Camphoric Acid

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  • Identifiers

    CAS number
    5394-83-2

    Molecular formula
    C10H16O4

    SMILES
    C[C@]1(CC[C@@H](C1(C)C)C(=O)O)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 37.16%
    Odorless 33.78%
    Herbal 32.44%
    Mint 31.29%
    Sour 30.62%
    Dry 26.61%
    Cooling 24.79%
    Woody 23.41%
    Spicy 22.76%
    Camphoreous 22.22%

     

    Flavor
    Fruity 43.6%
    Odorless 31.2%
    Sour 30.78%
    Cheese 24.94%
    Berry 24.53%
    Mild 22.31%
    Sweet 22.27%
    Stinky 22.22%
    Roquefort cheese 22.04%
    Molasses 21.23%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    5.62 (weak acid)

    Molecular weight
    200.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    344°C

    Flash point

    • 168.48 ˚C est.

  • Synonyms

    • 5394-83-2
    • 32K0C7JGCJ
    • 1,2,2-TRIMETHYL-1,3-CYCLOPENTANECARBOXYLIC ACID
    • NSC-60219
    • NSC-174634
    • Camphoric Acid, DlL-
    • RefChem:56900
    • 226-404-9
    • 1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid
    • Camphoric Acid
    • 124-83-4
    • d-Camphoric acid
    • D-(+)-Camphoric acid
    • (1R,3S)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid
    • (1R,3S)-(+)-Camphoric acid
    • (1R,3S)-camphoric acid
    • DL-CAMPHORIC ACID
    • MFCD00001375
    • 1,3-Cyclopentanedicarboxylic acid, 1,2,2-trimethyl-, (1R,3S)-
    • 17839-62-2
    • Levocarnitine EP Impurity B
    • Camphoric acid, (+)-
    • W77RM1CSD5
    • (1R,3S)-1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acid
    • dextrocamphoric acid
    • 1,3-Cyclopentanedicarboxylic acid, 1,2,2-trimethyl-, (1R,3S)-rel-
    • cis-1,2,2-Trimethylcyclopentane-1,3-dicarboxylicacid
    • 1,3-Cyclopentanedicarboxylic acid, 1,2,2-trimethyl-, (1R-cis)-
    • Camphoric acid, dl-
    • Levocarnitine Impurity B
    • UNII-W77RM1CSD5
    • d-Camphersaure
    • EINECS 204-715-0
    • (+-)-Camphersaeure
    • (?)-Camphoric acid
    • Camphor EP Impurity B
    • Camphoric acid [USP]
    • D-CamphersA currencyure
    • D-( )-Camphoric acid
    • AI3-18160
    • Levocarnitine Impurity 2
    • UNII-32K0C7JGCJ
    • CAMPHORIC ACID, D-
    • CAMPHORIC ACID [MI]
    • SCHEMBL52395
    • CAMPHORIC ACID D-FORM
    • CAMPHORIC ACID [WHO-DD]
    • SCHEMBL30078310
    • (+)-(1R,3S)-camphoric acid
    • CAMPHORICUM ACIDUM [HPUS]
    • DTXSID60883316
    • CHEBI:172083
    • DTXSID301021163
    • 1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acid, (1R-cis)-
    • CAMPHORIC ACID D-FORM [MI]
    • CAMPHORIC ACID, (+/-)-
    • STR02800
    • EINECS 226-404-9
    • SBB057929
    • CAMPHORIC ACID 1-METHYL ESTER
    • AKOS015960508
    • CS-W015618
    • FC61020
    • NSC 174634
    • (1R,3S)-(+)-Camphoric acid, 99%
    • AC-11594
    • AC-19818
    • SY039357
    • NS00041392
    • Levocarnitine Impurity 30 (D-Camphoric Acid)
    • EN300-1091741
    • (+-)-1,2,2-Trimethyl-1,3-cyclopentandicarbonsaeure
    • 1,3-Cyclopentanedicarboxylic acid, 1,2,2-trimethyl-, cis-
    • 2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane(camphene)
    • (3S,1R)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid
    • (1RS,3SR)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid;(1R,3S)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid/(1S,3R)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid
    • DL-Camphoric Acid; (1RS,3SR)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic Acid; Levocarnitine Imp. B (EP)
    • 5394-83-2

  • Applications

    Camphoric Acid (CAS 5394-83-2) is primarily used as an intermediate in organic synthesis, serving as a scaffold for chiral transformations and as a resolving agent to access defined stereoisomers in pharmaceutical and chemical manufacturing; it also acts as a precursor for camphor-derived ligands and catalysts used in asymmetric synthesis; in the polymer and plastics sector it is employed as a diacid building block for specialty polyesters and functional resins; in pharmaceutical and agrochemical production it is commonly used as an intermediate to access complex molecules; and in some industrial formulations it may function as a potential chelating agent or formulation additive, depending on conditions and regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 345.4
    methanol 776.02
    isopropanol 227.05
    water 29.8
    ethyl acetate 156.91
    n-propanol 193.95
    acetone 400.5
    n-butanol 142.63
    acetonitrile 152.21
    DMF 1365.94
    toluene 38.92
    isobutanol 106.58
    1,4-dioxane 860.23
    methyl acetate 155.19
    THF 1327.21
    2-butanone 165.7
    n-pentanol 86.49
    sec-butanol 108.77
    n-hexane 4.69
    ethylene glycol 234.41
    NMP 795.51
    cyclohexane 4.64
    DMSO 999.33
    n-butyl acetate 62.26
    n-octanol 70.37
    chloroform 138.81
    n-propyl acetate 64.14
    acetic acid 257.2
    dichloromethane 201.82
    cyclohexanone 235.53
    propylene glycol 219.62
    isopropyl acetate 101.8
    DMAc 410.6
    2-ethoxyethanol 279.76
    isopentanol 96.45
    n-heptane 5.74
    ethyl formate 143.65
    1,2-dichloroethane 149.49
    n-hexanol 106.18
    2-methoxyethanol 822.41
    isobutyl acetate 34.37
    tetrachloromethane 27.57
    n-pentyl acetate 68.38
    transcutol 338.62
    n-heptanol 75.19
    ethylbenzene 22.7
    MIBK 108.43
    2-propoxyethanol 377.35
    tert-butanol 236.03
    MTBE 85.18
    2-butoxyethanol 175.64
    propionic acid 169.57
    o-xylene 35.29
    formic acid 431.87
    diethyl ether 125.12
    m-xylene 46.92
    p-xylene 33.38
    chlorobenzene 63.23
    dimethyl carbonate 157.7
    n-octane 3.71
    formamide 677.45
    cyclopentanone 563.25
    2-pentanone 170.09
    anisole 86.79
    cyclopentyl methyl ether 236.12
    gamma-butyrolactone 821.5
    1-methoxy-2-propanol 577.63
    pyridine 233.61
    3-pentanone 92.91
    furfural 514.41
    n-dodecane 3.05
    diethylene glycol 407.97
    diisopropyl ether 36.03
    tert-amyl alcohol 107.45
    acetylacetone 293.65
    n-hexadecane 3.46
    acetophenone 90.6
    methyl propionate 174.8
    isopentyl acetate 56.98
    trichloroethylene 245.59
    n-nonanol 64.68
    cyclohexanol 96.92
    benzyl alcohol 96.24
    2-ethylhexanol 41.88
    isooctanol 55.31
    dipropyl ether 51.76
    1,2-dichlorobenzene 62.7
    ethyl lactate 65.39
    propylene carbonate 279.02
    n-methylformamide 627.7
    2-pentanol 85.97
    n-pentane 5.48
    1-propoxy-2-propanol 189.51
    1-methoxy-2-propyl acetate 141.39
    2-(2-methoxypropoxy) propanol 111.08
    mesitylene 34.87
    ε-caprolactone 235.1
    p-cymene 20.25
    epichlorohydrin 706.83
    1,1,1-trichloroethane 87.66
    2-aminoethanol 315.84
    morpholine-4-carbaldehyde 819.61
    sulfolane 853.0
    2,2,4-trimethylpentane 3.74
    2-methyltetrahydrofuran 349.61
    n-hexyl acetate 94.05
    isooctane 4.81
    2-(2-butoxyethoxy)ethanol 184.75
    sec-butyl acetate 40.98
    tert-butyl acetate 121.84
    decalin 4.59
    glycerin 385.34
    diglyme 308.4
    acrylic acid 193.15
    isopropyl myristate 37.63
    n-butyric acid 176.03
    acetyl acetate 106.64
    di(2-ethylhexyl) phthalate 44.64
    ethyl propionate 70.14
    nitromethane 622.36
    1,2-diethoxyethane 100.16
    benzonitrile 76.46
    trioctyl phosphate 40.01
    1-bromopropane 48.66
    gamma-valerolactone 885.89
    n-decanol 45.89
    triethyl phosphate 32.54
    4-methyl-2-pentanol 60.41
    propionitrile 86.12
    vinylene carbonate 243.63
    1,1,2-trichlorotrifluoroethane 318.26
    DMS 96.24
    cumene 19.23
    2-octanol 50.32
    2-hexanone 69.86
    octyl acetate 53.95
    limonene 28.33
    1,2-dimethoxyethane 386.57
    ethyl orthosilicate 30.17
    tributyl phosphate 34.91
    diacetone alcohol 209.49
    N,N-dimethylaniline 64.39
    acrylonitrile 153.83
    aniline 103.02
    1,3-propanediol 353.25
    bromobenzene 50.11
    dibromomethane 95.18
    1,1,2,2-tetrachloroethane 196.15
    2-methyl-cyclohexyl acetate 49.77
    tetrabutyl urea 55.88
    diisobutyl methanol 35.09
    2-phenylethanol 101.47
    styrene 24.43
    dioctyl adipate 52.94
    dimethyl sulfate 321.27
    ethyl butyrate 50.3
    methyl lactate 188.66
    butyl lactate 70.08
    diethyl carbonate 32.7
    propanediol butyl ether 147.68
    triethyl orthoformate 39.87
    p-tert-butyltoluene 24.54
    methyl 4-tert-butylbenzoate 116.51
    morpholine 774.6
    tert-butylamine 96.01
    n-dodecanol 31.34
    dimethoxymethane 735.69
    ethylene carbonate 184.59
    cyrene 176.45
    2-ethoxyethyl acetate 108.8
    2-ethylhexyl acetate 40.61
    1,2,4-trichlorobenzene 82.88
    4-methylpyridine 182.47
    dibutyl ether 38.26
    2,6-dimethyl-4-heptanol 35.09
    DEF 201.36
    dimethyl isosorbide 242.42
    tetrachloroethylene 124.6
    eugenol 110.86
    triacetin 91.97
    span 80 116.2
    1,4-butanediol 106.84
    1,1-dichloroethane 109.53
    2-methyl-1-pentanol 53.0
    methyl formate 503.51
    2-methyl-1-butanol 73.82
    n-decane 5.42
    butyronitrile 88.59
    3,7-dimethyl-1-octanol 46.41
    1-chlorooctane 25.2
    1-chlorotetradecane 9.69
    n-nonane 4.68
    undecane 3.96
    tert-butylcyclohexane 4.65
    cyclooctane 2.86
    cyclopentanol 204.99
    tetrahydropyran 276.45
    tert-amyl methyl ether 63.38
    2,5,8-trioxanonane 212.88
    1-hexene 16.02
    2-isopropoxyethanol 141.59
    2,2,2-trifluoroethanol 172.58
    methyl butyrate 85.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction