Cannabigerol

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  • Identifiers

    CAS number
    25654-31-3

    Molecular formula
    C21H32O2

    SMILES
    CCCCCC1=CC(=C(C(=C1)O)C/C=C(\C)/CCC=C(C)C)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fruity 42.68%
    Floral 39.7%
    Spicy 39.46%
    Woody 33.31%
    Balsamic 32.4%
    Waxy 25.38%
    Phenolic 24.89%
    Sweet 22.2%
    Dry 21.83%
    Animal 21.62%

     

    Flavor
    Woody 40.15%
    Herbal 32.37%
    Wood 28.9%
    Spice 28.85%
    Spicy 28.67%
    Balsam 28.07%
    Mild 25.81%
    Floral 23.0%
    Flower 22.97%
    Diterpene 22.45%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.4

    pKa est.
    10.32 (weak base)

    Molecular weight
    316.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    409°C

    Flash point

    • 181.51 ˚C est.

  • Synonyms

    • Cannabigerol
    • 25654-31-3
    • 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentylbenzene-1,3-diol
    • J1K406072N
    • CHEBI:69477
    • DTXSID701014168
    • 2-((2E)-3,7-Dimethylocta-2,6-dienyl)-5-pentylbenzene-1,3-diol
    • RefChem:123226
    • DTXCID001436709
    • 846-444-6
    • 875-470-0
    • Cannabigerol (CBG)
    • CHEMBL497318
    • 2808-33-5
    • 1,3-Benzenediol, 2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-, (E)-
    • 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-5-pentylbenzene-1,3-diol
    • CBG
    • (E)-2-(3,7-dimethylocta-2,6-dien-1-yl)-5-pentylbenzene-1,3-diol
    • 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol
    • geranylolivetol
    • UNII-J1K406072N
    • SCHEMBL144819
    • orb1297435
    • GTPL11094
    • Resorcinol, 2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-
    • (E)-2-(3,7-Dimethyl-2,6-octadienyl)-5-pentyl-1,3-benzenediol
    • 1,3-Benzenediol, 2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-
    • EX-A5335
    • BDBM50318487
    • MFCD00869599
    • AKOS024457386
    • DB14734
    • EBC-616702
    • FC42726
    • FC55149
    • FS-9666
    • Cannabigerol (1.0 mg/mL in Methanol)
    • Cannabigerol (CBG), 1mg/ml in Ethanol
    • SY326620
    • DB-250998
    • NS00017925
    • Cannabigerol - 20 mg/ml solution in methanol
    • C20219
    • Cannabigerol (CBG) 100 microg/mL in Methanol
    • F70893
    • Cannabigerol (CBG) 1000 microg/mL in Methanol
    • Cannabigerol (CBG) 250 microg/mL in Acetonitrile
    • Q412122
    • (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-resorcinol
    • 2-[(2E)-3,7-Dimethyl-2,6-octadienyl]-5-pentyl-1,3-benzenediol #
    • RESORCINOL, 2-(3,7-DIMETHYL-2,6-OCTADIENYL)-5-PENTYL-, (E)-
    • 1,3-BENZENEDIOL, 2-((2E)-3,7-DIMETHYL-2,6-OCTADIEN-1-YL)-5-PENTYL-
    • 25654-31-3

  • Applications

    Cannabigerol (CAS 25654-31-3) is used primarily as a chemical intermediate and research reference in cannabinoid synthesis, supporting laboratory development of related cannabinoids and analytical method development. It is commonly evaluated as a non-psychoactive cannabinoid ingredient in cosmetics and personal care formulations, where it can contribute to formulation performance without therapeutic claims. In pharmaceutical research, CBG is used as a substrate and analytical standard for assay development and structure-activity investigations under appropriate regulatory controls. It serves as a reference material for cannabinoid profiling in analytical laboratories, aiding quality control and regulatory submissions. In plant science and cannabis-breeding programs, CBG is studied to understand cannabinoid biosynthesis pathways and to inform selection and processing strategies for cannabinoid-rich extracts.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1941.27
    methanol 987.19
    isopropanol 1107.32
    water 0.02
    ethyl acetate 2051.66
    n-propanol 1520.62
    acetone 1971.95
    n-butanol 1448.08
    acetonitrile 332.31
    DMF 1070.12
    toluene 507.99
    isobutanol 801.15
    1,4-dioxane 1935.99
    methyl acetate 966.94
    THF 3915.02
    2-butanone 1943.72
    n-pentanol 683.32
    sec-butanol 1031.07
    n-hexane 42.37
    ethylene glycol 17.59
    NMP 685.68
    cyclohexane 82.67
    DMSO 1102.49
    n-butyl acetate 899.61
    n-octanol 193.42
    chloroform 1041.94
    n-propyl acetate 751.25
    acetic acid 321.03
    dichloromethane 1111.55
    cyclohexanone 1573.16
    propylene glycol 110.68
    isopropyl acetate 1062.09
    DMAc 1097.23
    2-ethoxyethanol 806.21
    isopentanol 965.96
    n-heptane 28.21
    ethyl formate 405.23
    1,2-dichloroethane 960.44
    n-hexanol 642.7
    2-methoxyethanol 1629.73
    isobutyl acetate 452.35
    tetrachloromethane 112.59
    n-pentyl acetate 513.36
    transcutol 3639.07
    n-heptanol 246.74
    ethylbenzene 168.11
    MIBK 773.29
    2-propoxyethanol 1149.82
    tert-butanol 1064.06
    MTBE 1707.79
    2-butoxyethanol 547.32
    propionic acid 324.97
    o-xylene 178.4
    formic acid 45.44
    diethyl ether 2219.71
    m-xylene 254.55
    p-xylene 206.65
    chlorobenzene 404.17
    dimethyl carbonate 232.08
    n-octane 10.24
    formamide 137.82
    cyclopentanone 1654.58
    2-pentanone 1845.81
    anisole 466.17
    cyclopentyl methyl ether 1346.7
    gamma-butyrolactone 1133.91
    1-methoxy-2-propanol 1381.58
    pyridine 1174.81
    3-pentanone 970.6
    furfural 571.68
    n-dodecane 8.1
    diethylene glycol 344.21
    diisopropyl ether 367.88
    tert-amyl alcohol 880.53
    acetylacetone 1293.9
    n-hexadecane 9.88
    acetophenone 337.85
    methyl propionate 1042.08
    isopentyl acetate 832.38
    trichloroethylene 1351.15
    n-nonanol 193.05
    cyclohexanol 676.48
    benzyl alcohol 305.66
    2-ethylhexanol 316.68
    isooctanol 218.55
    dipropyl ether 664.95
    1,2-dichlorobenzene 269.1
    ethyl lactate 192.13
    propylene carbonate 518.05
    n-methylformamide 387.13
    2-pentanol 803.97
    n-pentane 42.75
    1-propoxy-2-propanol 888.37
    1-methoxy-2-propyl acetate 908.41
    2-(2-methoxypropoxy) propanol 475.14
    mesitylene 135.03
    ε-caprolactone 1102.35
    p-cymene 103.91
    epichlorohydrin 2060.17
    1,1,1-trichloroethane 659.38
    2-aminoethanol 169.99
    morpholine-4-carbaldehyde 950.6
    sulfolane 972.08
    2,2,4-trimethylpentane 31.14
    2-methyltetrahydrofuran 2542.24
    n-hexyl acetate 629.15
    isooctane 25.42
    2-(2-butoxyethoxy)ethanol 850.77
    sec-butyl acetate 555.16
    tert-butyl acetate 1011.92
    decalin 34.69
    glycerin 123.77
    diglyme 1587.73
    acrylic acid 146.78
    isopropyl myristate 198.34
    n-butyric acid 993.93
    acetyl acetate 530.32
    di(2-ethylhexyl) phthalate 150.54
    ethyl propionate 629.28
    nitromethane 722.53
    1,2-diethoxyethane 1520.68
    benzonitrile 288.52
    trioctyl phosphate 116.08
    1-bromopropane 656.1
    gamma-valerolactone 1926.52
    n-decanol 128.82
    triethyl phosphate 164.05
    4-methyl-2-pentanol 342.8
    propionitrile 412.74
    vinylene carbonate 343.02
    1,1,2-trichlorotrifluoroethane 607.51
    DMS 344.59
    cumene 104.65
    2-octanol 158.12
    2-hexanone 775.26
    octyl acetate 264.69
    limonene 199.41
    1,2-dimethoxyethane 1603.43
    ethyl orthosilicate 194.92
    tributyl phosphate 151.47
    diacetone alcohol 877.79
    N,N-dimethylaniline 245.54
    acrylonitrile 319.39
    aniline 532.8
    1,3-propanediol 511.18
    bromobenzene 405.91
    dibromomethane 668.25
    1,1,2,2-tetrachloroethane 1134.59
    2-methyl-cyclohexyl acetate 355.19
    tetrabutyl urea 191.05
    diisobutyl methanol 164.35
    2-phenylethanol 371.7
    styrene 220.15
    dioctyl adipate 278.72
    dimethyl sulfate 273.18
    ethyl butyrate 560.51
    methyl lactate 236.09
    butyl lactate 302.63
    diethyl carbonate 266.44
    propanediol butyl ether 385.04
    triethyl orthoformate 365.27
    p-tert-butyltoluene 112.09
    methyl 4-tert-butylbenzoate 323.83
    morpholine 3169.15
    tert-butylamine 550.38
    n-dodecanol 88.06
    dimethoxymethane 1639.76
    ethylene carbonate 366.94
    cyrene 282.7
    2-ethoxyethyl acetate 769.4
    2-ethylhexyl acetate 605.34
    1,2,4-trichlorobenzene 355.03
    4-methylpyridine 1157.13
    dibutyl ether 414.48
    2,6-dimethyl-4-heptanol 164.35
    DEF 1261.66
    dimethyl isosorbide 766.62
    tetrachloroethylene 538.36
    eugenol 292.48
    triacetin 438.22
    span 80 402.4
    1,4-butanediol 99.44
    1,1-dichloroethane 895.37
    2-methyl-1-pentanol 562.74
    methyl formate 214.75
    2-methyl-1-butanol 843.11
    n-decane 16.76
    butyronitrile 698.68
    3,7-dimethyl-1-octanol 234.61
    1-chlorooctane 128.06
    1-chlorotetradecane 38.94
    n-nonane 14.99
    undecane 11.06
    tert-butylcyclohexane 37.0
    cyclooctane 21.53
    cyclopentanol 558.69
    tetrahydropyran 3242.3
    tert-amyl methyl ether 858.7
    2,5,8-trioxanonane 882.87
    1-hexene 266.76
    2-isopropoxyethanol 587.54
    2,2,2-trifluoroethanol 47.63
    methyl butyrate 790.3

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction