Calcium ascorbate dihydrate

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  • Identifiers

    CAS number
    5743-28-2

    Molecular formula
    C12H18CaO14

    SMILES
    C([C@@H]([C@@H]1C(=C(C(=O)O1)[O-])O)O)O.C([C@@H]([C@@H]1C(=C(C(=O)O1)[O-])O)O)O.O.O.[Ca+2]

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  • Odor profile

    Fragrance
    Odorless 76.05%
    Caramellic 34.23%
    Sweet 26.92%
    Burnt 19.91%
    Clean 18.41%
    Savory 18.02%
    Milky 16.77%
    Buttery 16.71%
    Sharp 16.18%
    Bitter 13.29%

     

    Flavor
    Odorless 48.92%
    Very mild 35.83%
    Bitter 33.31%
    Sweet-like 25.59%
    Bland 24.07%
    Cotton candy 20.02%
    Extremely sweet 19.91%
    Yeast 19.9%
    Seedy 19.9%
    Fenugreek 19.6%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    3.79 (weak acid)

    Molecular weight
    426.34 g/mol

    Flash point

    • 191.85 ˚C est.

  • Synonyms

    • Calcium ascorbate dihydrate
    • CALCIUM ASCORBATE DIHYDRATE [WHO-DD]
    • RefChem:573387
    • 5743-28-2
    • Calcium L-ascorbate dihydrate
    • Calcium ascorbate (USP)
    • Calcium ascorbate [USP]
    • Calcium (R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one salt dihydrate
    • DTXSID3047687
    • Ascorbic acid calcium salt dihydrate
    • calcium;(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-olate;dihydrate
    • Calcium ascorbate [USAN]
    • UNII-183E4W213W
    • SCHEMBL66327
    • Ascorbic acid calcium dihydrate
    • CALCIUM ASCORBATE [II]
    • SCHEMBL2461366
    • CALCIUM ASCORBATE [FCC]
    • CHEMBL3184533
    • DTXCID1027687
    • CALCIUM ASCORBATE [VANDF]
    • XBTRVIGNXIDJBU-FWCDDDAWSA-N
    • CALCIUM ASCORBATE [USP-RS]
    • Tox21_303536
    • Acetic acid, calcium salt, dihydrate
    • FC63873
    • CALCIUM ASCORBATE [EP MONOGRAPH]
    • CALCIUM ASCORBATE [USP MONOGRAPH]
    • NCGC00257476-01
    • E302
    • CAS-5743-28-2
    • D02293
    • D70308
    • Q283033
    • Calcium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate--water (1/2/2)
    • 5743-28-2

  • Applications

    Calcium ascorbate dihydrate (CAS 5743-28-2) is used primarily as a dietary source of calcium and ascorbic acid (vitamin C) in dietary supplements and fortified foods. In food processing it serves as an antioxidant to inhibit oxidation, help retain color, and extend shelf life, and it can function as a curing agent in meat and processed-product formulations. In cosmetics and personal care, the salt provides antioxidant protection and supplies vitamin C and calcium for skin-care formulations. In pharmaceutical and nutraceutical formulations, it acts as a stable vitamin C source and calcium supplement. In polymer and coatings applications, it is evaluated as an antioxidant stabilizer to improve the oxidative stability of formulations and products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 82.92
    methanol 307.28
    isopropanol 27.96
    water 279.31
    ethyl acetate 4.02
    n-propanol 26.79
    acetone 14.78
    n-butanol 17.11
    acetonitrile 6.63
    DMF 390.65
    toluene 1.22
    isobutanol 9.97
    1,4-dioxane 17.76
    methyl acetate 7.07
    THF 23.51
    2-butanone 7.65
    n-pentanol 8.63
    sec-butanol 13.83
    n-hexane 0.21
    ethylene glycol 384.96
    NMP 254.73
    cyclohexane 0.96
    DMSO 1299.01
    n-butyl acetate 2.96
    n-octanol 7.1
    chloroform 0.83
    n-propyl acetate 2.54
    acetic acid 41.72
    dichloromethane 2.37
    cyclohexanone 8.97
    propylene glycol 141.31
    isopropyl acetate 2.85
    DMAc 214.79
    2-ethoxyethanol 97.22
    isopentanol 10.85
    n-heptane 1.08
    ethyl formate 7.97
    1,2-dichloroethane 3.8
    n-hexanol 8.32
    2-methoxyethanol 269.12
    isobutyl acetate 0.92
    tetrachloromethane 0.44
    n-pentyl acetate 3.11
    transcutol 78.58
    n-heptanol 7.91
    ethylbenzene 0.88
    MIBK 4.14
    2-propoxyethanol 47.7
    tert-butanol 27.72
    MTBE 5.06
    2-butoxyethanol 28.46
    propionic acid 17.79
    o-xylene 2.13
    formic acid 440.08
    diethyl ether 4.91
    m-xylene 1.58
    p-xylene 0.89
    chlorobenzene 0.62
    dimethyl carbonate 17.6
    n-octane 0.55
    formamide 469.32
    cyclopentanone 13.89
    2-pentanone 6.0
    anisole 4.02
    cyclopentyl methyl ether 7.8
    gamma-butyrolactone 26.19
    1-methoxy-2-propanol 121.34
    pyridine 8.14
    3-pentanone 4.34
    furfural 37.1
    n-dodecane 0.4
    diethylene glycol 143.91
    diisopropyl ether 1.5
    tert-amyl alcohol 17.86
    acetylacetone 11.58
    n-hexadecane 0.43
    acetophenone 6.52
    methyl propionate 10.5
    isopentyl acetate 2.41
    trichloroethylene 3.13
    n-nonanol 6.42
    cyclohexanol 10.92
    benzyl alcohol 10.24
    2-ethylhexanol 3.81
    isooctanol 5.26
    dipropyl ether 4.37
    1,2-dichlorobenzene 0.98
    ethyl lactate 13.24
    propylene carbonate 8.87
    n-methylformamide 176.62
    2-pentanol 8.49
    n-pentane 0.58
    1-propoxy-2-propanol 24.76
    1-methoxy-2-propyl acetate 10.58
    2-(2-methoxypropoxy) propanol 26.1
    mesitylene 1.32
    ε-caprolactone 11.12
    p-cymene 1.68
    epichlorohydrin 19.78
    1,1,1-trichloroethane 0.58
    2-aminoethanol 220.93
    morpholine-4-carbaldehyde 141.72
    sulfolane 112.28
    2,2,4-trimethylpentane 0.32
    2-methyltetrahydrofuran 9.26
    n-hexyl acetate 4.46
    isooctane 0.2
    2-(2-butoxyethoxy)ethanol 38.33
    sec-butyl acetate 1.4
    tert-butyl acetate 4.71
    decalin 0.32
    glycerin 335.16
    diglyme 62.61
    acrylic acid 33.24
    isopropyl myristate 2.1
    n-butyric acid 10.99
    acetyl acetate 2.95
    di(2-ethylhexyl) phthalate 4.07
    ethyl propionate 3.08
    nitromethane 68.49
    1,2-diethoxyethane 7.14
    benzonitrile 3.04
    trioctyl phosphate 3.92
    1-bromopropane 1.16
    gamma-valerolactone 43.11
    n-decanol 4.92
    triethyl phosphate 3.91
    4-methyl-2-pentanol 4.18
    propionitrile 3.93
    vinylene carbonate 8.43
    1,1,2-trichlorotrifluoroethane 58.5
    DMS 5.68
    cumene 0.85
    2-octanol 4.27
    2-hexanone 2.85
    octyl acetate 3.54
    limonene 2.51
    1,2-dimethoxyethane 44.3
    ethyl orthosilicate 3.31
    tributyl phosphate 2.8
    diacetone alcohol 25.98
    N,N-dimethylaniline 5.9
    acrylonitrile 9.49
    aniline 5.41
    1,3-propanediol 145.59
    bromobenzene 0.42
    dibromomethane 1.26
    1,1,2,2-tetrachloroethane 3.54
    2-methyl-cyclohexyl acetate 3.21
    tetrabutyl urea 7.2
    diisobutyl methanol 3.03
    2-phenylethanol 8.69
    styrene 0.86
    dioctyl adipate 4.39
    dimethyl sulfate 55.23
    ethyl butyrate 3.39
    methyl lactate 51.78
    butyl lactate 7.27
    diethyl carbonate 2.64
    propanediol butyl ether 34.52
    triethyl orthoformate 3.77
    p-tert-butyltoluene 1.81
    methyl 4-tert-butylbenzoate 13.25
    morpholine 36.65
    tert-butylamine 8.2
    n-dodecanol 3.62
    dimethoxymethane 82.26
    ethylene carbonate 5.66
    cyrene 46.22
    2-ethoxyethyl acetate 6.55
    2-ethylhexyl acetate 1.72
    1,2,4-trichlorobenzene 1.58
    4-methylpyridine 5.59
    dibutyl ether 2.37
    2,6-dimethyl-4-heptanol 3.03
    DEF 26.51
    dimethyl isosorbide 33.84
    tetrachloroethylene 3.39
    eugenol 16.13
    triacetin 8.06
    span 80 19.52
    1,4-butanediol 62.62
    1,1-dichloroethane 0.8
    2-methyl-1-pentanol 5.52
    methyl formate 77.87
    2-methyl-1-butanol 9.64
    n-decane 0.62
    butyronitrile 3.07
    3,7-dimethyl-1-octanol 4.13
    1-chlorooctane 1.49
    1-chlorotetradecane 0.74
    n-nonane 0.61
    undecane 0.49
    tert-butylcyclohexane 0.21
    cyclooctane 0.62
    cyclopentanol 13.35
    tetrahydropyran 5.7
    tert-amyl methyl ether 5.76
    2,5,8-trioxanonane 51.9
    1-hexene 0.52
    2-isopropoxyethanol 33.4
    2,2,2-trifluoroethanol 43.92
    methyl butyrate 4.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction