containing monomers and crosslinkers used in polyurethane formulations. In organic synthesis, it acts as a building block and a source for carbamate protecting groups (for example Boc-type protections of amines) in multi-step sequences. In pharmaceuticals, it is evaluated as an intermediate for carbamate-containing drug candidates and related scaffolds. In agrochemicals, its derivatives serve as precursors to carbamate-based pesticides and related agents. In research contexts, it is involved in studies of amine–CO2–carbamate equilibria and urethane formation chemistry, with use always subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 17.5
    methanol 47.97
    isopropanol 8.73
    water 263.62
    ethyl acetate 3.92
    n-propanol 8.32
    acetone 16.63
    n-butanol 4.99
    acetonitrile 7.79
    DMF 251.65
    toluene 0.51
    isobutanol 5.28
    1,4-dioxane 17.54
    methyl acetate 8.48
    THF 20.25
    2-butanone 5.71
    n-pentanol 3.56
    sec-butanol 4.15
    n-hexane 0.31
    ethylene glycol 76.88
    NMP 76.15
    cyclohexane 0.21
    DMSO 78.12
    n-butyl acetate 3.33
    n-octanol 1.88
    chloroform 0.43
    n-propyl acetate 4.19
    acetic acid 36.17
    dichloromethane 0.72
    cyclohexanone 5.28
    propylene glycol 42.55
    isopropyl acetate 2.9
    DMAc 118.76
    2-ethoxyethanol 30.57
    isopentanol 3.59
    n-heptane 0.36
    ethyl formate 12.39
    1,2-dichloroethane 0.83
    n-hexanol 2.76
    2-methoxyethanol 72.94
    isobutyl acetate 2.74
    tetrachloromethane 0.32
    n-pentyl acetate 2.47
    transcutol 23.25
    n-heptanol 2.59
    ethylbenzene 0.36
    MIBK 2.98
    2-propoxyethanol 26.99
    tert-butanol 8.13
    MTBE 3.0
    2-butoxyethanol 16.51
    propionic acid 15.39
    o-xylene 0.78
    formic acid 115.82
    diethyl ether 2.7
    m-xylene 0.67
    p-xylene 0.59
    chlorobenzene 0.29
    dimethyl carbonate 17.44
    n-octane 0.14
    formamide 103.16
    cyclopentanone 11.16
    2-pentanone 4.12
    anisole 2.44
    cyclopentyl methyl ether 5.06
    gamma-butyrolactone 21.17
    1-methoxy-2-propanol 38.94
    pyridine 3.83
    3-pentanone 3.13
    furfural 28.12
    n-dodecane 0.12
    diethylene glycol 51.77
    diisopropyl ether 0.91
    tert-amyl alcohol 4.58
    acetylacetone 8.9
    n-hexadecane 0.12
    acetophenone 3.21
    methyl propionate 7.93
    isopentyl acetate 2.41
    trichloroethylene 0.89
    n-nonanol 1.83
    cyclohexanol 2.62
    benzyl alcohol 3.44
    2-ethylhexanol 1.53
    isooctanol 1.94
    dipropyl ether 3.16
    1,2-dichlorobenzene 0.32
    ethyl lactate 11.13
    propylene carbonate 11.21
    n-methylformamide 88.96
    2-pentanol 2.48
    n-pentane 0.27
    1-propoxy-2-propanol 14.29
    1-methoxy-2-propyl acetate 8.06
    2-(2-methoxypropoxy) propanol 14.07
    mesitylene 0.6
    ε-caprolactone 7.28
    p-cymene 0.57
    epichlorohydrin 9.11
    1,1,1-trichloroethane 0.42
    2-aminoethanol 53.35
    morpholine-4-carbaldehyde 85.21
    sulfolane 30.45
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 5.59
    n-hexyl acetate 2.62
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 16.2
    sec-butyl acetate 2.05
    tert-butyl acetate 3.47
    decalin 0.15
    glycerin 109.86
    diglyme 34.2
    acrylic acid 25.43
    isopropyl myristate 1.23
    n-butyric acid 8.53
    acetyl acetate 3.5
    di(2-ethylhexyl) phthalate 2.91
    ethyl propionate 4.35
    nitromethane 60.88
    1,2-diethoxyethane 4.2
    benzonitrile 1.8
    trioctyl phosphate 2.15
    1-bromopropane 0.38
    gamma-valerolactone 35.69
    n-decanol 1.43
    triethyl phosphate 3.02
    4-methyl-2-pentanol 1.73
    propionitrile 3.86
    vinylene carbonate 11.1
    1,1,2-trichlorotrifluoroethane 23.33
    DMS 5.17
    cumene 0.45
    2-octanol 1.3
    2-hexanone 3.1
    octyl acetate 1.97
    limonene 0.71
    1,2-dimethoxyethane 41.63
    ethyl orthosilicate 2.7
    tributyl phosphate 2.32
    diacetone alcohol 9.57
    N,N-dimethylaniline 3.28
    acrylonitrile 7.85
    aniline 2.18
    1,3-propanediol 33.76
    bromobenzene 0.15
    dibromomethane 0.35
    1,1,2,2-tetrachloroethane 1.03
    2-methyl-cyclohexyl acetate 2.45
    tetrabutyl urea 4.37
    diisobutyl methanol 1.17
    2-phenylethanol 2.68
    styrene 0.37
    dioctyl adipate 2.86
    dimethyl sulfate 33.44
    ethyl butyrate 3.38
    methyl lactate 25.92
    butyl lactate 6.63
    diethyl carbonate 3.17
    propanediol butyl ether 17.64
    triethyl orthoformate 3.71
    p-tert-butyltoluene 0.61
    methyl 4-tert-butylbenzoate 6.65
    morpholine 22.35
    tert-butylamine 3.17
    n-dodecanol 1.12
    dimethoxymethane 49.7
    ethylene carbonate 8.9
    cyrene 19.59
    2-ethoxyethyl acetate 4.89
    2-ethylhexyl acetate 1.78
    1,2,4-trichlorobenzene 0.46
    4-methylpyridine 3.73
    dibutyl ether 1.24
    2,6-dimethyl-4-heptanol 1.17
    DEF 15.8
    dimethyl isosorbide 17.01
    tetrachloroethylene 0.95
    eugenol 10.51
    triacetin 6.29
    span 80 9.87
    1,4-butanediol 17.34
    1,1-dichloroethane 0.51
    2-methyl-1-pentanol 2.34
    methyl formate 71.38
    2-methyl-1-butanol 3.48
    n-decane 0.16
    butyronitrile 2.96
    3,7-dimethyl-1-octanol 1.32
    1-chlorooctane 0.33
    1-chlorotetradecane 0.21
    n-nonane 0.15
    undecane 0.13
    tert-butylcyclohexane 0.17
    cyclooctane 0.15
    cyclopentanol 5.75
    tetrahydropyran 3.98
    tert-amyl methyl ether 2.78
    2,5,8-trioxanonane 25.81
    1-hexene 0.59
    2-isopropoxyethanol 14.27
    2,2,2-trifluoroethanol 36.49
    methyl butyrate 6.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction