Camphanediol

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  • Identifiers

    CAS number
    56614-57-4

    Molecular formula
    C10H18O2

    SMILES
    C[C@@]12CC[C@@H](C1(C)C)[C@H]([C@H]2O)O

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Woody 64.85%
    Camphoreous 61.96%
    Mint 54.14%
    Herbal 52.77%
    Cooling 48.47%
    Pine 45.48%
    Balsamic 43.84%
    Earthy 43.51%
    Sweet 40.73%
    Spicy 40.58%

     

    Flavor
    Herbal 47.26%
    Camphor 45.63%
    Woody 42.82%
    Bitter 41.21%
    Sweet 39.44%
    Pine 38.94%
    Minty 37.75%
    Balsam 36.31%
    Earthy 28.11%
    Earth 27.07%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    7.62 (neutral)

    Molecular weight
    170.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    296°C

    Flash point

    • 103.64 ˚C est.

  • Synonyms

    • Camphanediol
    • UNII-9K7U161D1G
    • 9K7U161D1G
    • DTXSID70205181
    • Bicyclo(2.2.1)heptane-2,3-diol, 1,7,7-trimethyl-, (exo,exo)-
    • Bicyclo(2.2.1)heptane-2,3-diol, 1,7,7-trimethyl-, (1R,2S,3R,4S)-rel-
    • RefChem:123138
    • CAMPHANEDIOL [INCI]
    • DTXCID70127672
    • (+-)-EXO,EXO-2,3-CAMPHANEDIOL
    • 624-106-7
    • 56614-57-4
    • (1R,2S,3R,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptane-2,3-diol
    • (+/-)-exo,exo-2,3-Camphanediol
    • MFCD18974999
    • (1R,2S,3R,4S)-1,7,7-Trimethylnorbornane-2,3-diol
    • (+/-)-EXO EXO-2 3-CAMPHANEDIOL 97
    • MFCD07784411
    • 2,3-cis/exo-camphanediol
    • SCHEMBL29761172
    • BBL102909
    • STL556718
    • AKOS015901882
    • BP-30021
    • MS-20520
    • PD063449
    • DB-309639
    • G86153
    • Q27272664
    • 59599-25-6
    • 56614-57-4

  • Applications

    Camphanediol (CAS 56614-57-4) is primarily used as a chiral building block and auxiliary in asymmetric synthesis, enabling the preparation of enantioenriched intermediates for pharmaceutical and agrochemical development. It serves as a precursor for camphor-derived chiral ligands and organocatalysts that facilitate enantioselective transformations. It also functions as a rigid diol building block for the synthesis of specialty polymers and coatings, providing defined stereochemistry for crosslinking in polyurethanes and epoxy resins. In synthetic workflows, camphanediol is often evaluated as a camphor-based chiral scaffold useful in the preparation of fine chemical and pharmaceutical intermediates, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 239.64
    methanol 411.15
    isopropanol 162.86
    water 71.82
    ethyl acetate 129.04
    n-propanol 161.87
    acetone 153.7
    n-butanol 130.29
    acetonitrile 148.91
    DMF 175.42
    toluene 33.1
    isobutanol 101.39
    1,4-dioxane 394.91
    methyl acetate 115.32
    THF 508.24
    2-butanone 92.45
    n-pentanol 64.45
    sec-butanol 89.35
    n-hexane 7.61
    ethylene glycol 170.17
    NMP 112.82
    cyclohexane 13.64
    DMSO 254.82
    n-butyl acetate 83.59
    n-octanol 63.05
    chloroform 216.8
    n-propyl acetate 63.23
    acetic acid 248.22
    dichloromethane 174.69
    cyclohexanone 119.0
    propylene glycol 107.19
    isopropyl acetate 107.74
    DMAc 102.67
    2-ethoxyethanol 197.45
    isopentanol 102.04
    n-heptane 12.68
    ethyl formate 106.34
    1,2-dichloroethane 115.4
    n-hexanol 116.17
    2-methoxyethanol 414.26
    isobutyl acetate 46.01
    tetrachloromethane 78.35
    n-pentyl acetate 64.02
    transcutol 381.62
    n-heptanol 85.14
    ethylbenzene 25.61
    MIBK 93.49
    2-propoxyethanol 289.4
    tert-butanol 165.51
    MTBE 101.78
    2-butoxyethanol 168.47
    propionic acid 126.01
    o-xylene 36.65
    formic acid 355.87
    diethyl ether 131.58
    m-xylene 43.29
    p-xylene 43.35
    chlorobenzene 57.48
    dimethyl carbonate 71.14
    n-octane 7.59
    formamide 447.41
    cyclopentanone 185.24
    2-pentanone 100.5
    anisole 70.52
    cyclopentyl methyl ether 137.47
    gamma-butyrolactone 257.81
    1-methoxy-2-propanol 307.46
    pyridine 113.95
    3-pentanone 66.06
    furfural 200.79
    n-dodecane 4.71
    diethylene glycol 299.56
    diisopropyl ether 57.05
    tert-amyl alcohol 97.39
    acetylacetone 160.33
    n-hexadecane 5.31
    acetophenone 65.45
    methyl propionate 97.85
    isopentyl acetate 81.19
    trichloroethylene 192.87
    n-nonanol 59.91
    cyclohexanol 79.15
    benzyl alcohol 61.32
    2-ethylhexanol 57.77
    isooctanol 67.91
    dipropyl ether 77.67
    1,2-dichlorobenzene 64.64
    ethyl lactate 52.76
    propylene carbonate 129.9
    n-methylformamide 211.64
    2-pentanol 82.99
    n-pentane 11.61
    1-propoxy-2-propanol 178.63
    1-methoxy-2-propyl acetate 153.64
    2-(2-methoxypropoxy) propanol 113.13
    mesitylene 37.27
    ε-caprolactone 126.63
    p-cymene 33.42
    epichlorohydrin 248.99
    1,1,1-trichloroethane 116.65
    2-aminoethanol 223.74
    morpholine-4-carbaldehyde 219.12
    sulfolane 212.77
    2,2,4-trimethylpentane 8.08
    2-methyltetrahydrofuran 183.52
    n-hexyl acetate 79.32
    isooctane 10.93
    2-(2-butoxyethoxy)ethanol 167.58
    sec-butyl acetate 49.47
    tert-butyl acetate 133.48
    decalin 9.75
    glycerin 211.33
    diglyme 281.86
    acrylic acid 125.52
    isopropyl myristate 35.98
    n-butyric acid 147.76
    acetyl acetate 106.5
    di(2-ethylhexyl) phthalate 37.7
    ethyl propionate 63.9
    nitromethane 348.6
    1,2-diethoxyethane 125.39
    benzonitrile 60.38
    trioctyl phosphate 33.56
    1-bromopropane 52.27
    gamma-valerolactone 272.63
    n-decanol 43.15
    triethyl phosphate 41.23
    4-methyl-2-pentanol 68.59
    propionitrile 90.66
    vinylene carbonate 120.23
    1,1,2-trichlorotrifluoroethane 207.81
    DMS 78.08
    cumene 27.64
    2-octanol 51.93
    2-hexanone 53.64
    octyl acetate 43.08
    limonene 37.47
    1,2-dimethoxyethane 223.99
    ethyl orthosilicate 44.57
    tributyl phosphate 33.09
    diacetone alcohol 148.52
    N,N-dimethylaniline 50.67
    acrylonitrile 114.68
    aniline 78.22
    1,3-propanediol 267.18
    bromobenzene 47.98
    dibromomethane 107.58
    1,1,2,2-tetrachloroethane 154.31
    2-methyl-cyclohexyl acetate 60.53
    tetrabutyl urea 39.67
    diisobutyl methanol 51.95
    2-phenylethanol 102.24
    styrene 24.59
    dioctyl adipate 43.54
    dimethyl sulfate 108.38
    ethyl butyrate 67.43
    methyl lactate 95.6
    butyl lactate 67.49
    diethyl carbonate 49.89
    propanediol butyl ether 110.58
    triethyl orthoformate 61.05
    p-tert-butyltoluene 37.04
    methyl 4-tert-butylbenzoate 97.59
    morpholine 329.47
    tert-butylamine 102.4
    n-dodecanol 30.83
    dimethoxymethane 243.95
    ethylene carbonate 111.76
    cyrene 87.2
    2-ethoxyethyl acetate 106.09
    2-ethylhexyl acetate 56.16
    1,2,4-trichlorobenzene 73.15
    4-methylpyridine 79.95
    dibutyl ether 44.74
    2,6-dimethyl-4-heptanol 51.95
    DEF 86.09
    dimethyl isosorbide 187.61
    tetrachloroethylene 150.19
    eugenol 100.98
    triacetin 83.07
    span 80 91.99
    1,4-butanediol 84.69
    1,1-dichloroethane 102.49
    2-methyl-1-pentanol 50.16
    methyl formate 173.75
    2-methyl-1-butanol 76.72
    n-decane 8.73
    butyronitrile 86.68
    3,7-dimethyl-1-octanol 54.94
    1-chlorooctane 28.51
    1-chlorotetradecane 11.45
    n-nonane 7.92
    undecane 6.2
    tert-butylcyclohexane 9.89
    cyclooctane 7.81
    cyclopentanol 120.8
    tetrahydropyran 185.02
    tert-amyl methyl ether 65.74
    2,5,8-trioxanonane 196.99
    1-hexene 20.02
    2-isopropoxyethanol 118.34
    2,2,2-trifluoroethanol 201.62
    methyl butyrate 67.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction